|Grant Number:||5R01CA106807-05 Interpret this number|
|Primary Investigator:||Lazovich, Deann|
|Organization:||University Of Minnesota|
|Project Title:||Indoor Tanning Use, DNA Repair and Risk of Melanoma|
DESCRIPTION (provided by applicant): The rising popularity of indoor tanning, an artificial source of ultraviolet radiation (UV) raises concerns that the melanoma epidemic will continue to cause unnecessary morbidity and mortality. Most epidemiologic studies of this risk factor and melanoma predate the introduction of modern tanning equipment (ca 1980), thus new epidemiologic studies are urgently needed among individuals with substantial levels of exposure and collection of detailed exposure information. In addition, our understanding of the role of DNA repair in modifying the risks of melanoma associated with UV exposure is just emerging. The specific aims of our proposal are to assess whether frequent and/or long-term use of modern era indoor tanning increases the risk of melanoma, and whether the risk of melanoma may be influenced by variation in inherited polymorphisms that affect DNA repair. We propose to conduct a population-based case-control study of melanoma among 2660 residents of Minnesota (1330 cases, 1330 controls), ages 25-59, a group found to have a high prevalence of exposure to indoor tanning. We will identify cases through the Minnesota Cancer Surveillance System, a pathology-based, statewide cancer registry of high quality and completeness for case ascertainment. Each case and control subject's history of exposure to indoor tanning, and to potential confounders will be collected during a telephone interview. Buccal cell samples from cases and controls will be collected for DNA. Associations between indoor tanning or impaired capacity to repair DNA and melanoma will be measured by the odds ratio, controlling for known confounders. Differences in risk of melanoma associated with exposure to solar or artificial ultraviolet radiation will be explored by skin type and by DNA repair pathways specific to the repair of UVB- or UVA-induced DNA damage in skin. Except for sun exposure, established risk factors for melanoma, such as skin type or family history, are not amenable to change. Indoor tanning behavior, however, is under the control of the individual. If well-designed epidemiologic studies confirm that indoor tanning is a risk factor for melanoma and that some individuals are particularly susceptible to its effects, public health action may be indicated to discourage use and reduce the risk of the melanoma.
Exposure to indoor tanning without burning and melanoma risk by sunburn history.
Authors: Vogel RI, Ahmed RL, Nelson HH, Berwick M, Weinstock MA, Lazovich D
Source: J Natl Cancer Inst, 2014 Jun;106(6), p. dju112.
EPub date: 2014 May 28.
A pilot study of genetic variants in dopamine regulators with indoor tanning and melanoma.
Authors: Flores KG, Erdei E, Luo L, White KA, Leng S, Berwick M, Lazovich D
Source: Exp Dermatol, 2013 Sep;22(9), p. 576-81.
DNA repair variants, indoor tanning, and risk of melanoma.
Authors: Torres SM, Luo L, Lilyquist J, Stidley CA, Flores K, White KA, Erdei E, Gonzales M, Paine S, Vogel RI, Lazovich D, Berwick M
Source: Pigment Cell Melanoma Res, 2013 Sep;26(5), p. 677-84.
EPub date: 2013 Jun 3.
Melanoma risk in relation to use of sunscreen or other sun protection methods.
Authors: Lazovich D, Vogel RI, Berwick M, Weinstock MA, Warshaw EM, Anderson KE
Source: Cancer Epidemiol Biomarkers Prev, 2011 Dec;20(12), p. 2583-93.
EPub date: 2011 Oct 20.
Association between non-steroidal anti-inflammatory drugs and keratinocyte carcinomas of the skin among participants in the Veterans Affairs Topical Tretinoin Chemoprevention Trial.
Authors: Nunes AP, Lapane KL, Weinstock MA, VATTC Trial Group
Source: Pharmacoepidemiol Drug Saf, 2011 Sep;20(9), p. 922-9.
EPub date: 2011 Jun 18.
Prospective quality of life impact of keratinocyte carcinomas: observations from the Veterans Affairs Topical Tretinoin Chemoprevention Trial.
Authors: Lee KC, Weinstock MA, Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) Trial Group
Source: J Am Acad Dermatol, 2010 Dec;63(6), p. 1107-9.
Indoor tanning and risk of melanoma: a case-control study in a highly exposed population.
Authors: Lazovich D, Vogel RI, Berwick M, Weinstock MA, Anderson KE, Warshaw EM
Source: Cancer Epidemiol Biomarkers Prev, 2010 Jun;19(6), p. 1557-68.
EPub date: 2010 May 26.
Incidence estimate of nonmelanoma skin cancer in the United States, 2006.
Authors: Rogers HW, Weinstock MA, Harris AR, Hinckley MR, Feldman SR, Fleischer AB, Coldiron BM
Source: Arch Dermatol, 2010 Mar;146(3), p. 283-7.
Melanoma thickness trends in the United States, 1988-2006.
Authors: Criscione VD, Weinstock MA
Source: J Invest Dermatol, 2010 Mar;130(3), p. 793-7.
EPub date: 2009 Oct 15.
Mortality of bullous skin disorders from 1979 through 2002 in the United States.
Authors: Risser J, Lewis K, Weinstock MA
Source: Arch Dermatol, 2009 Sep;145(9), p. 1005-8.
Tolerability of high-dose topical tretinoin: the Veterans Affairs Topical Tretinoin Chemoprevention Trial.
Authors: Geng A, Weinstock MA, Hall R, Eilers D, Naylor M, Kalivas J, VATTC Trial Group
Source: Br J Dermatol, 2009 Oct;161(4), p. 918-24.
EPub date: 2009 Jun 11.
Actinic keratoses: Natural history and risk of malignant transformation in the Veterans Affairs Topical Tretinoin Chemoprevention Trial.
Authors: Criscione VD, Weinstock MA, Naylor MF, Luque C, Eide MJ, Bingham SF, Department of Veteran Affairs Topical Tretinoin Chemoprevention Trial Group
Source: Cancer, 2009 Jun 1;115(11), p. 2523-30.
Association between statin use and risk for keratinocyte carcinoma in the veterans affairs topical tretinoin chemoprevention trial.
Authors: Dore DD, Lapane KL, Trivedi AN, Mor V, Weinstock MA
Source: Ann Intern Med, 2009 Jan 6;150(1), p. 9-18.
Components of a successful intervention for monthly skin self-examination for early detection of melanoma: the "Check It Out" trial.
Authors: Lee KB, Weinstock MA, Risica PM
Source: J Am Acad Dermatol, 2008 Jun;58(6), p. 1006-12.
EPub date: 2008 Apr 11.
Melanoma early detection with thorough skin self-examination: the "Check It Out" randomized trial.
Authors: Weinstock MA, Risica PM, Martin RA, Rakowski W, Dubé C, Berwick M, Goldstein MG, Acharyya S, Lasater T
Source: Am J Prev Med, 2007 Jun;32(6), p. 517-24.
Trends in nonmelanoma skin cancer mortality rates in the United States, 1969 through 2000.
Authors: Lewis KG, Weinstock MA
Source: J Invest Dermatol, 2007 Oct;127(10), p. 2323-7.
EPub date: 2007 May 24.
Progress and prospects on melanoma: the way forward for early detection and reduced mortality.
Authors: Weinstock MA
Source: Clin Cancer Res, 2006 Apr 1;12(7 Pt 2), p. 2297s-2300s.