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Grant Details

Grant Number: 5R01CA105204-05 Interpret this number
Primary Investigator: Mctiernan, Anne
Organization: Fred Hutchinson Cancer Research Center
Project Title: Exercise, Diet, and Sex Hormones in Postmenopausal Women
Fiscal Year: 2008
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Abstract

DESCRIPTION (provided by applicant): In a randomized trial of 173 postmenopausal women aged 50-75 years, we found that a facility-based moderate-intensity (45 min/day, 5 d/wk) aerobic exercise intervention significantly decreased serum estrone and free estradiol in 3 months, that is, a decrease in two established biomarkers of postmenopausal breast cancer risk. We propose here to conduct another randomized trial to test whether a combined reduced-calorie diet plus aerobic exercise intervention could extend the reduction of serum estrogens over and beyond the degree of reduction achieved by either an exercise-alone intervention or a reduced-calorie diet alone intervention. The proposed study will test and compare the effects over one year of two lifestyle interventions in 503 postmenopausal women in a 4-arm randomized controlled trial: 1) a moderate-intensity aerobic exercise intervention (N=135); 2) a reduced-calorie diet intervention (N=135); 3) the combined exercise and reduced calorie diet interventions (N=135); and 4) control (no intervention) (N=98). The primary endpoint will be serum estrone. Secondary endpoints will include serum estradiol, free estradiol, testosterone, free testosterone, sex hormone binding protein, insulin-like growth factor IFG)-I, IGF binding protein-3, insulin, mammogram density, adiposity (weight, BMI, waist and hip; circumferences, total body fat and % fat from DXA), and Quality of Life. Women will be eligible if they are postmenopausal, aged 50-75 years, healthy, overweight or obese (BMI > 25.0 kg/m2), sedentary (less than 30 min/week in moderate activity), not using HRT X 6 mos., and nonsmokers. The calorie reduction intervention will use a modification of the Diabetes Prevention Program lifestyle behavior change program, with goals of 1200-1800 kcal/day and 7% reduction in body weight. The exercise intervention will be 45 min/day, 5 days/week, moderate-intensity aerobic (e.g. walking), combined facility and home exercise with behavioral training. Participants will be recruited through mass mailings and media placements and will undergo several screening activities. Participants will be followed for 12 months and baseline, interim, and end-of-intervention measures will be assessed and compared. Intervention adherence will be monitored via exercise and diet logs and weekly weighing. Potential adverse effects will be measured including injuries, overall bone density (DEXA), and Quality of Life.

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Publications

The effects of separate and combined dietary weight loss and exercise on fasting ghrelin concentrations in overweight and obese women: a randomized controlled trial.
Authors: Mason C, Xiao L, Imayama I, Duggan CR, Campbell KL, Kong A, Wang CY, Alfano CM, Blackburn GL, Foster-Schubert KE, McTiernan A
Source: Clin Endocrinol (Oxf), 2014 May 5;null, p. null.
EPub date: 2014 May 5.
PMID: 24796864
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Weight and metabolic effects of dietary weight loss and exercise interventions in postmenopausal antidepressant medication users and non-users: a randomized controlled trial.
Authors: Imayama I, Alfano CM, Mason C, Wang C, Duggan C, Campbell KL, Kong A, Foster-Schubert KE, Blackburn GL, Wang CY, McTiernan A
Source: Prev Med, 2013 Nov;57(5), p. 525-32.
EPub date: 2013 Jul 13.
PMID: 23859929
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Effects of dietary weight loss and exercise on insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in postmenopausal women: a randomized controlled trial.
Authors: Mason C, Xiao L, Duggan C, Imayama I, Foster-Schubert KE, Kong A, Campbell KL, Wang CY, Alfano CM, Blackburn GL, Pollack M, McTiernan A
Source: Cancer Epidemiol Biomarkers Prev, 2013 Aug;22(8), p. 1457-63.
EPub date: 2013 Jun 11.
PMID: 23756654
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Independent and combined effects of dietary weight loss and exercise on leukocyte telomere length in postmenopausal women.
Authors: Mason C, Risques RA, Xiao L, Duggan CR, Imayama I, Campbell KL, Kong A, Foster-Schubert KE, Wang CY, Alfano CM, Blackburn GL, Rabinovitch PS, McTiernan A
Source: Obesity (Silver Spring), 2013 Dec;21(12), p. E549-54.
EPub date: 2013 Jul 29.
PMID: 23640743
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Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels.
Authors: Abbenhardt C, McTiernan A, Alfano CM, Wener MH, Campbell KL, Duggan C, Foster-Schubert KE, Kong A, Toriola AT, Potter JD, Mason C, Xiao L, Blackburn GL, Bain C, Ulrich CM
Source: J Intern Med, 2013 Aug;274(2), p. 163-75.
EPub date: 2013 Mar 29.
PMID: 23432360
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Influence of diet, exercise, and serum vitamin d on sarcopenia in postmenopausal women.
Authors: Mason C, Xiao L, Imayama I, Duggan CR, Foster-Schubert KE, Kong A, Campbell KL, Wang CY, Villasenor A, Neuhouser ML, Alfano CM, Blackburn GL, McTiernan A
Source: Med Sci Sports Exerc, 2013 Apr;45(4), p. 607-14.
PMID: 23190588
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History of weight cycling does not impede future weight loss or metabolic improvements in postmenopausal women.
Authors: Mason C, Foster-Schubert KE, Imayama I, Xiao L, Kong A, Campbell KL, Duggan CR, Wang CY, Alfano CM, Ulrich CM, Blackburn GL, McTiernan A
Source: Metabolism, 2013 Jan;62(1), p. 127-36.
EPub date: 2012 Aug 14.
PMID: 22898251
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Self-monitoring and eating-related behaviors are associated with 12-month weight loss in postmenopausal overweight-to-obese women.
Authors: Kong A, Beresford SA, Alfano CM, Foster-Schubert KE, Neuhouser ML, Johnson DB, Duggan C, Wang CY, Xiao L, Jeffery RW, Bain CE, McTiernan A
Source: J Acad Nutr Diet, 2012 Sep;112(9), p. 1428-35.
EPub date: 2012 Jul 13.
PMID: 22795495
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Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: randomized controlled trial.
Authors: Campbell KL, Foster-Schubert KE, Alfano CM, Wang CC, Wang CY, Duggan CR, Mason C, Imayama I, Kong A, Xiao L, Bain CE, Blackburn GL, Stanczyk FZ, McTiernan A
Source: J Clin Oncol, 2012 Jul 1;30(19), p. 2314-26.
EPub date: 2012 May 21.
PMID: 22614972
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Adoption of diet-related self-monitoring behaviors varies by race/ethnicity, education, and baseline binge eating score among overweight-to-obese postmenopausal women in a 12-month dietary weight loss intervention.
Authors: Kong A, Beresford SA, Imayama I, Duggan C, Alfano CM, Foster-Schubert KE, Neuhouser ML, Johnson DB, Wang CY, Xiao L, Bain CE, McTiernan A
Source: Nutr Res, 2012 Apr;32(4), p. 260-5.
EPub date: 2012 Apr 30.
PMID: 22575038
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Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial.
Authors: Imayama I, Ulrich CM, Alfano CM, Wang C, Xiao L, Wener MH, Campbell KL, Duggan C, Foster-Schubert KE, Kong A, Mason CE, Wang CY, Blackburn GL, Bain CE, Thompson HJ, McTiernan A
Source: Cancer Res, 2012 May 1;72(9), p. 2314-26.
PMID: 22549948
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Associations between snacking and weight loss and nutrient intake among postmenopausal overweight to obese women in a dietary weight-loss intervention.
Authors: Kong A, Beresford SA, Alfano CM, Foster-Schubert KE, Neuhouser ML, Johnson DB, Duggan C, Wang CY, Xiao L, Bain CE, McTiernan A
Source: J Am Diet Assoc, 2011 Dec;111(12), p. 1898-903.
PMID: 22117666
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Dietary weight loss and exercise interventions effects on quality of life in overweight/obese postmenopausal women: a randomized controlled trial.
Authors: Imayama I, Alfano CM, Kong A, Foster-Schubert KE, Bain CE, Xiao L, Duggan C, Wang CY, Campbell KL, Blackburn GL, McTiernan A
Source: Int J Behav Nutr Phys Act, 2011 Oct 25;8, p. 118.
EPub date: 2011 Oct 25.
PMID: 22026966
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Dietary weight loss and exercise effects on insulin resistance in postmenopausal women.
Authors: Mason C, Foster-Schubert KE, Imayama I, Kong A, Xiao L, Bain C, Campbell KL, Wang CY, Duggan CR, Ulrich CM, Alfano CM, Blackburn GL, McTiernan A
Source: Am J Prev Med, 2011 Oct;41(4), p. 366-75.
PMID: 21961463
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Effects of weight loss on serum vitamin D in postmenopausal women.
Authors: Mason C, Xiao L, Imayama I, Duggan CR, Bain C, Foster-Schubert KE, Kong A, Campbell KL, Wang CY, Neuhouser ML, Li L, W Jeffery R, Robien K, Alfano CM, Blackburn GL, McTiernan A
Source: Am J Clin Nutr, 2011 Jul;94(1), p. 95-103.
EPub date: 2011 May 25.
PMID: 21613554
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Effect of diet and exercise, alone or combined, on weight and body composition in overweight-to-obese postmenopausal women.
Authors: Foster-Schubert KE, Alfano CM, Duggan CR, Xiao L, Campbell KL, Kong A, Bain CE, Wang CY, Blackburn GL, McTiernan A
Source: Obesity (Silver Spring), 2012 Aug;20(8), p. 1628-38.
EPub date: 2011 Apr 14.
PMID: 21494229
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Weight, physical activity, diet, and prognosis in breast and gynecologic cancers.
Authors: McTiernan A, Irwin M, Vongruenigen V
Source: J Clin Oncol, 2010 Sep 10;28(26), p. 4074-80.
EPub date: 2010 Jul 19.
PMID: 20644095
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