Skip Navigation
National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R03CA119682-02 Interpret this number
Primary Investigator: Le Marchand, Loic
Organization: University Of Hawaii At Manoa
Project Title: Case-Control Study of Adenoma in Sao Paulo Japanese
Fiscal Year: 2008
Back to top


DESCRIPTION (provided by applicant): Smoking, alcohol, overnutrition and a high red meat and low folate, fiber and calcium diet have been associated with colorectal cancer (CRC) and adenoma. Past work, including ours, suggests the importance of the modifying effects of genetic susceptibility factors on most of these associations. Our investigation of the rapid rise in CRC risk among Japanese migrants to Hawaii suggests that Japanese may be more genetically susceptible to the carcinogenic effects of red meat and processed meat, compared to whites, and that they may be particularly protected by a high folate intake. These results are entirely consistent with the sharp rise in CRC incidence observed in Japan over the last 30 years, presumably as a result of the westernization of the diet. However, we have identified another population of Japanese migrants in Sao Paulo, Brazil, for whom CRC rates have remained low, compared to Japanese in Japan an Hawaii, despite a high fat and red meat intake and an affluent western lifestyle. Because this anomaly might provide critical information about protective factors for CRC, we are seeking funding to conduct a colonoscopy-based case- control study of adenoma among Japanese Brazilians in Sao Paulo and to compare findings with our on- going adenoma study (CA 72520) in Hawaii Japanese (565 cases, 660 controls) and with a third (separately funded) companion study (800 cases, 800 controls) conducted in Tokyo. In Sao Paulo, a lifestyle questionnaire will be administered in-person to 550 adenoma cases and 550 endoscopically normal controls matched on age, sex, hospital and date of colonoscopy. In addition to estimating the total intake of energy, nutrients and other dietary components, consumption of meat and fish prepared by high-temperature methods and doneness of meat will be assessed. A blood sample will also be stored for the future testing of exposure markers and genes related to growth hormones, insulin resistance, carcinogen bioactivation and folate metabolism which are being assessed in the Hawaii and Tokyo studies.

Back to top


Comparison of plasma levels of nutrient-related biomarkers among Japanese populations in Tokyo, Japan, São Paulo, Brazil, and Hawaii, USA.
Authors: Iwasaki M. , Franke A.A. , Hamada G.S. , Miyajima N.T. , Sharma S. , Ishihara J. , Takachi R. , Tsugane S. , Le Marchand L. .
Source: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2015 Mar; 24(2), p. 155-61.
PMID: 25633435
Related Citations

Validation of a quantitative FFQ for a study of diet and risk of colorectal adenoma among Japanese Brazilians.
Authors: Pakseresht M. , Miyajima N.T. , Shelton A. , Iwasaki M. , Tsugane S. , Le Marchand L. , Sharma S. .
Source: Public health nutrition, 2013 Aug; 16(8), p. 1445-53.
EPub date: 2012-08-14.
PMID: 22892172
Related Citations

Nutritional composition of dishes commonly consumed by Japanese Brazilians in São Paulo, Brazil.
Authors: Sharma S. , Brambilla A. , Cao X. , Iwasaki M. , Hamada G. , Miyajima N.T. , Tsugane S. , Le Marchand L. .
Source: International journal of food sciences and nutrition, 2010 Sep; 61(6), p. 549-72.
PMID: 20397835
Related Citations

Heterocyclic amines content of meat and fish cooked by Brazilian methods.
Authors: Iwasaki M. , Kataoka H. , Ishihara J. , Takachi R. , Hamada G.S. , Sharma S. , Le Marchand L. , Tsugane S. .
Source: Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems, 2010-02-01; 23(1), p. 61-69.
PMID: 20383312
Related Citations

Development of a quantitative food frequency questionnaire for assessing food, nutrient, and heterocyclic aromatic amines intake in Japanese Brazilians for a colorectal adenoma case-control study.
Authors: Sharma S. , Iwasaki M. , Kunieda C. , Cao X. , Ishihara J. , Hamada G. , Miyajima N.T. , Tsugane S. , Le Marchand L. .
Source: International journal of food sciences and nutrition, 2009; 60 Suppl 7, p. 128-39.
EPub date: 2009-04-18.
PMID: 19381993
Related Citations