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Grant Details

Grant Number: 5R01CA106592-04 Interpret this number
Primary Investigator: Weinstock, Martin
Organization: Rhode Island Hospital
Project Title: Efficacy of Web-Based Training in Skin Cancer Triage
Fiscal Year: 2007
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Abstract

DESCRIPTION (provided by applicant): Melanoma is a major public health problem with significant morbidity and mortality, and is increasing in frequency, unlike most cancer sites. The vast majority of the ultimately fatal melanomas were perfectly visible on the skin surface before they metastasized, yet they were not detected in time, hence not excised until it was too late for cure. Primary care clinicians are well-positioned to have a substantial impact on melanoma mortality by detecting these lesions on the skin surface prior to metastasis, yet we have found that they generally do not inspect the areas of the skin on which melanomas most commonly arise. This proposal seeks to change the skin examination practices of primary care physicians by developing the Basic Skin Cancer Triage curriculum into a web-based course and evaluating its efficacy in a geographically diverse sample of community-based primary care physicians. Specifically, we will develop the above course and compare it, in a randomized trial, to a web-based course in weight, diet, and physical activity assessment and counseling. Our primary outcomes will be performance of skin examination and counseling during routine primary care visits, as assessed by patient exit interviews. We will also assess self-reported practices and other measures. If this course is found to be efficacious, it will be made freely available on the web, and we will plan efforts to encourage its broad dissemination.

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Publications

The role of gender in examination and counseling for melanoma in primary care.
Authors: Markova A, Weinstock MA, Risica P, Kirtania U, Ombao H
Source: Arch Intern Med, 2011 Dec 12;171(22), p. 2061-3.
PMID: 22158580
Related Citations

Grant Numbers:
NCI NIH HHS - CA106592

MeSH Terms:
Sex Factors Humans Adult
Primary Health Care Middle Aged Skin Neoplasms
Counseling Physical Examination Male
Female Melanoma

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Association between non-steroidal anti-inflammatory drugs and keratinocyte carcinomas of the skin among participants in the Veterans Affairs Topical Tretinoin Chemoprevention Trial.
Authors: Nunes AP, Lapane KL, Weinstock MA, VATTC Trial Group
Source: Pharmacoepidemiol Drug Saf, 2011 Sep;20(9), p. 922-9.
EPub date: 2011 Jun 18.
PMID: 21688346
Related Citations

Grant Numbers:
NCI NIH HHS - R01CA106592 NIAMS NIH HHS - R01AR49342 NCI NIH HHS - R01CA106807
NCI NIH HHS - R25CA087972

MeSH Terms:
United States Double-Blind Method Humans
Aged Skin Neoplasms Carcinoma
Aged, 80 and over United States Department of Veterans Affairs Cohort Studies
Tretinoin Anti-Inflammatory Agents, Non-Steroidal Middle Aged
Keratinocytes Administration, Topical Female
Male

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Prospective quality of life impact of keratinocyte carcinomas: observations from the Veterans Affairs Topical Tretinoin Chemoprevention Trial.
Authors: Lee KC, Weinstock MA, Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) Trial Group
Source: J Am Acad Dermatol, 2010 Dec;63(6), p. 1107-9.
PMID: 21093671
Related Citations

Grant Numbers:
NCI NIH HHS - R01CA106592 NIAMS NIH HHS - R01AR49342 NCI NIH HHS - R01CA106807
NCI NIH HHS - R25CA087972

MeSH Terms:
United States Randomized Controlled Trials as Topic Antineoplastic Agents
United States Department of Veterans Affairs Humans Tretinoin
Quality of Life Carcinoma, Basal Cell Keratinocytes
Skin Neoplasms Carcinoma, Squamous Cell

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Incidence estimate of nonmelanoma skin cancer in the United States, 2006.
Authors: Rogers HW, Weinstock MA, Harris AR, Hinckley MR, Feldman SR, Fleischer AB, Coldiron BM
Source: Arch Dermatol, 2010 Mar;146(3), p. 283-7.
PMID: 20231499
Related Citations

Grant Numbers:
NCI NIH HHS - R01CA106592 NCI NIH HHS - R01CA106807 NCI NIH HHS - R25CA087972

MeSH Terms:
United States Cross-Sectional Studies Risk Factors
Humans Retrospective Studies Medicare
Incidence Aged Skin Neoplasms
Risk Assessment Population Surveillance

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Melanoma thickness trends in the United States, 1988-2006.
Authors: Criscione VD, Weinstock MA
Source: J Invest Dermatol, 2010 Mar;130(3), p. 793-7.
EPub date: 2009 Oct 15.
PMID: 19829301
Related Citations

Grant Numbers:
NCI NIH HHS - R01CA106592 NCI NIH HHS - R01CA106807 NCI NIH HHS - R25CA087972

MeSH Terms:
United States Registries Humans
Carcinoma in Situ SEER Program Prognosis
Skin Neoplasms Survival Analysis Melanoma

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Mortality of bullous skin disorders from 1979 through 2002 in the United States.
Authors: Risser J, Lewis K, Weinstock MA
Source: Arch Dermatol, 2009 Sep;145(9), p. 1005-8.
PMID: 19770439
Related Citations

Grant Numbers:
NCI NIH HHS - R01CA106592 NIAMS NIH HHS - R01AR49342 NCI NIH HHS - R01CA106807
NCI NIH HHS - R25CA087972

MeSH Terms:
United States Young Adult Questionnaires
Skin Diseases, Vesiculobullous Humans Aged
Alcohol Drinking Age Distribution Smoking
Prospective Studies Survival Rate Risk Factors
Adult Case-Control Studies Middle Aged
Adolescent Time Factors Female
Male Prevalence

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Tolerability of high-dose topical tretinoin: the Veterans Affairs Topical Tretinoin Chemoprevention Trial.
Authors: Geng A, Weinstock MA, Hall R, Eilers D, Naylor M, Kalivas J, VATTC Trial Group
Source: Br J Dermatol, 2009 Oct;161(4), p. 918-24.
EPub date: 2009 Jun 11.
PMID: 19681859
Related Citations

Grant Numbers:
NCI NIH HHS - R01CA106592 NIAMS NIH HHS - R01AR49342 NCI NIH HHS - R01CA106807
NCI NIH HHS - R25CA087972

MeSH Terms:
Drug Administration Schedule Double-Blind Method Antineoplastic Agents
Dose-Response Relationship, Drug Humans Aged
Carcinoma, Basal Cell Skin Neoplasms Veterans
Ear Neoplasms Treatment Outcome Ear, External
Facial Neoplasms Tretinoin Carcinoma, Squamous Cell
Time Factors Male Administration, Topical
Female

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Actinic keratoses: Natural history and risk of malignant transformation in the Veterans Affairs Topical Tretinoin Chemoprevention Trial.
Authors: Criscione VD, Weinstock MA, Naylor MF, Luque C, Eide MJ, Bingham SF, Department of Veteran Affairs Topical Tretinoin Chemoprevention Trial Group
Source: Cancer, 2009 Jun 1;115(11), p. 2523-30.
PMID: 19382202
Related Citations

Grant Numbers:
NCI NIH HHS - R01CA106592 NIAMS NIH HHS - R01AR49342 NCI NIH HHS - R01CA106807
NCI NIH HHS - R25CA087972

MeSH Terms:
Keratosis, Actinic Precancerous Conditions Humans
Disease Progression Aged Carcinoma, Basal Cell
Skin Neoplasms Risk Aged, 80 and over
Adult Middle Aged Carcinoma, Squamous Cell
Time Factors Female Male

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Demographic and socioeconomic predictors of melanoma prognosis in the United States.
Authors: Eide MJ, Weinstock MA, Clark MA
Source: J Health Care Poor Underserved, 2009 Feb;20(1), p. 227-45.
PMID: 19202259
Related Citations

Grant Numbers:
AHRQ HHS - HS00011-16 NCI NIH HHS - CA 106592

MeSH Terms:
United States Socioeconomic Factors Demography
Humans SEER Program Prognosis
Residence Characteristics Geographic Information Systems Population Surveillance
Melanoma

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Association between statin use and risk for keratinocyte carcinoma in the veterans affairs topical tretinoin chemoprevention trial.
Authors: Dore DD, Lapane KL, Trivedi AN, Mor V, Weinstock MA
Source: Ann Intern Med, 2009 Jan 6;150(1), p. 9-18.
PMID: 19124815
Related Citations

Grant Numbers:
NCI NIH HHS - R01CA106592 AHRQ HHS - 5T32HS000011-21 AHRQ HHS - T32 HS000011
NIAMS NIH HHS - R01AR49342 NCI NIH HHS - R01CA106807 NCI NIH HHS - R01 CA106592
NCI NIH HHS - R25CA087972

MeSH Terms:
Drug Administration Schedule Double-Blind Method Antineoplastic Agents
Humans Aged Carcinoma, Basal Cell
Skin Neoplasms Ear Neoplasms Aged, 80 and over
Risk Factors Confounding Factors (Epidemiology) Facial Neoplasms
Tretinoin Middle Aged Neoplasm Recurrence, Local
Carcinoma, Squamous Cell Male Administration, Topical
Female

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The association of physician-specialty density and melanoma prognosis in the United States, 1988 to 1993.
Authors: Eide MJ, Weinstock MA, Clark MA
Source: J Am Acad Dermatol, 2009 Jan;60(1), p. 51-8.
EPub date: 2008 Oct 19.
PMID: 18937998
Related Citations

Grant Numbers:
NCI NIH HHS - R01 CA106592-01 NCI NIH HHS - CA 106592 NIA NIH HHS - T32 AG023482-01

MeSH Terms:
United States Family Practice Humans
SEER Program Prognosis Internal Medicine
Dermatology Skin Neoplasms Melanoma

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Components of a successful intervention for monthly skin self-examination for early detection of melanoma: the "Check It Out" trial.
Authors: Lee KB, Weinstock MA, Risica PM
Source: J Am Acad Dermatol, 2008 Jun;58(6), p. 1006-12.
EPub date: 2008 Apr 11.
PMID: 18406492
Related Citations

Grant Numbers:
NCI NIH HHS - R01CA78800 NCI NIH HHS - R01CA106592 NIAMS NIH HHS - R01AR49342
NCI NIH HHS - R01CA106807 NCI NIH HHS - R25CA087972

MeSH Terms:
Self-Examination Video Recording Skin
Humans Middle Aged Skin Neoplasms
Early Diagnosis Male Female
Melanoma

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Incidence of cutaneous T-cell lymphoma in the United States, 1973-2002.
Authors: Criscione VD, Weinstock MA
Source: Arch Dermatol, 2007 Jul;143(7), p. 854-9.
PMID: 17638728
Related Citations

Grant Numbers:
NCI NIH HHS - CA 106592

MeSH Terms:
United States Humans SEER Program
Infant, Newborn Aged Child
Skin Neoplasms Age Distribution Child, Preschool
Registries Infant Aged, 80 and over
Ethnic Groups Adult Incidence
Middle Aged Adolescent Sex Distribution
Male Female Lymphoma, T-Cell, Cutaneous

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Melanoma early detection with thorough skin self-examination: the "Check It Out" randomized trial.
Authors: Weinstock MA, Risica PM, Martin RA, Rakowski W, Dubé C, Berwick M, Goldstein MG, Acharyya S, Lasater T
Source: Am J Prev Med, 2007 Jun;32(6), p. 517-24.
PMID: 17533068
Related Citations

Grant Numbers:
NCI NIH HHS - R01 CA078800-04 NCI NIH HHS - R01 CA 78800 NIAMS NIH HHS - R01 AR 49342
NCI NIH HHS - R01 CA078800-01A1 NCI NIH HHS - R01 CA 106592 NCI NIH HHS - R01 CA078800-03
NCI NIH HHS - R01 CA078800-02 NCI NIH HHS - R01 CA 106807

MeSH Terms:
Self-Examination Humans Dermatologic Surgical Procedures
Adult New England Interviews as Topic
Aged Middle Aged Early Diagnosis
Male Female Melanoma

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Trends in nonmelanoma skin cancer mortality rates in the United States, 1969 through 2000.
Authors: Lewis KG, Weinstock MA
Source: J Invest Dermatol, 2007 Oct;127(10), p. 2323-7.
EPub date: 2007 May 24.
PMID: 17522705
Related Citations

Grant Numbers:
NCI NIH HHS - R01CA106592 NIAMS NIH HHS - R01AR49342 NCI NIH HHS - R01CA106807

MeSH Terms:
United States Mortality Humans
Retrospective Studies African Americans Aged
Child Skin Neoplasms Genital Diseases, Male
Child, Preschool Infant Genital Diseases, Female
Aged, 80 and over European Continental Ancestry Group Adult
Incidence Middle Aged Adolescent
Male Female Survival Analysis

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Descriptive epidemiology of dermatofibrosarcoma protuberans in the United States, 1973 to 2002.
Authors: Criscione VD, Weinstock MA
Source: J Am Acad Dermatol, 2007 Jun;56(6), p. 968-73.
EPub date: 2006 Dec 1.
PMID: 17141362
Related Citations

Grant Numbers:
NCI NIH HHS - CA 106592

MeSH Terms:
United States Humans SEER Program
African Americans Aged Child
Dermatofibrosarcoma Child, Preschool Aged, 80 and over
European Continental Ancestry Group Adult Incidence
Middle Aged Adolescent Female
Male Survival Analysis

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The use of mole-mapping diagrams to increase skin self-examination accuracy.
Authors: Chiu V, Won E, Malik M, Weinstock MA
Source: J Am Acad Dermatol, 2006 Aug;55(2), p. 245-50.
EPub date: 2006 May 15.
PMID: 16844506
Related Citations

Grant Numbers:
NCI NIH HHS - R01CA106592

MeSH Terms:
Sensitivity and Specificity Self-Examination Patient Education as Topic
Humans Middle Aged Skin Neoplasms
Photography Male Female
Melanoma

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Progress and prospects on melanoma: the way forward for early detection and reduced mortality.
Authors: Weinstock MA
Source: Clin Cancer Res, 2006 Apr 1;12(7 Pt 2), p. 2297s-2300s.
PMID: 16609048
Related Citations

Grant Numbers:
NCI NIH HHS - CA106807 NCI NIH HHS - CA106592 NIAMS NIH HHS - AR49342

MeSH Terms:
Survival Rate Humans Skin Neoplasms
Melanoma

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Public health challenges in sun protection.
Authors: Eide MJ, Weinstock MA
Source: Dermatol Clin, 2006 Jan;24(1), p. 119-24.
PMID: 16311174
Related Citations

Grant Numbers:
NCI NIH HHS - CA 106592

MeSH Terms:
Ultraviolet Rays Public Health Humans
Sunscreening Agents Neoplasms, Radiation-Induced Sunlight
Health Policy Skin Neoplasms Health Education
Health Promotion

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Last Updated: August 24, 2012
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