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Grant Details

Grant Number: 5R01CA045762-18 Interpret this number
Primary Investigator: Rosenberg, Lynn
Organization: Boston University Medical Campus
Project Title: Case-Control Surveillance of Serious Illnesses and Drugs
Fiscal Year: 2007
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Abstract

DESCRIPTION (provided by applicant): We propose to continue Case-Control Surveillance (CCS) to assess the effects of prescription and nonprescription medications and other factors on the risk of cancers. Multiple case-control studies are conducted within a single data collection system. Nurse-interviewers in participating hospitals administer standard questionnaires to patients admitted for recently diagnosed cancers and other illnesses to obtain information on prescription and nonprescription medication use and on potential confounders or modifiers of exposure-disease associations. Data collection includes information on the newly popular class of nonprescription medications, herbals, and we have modified our drug dictionary in order to code these preparations. DNA is collected (from buccal cell samples) to allow for assessment of modification of drug disease associations by inherited genotype. We will continue to interview new cases and controls and to collect buccal samples. Enrollment of new patients is necessary because new drugs are constantly being introduced to the market, prescription drugs continue to be switched to nonprescription, and nonprescription drugs including herbals which have only recently become widely used are not otherwise monitored. Some herbals have been shown to have carcinogenic effects, affect estrogen levels, and influence the cytochrome p450 system involved with drug metabolism. One focus of CCS analyses will be the relation of the widely used drug classes, statins, histamine H2 antagonists, and selective serotonin uptake inhibitors, to risk of common cancers. We will also assess the relation of use of herbals to these cancers because the effects of these substances on cancer risk are largely unknown. We will assess modification by specific genetic polymorphisms of the relation of colon and breast cancer risk to use of nonsteroidal anti-inflammatory drugs. The usefulness of CCS for quantifying positive and inverse associations with cancer risk, documenting safety, and discovering associations has been extensively documented. Other systems do not have the capacity to assess a range of drug/genotype interactions or to systematically assess nonprescription drugs. CCS results have repeatedly been confirmed in other studies, indicating the success of efforts to minimize bias. CCS is a unique resource for cancer epidemiology.

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Publications

Antidepressant use and colorectal cancer risk.
Authors: Coogan PF, Strom BL, Rosenberg L
Source: Pharmacoepidemiol Drug Saf, 2009 Nov;18(11), p. 1111-4.
PMID: 19623565
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Vitamin and mineral use and risk of prostate cancer: the case-control surveillance study.
Authors: Zhang Y, Coogan P, Palmer JR, Strom BL, Rosenberg L
Source: Cancer Causes Control, 2009 Jul;20(5), p. 691-8.
EPub date: 2008 Dec 18.
PMID: 19093214
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A case-control study of oral contraceptive use and incident breast cancer.
Authors: Rosenberg L, Zhang Y, Coogan PF, Strom BL, Palmer JR
Source: Am J Epidemiol, 2009 Feb 15;169(4), p. 473-9.
EPub date: 2008 Dec 13.
PMID: 19074777
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Lung cancer and regular use of aspirin and nonaspirin nonsteroidal anti-inflammatory drugs.
Authors: Kelly JP, Coogan P, Strom BL, Rosenberg L
Source: Pharmacoepidemiol Drug Saf, 2008 Apr;17(4), p. 322-7.
PMID: 18041807
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SSRI use and breast cancer risk by hormone receptor status.
Authors: Coogan PF, Strom BL, Rosenberg L
Source: Breast Cancer Res Treat, 2008 Jun;109(3), p. 527-31.
EPub date: 2007 Jul 19.
PMID: 17638067
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Statin use and the risk of 10 cancers.
Authors: Coogan PF, Rosenberg L, Strom BL
Source: Epidemiology, 2007 Mar;18(2), p. 213-9.
PMID: 17235211
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Risk of non-Hodgkin lymphoma and use of non-steroidal anti-inflammatory drugs.
Authors: Zhang Y, Coogan PF, Palmer JR, Strom BL, Rosenberg L
Source: Cancer Detect Prev, 2006;30(1), p. 99-101.
EPub date: 2006 Feb 21.
PMID: 16495019
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Use of nonsteroidal antiinflammatory drugs and risk of breast cancer: the Case-Control Surveillance Study revisited.
Authors: Zhang Y, Coogan PF, Palmer JR, Strom BL, Rosenberg L
Source: Am J Epidemiol, 2005 Jul 15;162(2), p. 165-70.
EPub date: 2005 Jun 22.
PMID: 15972932
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Cimetidine and other histamine2-receptor antagonist use in relation to risk of breast cancer.
Authors: Coogan PF, Zhang Y, Palmer JR, Strom BL, Rosenberg L
Source: Cancer Epidemiol Biomarkers Prev, 2005 Apr;14(4), p. 1012-5.
PMID: 15824181
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Cigarette smoking and increased risk of mucinous epithelial ovarian cancer.
Authors: Zhang Y, Coogan PF, Palmer JR, Strom BL, Rosenberg L
Source: Am J Epidemiol, 2004 Jan 15;159(2), p. 133-9.
PMID: 14718214
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Menthol cigarettes and risk of lung cancer.
Authors: Brooks DR, Palmer JR, Strom BL, Rosenberg L
Source: Am J Epidemiol, 2003 Oct 1;158(7), p. 609-16; discussion 617-20.
PMID: 14507595
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Estrogen replacement therapy and risk of lung cancer.
Authors: Blackman JA, Coogan PF, Rosenberg L, Strom BL, Zauber AG, Palmer JR, Langenberg P, Shapiro S
Source: Pharmacoepidemiol Drug Saf, 2002 Oct-Nov;11(7), p. 561-7.
PMID: 12462132
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Statin use and the risk of breast and prostate cancer.
Authors: Coogan PF, Rosenberg L, Palmer JR, Strom BL, Zauber AG, Shapiro S
Source: Epidemiology, 2002 May;13(3), p. 262-7.
PMID: 11964926
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Risk of ovarian cancer according to use of antidepressants, phenothiazines, and benzodiazepines (United States).
Authors: Coogan- PF, Rosenberg L, Palmer JR, Strom BL, Stolley PD, Zauber AG, Shapiro S
Source: Cancer Causes Control, 2000 Oct;11(9), p. 839-45.
PMID: 11075873
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A case-control study of analgesic use and ovarian cancer.
Authors: Rosenberg L, Palmer JR, Rao RS, Coogan PF, Strom BL, Zauber AG, Stolley PD, Shapiro S
Source: Cancer Epidemiol Biomarkers Prev, 2000 Sep;9(9), p. 933-7.
PMID: 11008911
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NSAIDs and risk of colorectal cancer according to presence or absence of family history of the disease.
Authors: Coogan PF, Rosenberg L, Louik C, Zauber AG, Stolley PD, Strom BL, Shapiro S
Source: Cancer Causes Control, 2000 Mar;11(3), p. 249-55.
PMID: 10782659
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Nonsteroidal anti-inflammatory drugs and risk of digestive cancers at sites other than the large bowel.
Authors: Coogan PF, Rosenberg L, Palmer JR, Strom BL, Zauber AG, Stolley PD, Shapiro S
Source: Cancer Epidemiol Biomarkers Prev, 2000 Jan;9(1), p. 119-23.
PMID: 10667472
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The diagnosis of renal cell cancer in relation to hypertension (United States).
Authors: Rosenberg L, Stephenson WP, Rao RS, Palmer JR, Strom BL, Shapiro S
Source: Cancer Causes Control, 1998 Dec;9(6), p. 611-4.
PMID: 10189046
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Calcium channel blockers and the risk of cancer.
Authors: Rosenberg L, Rao RS, Palmer JR, Strom BL, Stolley PD, Zauber AG, Warshauer ME, Shapiro S
Source: JAMA, 1998 Apr 1;279(13), p. 1000-4.
PMID: 9533498
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Transitional cell cancer of the urinary tract and renal cell cancer in relation to acetaminophen use (United States).
Authors: Rosenberg L, Rao RS, Palmer JR, Strom BL, Zauber A, Warshauer ME, Stolley PD, Shapiro S
Source: Cancer Causes Control, 1998 Jan;9(1), p. 83-8.
PMID: 9486467
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Induced and spontaneous abortion in relation to risk of breast cancer (United States).
Authors: Palmer JR, Rosenberg L, Rao RS, Zauber A, Strom BL, Warshauer ME, Stolley PD, Shapiro S
Source: Cancer Causes Control, 1997 Nov;8(6), p. 841-9.
PMID: 9427426
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Case-control study of oral contraceptive use and risk of breast cancer.
Authors: Rosenberg L, Palmer JR, Rao RS, Zauber AG, Strom BL, Warshauer ME, Harlap S, Shapiro S
Source: Am J Epidemiol, 1996 Jan 1;143(1), p. 25-37.
PMID: 8533744
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Oral contraceptive use and breast cancer risk among African-American women.
Authors: Palmer JR, Rosenberg L, Rao RS, Strom BL, Warshauer ME, Harlap S, Zauber A, Shapiro S
Source: Cancer Causes Control, 1995 Jul;6(4), p. 321-31.
PMID: 7548719
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Relation of benzodiazepine use to the risk of selected cancers: breast, large bowel, malignant melanoma, lung, endometrium, ovary, non-Hodgkin's lymphoma, testis, Hodgkin's disease, thyroid, and liver.
Authors: Rosenberg L, Palmer JR, Zauber AG, Warshauer ME, Strom BL, Harlap S, Shapiro S
Source: Am J Epidemiol, 1995 Jun 15;141(12), p. 1153-60.
PMID: 7771453
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Adult height and risk of breast cancer among US black women.
Authors: Palmer JR, Rosenberg L, Harlap S, Strom BL, Warshauer ME, Zauber AG, Shapiro S
Source: Am J Epidemiol, 1995 May 1;141(9), p. 845-9.
PMID: 7717361
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The relation of vasectomy to the risk of cancer.
Authors: Rosenberg L, Palmer JR, Zauber AG, Warshauer ME, Strom BL, Harlap S, Shapiro S
Source: Am J Epidemiol, 1994 Sep 1;140(5), p. 431-8.
PMID: 8067335
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A case-control study of oral contraceptive use and invasive epithelial ovarian cancer.
Authors: Rosenberg L, Palmer JR, Zauber AG, Warshauer ME, Lewis JL Jr, Strom BL, Harlap S, Shapiro S
Source: Am J Epidemiol, 1994 Apr 1;139(7), p. 654-61.
PMID: 8166126
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Hormone replacement therapy: the need for reconsideration.
Authors: Rosenberg L
Source: Am J Public Health, 1993 Dec;83(12), p. 1670-3.
PMID: 8259791
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Side of origin of epithelial ovarian cancer.
Authors: Johannes CB, Kaufman DW, Rosenberg L, Palmer JR, Stolley PD, Lewis JL Jr, Zauber AG, Warshauer ME, Shapiro S
Source: BMJ, 1992 Jan 4;304(6818), p. 27-8.
PMID: 1734989
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