|Grant Number:||5R01CA080205-08 Interpret this number|
|Primary Investigator:||Yu, Mimi|
|Organization:||University Of Minnesota|
|Project Title:||The Singapore Cohort Study of Diet and Cancer|
This is a request for continued funding of a residential cohort of 63,257 middle-aged and older (45-74 years) Singapore Chinese men and women accrued between 1993 and 1998. The primary goal of this long-term, population-based cohort study is to elucidate the role of diet and its interaction with genetic factors in the causation of human cancer. At recruitment, each study subject was interviewed in person by a trained interviewer using a structured questionnaire that emphasized current diet assessed via a validated, 165-item food frequency questionnaire. Beginning in April 1994, a random 3% sample of cohort participants were asked to provide blood or buccal cell, and spot urine samples. We extended this biospecimen collection to all surviving cohort participants starting in January 2000. By May 2004, all surviving cohort subjects had been contacted, and biospecimens were collected from 31,318 subjects, representing a consent rate of about 60%. We also asked for blood/buccal/urine specimens from all incident cases of female breast and colorectal cancers beginning in April 1994. To date, the number of cancer cases with pre- or post-diagnostic biospecimens totals 686 (304 female breast, 223 colon, 159 rectum). Between July 1999 and December 2003, all surviving cohort subjects were recontacted for consent to a telephone interview to update information on selected exposures and medical history. Interviews were completed on 52,326 subjects, representing a consent rate of over 90%. The cohort has been passively followed for death and cancer occurrence through regular record linkage with the population-based Singapore Cancer Registry and the Singapore Registry of Births and Deaths. The observed numbers of incident cancers and deaths within the cohort are comparable to corresponding expected numbers based on age-sex-specific incidence rates for all Chinese in Singapore. We will continue to take advantage of this cohort to examine potential cancer protective dietary factors that are rarely consumed among the well-studied occidental populations. Our specific aims for the next 5 years are: (1) to assess the role of tea intake in cancer protection, with consideration for the type of tea drunk (green vs. black tea) and for individual susceptibility factors including key polymorphic genes controlling the 3 major excretion pathways (O-methylation, glucuronidation, sulfation) for tea polyphenols; and (2) to assess the potential roles of genes involved in repair of DMA damage and in cell cycle regulation in modifying a given association between tea as well as other identified dietary protective factors and cancer.
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.
Authors: SIGMA Type 2 Diabetes Consortium, Estrada K, Aukrust I, Bjørkhaug L, Burtt NP, Mercader JM, García-Ortiz H, Huerta-Chagoya A, Moreno-Macías H, Walford G, Flannick J, Williams AL, Gómez-Vázquez MJ, Fernandez-Lopez JC, Martínez-Hernández A, Centeno-Cruz F, Mendoza-Caamal E, Revilla-Monsalve C, Islas-Andrade S, Córdova EJ, Soberón X, González-Villalpando ME, Henderson E, Wilkens LR, Le Marchand L, Arellano-Campos O, Ordóñez-Sánchez ML, Rodríguez-Torres M, Rodríguez-Guillén R, Riba L, Najmi LA, Jacobs SB, Fennell T, Gabriel S, Fontanillas P, Hanis CL, Lehman DM, Jenkinson CP, Abboud HE, Bell GI, Cortes ML, Boehnke M, González-Villalpando C, Orozco L, Haiman CA, Tusié-Luna T, Aguilar-Salinas CA, Altshuler D, Njølstad PR, Florez JC, MacArthur DG
Source: JAMA, 2014 Jun 11;311(22), p. 2305-14.
Cigarette smoking and risk of total knee replacement for severe osteoarthritis among Chinese in Singapore--the Singapore Chinese health study.
Authors: Leung YY, Ang LW, Thumboo J, Wang R, Yuan JM, Koh WP
Source: Osteoarthritis Cartilage, 2014 Jun;22(6), p. 764-70.
EPub date: 2014 Mar 28.
Adherence to a vegetable-fruit-soy dietary pattern or the Alternative Healthy Eating Index is associated with lower hip fracture risk among Singapore Chinese.
Authors: Dai Z, Butler LM, van Dam RM, Ang LW, Yuan JM, Koh WP
Source: J Nutr, 2014 Apr;144(4), p. 511-8.
EPub date: 2014 Feb 26.
Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: the Singapore Chinese health study.
Authors: Chen Z, Pereira MA, Seielstad M, Koh WP, Tai ES, Teo YY, Liu J, Hsu C, Wang R, Odegaard AO, Thyagarajan B, Koratkar R, Yuan JM, Gross MD, Stram DO
Source: PLoS One, 2014;9(2), p. e87762.
EPub date: 2014 Feb 10.
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
Authors: SIGMA Type 2 Diabetes Consortium, Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C, Márquez-Luna C, García-Ortíz H, Gómez-Vázquez MJ, Burtt NP, Aguilar-Salinas CA, González-Villalpando C, Florez JC, Orozco L, Haiman CA, Tusié-Luna T, Altshuler D
Source: Nature, 2014 Feb 6;506(7486), p. 97-101.
EPub date: 2013 Dec 25.
Serum estrogen receptor bioactivity and breast cancer risk among postmenopausal women.
Authors: Lim VW, Li J, Gong Y, Jin A, Yuan JM, Yong EL, Koh WP
Source: Endocr Relat Cancer, 2014 Apr;21(2), p. 263-73.
EPub date: 2014 Feb 27.
Dietary fiber intake modifies the association between secondhand smoke exposure and coronary heart disease mortality among Chinese non-smokers in Singapore.
Authors: Clark ML, Butler LM, Koh WP, Wang R, Yuan JM
Source: Nutrition, 2013 Nov-Dec;29(11-12), p. 1304-9.
EPub date: 2013 Jul 30.
Protective effects of dietary carotenoids on risk of hip fracture in men: the Singapore Chinese Health Study.
Authors: Dai Z, Wang R, Ang LW, Low YL, Yuan JM, Koh WP
Source: J Bone Miner Res, 2014 Feb;29(2), p. 408-17.
Mitochondrial DNA copy number is associated with breast cancer risk.
Authors: Thyagarajan B, Wang R, Nelson H, Barcelo H, Koh WP, Yuan JM
Source: PLoS One, 2013;8(6), p. e65968.
EPub date: 2013 Jun 12.
Smoking and risk of kidney failure in the Singapore Chinese health study.
Authors: Jin A, Koh WP, Chow KY, Yuan JM, Jafar TH
Source: PLoS One, 2013;8(5), p. e62962.
EPub date: 2013 May 9.
Serum urate levels and consumption of common beverages and alcohol among Chinese in Singapore.
Authors: Teng GG, Tan CS, Santosa A, Saag KG, Yuan JM, Koh WP
Source: Arthritis Care Res (Hoboken), 2013 Sep;65(9), p. 1432-40.
Hormone metabolism genes and mammographic density in Singapore Chinese women.
Authors: Lee E, Su YC, Lewinger JP, Hsu C, Van Den Berg D, Ursin G, Koh WP, Yuan JM, Stram DO, Yu MC, Wu AH
Source: Cancer Epidemiol Biomarkers Prev, 2013 May;22(5), p. 984-6.
EPub date: 2013 Feb 21.
Genetic polymorphisms of epidermal growth factor in relation to risk of hepatocellular carcinoma: two case-control studies.
Authors: Yuan JM, Fan Y, Ognjanovic S, Wang R, Van Den Berg D, Govindarajan S, Yu MC
Source: BMC Gastroenterol, 2013 Feb 18;13, p. 32.
EPub date: 2013 Feb 18.
Diabetes mellitus and risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study.
Authors: Koh WP, Wang R, Jin A, Yu MC, Yuan JM
Source: Br J Cancer, 2013 Mar 19;108(5), p. 1182-8.
EPub date: 2013 Jan 31.
Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women.
Authors: Lee E, Van Den Berg D, Hsu C, Ursin G, Koh WP, Yuan JM, Stram DO, Yu MC, Wu AH
Source: Cancer Res, 2013 Mar 15;73(6), p. 1876-82.
EPub date: 2013 Jan 18.
Calcium intake is not related to breast cancer risk among Singapore Chinese women.
Authors: Li J, Koh WP, Jin AZ, Yuan JM, Yu MC, Butler LM
Source: Int J Cancer, 2013 Aug 1;133(3), p. 680-6.
EPub date: 2013 Mar 13.
Dietary B vitamin intake and risk of hip fracture: the Singapore Chinese Health Study.
Authors: Dai Z, Wang R, Ang LW, Yuan JM, Koh WP
Source: Osteoporos Int, 2013 Jul;24(7), p. 2049-59.
EPub date: 2012 Dec 13.
All-cause and cause-specific mortality after hip fracture among Chinese women and men: the Singapore Chinese Health Study.
Authors: Koh GC, Tai BC, Ang LW, Heng D, Yuan JM, Koh WP
Source: Osteoporos Int, 2013 Jul;24(7), p. 1981-9.
EPub date: 2012 Dec 9.
Association of Caucasian-identified variants with colorectal cancer risk in Singapore Chinese.
Authors: Thean LF, Li HH, Teo YY, Koh WP, Yuan JM, Teoh ML, Koh PK, Tang CL, Cheah PY
Source: PLoS One, 2012;7(8), p. e42407.
EPub date: 2012 Aug 3.
Mitochondrial copy number is associated with colorectal cancer risk.
Authors: Thyagarajan B, Wang R, Barcelo H, Koh WP, Yuan JM
Source: Cancer Epidemiol Biomarkers Prev, 2012 Sep;21(9), p. 1574-81.
EPub date: 2012 Jul 11.
Plasma vitamin E and coenzyme Q10 are not associated with a lower risk of acute myocardial infarction in Singapore Chinese adults.
Authors: Naidoo N, van Dam RM, Koh WP, Chen C, Lee YP, Yuan JM, Ong CN
Source: J Nutr, 2012 Jun;142(6), p. 1046-52.
EPub date: 2012 Apr 18.
Serum free estradiol and estrogen receptor-? mediated activity are related to decreased incident hip fractures in older women.
Authors: Lim VW, Li J, Gong Y, Yuan JM, Wu TS, Hammond GL, Jin A, Koh WP, Yong EL
Source: Bone, 2012 Jun;50(6), p. 1311-6.
EPub date: 2012 Mar 16.