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Grant Details

Grant Number: 5R01CA098497-06 Interpret this number
Primary Investigator: Yuan, Jian-Min
Organization: University Of Minnesota
Project Title: Dietary Factors in the Etiology of Colorectal Cancer
Fiscal Year: 2008
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Abstract

DESCRIPTION (provided by applicant): Environmental and genetic factors play a role in the development of colorectal cancer. Heterocyclic aromatic amines (HAAs) in high-temperature cooked meat and cigarette smoke are potential human colorectal carcinogens. HAAs need to be metabolically activated before they exert their carcinogenic effects. Several enzymes that are encoded by cytochrome P4501A2 (CYP1A2), N-acetyltransferase 2 (NAT2) and possibly NAT1 are involved in this HAA activating pathway. Tea polyphenols are found to inhibit the formation of HAA adducts in animals, and therefore, may protect against the development of colorectal cancer in humans. The proposed study will utilize two established residential cohorts of Chinese to study the effects of dietary and non-dietary HAAs and green tea consumption on the risk of colorectal cancer. The Shanghai Cohort Study enrolled 18,244 men aged 45-64 years in Shanghai, China, during 1986-89. The Singapore Chinese Health Study enrolled 27,959 men and 35,298 women aged 45-74 years during 1993-1998. At recruitment, all cohort members provided detailed dietary and medical histories. Blood and urine specimens were collected from all Shanghai cohort members and about 50% of Singapore cohort members. The cohorts have been followed for the occurrence of cancer and death through routine ascertainment of new cases from the population-based Shanghai and Singapore cancer registries and vital statistical databases, and for the Shanghai Cohort Study, annual visits to all known surviving cohort members. To date, the cohorts have accumulated more than 680,000 person-years of observation. Among cohort members, 8,255 subjects have died and 5,735 have developed cancer, including 793 colorectal cancers. During the next 5 years, study investigators will assess the roles of dietary HAAs and tea polyphenol in the development of colorectal cancer using validated biomarker assays. The potential modifying effects of HAA activating genes and tea polyphenols on the HAA-colorectal cancer association will be explored.

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Publications

Association of Caucasian-identified variants with colorectal cancer risk in Singapore Chinese.
Authors: Thean LF, Li HH, Teo YY, Koh WP, Yuan JM, Teoh ML, Koh PK, Tang CL, Cheah PY
Source: PLoS One, 2012;7(8), p. e42407.
EPub date: 2012 Aug 3.
PMID: 22879968
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Plasma vitamin E and coenzyme Q10 are not associated with a lower risk of acute myocardial infarction in Singapore Chinese adults.
Authors: Naidoo N, van Dam RM, Koh WP, Chen C, Lee YP, Yuan JM, Ong CN
Source: J Nutr, 2012 Jun;142(6), p. 1046-52.
EPub date: 2012 Apr 18.
PMID: 22513986
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Mortality due to coronary heart disease and kidney disease among middle-aged and elderly men and women with gout in the Singapore Chinese Health Study.
Authors: Teng GG, Ang LW, Saag KG, Yu MC, Yuan JM, Koh WP
Source: Ann Rheum Dis, 2012 Jun;71(6), p. 924-8.
EPub date: 2011 Dec 15.
PMID: 22172492
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Smoking as an independent risk factor for hepatocellular carcinoma: the Singapore Chinese Health Study.
Authors: Koh WP, Robien K, Wang R, Govindarajan S, Yuan JM, Yu MC
Source: Br J Cancer, 2011 Oct 25;105(9), p. 1430-5.
EPub date: 2011 Sep 13.
PMID: 21915129
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DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes.
Authors: Nauwelaers G, Bessette EE, Gu D, Tang Y, Rageul J, Fessard V, Yuan JM, Yu MC, LangouŽt S, Turesky RJ
Source: Chem Res Toxicol, 2011 Jun 20;24(6), p. 913-25.
EPub date: 2011 Apr 19.
PMID: 21456541
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Aromatase (CYP19) promoter gene polymorphism and risk of nonviral hepatitis-related hepatocellular carcinoma.
Authors: Koh WP, Yuan JM, Wang R, Govindarajan S, Oppenheimer R, Zhang ZQ, Yu MC, Ingles SA
Source: Cancer, 2011 Aug 1;117(15), p. 3383-92.
EPub date: 2011 Feb 11.
PMID: 21319151
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Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study.
Authors: Stern MC, Butler LM, Corral R, Joshi AD, Yuan JM, Koh WP, Yu MC
Source: J Nutrigenet Nutrigenomics, 2009;2(6), p. 273-9.
EPub date: 2010 Jun 19.
PMID: 20559012
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Coffee intake and risk of colorectal cancer among Chinese in Singapore: the Singapore Chinese Health Study.
Authors: Peterson S, Yuan JM, Koh WP, Sun CL, Wang R, Turesky RJ, Yu MC
Source: Nutr Cancer, 2010;62(1), p. 21-9.
PMID: 20043256
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Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA.
Authors: Ognjanovic S, Yuan JM, Chaptman AK, Fan Y, Yu MC
Source: Carcinogenesis, 2009 May;30(5), p. 758-62.
EPub date: 2009 Jan 6.
PMID: 19126646
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Sleep duration and coronary heart disease mortality among Chinese adults in Singapore: a population-based cohort study.
Authors: Shankar A, Koh WP, Yuan JM, Lee HP, Yu MC
Source: Am J Epidemiol, 2008 Dec 15;168(12), p. 1367-73.
EPub date: 2008 Oct 23.
PMID: 18952563
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Insulin-like growth factor-1 promoter polymorphisms and colorectal cancer: a functional genomics approach.
Authors: Wong HL, Koh WP, Probst-Hensch NM, Van den Berg D, Yu MC, Ingles SA
Source: Gut, 2008 Aug;57(8), p. 1090-6.
EPub date: 2008 Feb 28.
PMID: 18308828
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DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study.
Authors: Stern MC, Conti DV, Siegmund KD, Corral R, Yuan JM, Koh WP, Yu MC
Source: Cancer Epidemiol Biomarkers Prev, 2007 Nov;16(11), p. 2363-72.
PMID: 18006925
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Green tea and black tea consumption in relation to colorectal cancer risk: the Singapore Chinese Health Study.
Authors: Sun CL, Yuan JM, Koh WP, Lee HP, Yu MC
Source: Carcinogenesis, 2007 Oct;28(10), p. 2143-8.
EPub date: 2007 Aug 27.
PMID: 17724377
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Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma.
Authors: Yuan JM, Lu SC, Van Den Berg D, Govindarajan S, Zhang ZQ, Mato JM, Yu MC
Source: Hepatology, 2007 Sep;46(3), p. 749-58.
PMID: 17659576
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Cigarettes and alcohol in relation to colorectal cancer: the Singapore Chinese Health Study.
Authors: Tsong WH, Koh WP, Yuan JM, Wang R, Sun CL, Yu MC
Source: Br J Cancer, 2007 Mar 12;96(5), p. 821-7.
EPub date: 2007 Feb 20.
PMID: 17311023
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Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma.
Authors: Yuan JM, Gao YT, Ong CN, Ross RK, Yu MC
Source: J Natl Cancer Inst, 2006 Apr 5;98(7), p. 482-90.
PMID: 16595784
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Peroxisome proliferator-activated receptor (PPAR) gamma gene polymorphisms and colorectal cancer risk among Chinese in Singapore.
Authors: Koh WP, Yuan JM, Van Den Berg D, Ingles SA, Yu MC
Source: Carcinogenesis, 2006 Sep;27(9), p. 1797-802.
EPub date: 2006 Mar 2.
PMID: 16513680
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Diabetes mellitus and risk of colorectal cancer in the Singapore Chinese Health Study.
Authors: Seow A, Yuan JM, Koh WP, Lee HP, Yu MC
Source: J Natl Cancer Inst, 2006 Jan 18;98(2), p. 135-8.
PMID: 16418516
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