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Grant Details

Grant Number: 5R01CA047147-17 Interpret this number
Primary Investigator: Newcomb, Polly
Organization: University Of Wisconsin-Madison
Project Title: Medications, Genetic Variability & Breast Cancer
Fiscal Year: 2007
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Abstract

DESCRIPTION (provided by applicant): Recent evidence suggests that commonly used medications may be determinants of breast cancer risk. In this fourth renewal of our highly successful breast cancer case-control studies, we propose a new project to investigate the relation between breast cancer incidence and the use of non-steroidal anti-inflammatory drugs (NSAIDs), antidepressants, and drugs to treat osteoporosis. Specific hypotheses include: 1) regular use of NSAIDs is associated with a decreased risk of breast cancer; 2) antidepressant use is associated with increased risk of breast cancer; 3) use of drugs to prevent or treat osteoporosis is associated with a decreased risk of breast cancer; and 4) these associations are modified by genetic predisposition, specifically in polymorphisms related to the oxidation and glucoronidation of these compounds. To test these and other hypotheses, we will interview 3,564 women under 70 years of age with newly diagnosed breast cancer, identified through Wisconsin's statewide mandatory tumor registry. For comparison, we will interview 3,546 similarly-d female community members selected at random from the population using lists of licensed drivers. Study subjects will be interviewed by telephone regarding their use of the medications of interest and breast cancer risk factors. Participants will contribute buccal cells for DNA to be genotyped for CYP2C9, UGTIA6, and CYP2D6 polymorphisms. We will also bank DNA for future gene-environment studies. Building on existing and long-standing protocols allows us to evaluate the association of these increasingly common exposures with breast cancer risk in an efficient and timely manner. Further study of these modifiable exposures and relevant genotypes will provide more information on which women and their physicians can base decisions regarding behavior and may provide insights into the biology of this common tumor.

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Publications

Breast cancer susceptibility loci in association with age at menarche, age at natural menopause and the reproductive lifespan.
Authors: Warren Andersen S, Trentham-Dietz A, Gangnon RE, Hampton JM, Skinner HG, Engelman CD, Klein BE, Titus LJ, Egan KM, Newcomb PA
Source: Cancer Epidemiol, 2014 Feb;38(1), p. 62-5.
EPub date: 2013 Dec 25.
PMID: 24373701
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Pre-diagnosis oophorectomy, estrogen therapy and mortality in a cohort of women diagnosed with breast cancer.
Authors: Nichols HB, Trentham-Dietz A, Newcomb PA, Egan KM, Titus LJ, Hampton JM, Visvanathan K
Source: Breast Cancer Res, 2013;15(5), p. R99.
PMID: 24152546
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Disease-free survival by treatment after a DCIS diagnosis in a population-based cohort study.
Authors: Sprague BL, McLaughlin V, Hampton JM, Newcomb PA, Trentham-Dietz A
Source: Breast Cancer Res Treat, 2013 Aug;141(1), p. 145-54.
EPub date: 2013 Aug 25.
PMID: 23979007
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Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.
Authors: Nickels S, Truong T, Hein R, Stevens K, Buck K, Behrens S, Eilber U, Schmidt M, Häberle L, Vrieling A, Gaudet M, Figueroa J, Schoof N, Spurdle AB, Rudolph A, Fasching PA, Hopper JL, Makalic E, Schmidt DF, Southey MC, Beckmann MW, Ekici AB, Fletcher O, Gibson L, Silva Idos S, Peto J, Humphreys MK, Wang J, Cordina-Duverger E, Menegaux F, Nordestgaard BG, Bojesen SE, Lanng C, Anton-Culver H, Ziogas A, Bernstein L, Clarke CA, Brenner H, Müller H, Arndt V, Stegmaier C, Brauch H, Brüning T, Harth V, Genica Network, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, kConFab, AOCS Management Group, Lambrechts D, Smeets D, Neven P, Paridaens R, Flesch-Janys D, Obi N, Wang-Gohrke S, Couch FJ, Olson JE, Vachon CM, Giles GG, Severi G, Baglietto L, Offit K, John EM, Miron A, Andrulis IL, Knight JA, Glendon G, Mulligan AM, Chanock SJ, Lissowska J, Liu J, Cox A, Cramp H, Connley D, Balasubramanian S, Dunning AM, Shah M, Trentham-Dietz A, Newcomb P, Titus L, Egan K, Cahoon EK, Rajaraman P, Sigurdson AJ, Doody MM, Guénel P, Pharoah PD, Schmidt MK, Hall P, Easton DF, Garcia-Closas M, Milne RL, Chang-Claude J
Source: PLoS Genet, 2013;9(3), p. e1003284.
EPub date: 2013 Mar 27.
PMID: 23544014
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Breast cancer susceptibility associated with rs1219648 (fibroblast growth factor receptor 2) and postmenopausal hormone therapy use in a population-based United States study.
Authors: Andersen SW, Trentham-Dietz A, Figueroa JD, Titus LJ, Cai Q, Long J, Hampton JM, Egan KM, Newcomb PA
Source: Menopause, 2013 Mar;20(3), p. 354-8.
PMID: 23435034
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Postoophorectomy estrogen use and breast cancer risk.
Authors: Nichols HB, Trentham-Dietz A, Newcomb PA, Titus LJ, Egan KM, Hampton JM, Visvanathan K
Source: Obstet Gynecol, 2012 Jul;120(1), p. 27-36.
PMID: 22914389
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Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC).
Authors: Hein R, Maranian M, Hopper JL, Kapuscinski MK, Southey MC, Park DJ, Schmidt MK, Broeks A, Hogervorst FB, Bueno-de-Mesquita HB, Muir KR, Lophatananon A, Rattanamongkongul S, Puttawibul P, Fasching PA, Hein A, Ekici AB, Beckmann MW, Fletcher O, Johnson N, dos Santos Silva I, Peto J, Sawyer E, Tomlinson I, Kerin M, Miller N, Marmee F, Schneeweiss A, Sohn C, Burwinkel B, Guénel P, Cordina-Duverger E, Menegaux F, Truong T, Bojesen SE, Nordestgaard BG, Flyger H, Milne RL, Perez JI, Zamora MP, Benítez J, Anton-Culver H, Ziogas A, Bernstein L, Clarke CA, Brenner H, Müller H, Arndt V, Stegmaier C, Rahman N, Seal S, Turnbull C, Renwick A, Meindl A, Schott S, Bartram CR, Schmutzler RK, Brauch H, Hamann U, Ko YD, GENICA Network, Wang-Gohrke S, Dörk T, Schürmann P, Karstens JH, Hillemanns P, Nevanlinna H, Heikkinen T, Aittomäki K, Blomqvist C, Bogdanova NV, Zalutsky IV, Antonenkova NN, Bermisheva M, Prokovieva D, Farahtdinova A, Khusnutdinova E, Lindblom A, Margolin S, Mannermaa A, Kataja V, Kosma VM, Hartikainen J, Chen X, Beesley J, Kconfab Investigators, AOCS Group, Lambrechts D, Zhao H, Neven P, Wildiers H, Nickels S, Flesch-Janys D, Radice P, Peterlongo P, Manoukian S, Barile M, Couch FJ, Olson JE, Wang X, Fredericksen Z, Giles GG, Baglietto L, McLean CA, Severi G, Offit K, Robson M, Gaudet MM, Vijai J, Alnæs GG, Kristensen V, Børresen-Dale AL, John EM, Miron A, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, Andrulis IL, Knight JA, Glendon G, Mulligan AM, Figueroa JD, García-Closas M, Lissowska J, Sherman ME, Hooning M, Martens JW, Seynaeve C, Collée M, Hall P, Humpreys K, Czene K, Liu J, Cox A, Brock IW, Cross SS, Reed MW, Ahmed S, Ghoussaini M, Pharoah PD, Kang D, Yoo KY, Noh DY, Jakubowska A, Jaworska K, Durda K, Z?owocka E, Sangrajrang S, Gaborieau V, Brennan P, McKay J, Shen CY, Yu JC, Hsu HM, Hou MF, Orr N, Schoemaker M, Ashworth A, Swerdlow A, Trentham-Dietz A, Newcomb PA, Titus L, Egan KM, Chenevix-Trench G, Antoniou AC, Humphreys MK, Morrison J, Chang-Claude J, Easton DF, Dunning AM
Source: PLoS One, 2012;7(8), p. e42380.
EPub date: 2012 Aug 7.
PMID: 22879957
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A multistage genetic association study identifies breast cancer risk loci at 10q25 and 16q24.
Authors: Higginbotham KS, Breyer JP, McReynolds KM, Bradley KM, Schuyler PA, Plummer WD, Freudenthal ME, Trentham-Dietz A, Newcomb PA, Parl FF, Sanders ME, Page DL, Egan KM, Dupont WD, Smith JR
Source: Cancer Epidemiol Biomarkers Prev, 2012 Sep;21(9), p. 1565-73.
EPub date: 2012 Jul 17.
PMID: 22806168
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Selection bias in population-based cancer case-control studies due to incomplete sampling frame coverage.
Authors: Walsh MC, Trentham-Dietz A, Gangnon RE, Nieto FJ, Newcomb PA, Palta M
Source: Cancer Epidemiol Biomarkers Prev, 2012 Jun;21(6), p. 881-6.
EPub date: 2012 Apr 6.
PMID: 22490319
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Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium.
Authors: Figueroa JD, Garcia-Closas M, Humphreys M, Platte R, Hopper JL, Southey MC, Apicella C, Hammet F, Schmidt MK, Broeks A, Tollenaar RA, Van't Veer LJ, Fasching PA, Beckmann MW, Ekici AB, Strick R, Peto J, dos Santos Silva I, Fletcher O, Johnson N, Sawyer E, Tomlinson I, Kerin M, Burwinkel B, Marme F, Schneeweiss A, Sohn C, Bojesen S, Flyger H, Nordestgaard BG, Benítez J, Milne RL, Ignacio Arias J, Zamora MP, Brenner H, Müller H, Arndt V, Rahman N, Turnbull C, Seal S, Renwick A, Brauch H, Justenhoven C, Brüning T, GENICA Network, Chang-Claude J, Hein R, Wang-Gohrke S, Dörk T, Schürmann P, Bremer M, Hillemanns P, Nevanlinna H, Heikkinen T, Aittomäki K, Blomqvist C, Bogdanova N, Antonenkova N, Rogov YI, Karstens JH, Bermisheva M, Prokofieva D, Gantcev SH, Khusnutdinova E, Lindblom A, Margolin S, Chenevix-Trench G, Beesley J, Chen X, kConFab AOCS Management Group, Mannermaa A, Kosma VM, Soini Y, Kataja V, Lambrechts D, Yesilyurt BT, Chrisiaens MR, Peeters S, Radice P, Peterlongo P, Manoukian S, Barile M, Couch F, Lee AM, Diasio R, Wang X, Giles GG, Severi G, Baglietto L, Maclean C, Offit K, Robson M, Joseph V, Gaudet M, John EM, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, Andrulis I, Knight JA, Mulligan AM, O'Malley FP, Brinton LA, Sherman ME, Lissowska J, Chanock SJ, Hooning M, Martens JW, van den Ouweland AM, Collée JM, Hall P, Czene K, Cox A, Brock IW, Reed MW, Cross SS, Pharoah P, Dunning AM, Kang D, Yoo KY, Noh DY, Ahn SH, Jakubowska A, Lubinski J, Jaworska K, Durda K, Sangrajrang S, Gaborieau V, Brennan P, McKay J, Shen CY, Ding SL, Hsu HM, Yu JC, Anton-Culver H, Ziogas A, Ashworth A, Swerdlow A, Jones M, Orr N, Trentham-Dietz A, Egan K, Newcomb P, Titus-Ernstoff L, Easton D, Spurdle AB
Source: Hum Mol Genet, 2011 Dec 1;20(23), p. 4693-706.
EPub date: 2011 Aug 18.
PMID: 21852249
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Reproductive factors and histologic subtype in relation to mortality after a breast cancer diagnosis.
Authors: Warren Andersen S, Newcomb PA, Hampton JM, Titus-Ernstoff L, Egan KM, Trentham-Dietz A
Source: Breast Cancer Res Treat, 2011 Dec;130(3), p. 975-80.
EPub date: 2011 Jul 19.
PMID: 21769659
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A multistage association study identifies a breast cancer genetic locus at NCOA7.
Authors: Higginbotham KS, Breyer JP, Bradley KM, Schuyler PA, Plummer WD Jr, Freudenthal ME, Trentham-Dietz A, Newcomb PA, Sanders ME, Page DL, Parl FF, Egan KM, Dupont WD, Smith JR
Source: Cancer Res, 2011 Jun 1;71(11), p. 3881-8.
EPub date: 2011 May 24.
PMID: 21610108
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Availability of driver's license master lists for use in government-sponsored public health research.
Authors: Walsh MC, Trentham-Dietz A, Palta M
Source: Am J Epidemiol, 2011 Jun 15;173(12), p. 1414-8.
EPub date: 2011 May 13.
PMID: 21571870
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Bilateral oophorectomy in relation to risk of postmenopausal breast cancer: confounding by nonmalignant indications for surgery?
Authors: Nichols HB, Visvanathan K, Newcomb PA, Hampton JM, Egan KM, Titus-Ernstoff L, Trentham-Dietz A
Source: Am J Epidemiol, 2011 May 15;173(10), p. 1111-20.
EPub date: 2011 Mar 23.
PMID: 21430192
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Socioeconomic status and survival after an invasive breast cancer diagnosis.
Authors: Sprague BL, Trentham-Dietz A, Gangnon RE, Ramchandani R, Hampton JM, Robert SA, Remington PL, Newcomb PA
Source: Cancer, 2011 Apr 1;117(7), p. 1542-51.
EPub date: 2010 Nov 8.
PMID: 21425155
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Replication and functional genomic analyses of the breast cancer susceptibility locus at 6q25.1 generalize its importance in women of chinese, Japanese, and European ancestry.
Authors: Cai Q, Wen W, Qu S, Li G, Egan KM, Chen K, Deming SL, Shen H, Shen CY, Gammon MD, Blot WJ, Matsuo K, Haiman CA, Khoo US, Iwasaki M, Santella RM, Zhang L, Fair AM, Hu Z, Wu PE, Signorello LB, Titus-Ernstoff L, Tajima K, Henderson BE, Chan KY, Kasuga Y, Newcomb PA, Zheng H, Cui Y, Wang F, Shieh YL, Iwata H, Le Marchand L, Chan SY, Shrubsole MJ, Trentham-Dietz A, Tsugane S, Garcia-Closas M, Long J, Li C, Shi J, Huang B, Xiang YB, Gao YT, Lu W, Shu XO, Zheng W
Source: Cancer Res, 2011 Feb 15;71(4), p. 1344-55.
EPub date: 2011 Feb 8.
PMID: 21303983
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Use of antidepressants and NSAIDs in relation to mortality in long-term breast cancer survivors.
Authors: Wernli KJ, Hampton JM, Trentham-Dietz A, Newcomb PA
Source: Pharmacoepidemiol Drug Saf, 2011 Feb;20(2), p. 131-7.
EPub date: 2010 Nov 8.
PMID: 21254283
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Post-diagnosis dietary factors and survival after invasive breast cancer.
Authors: Beasley JM, Newcomb PA, Trentham-Dietz A, Hampton JM, Bersch AJ, Passarelli MN, Holick CN, Titus-Ernstoff L, Egan KM, Holmes MD, Willett WC
Source: Breast Cancer Res Treat, 2011 Jul;128(1), p. 229-36.
EPub date: 2011 Jan 1.
PMID: 21197569
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Social networks and survival after breast cancer diagnosis.
Authors: Beasley JM, Newcomb PA, Trentham-Dietz A, Hampton JM, Ceballos RM, Titus-Ernstoff L, Egan KM, Holmes MD
Source: J Cancer Surviv, 2010 Dec;4(4), p. 372-80.
EPub date: 2010 Jul 23.
PMID: 20652435
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Sleep duration and obesity in a population-based study.
Authors: Anic GM, Titus-Ernstoff L, Newcomb PA, Trentham-Dietz A, Egan KM
Source: Sleep Med, 2010 May;11(5), p. 447-51.
EPub date: 2010 Apr 3.
PMID: 20363668
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Change in lifestyle behaviors and medication use after a diagnosis of ductal carcinoma in situ.
Authors: Sprague BL, Trentham-Dietz A, Nichols HB, Hampton JM, Newcomb PA
Source: Breast Cancer Res Treat, 2010 Nov;124(2), p. 487-95.
EPub date: 2010 Apr 2.
PMID: 20361251
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Bisphosphonates for osteoporosis treatment are associated with reduced breast cancer risk.
Authors: Newcomb PA, Trentham-Dietz A, Hampton JM
Source: Br J Cancer, 2010 Mar 2;102(5), p. 799-802.
EPub date: 2010 Feb 16.
PMID: 20160722
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Association of COMT haplotypes and breast cancer risk in caucasian women.
Authors: Peterson NB, Trentham-Dietz A, Garcia-Closas M, Newcomb PA, Titus-Ernstoff L, Huang Y, Chanock SJ, Haines JL, Egan KM
Source: Anticancer Res, 2010 Jan;30(1), p. 217-20.
PMID: 20150638
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Body mass index before and after breast cancer diagnosis: associations with all-cause, breast cancer, and cardiovascular disease mortality.
Authors: Nichols HB, Trentham-Dietz A, Egan KM, Titus-Ernstoff L, Holmes MD, Bersch AJ, Holick CN, Hampton JM, Stampfer MJ, Willett WC, Newcomb PA
Source: Cancer Epidemiol Biomarkers Prev, 2009 May;18(5), p. 1403-9.
EPub date: 2009 Apr 14.
PMID: 19366908
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Exposure to breast milk in infancy and risk of breast cancer.
Authors: Wise LA, Titus-Ernstoff L, Newcomb PA, Trentham-Dietz A, Trichopoulos D, Hampton JM, Egan KM
Source: Cancer Causes Control, 2009 Sep;20(7), p. 1083-90.
EPub date: 2009 Mar 29.
PMID: 19330531
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No difference between red wine or white wine consumption and breast cancer risk.
Authors: Newcomb PA, Nichols HB, Beasley JM, Egan K, Titus-Ernstoff L, Hampton JM, Trentham-Dietz A
Source: Cancer Epidemiol Biomarkers Prev, 2009 Mar;18(3), p. 1007-10.
PMID: 19273487
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Antidepressant medication use and breast cancer risk.
Authors: Wernli KJ, Hampton JM, Trentham-Dietz A, Newcomb PA
Source: Pharmacoepidemiol Drug Saf, 2009 Apr;18(4), p. 284-90.
PMID: 19226540
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