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Grant Details

Grant Number: 2R44CA117171-02 Interpret this number
Primary Investigator: Jacquez, Geoffrey
Organization: Biomedware
Project Title: Cancer Clustering for Residential Histories
Fiscal Year: 2007
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Abstract

DESCRIPTION (provided by applicant): Cancer Clustering for Residential Histories Abstract: This project will develop a new, comprehensive approach for evaluating clustering in case-control data that accounts for residential histories, risk factors, covariates and cancer induction and latency periods. To date, two of the major deficiencies of geographic studies of cancer are that they lack an appropriate methodology for investigating clusters over the life course and risk factors/covariates are not included in the analysis. These limitations are overcome by this project. Local, global and focused tests for residential histories will be developed based on sets of matrices of nearest neighbor relationships that reflect the changing space-time geometry of the residential addresses of cases and controls. Exposure traces that account for the latency between exposure and disease manifestation, and that use exposure windows of varying duration will be defined. Several of the methods so derived will be applied to evaluate clustering of residential histories in an ongoing case-control study of bladder cancer in south eastern Michigan, and to identify local excesses of breast cancer in Marin County, California. Because humans are mobile, these new methods are a significant advance over approaches that ignore residential histories and instead rely only on place of residence at time of diagnosis or death. The major innovation is the creation of methods for analyzing and modeling the residential histories of cases and controls to identify geographic excesses of cancer risk, both in the study population itself as well as in relation to putative hazards such as point-source releases of carcinogens. Cancer Clustering for Residential Histories Relevance: The techniques and software to be developed in this project will provide a more concise and accurate description of clustering of cancer cases that accounts for risk factors, covariates, residential history, cancer latency, time of diagnosis, and the exposure windows during which causative exposures are hypothesized to have occurred. To our knowledge the techniques and software from this project will be the first to address all of these factors within a single, comprehensive framework.

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Publications

Residential mobility and breast cancer in Marin County, California, USA.
Authors: Jacquez GM, Barlow J, Rommel R, Kaufmann A, Rienti M Jr, AvRuskin G, Rasul J
Source: Int J Environ Res Public Health, 2013 Dec 23;11(1), p. 271-95.
EPub date: 2013 Dec 23.
PMID: 24366047
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Evaluation of the risk of neighbourhood infection of H7N1 Highly Pathogenic Avian Influenza in Italy using Q statistic.
Authors: Mulatti P, Kitron U, Jacquez GM, Mannelli A, Marangon S
Source: Prev Vet Med, 2010 Jul 1;95(3-4), p. 267-74.
EPub date: 2010 May 6.
PMID: 20451272
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Space-time clustering of case-control data with residential histories: insights into empirical induction periods, age-specific susceptibility, and calendar year-specific effects.
Authors: Meliker JR, Jacquez GM
Source: Stoch Environ Res Risk Assess, 2007 Aug;21(5), p. 625-634.
PMID: 18560470
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Using satellite derived land cover information for a multi-temporal study of self-reported recall of proximity to farmland.
Authors: Avruskin GA, Meliker JR, Jacquez GM
Source: J Expo Sci Environ Epidemiol, 2008 Jul;18(4), p. 381-91.
EPub date: 2007 Sep 5.
PMID: 17805231
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In search of induction and latency periods: space-time interaction accounting for residential mobility, risk factors and covariates.
Authors: Jacquez GM, Meliker J, Kaufmann A
Source: Int J Health Geogr, 2007 Aug 23;6, p. 35.
EPub date: 2007 Aug 23.
PMID: 17716380
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Individual lifetime exposure to inorganic arsenic using a space-time information system.
Authors: Meliker JR, Slotnick MJ, Avruskin GA, Kaufmann A, Fedewa SA, Goovaerts P, Jacquez GJ, Nriagu JO
Source: Int Arch Occup Environ Health, 2007 Jan;80(3), p. 184-97.
EPub date: 2006 Aug 9.
PMID: 16897097
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Case-control geographic clustering for residential histories accounting for risk factors and covariates.
Authors: Jacquez GM, Meliker JR, Avruskin GA, Goovaerts P, Kaufmann A, Wilson ML, Nriagu J
Source: Int J Health Geogr, 2006 Aug 3;5, p. 32.
EPub date: 2006 Aug 3.
PMID: 16887016
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Global, local and focused geographic clustering for case-control data with residential histories.
Authors: Jacquez GM, Kaufmann A, Meliker J, Goovaerts P, AvRuskin G, Nriagu J
Source: Environ Health, 2005 Mar 22;4(1), p. 4.
EPub date: 2005 Mar 22.
PMID: 15784151
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