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Grant Details

Grant Number: 5R01CA096002-05 Interpret this number
Primary Investigator: Nriagu, Jerome
Organization: University Of Michigan At Ann Arbor
Project Title: Arsenic Exposure and Bladder Cancer in Michigan
Fiscal Year: 2006
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Abstract

DESCRIPTION (provided by applicant): The objective of this proposal is to explore the factors that have contributed to the observed geographic co-clustering in bladder cancer mortality and arsenic concentrations in drinking water in Michigan. The focus will be on the spatial and spatio-temporal patterns of arsenic exposure and how these may relate to the incidence of bladder cancer in those areas of Michigan with elevated levels of arsenic in their drinking water. Reported arsenic concentrations in well waters in the study area range from 1 to 1310 mg/I, with most common levels being 5-50 mg/L. The project being proposed will consist of three components: (1) Construction of exposure scenarios with time dimension that will involve development of the novel space-time information system (STIS) model to be validated using a combination of space-and-time-dependent concentrations of arsenic measured in the study, supplementary historical information on arsenic levels in water supplies, hydrogeochemistry of the area, and self-reported residence information and water drinking habits; (2) Biomonitoring of arsenic exposure to be based on analysis of toenails (known to indicate average exposure over a relatively long time) for arsenic and a number of confounding trace elements such as selenium, zinc, copper and antimony; (3) A population-based, case-control bladder cancer study which will be used as an outcome measure for exposure to arsenic in drinking water. Bladder cancer cases (700) and controls (700, matched to cases by sex, race, and +/- 5-year age groups) will be recruited from long-term residents of the 11 counties (Genesee, Huron, lngham, Jackson, Lapeer, Livingston, Oakland, Sanilac, Shiawassee, Tuscola and Washtenaw) with elevated levels of arsenic in their groundwater. Structured personal interviews will be administered to obtain information on lifetime residential history, current and past water consumption patterns, life-style risk factors (including cigarette smoking and alcohol use), medical history, occupational history, family history of cancer, and dietary habits. The study is designed to shed some light on the dose-response relations for exposure of the U.S. population to arsenic concentrations in the 5-100 mg/L range where no information currently exists. Current efforts by the U.S. Environmental Protection Agency to reduce the maximum contaminant level for arsenic in our drinking water have been bedeviled by contradictory and unvalidated predictions of the risks of chronic exposure to low levels (< 100 mg/L) of arsenic in water.

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Publications

Urinary arsenic species, toenail arsenic, and arsenic intake estimates in a Michigan population with low levels of arsenic in drinking water.
Authors: Rivera-Nez Z, Meliker JR, Meeker JD, Slotnick MJ, Nriagu JO
Source: J Expo Sci Environ Epidemiol, 2012 Mar-Apr;22(2), p. 182-90.
EPub date: 2011 Aug 31.
PMID: 21878987
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Accuracy of commercially available residential histories for epidemiologic studies.
Authors: Jacquez GM, Slotnick MJ, Meliker JR, AvRuskin G, Copeland G, Nriagu J
Source: Am J Epidemiol, 2011 Jan 15;173(2), p. 236-43.
EPub date: 2010 Nov 17.
PMID: 21084554
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Incorporating individual-level distributions of exposure error in epidemiologic analyses: an example using arsenic in drinking water and bladder cancer.
Authors: Meliker JR, Goovaerts P, Jacquez GM, Nriagu JO
Source: Ann Epidemiol, 2010 Oct;20(10), p. 750-8.
PMID: 20816314
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Lifetime exposure to arsenic in drinking water and bladder cancer: a population-based case-control study in Michigan, USA.
Authors: Meliker JR, Slotnick MJ, AvRuskin GA, Schottenfeld D, Jacquez GM, Wilson ML, Goovaerts P, Franzblau A, Nriagu JO
Source: Cancer Causes Control, 2010 May;21(5), p. 745-57.
EPub date: 2010 Jan 19.
PMID: 20084543
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Automobile industry occupations and bladder cancer: a population-based case-control study in southeastern Michigan, USA.
Authors: Kobrosly RW, Meliker JR, Nriagu JO
Source: Occup Environ Med, 2009 Oct;66(10), p. 650-6.
EPub date: 2009 May 21.
PMID: 19465410
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Effects of nutritional measures on toenail arsenic concentration as a biomarker of arsenic exposure.
Authors: Slotnick MJ, Meliker JR, Kannan S, Nriagu JO
Source: Biomarkers, 2008 Aug;13(5), p. 451-66.
PMID: 18979638
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Validity of spatial models of arsenic concentrations in private well water.
Authors: Meliker JR, AvRuskin GA, Slotnick MJ, Goovaerts P, Schottenfeld D, Jacquez GM, Nriagu JO
Source: Environ Res, 2008 Jan;106(1), p. 42-50.
EPub date: 2007 Oct 17.
PMID: 17942092
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Using satellite derived land cover information for a multi-temporal study of self-reported recall of proximity to farmland.
Authors: Avruskin GA, Meliker JR, Jacquez GM
Source: J Expo Sci Environ Epidemiol, 2008 Jul;18(4), p. 381-91.
EPub date: 2007 Sep 5.
PMID: 17805231
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Intra-individual variability in toenail arsenic concentrations in a Michigan population, USA.
Authors: Slotnick MJ, Meliker JR, Nriagu JO
Source: J Expo Sci Environ Epidemiol, 2008 Mar;18(2), p. 149-57.
EPub date: 2007 Apr 11.
PMID: 17426735
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Toenails as a biomarker of inorganic arsenic intake from drinking water and foods.
Authors: Slotnick MJ, Meliker JR, AvRuskin GA, Ghosh D, Nriagu JO
Source: J Toxicol Environ Health A, 2007 Jan 15;70(2), p. 148-58.
PMID: 17365576
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Arsenic in drinking water and cerebrovascular disease, diabetes mellitus, and kidney disease in Michigan: a standardized mortality ratio analysis.
Authors: Meliker JR, Wahl RL, Cameron LL, Nriagu JO
Source: Environ Health, 2007 Feb 2;6, p. 4.
EPub date: 2007 Feb 2.
PMID: 17274811
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Individual lifetime exposure to inorganic arsenic using a space-time information system.
Authors: Meliker JR, Slotnick MJ, Avruskin GA, Kaufmann A, Fedewa SA, Goovaerts P, Jacquez GJ, Nriagu JO
Source: Int Arch Occup Environ Health, 2007 Jan;80(3), p. 184-97.
EPub date: 2006 Aug 9.
PMID: 16897097
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Effects of time and point-of-use devices on arsenic levels in Southeastern Michigan drinking water, USA.
Authors: Slotnick MJ, Meliker JR, Nriagu JO
Source: Sci Total Environ, 2006 Oct 1;369(1-3), p. 42-50.
EPub date: 2006 Jun 5.
PMID: 16750243
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Validity of human nails as a biomarker of arsenic and selenium exposure: A review.
Authors: Slotnick MJ, Nriagu JO
Source: Environ Res, 2006 Sep;102(1), p. 125-39.
EPub date: 2006 Jan 26.
PMID: 16442520
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Global, local and focused geographic clustering for case-control data with residential histories.
Authors: Jacquez GM, Kaufmann A, Meliker J, Goovaerts P, AvRuskin G, Nriagu J
Source: Environ Health, 2005 Mar 22;4(1), p. 4.
EPub date: 2005 Mar 22.
PMID: 15784151
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