||3U24CA078134-05S4 Interpret this number
||University Of California Irvine
||Uci Ucsd Cancer Genetics Network
DESCRIPTION: (Applicant's Description) Newly emerging technology for
mutation detection and high-throughput sequencing of genes will make
obsolete many of the previous and some of the current research strategies in
the genetic epidemiology of cancer. The proposed UCI-UCSD Cancer Genetics
Network (UCI-UCSD CGN) will be accomplished through the existing strengths
of its co-investigators, community clinicians, existing resources, and
previous experience in genetic epidemiology of cancer. Fundamental to the
new NCI direction is the participation of clinicians, the community they
serve, and basic scientists and epidemiologists. Also integral to the
strategy is the dissemination of the growing body of genetic information to
all participants and the provision of genetic counseling to those affected
by the discovery of cancer mutations.
The UCI-UCSD CGN will serve as an infrastructure for collaborative research
investigations into the genetic basis of human cancer susceptibility. 1)
The infrastructure will include basic network activities. These activities
include the recruitment and follow-up of Network Participants, the
collection and storage of core information, the maintenance of a local
informatics system, a core laboratory for the processing and storage of
biological specimens for specific projects, and the maintenance of
informatics and communications technology to interface with the Nationwide
Network. The UCI-- UCSD CGN will recruit potential enrollees from a total
population of approximately 264,450 individuals. This population will
include individuals at high-risk for cancer due to family history, members
of the VA Desert Pacific Health Care Network, cancer patients including
those with multiple primary cancer from the Cancer Surveillance Program of
Orange, San Diego, and Imperial Counties, referrals from community clinics,
physicians, and hospitals, and cancer survivors who are members of advocacy
and community groups. Once enrolled, network members will complete a
one-page interview of basic family history and risk factor information and
will be followed annually. Genetic counseling and education will be made
available to network members and referral physicians. 2) UCI-UCSD CGN will
expand research capabilities to support Network activities, specifically in
areas of molecular genetics, clinical genetics, genetic counseling, and
education. A network of top quality principal investigators and
co-investigators will provide an infrastructure for joint research efforts
between scientists and clinicians. The UCI-UCSD CGN will sponsor scientific
seminars and conferences that will facilitate the translation of molecular
genetics research into clinical practice. The majority of the elements of
the proposed network have already been established by our group and
communications among them are in place.
Activating mutation in MET oncogene in familial colorectal cancer.
Neklason DW, Done MW, Sargent NR, Schwartz AG, Anton-Culver H, Griffin CA, Ahnen DJ, Schildkraut JM, Tomlinson GE, Strong LC, Miller AR, Stopfer JE, Burt RW
BMC Cancer, 2011 Oct 4;11, p. 424.
2011 Oct 4.
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