Grant Details
| Grant Number: | 5R01CA104836-06 Interpret this number |
| Primary Investigator: | Graham, Amanda |
| Organization: | Georgetown University |
| Project Title: | Internet and Telephone Treatment for Smoking Cessation |
| Fiscal Year: | 2008 |
Abstract
DESCRIPTION (provided by applicant): Tobacco use is the major preventable cause of cancer and disease burden in the U.S. While effective treatments exist, innovative means of efficient delivery are needed to accelerate reduction in smoking prevalence. Telephone counseling and tailored self-change programs have an evidence-base of efficacy and the capability to make an impact on population prevalence. There is a growing movement to provide comprehensive tobacco control services, both through telephone quit lines and tailored self-change via the Internet. Scientists, policy makers and the public need to know if these programs work, for whom, by what mechanisms, and at what cost. There are no rigorous evaluations of the efficacy of Internet-driven cessation services or of combined telephone and Internet treatment At the same time, Internet-based programs are already available to the public and are being used at a very high volume without any evidence that they are effective. This study aims to extend existing theory and application by comparing the efficacy of a popular, full service, Internet intervention (Premium Internet) alone or in conjunction with proactive telephone counseling (Premium Internet plus Telephone) against a standard Internet control (Basic Interact). This study will recruit motivated smokers (N=2,055) who use an Internet search engine to find smoking cessation programs. A subset will be directed to a Web page that will describe the study and enrollment procedures. Using a 3-condition randomized design with repeated measures at baseline, 3, 6, 12, and 18-months post-randomization, consented smokers will be assigned to: 1) Basic Internet; 2) Premium Internet; and 3) Premium Internet plus Proactive Telephone Counseling. The hypotheses tested are that Premium Interact plus Telephone will outperform Premium Internet alone and both will outperform Basic Internet on 7-day point prevalence abstinence measured at 12 months post-randomization (6-months post treatment). Cost-effectiveness will also be examined along with exploratory analyses of theory-driven hypotheses about the mediators and moderators of outcome (e.g., gender, amount and frequency of service use, type of content used, and behavior change variables including self-efficacy, social support, and motivation). Market demand and State health departments are stimulating delivery of Interact and telephone cessation services. There is an urgent need for science to fill the gap and evaluate their efficacy. If effective, such treatments can be widely disseminated and can make a significant impact on population health.
Publications
Cost-effectiveness of internet and telephone treatment for smoking cessation: an economic evaluation of The iQUITT Study.
Authors: Graham AL, Chang Y, Fang Y, Cobb NK, Tinkelman DS, Niaura RS, Abrams DB, Mandelblatt JS
Source: Tob Control, 2012 Dec 21;null, p. null.
EPub date: 2012 Dec 21.
PMID: 23010696
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA104836 |
Development and validation of the online social support for smokers scale.
Authors: Graham AL, Papandonatos GD, Kang H, Moreno JL, Abrams DB
Source: J Med Internet Res, 2011 Sep 28;13(3), p. e69.
EPub date: 2011 Sep 28.
PMID: 21955465
Related Citations
Grant Numbers:
| NCI NIH HHS - R01CA104836 |
MeSH Terms:
A randomized trial of Internet and telephone treatment for smoking cessation.
Authors: Graham AL, Cobb NK, Papandonatos GD, Moreno JL, Kang H, Tinkelman DG, Bock BC, Niaura RS, Abrams DB
Source: Arch Intern Med, 2011 Jan 10;171(1), p. 46-53.
PMID: 21220660
Related Citations
Grant Numbers:
| NCI NIH HHS - R01-CA104836 | NCI NIH HHS - R01 CA104836-06 | NCI NIH HHS - R01 CA104836-01A1 |
MeSH Terms:
| United States | Telephone | Directive Counseling |
| Humans | Aged | Smoking |
| Adult | Smoking Cessation | Treatment Outcome |
| Middle Aged | Female | Internet |
| Male |
Social network structure of a large online community for smoking cessation.
Authors: Cobb NK, Graham AL, Abrams DB
Source: Am J Public Health, 2010 Jul;100(7), p. 1282-9.
EPub date: 2010 May 13.
PMID: 20466971
Related Citations
Grant Numbers:
| NCI NIH HHS - R01-CA104836 | NHLBI NIH HHS - T32-HL00787 | NCI NIH HHS - R01 CA104836-06 |
MeSH Terms:
| Humans | Smoking Cessation | Adult |
| Social Support | Middle Aged | Self-Help Groups |
| Systems Theory | Male | Internet |
| Female |
Online advertising as a public health and recruitment tool: comparison of different media campaigns to increase demand for smoking cessation interventions.
Authors: Graham AL, Milner P, Saul JE, Pfaff L
Source: J Med Internet Res, 2008 Dec 15;10(5), p. e50.
EPub date: 2008 Dec 15.
PMID: 19073542
Related Citations
Grant Numbers:
| NCI NIH HHS - R01CA104836 | NCI NIH HHS - R01 CA104836-06 |
MeSH Terms:
Reliability of internet- versus telephone-administered questionnaires in a diverse sample of smokers.
Authors: Graham AL, Papandonatos GD
Source: J Med Internet Res, 2008 Mar 26;10(1), p. e8.
EPub date: 2008 Mar 26.
PMID: 18364345
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA104836-05 |
MeSH Terms:
Internet- vs. telephone-administered questionnaires in a randomized trial of smoking cessation.
Authors: Graham AL, Papandonatos GD, Bock BC, Cobb NK, Baskin-Sommers A, Niaura R, Abrams DB
Source: Nicotine Tob Res, 2006 Dec;8 Suppl 1, p. S49-57.
PMID: 17491171
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA104836-04 | NCI NIH HHS - 5R01CA104836-02 |
MeSH Terms:
Characteristics of smokers reached and recruited to an internet smoking cessation trial: a case of denominators.
Authors: Graham AL, Bock BC, Cobb NK, Niaura R, Abrams DB
Source: Nicotine Tob Res, 2006 Dec;8 Suppl 1, p. S43-8.
PMID: 17491170
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA104836-04 | NCI NIH HHS - 5R01CA104836-02 |
MeSH Terms:
Characterizing Internet searchers of smoking cessation information.
Authors: Cobb NK, Graham AL
Source: J Med Internet Res, 2006 Sep 19;8(3), p. e17.
EPub date: 2006 Sep 19.
PMID: 17032633
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA104836-03 |
MeSH Terms:
| Information Services | Humans | Aged |
| Consumer Satisfaction | Recurrence | Consumer Participation |
| Triage | Smoking Cessation | Adult |
| Data Collection | Middle Aged | Adolescent |
| Female | Internet | Male |
Initial evaluation of a real-world Internet smoking cessation system.
Authors: Cobb NK, Graham AL, Bock BC, Papandonatos G, Abrams DB
Source: Nicotine Tob Res, 2005 Apr;7(2), p. 207-16.
PMID: 16036277
Related Citations
Grant Numbers:
| NCI NIH HHS - CA84719 | NCI NIH HHS - R01 CA104836-01A1 | NCI NIH HHS - R43CA09921101 |
| NCI NIH HHS - 1R43CA09790301A1 |
MeSH Terms:
Reducing the cancer burden of lifestyle factors: opportunities and challenges of the Internet.
Authors: Graham AL, Abrams DB
Source: J Med Internet Res, 2005 Jul 1;7(3), p. e26.
EPub date: 2005 Jul 1.
PMID: 15998617
Related Citations
Grant Numbers:
| NCI NIH HHS - P50 CA84719 | NCI NIH HHS - 1 R01 CA10483-01A1 | NCI NIH HHS - R01 CA104836-02 |
MeSH Terms:
| United States | Life Style | Health Services |
| Neoplasms | Cost of Illness | Behavior |
| Attitude to Health | Humans | National Institutes of Health (U.S.) |
| Delivery of Health Care | Online Systems | Internet |
