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Grant Details

Grant Number: 5R01CA109250-04 Interpret this number
Primary Investigator: Audrain, Janet
Organization: University Of Pennsylvania
Project Title: Longitudinal Patterns and Predictors of Smoking Behavior
Fiscal Year: 2007
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Abstract

DESCRIPTION (provided by applicant): While adolescent smoking rates have declined since the late 1990's, cigarette smoking among young adults (18-22) is an emerging problem. The prevalence of cigarette smoking is one of the highest in this age group and only 22% of young adults who have ever smoked regularly have quit. Despite the public health significance of smoking among young adults, our understanding of the determinants of smoking patterns and transitions in this group is very limited. In order to develop well-informed smoking prevention and treatment programs for young adults, a much more comprehensive understanding of the natural history and determinants of smoking in this population are needed. We propose to address this gap by following our established cohort of about 1,000 adolescents (initiated at age 14 years) into young adulthood (to age 22). Comprehensive data on the socio-environmental and psychological influences on smoking behavior during the adolescent phase (age 14 to age 18) will be supplemented with data collected as these individuals make the transition to young adulthood (age 18 to age 22). Specific phenotypes of interest include longitudinal patterns (trajectories) of smoking, rates of progression to regular smoking and nicotine dependence, and smoking persistence. The primary aims of the proposed study are to empirically identify the longitudinal patterns of smoking behavior (smoking trajectories) from adolescence (age 14) to young adulthood (age 22), to characterize the smoking trajectories by socio-environmental and psychological determinants, and to test mechanisms by which these determinants impact on smoking behavior. This will be one of the first studies to capture smoking transitions from adolescence to young adulthood and to evaluate smoking and its determinants in a longitudinal fashion. Results from this study can be used to inform the timing, level, type, and specific target of smoking interventions.

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Publications

Declining alternative reinforcers link depression to young adult smoking.
Authors: Audrain-McGovern J, Rodriguez D, Rodgers K, Cuevas J
Source: Addiction, 2011 Jan;106(1), p. 178-87.
EPub date: 2010 Sep 15.
PMID: 20840206
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Adolescent smoking and depression: evidence for self-medication and peer smoking mediation.
Authors: Audrain-McGovern J, Rodriguez D, Kassel JD
Source: Addiction, 2009 Oct;104(10), p. 1743-56.
EPub date: 2009 Jun 22.
PMID: 19549056
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Mechanisms underlying the comorbidity of tobacco use in mental health and addictive disorders.
Authors: Morisano D, Bacher I, Audrain-McGovern J, George TP
Source: Can J Psychiatry, 2009 Jun;54(6), p. 356-67.
PMID: 19527556
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Does delay discounting play an etiological role in smoking or is it a consequence of smoking?
Authors: Audrain-McGovern J, Rodriguez D, Epstein LH, Cuevas J, Rodgers K, Wileyto EP
Source: Drug Alcohol Depend, 2009 Aug 1;103(3), p. 99-106.
EPub date: 2009 May 14.
PMID: 19443136
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Tobacco use and cessation in psychiatric disorders: National Institute of Mental Health report.
Authors: Ziedonis D, Hitsman B, Beckham JC, Zvolensky M, Adler LE, Audrain-McGovern J, Breslau N, Brown RA, George TP, Williams J, Calhoun PS, Riley WT
Source: Nicotine Tob Res, 2008 Dec;10(12), p. 1691-715.
PMID: 19023823
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Contextual consistency and adolescent smoking: testing the indirect effect of home indoor smoking restrictions on adolescent smoking through peer smoking.
Authors: Rodriguez D, Tscherne J, Audrain-McGovern J
Source: Nicotine Tob Res, 2007 Nov;9(11), p. 1155-61.
PMID: 17978989
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Effects of inattention and hyperactivity/impulsivity symptoms on development of nicotine dependence from mid adolescence to young adulthood.
Authors: Rodriguez D, Tercyak KP, Audrain-McGovern J
Source: J Pediatr Psychol, 2008 Jul;33(6), p. 563-75.
EPub date: 2007 Oct 23.
PMID: 17956929
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High school seniors' smoking initiation and progression 1 year after graduation.
Authors: Tercyak KP, Rodriguez D, Audrain-McGovern J
Source: Am J Public Health, 2007 Aug;97(8), p. 1397-8.
EPub date: 2007 Jun 28.
PMID: 17600259
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The role of CYP2A6 in the emergence of nicotine dependence in adolescents.
Authors: Audrain-McGovern J, Al Koudsi N, Rodriguez D, Wileyto EP, Shields PG, Tyndale RF
Source: Pediatrics, 2007 Jan;119(1), p. e264-74.
EPub date: 2006 Nov 27.
PMID: 17130279
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