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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R01CA096002-05 Interpret this number
Primary Investigator: Nriagu, Jerome
Organization: University Of Michigan
Project Title: Arsenic Exposure and Bladder Cancer in Michigan
Fiscal Year: 2006
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Abstract

DESCRIPTION (provided by applicant): The objective of this proposal is to explore the factors that have contributed to the observed geographic co-clustering in bladder cancer mortality and arsenic concentrations in drinking water in Michigan. The focus will be on the spatial and spatio-temporal patterns of arsenic exposure and how these may relate to the incidence of bladder cancer in those areas of Michigan with elevated levels of arsenic in their drinking water. Reported arsenic concentrations in well waters in the study area range from 1 to 1310 mg/I, with most common levels being 5-50 mg/L. The project being proposed will consist of three components: (1) Construction of exposure scenarios with time dimension that will involve development of the novel space-time information system (STIS) model to be validated using a combination of space-and-time-dependent concentrations of arsenic measured in the study, supplementary historical information on arsenic levels in water supplies, hydrogeochemistry of the area, and self-reported residence information and water drinking habits; (2) Biomonitoring of arsenic exposure to be based on analysis of toenails (known to indicate average exposure over a relatively long time) for arsenic and a number of confounding trace elements such as selenium, zinc, copper and antimony; (3) A population-based, case-control bladder cancer study which will be used as an outcome measure for exposure to arsenic in drinking water. Bladder cancer cases (700) and controls (700, matched to cases by sex, race, and +/- 5-year age groups) will be recruited from long-term residents of the 11 counties (Genesee, Huron, lngham, Jackson, Lapeer, Livingston, Oakland, Sanilac, Shiawassee, Tuscola and Washtenaw) with elevated levels of arsenic in their groundwater. Structured personal interviews will be administered to obtain information on lifetime residential history, current and past water consumption patterns, life-style risk factors (including cigarette smoking and alcohol use), medical history, occupational history, family history of cancer, and dietary habits. The study is designed to shed some light on the dose-response relations for exposure of the U.S. population to arsenic concentrations in the 5-100 mg/L range where no information currently exists. Current efforts by the U.S. Environmental Protection Agency to reduce the maximum contaminant level for arsenic in our drinking water have been bedeviled by contradictory and unvalidated predictions of the risks of chronic exposure to low levels (< 100 mg/L) of arsenic in water.

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Publications

Global, Local And Focused Geographic Clustering For Case-control Data With Residential Histories
Authors: Jacquez G.M. , Kaufmann A. , Meliker J. , Goovaerts P. , AvRuskin G. , Nriagu J. .
Source: Environmental Health : A Global Access Science Source, 2005; 4(1), p. 4.
PMID: 15784151
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Validity Of Human Nails As A Biomarker Of Arsenic And Selenium Exposure: A Review
Authors: Slotnick M.J. , Nriagu J.O. .
Source: Environmental Research, 2006 Sep; 102(1), p. 125-39.
PMID: 16442520
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Effects Of Time And Point-of-use Devices On Arsenic Levels In Southeastern Michigan Drinking Water, Usa
Authors: Slotnick M.J. , Meliker J.R. , Nriagu J.O. .
Source: The Science Of The Total Environment, 2006-10-01 00:00:00.0; 369(1-3), p. 42-50.
PMID: 16750243
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Individual Lifetime Exposure To Inorganic Arsenic Using A Space-time Information System
Authors: Meliker J.R. , Slotnick M.J. , Avruskin G.A. , Kaufmann A. , Fedewa S.A. , Goovaerts P. , Jacquez G.J. , Nriagu J.O. .
Source: International Archives Of Occupational And Environmental Health, 2007 Jan; 80(3), p. 184-97.
PMID: 16897097
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Arsenic In Drinking Water And Cerebrovascular Disease, Diabetes Mellitus, And Kidney Disease In Michigan: A Standardized Mortality Ratio Analysis
Authors: Meliker J.R. , Wahl R.L. , Cameron L.L. , Nriagu J.O. .
Source: Environmental Health : A Global Access Science Source, 2007; 6, p. 4.
PMID: 17274811
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Toenails As A Biomarker Of Inorganic Arsenic Intake From Drinking Water And Foods
Authors: Slotnick M.J. , Meliker J.R. , AvRuskin G.A. , Ghosh D. , Nriagu J.O. .
Source: Journal Of Toxicology And Environmental Health. Part A, 2007-01-15 00:00:00.0; 70(2), p. 148-58.
PMID: 17365576
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Intra-individual Variability In Toenail Arsenic Concentrations In A Michigan Population, Usa
Authors: Slotnick M.J. , Meliker J.R. , Nriagu J.O. .
Source: Journal Of Exposure Science & Environmental Epidemiology, 2008 Mar; 18(2), p. 149-57.
PMID: 17426735
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Using Satellite Derived Land Cover Information For A Multi-temporal Study Of Self-reported Recall Of Proximity To Farmland
Authors: Avruskin G.A. , Meliker J.R. , Jacquez G.M. .
Source: Journal Of Exposure Science & Environmental Epidemiology, 2008 Jul; 18(4), p. 381-91.
PMID: 17805231
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Validity Of Spatial Models Of Arsenic Concentrations In Private Well Water
Authors: Meliker J.R. , AvRuskin G.A. , Slotnick M.J. , Goovaerts P. , Schottenfeld D. , Jacquez G.M. , Nriagu J.O. .
Source: Environmental Research, 2008 Jan; 106(1), p. 42-50.
PMID: 17942092
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Effects Of Nutritional Measures On Toenail Arsenic Concentration As A Biomarker Of Arsenic Exposure
Authors: Slotnick M.J. , Meliker J.R. , Kannan S. , Nriagu J.O. .
Source: Biomarkers : Biochemical Indicators Of Exposure, Response, And Susceptibility To Chemicals, 2008 Aug; 13(5), p. 451-66.
PMID: 18979638
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Automobile Industry Occupations And Bladder Cancer: A Population-based Case-control Study In Southeastern Michigan, Usa
Authors: Kobrosly R.W. , Meliker J.R. , Nriagu J.O. .
Source: Occupational And Environmental Medicine, 2009 Oct; 66(10), p. 650-6.
PMID: 19465410
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Lifetime Exposure To Arsenic In Drinking Water And Bladder Cancer: A Population-based Case-control Study In Michigan, Usa
Authors: Meliker J.R. , Slotnick M.J. , AvRuskin G.A. , Schottenfeld D. , Jacquez G.M. , Wilson M.L. , Goovaerts P. , Franzblau A. , Nriagu J.O. .
Source: Cancer Causes & Control : Ccc, 2010 May; 21(5), p. 745-57.
PMID: 20084543
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Incorporating Individual-level Distributions Of Exposure Error In Epidemiologic Analyses: An Example Using Arsenic In Drinking Water And Bladder Cancer
Authors: Meliker J.R. , Goovaerts P. , Jacquez G.M. , Nriagu J.O. .
Source: Annals Of Epidemiology, 2010 Oct; 20(10), p. 750-8.
PMID: 20816314
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Accuracy Of Commercially Available Residential Histories For Epidemiologic Studies
Authors: Jacquez G.M. , Slotnick M.J. , Meliker J.R. , AvRuskin G. , Copeland G. , Nriagu J. .
Source: American Journal Of Epidemiology, 2011-01-15 00:00:00.0; 173(2), p. 236-43.
PMID: 21084554
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Urinary Arsenic Species, Toenail Arsenic, And Arsenic Intake Estimates In A Michigan Population With Low Levels Of Arsenic In Drinking Water
Authors: Rivera-Nez Z. , Meliker J.R. , Meeker J.D. , Slotnick M.J. , Nriagu J.O. .
Source: Journal Of Exposure Science & Environmental Epidemiology, 2012 Mar-Apr; 22(2), p. 182-90.
PMID: 21878987
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