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Grant Details

Grant Number: 5R01CA102065-05 Interpret this number
Primary Investigator: Wu, Anna
Organization: University Of Southern California
Project Title: Dietary and Genetic Determinants of Mammographic Density
Fiscal Year: 2008
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Abstract

DESCRIPTION (provided by applicant): Mammographic density is currently considered our best surrogate endpoint for breast cancer risk. However, determinants of mammographic density are not well understood. Age, menopausal status, body size, and parity collectively explain less than half of the total variance in mammographic density. The main objective of this grant application is to follow-up on our previous leads on dietary and genetic determinants of mammographic density. We propose to conduct a cost-effective cross-sectional study among 2,200 postmenopausal Chinese women in Singapore who were participants of both the Singapore Chinese Health Study, a prospective cohort study of cancer, and the nationwide mammography screening program. As part of entry into the cohort study, these women were interviewed in person and provided detailed lifestyle information and completed a validated 165-item food frequency questionnaire. Blood specimens (for genotyping) and mammograms are already available on these 2,200 women. We propose to assess mammographic density using a computer-assisted method we developed and have successfully employed in epidemiological and clinical studies. Our primary specific aims are: (1) To assess diet, especially soy intake, in relation to mammographic density. In addition, we will assess the potential modifying and/or confounding effect of dietary factors such as dietary fat, fiber, carotenoids, cruciferous vegetables/isothiocyanates, on the soy-mammographic density association. (2) To assess whether genotypes modify the associations between dietary factors (such as soy intake) and mammographic density. For example, we will evaluate whether the associations between estrogen metabolizing genes (e.g., HSD17B1, CYP1B1, COMT, SULT1A1) and mammographic density are stronger among low soy consumers. Our secondary specific aims are: (3) To assess genotypes of a panel of sex-steroid hormone metabolism genes, in relation to mammographic density. (4) To assess genotypes of other mitogenesis-related genes including the angiotensin I-converting enzyme (ACE), transforming growth factor beta-1(TGFbeta-1), insulin-like growth factor- I (IGF-1) and IGF binding protein (BP)-3), in relation to mammographic density.

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Publications

Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women.
Authors: Lee E, Van Den Berg D, Hsu C, Ursin G, Koh WP, Yuan JM, Stram DO, Yu MC, Wu AH
Source: Cancer Res, 2013 Mar 15;73(6), p. 1876-82.
EPub date: 2013 Jan 18.
PMID: 23333936
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Sleep duration, spot urinary 6-sulfatoxymelatonin levels and risk of breast cancer among Chinese women in Singapore.
Authors: Wu AH, Stanczyk FZ, Wang R, Koh WP, Yuan JM, Yu MC
Source: Int J Cancer, 2013 Feb 15;132(4), p. 891-6.
EPub date: 2012 Jun 28.
PMID: 22644618
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Alcohol intake and mammographic density in postmenopausal Norwegian women.
Authors: Qureshi SA, Couto E, Hofvind S, Wu AH, Ursin G
Source: Breast Cancer Res Treat, 2012 Feb;131(3), p. 993-1002.
EPub date: 2011 Oct 13.
PMID: 21993860
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Mammographic density and intake of selected nutrients and vitamins in Norwegian women.
Authors: Qureshi SA, Couto E, Hilsen M, Hofvind S, Wu AH, Ursin G
Source: Nutr Cancer, 2011;63(7), p. 1011-20.
EPub date: 2011 Sep 14.
PMID: 21916704
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Green tea and breast cancer.
Authors: Wu AH, Butler LM
Source: Mol Nutr Food Res, 2011 Jun;55(6), p. 921-30.
EPub date: 2011 Apr 29.
PMID: 21538855
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A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal Singapore Chinese women.
Authors: Butler LM, Wu AH, Wang R, Koh WP, Yuan JM, Yu MC
Source: Am J Clin Nutr, 2010 Apr;91(4), p. 1013-9.
EPub date: 2010 Feb 24.
PMID: 20181808
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Green tea, soy, and mammographic density in Singapore Chinese women.
Authors: Wu AH, Ursin G, Koh WP, Wang R, Yuan JM, Khoo KS, Yu MC
Source: Cancer Epidemiol Biomarkers Prev, 2008 Dec;17(12), p. 3358-65.
PMID: 19064551
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Soy intake and breast cancer risk in Singapore Chinese Health Study.
Authors: Wu AH, Koh WP, Wang R, Lee HP, Yu MC
Source: Br J Cancer, 2008 Jul 8;99(1), p. 196-200.
PMID: 18594543
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Sleep duration, melatonin and breast cancer among Chinese women in Singapore.
Authors: Wu AH, Wang R, Koh WP, Stanczyk FZ, Lee HP, Yu MC
Source: Carcinogenesis, 2008 Jun;29(6), p. 1244-8.
EPub date: 2008 Apr 30.
PMID: 18448486
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