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Grant Details

Grant Number: 5R01CA105203-05 Interpret this number
Primary Investigator: Spitz, Margaret
Organization: University Of Tx Md Anderson Can Ctr
Project Title: Biobehavioral-Smoking Profiles in Mexican-American Youth
Fiscal Year: 2008
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Abstract

DESCRIPTION (provided by applicant): Survey data show that Mexican-American (MA) youth report the highest rates of experimenting with cigarettes. This transdisciplinary project will determine the relative influences of both non-genetic (psychosocial, behavioral, and contextual) and genetic factors in susceptibility to smoking, initiation of smoking, and dependency on nicotine in a cohort of urban MA youth in the Houston metropolitan area. The proposal builds upon an existing population-based resource of MA households created and maintained in the Department of Epidemiology at M. D. Anderson Cancer Center, and capitalizes upon the experience in studying adolescent smoking trajectories in the Department of Behavioral Science. The study design will include an initial cross-sectional survey with the following specific aims: 1) to assess baseline prevalence of susceptibility to smoking and experimentation with cigarettes in the prior six months in unrelated MA adolescents between the ages of 11 to 13 years (n =1300). 2) to conduct a systematic telephone follow-up every six months to ascertain changes in smoking status (using widely accepted measures of cognitive susceptibility to smoking and nicotine dependence) and to collect saliva samples (as needed) for cotinine measurement. We will evaluate changes in psychosocial and contextual factors by conducting a follow-up home interview in the final year of the study. The hypothesis is that adolescents with lower levels of psychosocial resources or in smoking permissive contexts are more susceptible to smoking and to the development of dependent smoking. 3) to determine how variation in candidate genes, including those related to nicotine metabolism, dopamine and serotonin pathways, and genes encoding enzymes involved in synthesis or metabolism of neurotransmitters may influence the initiation, establishment of smoking, and nicotine dependence following experimentation. We will explore how genetic predisposing factors interact with psychosocial factors to impact smoking status. We will also evaluate whether genetic predisposition will modify the impact of the social, contextual, and psychological factors on the transition from experimentation to nicotine dependence. The long-term goal is to develop quantitative multivariate risk assessment models for experimentation, initiation and dependence, and genetic susceptibility in order to identify high-risk adolescent subgroups. These findings will enable us to develop culturally and age-appropriate school- and community-based smoking cessation interventions.

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Publications

A risk prediction model for smoking experimentation in Mexican American youth.
Authors: Talluri R, Wilkinson AV, Spitz MR, Shete S
Source: Cancer Epidemiol Biomarkers Prev, 2014 Oct;23(10), p. 2165-74.
EPub date: 2014 Jul 25.
PMID: 25063521
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The associations of body image, anxiety, and smoking among Mexican-origin youth.
Authors: Okeke NL, Spitz MR, Forman MR, Wilkinson AV
Source: J Adolesc Health, 2013 Aug;53(2), p. 209-14.
EPub date: 2013 May 10.
PMID: 23669646
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Exposure to pro-tobacco messages and smoking status among Mexican origin youth.
Authors: Wilkinson AV, Vandewater EA, Carey FR, Spitz MR
Source: J Immigr Minor Health, 2014 Jun;16(3), p. 385-93.
PMID: 23584711
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Cigarette experimentation and the population attributable fraction for associated genetic and non-genetic risk factors.
Authors: Wilkinson AV, Swartz MD, Yu X, Spitz MR, Shete S
Source: PLoS One, 2013;8(1), p. e53868.
EPub date: 2013 Jan 16.
PMID: 23342024
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Sensation-seeking genes and physical activity in youth.
Authors: Wilkinson AV, Gabriel KP, Wang J, Bondy ML, Dong Q, Wu X, Shete S, Spitz MR
Source: Genes Brain Behav, 2013 Mar;12(2), p. 181-8.
EPub date: 2012 Dec 24.
PMID: 23190435
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Experimenting with cigarettes and physical activity among Mexican origin youth: a cross sectional analysis of the interdependent associations among sensation seeking, acculturation, and gender.
Authors: Wilkinson AV, Okeke NL, Springer AE, Stigler MH, Gabriel KP, Bondy ML, Prokhorov AV, Spitz MR
Source: BMC Public Health, 2012 May 4;12, p. 332.
EPub date: 2012 May 4.
PMID: 22559717
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Cigarette experimentation in Mexican origin youth: psychosocial and genetic determinants.
Authors: Wilkinson AV, Bondy ML, Wu X, Wang J, Dong Q, D'Amelio AM Jr, Prokhorov AV, Pu X, Yu RK, Etzel CJ, Shete S, Spitz MR
Source: Cancer Epidemiol Biomarkers Prev, 2012 Jan;21(1), p. 228-38.
EPub date: 2011 Oct 25.
PMID: 22028400
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Gender differences in sociodemographic and behavioral influences of physical activity in Mexican-origin adolescents.
Authors: Strong LL, Anderson CB, Miranda PY, Bondy ML, Zhou R, Etzel C, Spitz M, Wilkinson AV
Source: J Phys Act Health, 2012 Aug;9(6), p. 829-39.
EPub date: 2011 Aug 2.
PMID: 21952224
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Psychosocial risk and correlates of early menarche in Mexican-American girls.
Authors: Jean RT, Wilkinson AV, Spitz MR, Prokhorov A, Bondy M, Forman MR
Source: Am J Epidemiol, 2011 May 15;173(10), p. 1203-10.
EPub date: 2011 Mar 31.
PMID: 21454827
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Sensation seeking, risk behaviors, and alcohol consumption among Mexican origin youth.
Authors: Wilkinson AV, Shete S, Spitz MR, Swann AC
Source: J Adolesc Health, 2011 Jan;48(1), p. 65-72.
PMID: 21185526
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Cognitive susceptibility to smoking: Two paths to experimenting among Mexican origin youth.
Authors: Spelman AR, Spitz MR, Kelder SH, Prokhorov AV, Bondy ML, Frankowski RF, Wilkinson AV
Source: Cancer Epidemiol Biomarkers Prev, 2009 Dec;18(12), p. 3459-67.
PMID: 19959696
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Exposure to smoking imagery in the movies and experimenting with cigarettes among Mexican heritage youth.
Authors: Wilkinson AV, Spitz MR, Prokhorov AV, Bondy ML, Shete S, Sargent JD
Source: Cancer Epidemiol Biomarkers Prev, 2009 Dec;18(12), p. 3435-43.
PMID: 19959693
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Maternal current smoking: concordance between adolescent proxy and mother's self-report.
Authors: Vasudevan V, Etzel CJ, Spitz MR, Wilkinson AV
Source: Nicotine Tob Res, 2009 Aug;11(8), p. 1016-9.
EPub date: 2009 Jun 16.
PMID: 19531668
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Influence of subjective social status on the relationship between positive outcome expectations and experimentation with cigarettes.
Authors: Wilkinson AV, Shete S, Vasudevan V, Prokhorov AV, Bondy ML, Spitz MR
Source: J Adolesc Health, 2009 Apr;44(4), p. 342-8.
EPub date: 2008 Oct 29.
PMID: 19306792
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Sociodemographic characteristics, health beliefs, and the accuracy of cancer knowledge.
Authors: Wilkinson AV, Vasudevan V, Honn SE, Spitz MR, Chamberlain RM
Source: J Cancer Educ, 2009;24(1), p. 58-64.
PMID: 19259867
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Correlates of susceptibility to smoking among Mexican origin youth residing in Houston, Texas: a cross-sectional analysis.
Authors: Wilkinson AV, Waters AJ, Vasudevan V, Bondy ML, Prokhorov AV, Spitz MR
Source: BMC Public Health, 2008 Sep 26;8, p. 337.
EPub date: 2008 Sep 26.
PMID: 18822130
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The moderating role of parental smoking on their children's attitudes toward smoking among a predominantly minority sample: a cross-sectional analysis.
Authors: Wilkinson AV, Shete S, Prokhorov AV
Source: Subst Abuse Treat Prev Policy, 2008 Jul 14;3, p. 18.
EPub date: 2008 Jul 14.
PMID: 18625061
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Maternal BMI and country of birth as indicators of childhood obesity in children of Mexican origin.
Authors: Hernández-Valero MA, Wilkinson AV, Forman MR, Etzel CJ, Cao Y, Bárcenas CH, Strom SS, Spitz MR, Bondy ML
Source: Obesity (Silver Spring), 2007 Oct;15(10), p. 2512-9.
PMID: 17925478
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Age-related differences in factors associated with smoking initiation.
Authors: Wilkinson AV, Schabath MB, Prokhorov AV, Spitz MR
Source: Cancer Causes Control, 2007 Aug;18(6), p. 635-44.
EPub date: 2007 May 1.
PMID: 17473909
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Effects of nativity, age at migration, and acculturation on smoking among adult Houston residents of Mexican descent.
Authors: Wilkinson AV, Spitz MR, Strom SS, Prokhorov AV, Barcenas CH, Cao Y, Saunders KC, Bondy ML
Source: Am J Public Health, 2005 Jun;95(6), p. 1043-9.
PMID: 15914831
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