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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R01CA102065-05 Interpret this number
Primary Investigator: Wu, Anna
Organization: University Of Southern California
Project Title: Dietary and Genetic Determinants of Mammographic Density
Fiscal Year: 2008
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Abstract

DESCRIPTION (provided by applicant): Mammographic density is currently considered our best surrogate endpoint for breast cancer risk. However, determinants of mammographic density are not well understood. Age, menopausal status, body size, and parity collectively explain less than half of the total variance in mammographic density. The main objective of this grant application is to follow-up on our previous leads on dietary and genetic determinants of mammographic density. We propose to conduct a cost-effective cross-sectional study among 2,200 postmenopausal Chinese women in Singapore who were participants of both the Singapore Chinese Health Study, a prospective cohort study of cancer, and the nationwide mammography screening program. As part of entry into the cohort study, these women were interviewed in person and provided detailed lifestyle information and completed a validated 165-item food frequency questionnaire. Blood specimens (for genotyping) and mammograms are already available on these 2,200 women. We propose to assess mammographic density using a computer-assisted method we developed and have successfully employed in epidemiological and clinical studies. Our primary specific aims are: (1) To assess diet, especially soy intake, in relation to mammographic density. In addition, we will assess the potential modifying and/or confounding effect of dietary factors such as dietary fat, fiber, carotenoids, cruciferous vegetables/isothiocyanates, on the soy-mammographic density association. (2) To assess whether genotypes modify the associations between dietary factors (such as soy intake) and mammographic density. For example, we will evaluate whether the associations between estrogen metabolizing genes (e.g., HSD17B1, CYP1B1, COMT, SULT1A1) and mammographic density are stronger among low soy consumers. Our secondary specific aims are: (3) To assess genotypes of a panel of sex-steroid hormone metabolism genes, in relation to mammographic density. (4) To assess genotypes of other mitogenesis-related genes including the angiotensin I-converting enzyme (ACE), transforming growth factor beta-1(TGFbeta-1), insulin-like growth factor- I (IGF-1) and IGF binding protein (BP)-3), in relation to mammographic density.

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Publications

Author's reply to: Sleep duration, melatonin and breast cancer in the Singapore Chinese Health Study: on null results and their interpretation.
Authors: Wu A.H. , Yu M.C. .
Source: International journal of cancer, 2013-10-15; 133(8), p. 2012.
EPub date: 2013-05-15.
PMID: 23588716
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Hormone metabolism genes and mammographic density in Singapore Chinese women.
Authors: Lee E. , Su Y.C. , Lewinger J.P. , Hsu C. , Van Den Berg D. , Ursin G. , Koh W.P. , Yuan J.M. , Stram D.O. , Yu M.C. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013 May; 22(5), p. 984-6.
EPub date: 2013-02-21.
PMID: 23429186
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Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women.
Authors: Lee E. , Van Den Berg D. , Hsu C. , Ursin G. , Koh W.P. , Yuan J.M. , Stram D.O. , Yu M.C. , Wu A.H. .
Source: Cancer research, 2013-03-15; 73(6), p. 1876-82.
EPub date: 2013-01-18.
PMID: 23333936
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Sleep duration, spot urinary 6-sulfatoxymelatonin levels and risk of breast cancer among Chinese women in Singapore.
Authors: Wu A.H. , Stanczyk F.Z. , Wang R. , Koh W.P. , Yuan J.M. , Yu M.C. .
Source: International journal of cancer, 2013-02-15; 132(4), p. 891-6.
EPub date: 2012-06-28.
PMID: 22644618
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Alcohol intake and mammographic density in postmenopausal Norwegian women.
Authors: Qureshi S.A. , Couto E. , Hofvind S. , Wu A.H. , Ursin G. .
Source: Breast cancer research and treatment, 2012 Feb; 131(3), p. 993-1002.
EPub date: 2011-10-13.
PMID: 21993860
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Mammographic density and intake of selected nutrients and vitamins in Norwegian women.
Authors: Qureshi S.A. , Couto E. , Hilsen M. , Hofvind S. , Wu A.H. , Ursin G. .
Source: Nutrition and cancer, 2011; 63(7), p. 1011-20.
EPub date: 2011-09-14.
PMID: 21916704
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Birth weight and other prenatal factors and risk of breast cancer in Asian-Americans.
Authors: Wu A.H. , McKean-Cowdin R. , Tseng C.C. .
Source: Breast cancer research and treatment, 2011 Dec; 130(3), p. 917-25.
EPub date: 2011-06-28.
PMID: 21710135
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Green tea and breast cancer.
Authors: Wu A.H. , Butler L.M. .
Source: Molecular nutrition & food research, 2011 Jun; 55(6), p. 921-30.
EPub date: 2011-04-29.
PMID: 21538855
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A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal Singapore Chinese women.
Authors: Butler L.M. , Wu A.H. , Wang R. , Koh W.P. , Yuan J.M. , Yu M.C. .
Source: The American journal of clinical nutrition, 2010 Apr; 91(4), p. 1013-9.
EPub date: 2010-02-24.
PMID: 20181808
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Green tea, soy, and mammographic density in Singapore Chinese women.
Authors: Wu A.H. , Ursin G. , Koh W.P. , Wang R. , Yuan J.M. , Khoo K.S. , Yu M.C. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008 Dec; 17(12), p. 3358-65.
PMID: 19064551
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Soy intake and breast cancer risk in Singapore Chinese Health Study.
Authors: Wu A.H. , Koh W.P. , Wang R. , Lee H.P. , Yu M.C. .
Source: British journal of cancer, 2008-07-08; 99(1), p. 196-200.
PMID: 18594543
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Sleep duration, melatonin and breast cancer among Chinese women in Singapore.
Authors: Wu A.H. , Wang R. , Koh W.P. , Stanczyk F.Z. , Lee H.P. , Yu M.C. .
Source: Carcinogenesis, 2008 Jun; 29(6), p. 1244-8.
EPub date: 2008-04-30.
PMID: 18448486
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