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Grant Details

Grant Number: 5P50CA084718-11 Interpret this number
Primary Investigator: Lerman, Caryn
Organization: University Of Pennsylvania
Project Title: Transdisciplinary Tobacco Use Research Centers
Fiscal Year: 2008
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Abstract

Despite almost two decades of tobacco treatment research, treatment options for smoking cessation remain limited. Over the past 4 years, our TTURC has begun to address this gap in knowledge and practice. In our pharmacogenetic trials of nicotine dependence treatment, we have provided the first evidence for effects of specific genetic variants on smoking cessation and response to pharmacotherapy, generated new data on bio-behavioral mechanisms of response to treatment, developed new tools and applied new methods to analyze smoking cessation clinical trial data, and identified pre-treatment measures that can be used in clinical practice to tailor choice of treatment for individual smokers. In addition, we have completed a national survey of over 1000 physicians in the AMA, and have begun to identify emerging health policy and ethical issues in the translation of our research to clinical practice. A milestone event in the evolution of our TTURC was the move to the University of Pennsylvania in 2001. This move provided new opportunities for transdisciplinary collaboration, an enhanced institutional commitment, and access to state-of-the art facilities for biomedical informatics, genotyping, and animal models research. The mission of this competing renewal application for the Penn TTURC is to translate new discoveries in basic neuroscience, pharmacology, genetics, and behavioral science to improve treatment for nicotine dependence. The specific aims are: (1) To conduct 4 inter-related projects which test new treatments for nicotine dependence and test novel approaches to optimize the use of existing treatments; (2) To support and integrate TTURC research through a state-of-the-art Biomedical Informatics Core and Genetics Core; (3) To facilitate the diffusion and clinical integration of TTURC research through a novel Research to Practice Core which addresses key policy and ethical issues; (4) To train tobacco control scientists through a Training Core; and (5) To coordinate and facilitate transdisciplinary collaboration through an Administrative Core. Spanning from basic animal research to clinical trials ("bench to trench"), the ultimate objective of the TTURC is to develop new treatment models that can be readily translated to the clinical setting in order to maximize the efficacy of pharmacotherapy for individual smokers.

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Publications

Cues must increase smoking behaviour to be clinically relevant.
Authors: Perkins KA
Source: Addiction, 2009 Oct;104(10), p. 1620-2.
EPub date: 2009 Jun 25.
PMID: 19558569
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Dopamine genes and nicotine dependence in treatment-seeking and community smokers.
Authors: Bergen AW, Conti DV, Van Den Berg D, Lee W, Liu J, Li D, Guo N, Mi H, Thomas PD, Lessov-Schlaggar CN, Krasnow R, He Y, Nishita D, Jiang R, McClure JB, Tildesley E, Hops H, Tyndale RF, Benowitz NL, Lerman C, Swan GE
Source: Neuropsychopharmacology, 2009 Sep;34(10), p. 2252-64.
EPub date: 2009 Jun 3.
PMID: 19494806
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Predictors of enrollment in a smoking cessation clinical trial after eligibility screening.
Authors: Dahm JL, Cook E, Baugh K, Wileyto EP, Pinto A, Leone F, Halbert CH, Schnoll RA
Source: J Natl Med Assoc, 2009 May;101(5), p. 450-5.
PMID: 19476198
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Does smoking cue-induced craving tell us anything important about nicotine dependence?
Authors: Perkins KA
Source: Addiction, 2009 Oct;104(10), p. 1610-6.
EPub date: 2009 Apr 29.
PMID: 19426293
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Discriminative stimulus effects of nicotine in humans.
Authors: Perkins KA
Source: Handb Exp Pharmacol, 2009;null(192), p. 369-400.
PMID: 19184656
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Sex differences in nicotine reinforcement and reward: influences on the persistence of tobacco smoking.
Authors: Perkins KA
Source: Nebr Symp Motiv, 2009;55, p. 143-69.
PMID: 19013943
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Time to first cigarette in the morning as an index of ability to quit smoking: implications for nicotine dependence.
Authors: Transdisciplinary Tobacco Use Research Center (TTURC) Tobacco Dependence, Baker TB, Piper ME, McCarthy DE, Bolt DM, Smith SS, Kim SY, Colby S, Conti D, Giovino GA, Hatsukami D, Hyland A, Krishnan-Sarin S, Niaura R, Perkins KA, Toll BA
Source: Nicotine Tob Res, 2007 Nov;9 Suppl 4, p. S555-70.
PMID: 18067032
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Sex differences in long-term smoking cessation rates due to nicotine patch.
Authors: Perkins KA, Scott J
Source: Nicotine Tob Res, 2008 Jul;10(7), p. 1245-50.
PMID: 18629735
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Anticipating clinical integration of pharmacogenetic treatment strategies for addiction: are primary care physicians ready?
Authors: Shields AE, Lerman C
Source: Clin Pharmacol Ther, 2008 Apr;83(4), p. 635-9.
EPub date: 2008 Mar 5.
PMID: 18323859
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Chronic cigarette smoking and the microstructural integrity of white matter in healthy adults: a diffusion tensor imaging study.
Authors: Paul RH, Grieve SM, Niaura R, David SP, Laidlaw DH, Cohen R, Sweet L, Taylor G, Clark RC, Pogun S, Gordon E
Source: Nicotine Tob Res, 2008 Jan;10(1), p. 137-47.
PMID: 18188754
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Bupropion efficacy for smoking cessation is influenced by the DRD2 Taq1A polymorphism: analysis of pooled data from two clinical trials.
Authors: David SP, Strong DR, Munaf˛ MR, Brown RA, Lloyd-Richardson EE, Wileyto PE, Evins EA, Shields PG, Lerman C, Niaura R
Source: Nicotine Tob Res, 2007 Dec;9(12), p. 1251-7.
PMID: 18058343
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Genetics and smoking cessation improving outcomes in smokers at risk.
Authors: Lerman CE, Schnoll RA, Munaf˛ MR
Source: Am J Prev Med, 2007 Dec;33(6 Suppl), p. S398-405.
PMID: 18021915
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Medication screening for smoking cessation: a proposal for new methodologies.
Authors: Perkins KA, Stitzer M, Lerman C
Source: Psychopharmacology (Berl), 2006 Mar;184(3-4), p. 628-36.
EPub date: 2005 Sep 15.
PMID: 16163529
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Recurrent event analysis of lapse and recovery in a smoking cessation clinical trial using bupropion.
Authors: Wileyto EP, Patterson F, Niaura R, Epstein LH, Brown RA, Audrain-McGovern J, Hawk LW Jr, Lerman C
Source: Nicotine Tob Res, 2005 Apr;7(2), p. 257-68.
PMID: 16036283
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Monoamine reuptake inhibition and nicotine receptor antagonism reduce amplitude and gating of auditory evoked potentials.
Authors: Siegel SJ, Maxwell CR, Majumdar S, Trief DF, Lerman C, Gur RE, Kanes SJ, Liang Y
Source: Neuroscience, 2005;133(3), p. 729-38.
PMID: 15908134
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Barriers to translating emerging genetic research on smoking into clinical practice. Perspectives of primary care physicians.
Authors: Shields AE, Blumenthal D, Weiss KB, Comstock CB, Currivan D, Lerman C
Source: J Gen Intern Med, 2005 Feb;20(2), p. 131-8.
PMID: 15836545
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Informal mentoring between faculty and medical students.
Authors: Rose GL, Rukstalis MR, Schuckit MA
Source: Acad Med, 2005 Apr;80(4), p. 344-8.
PMID: 15793017
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Quantitative comparisons between a nicotine delivery device (Eclipse) and conventional cigarette smoking.
Authors: Lee EM, Malson JL, Moolchan ET, Pickworth WB
Source: Nicotine Tob Res, 2004 Feb;6(1), p. 95-102.
PMID: 14982693
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Influence of methylphenidate on eating in obese men.
Authors: Leddy JJ, Epstein LH, Jaroni JL, Roemmich JN, Paluch RA, Goldfield GS, Lerman C
Source: Obes Res, 2004 Feb;12(2), p. 224-32.
PMID: 14981214
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Personality differences associated with smoking experimentation among adolescents with and without comorbid symptoms of ADHD.
Authors: Tercyak KP, Audrain-McGovern J
Source: Subst Use Misuse, 2003 Dec;38(14), p. 1953-70.
PMID: 14677777
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Nicotine dependence treatment for patients with cancer.
Authors: Cox LS, Africano NL, Tercyak KP, Taylor KL
Source: Cancer, 2003 Aug 1;98(3), p. 632-44.
PMID: 12879483
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Individual differences in nicotine intake per cigarette.
Authors: Patterson F, Benowitz N, Shields P, Kaufmann V, Jepson C, Wileyto P, Kucharski S, Lerman C
Source: Cancer Epidemiol Biomarkers Prev, 2003 May;12(5), p. 468-71.
PMID: 12750245
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Applying genetic approaches to the treatment of nicotine dependence.
Authors: Lerman C, Niaura R
Source: Oncogene, 2002 Oct 21;21(48), p. 7412-20.
PMID: 12379882
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Psychosocial correlates of alternate tobacco product use during early adolescence.
Authors: Tercyak KP, Audrain J
Source: Prev Med, 2002 Aug;35(2), p. 193-8.
PMID: 12200105
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Interacting effects of depression and tobacco advertising receptivity on adolescent smoking.
Authors: Tercyak KP, Goldman P, Smith A, Audrain J
Source: J Pediatr Psychol, 2002 Mar;27(2), p. 145-54.
PMID: 11821498
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