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Grant Details

Grant Number: 5R01CA102777-04 Interpret this number
Primary Investigator: Jeffe, Donna
Organization: Washington University
Project Title: Quality of Life Over Time: Dcis Vs Early Breast Cancer
Fiscal Year: 2006
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Abstract

DESCRIPTION (provided by applicant): Diagnosis of ductal carcinoma in situ (DCIS) of the breast has increased with more widespread use of screening mammography. Although there is considerable research about quality of life (QOL) in women with invasive breast cancer, there is little pertaining to QOL in women with DCIS, and there are no longitudinal QOL studies comparing women with DCIS, women with early-stage (Stages I and II) breast cancer, and women without breast cancer. Therefore, this study will describe and compare QOL among these three groups of women. The specific aims are to 1) characterize the QOL of women with DCIS over time, 2) Identify differences in the QOL over time among DCIS and early-stage breast cancer patients and healthy controls, and 3) identify predictors of QOL among women with DCIS from among demographic, clinical, and psychosocial factors assessed at baseline. DCIS and breast cancer patients will be identified prospectively by collaborating surgeons. Women with normal or benign mammograms will be identified prospectively at I time of screening and randomly selected for the control group after being matched by age group (40-49, 50-69, and 70+) with the patients. Recruitment letters signed by the collaborating surgeons or radiologist (controls) will be mailed with consent forms and followed up with a telephone call to answer questions. Following consent, telephone interviews at 1 month, 6 months, 1 year, and 2 years after surgery (patients) or after a screening mammogram (controls) will be used to collect data. The Functional Assessment of Cancer Therapy-Breast (FACT-B) will be used to compare QOL of women with DCIS and early breast cancer and the RAND 36-Item Health Survey 1.0 wilt be used to compare the QOL between healthy controls and women with DCIS and early breast cancer. In addition, data about demographic, clinical, and psychosocial factors that may be important predictors of QOL will be collected. Differences in QOL among the three groups over time will be tested using generalized estimating equations. Multi-level models, which take into account the longitudinal approach of the study, will identify predictors of QOL among the three groups. Findings from this study may lead to ways to improve the QOL of women diagnosed with DCIS.

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Publications

Perceived social support change in patients with early stage breast cancer and controls.
Authors: Thompson T, Rodebaugh TL, Pérez M, Schootman M, Jeffe DB
Source: Health Psychol, 2013 Aug;32(8), p. 886-95.
EPub date: 2013 Mar 11.
PMID: 23477582
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Worry about cancer progression and low perceived social support: implications for quality of life among early-stage breast cancer patients.
Authors: Waters EA, Liu Y, Schootman M, Jeffe DB
Source: Ann Behav Med, 2013 Feb;45(1), p. 57-68.
PMID: 22983622
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Quality of life over time in women diagnosed with ductal carcinoma in situ, early-stage invasive breast cancer, and age-matched controls.
Authors: Jeffe DB, Pérez M, Liu Y, Collins KK, Aft RL, Schootman M
Source: Breast Cancer Res Treat, 2012 Jul;134(1), p. 379-91.
EPub date: 2012 Apr 8.
PMID: 22484800
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Correlates of fear of cancer recurrence in women with ductal carcinoma in situ and early invasive breast cancer.
Authors: Liu Y, Pérez M, Schootman M, Aft RL, Gillanders WE, Jeffe DB
Source: Breast Cancer Res Treat, 2011 Nov;130(1), p. 165-73.
EPub date: 2011 May 8.
PMID: 21553295
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A letter to the editor regarding the article by Panjari et?al.
Authors: Pérez M, Jeffe DB
Source: J Sex Med, 2011 Apr;8(4), p. 1254.
EPub date: 2011 Jan 26.
PMID: 21269405
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Effects of breast cancer surgery and surgical side effects on body image over time.
Authors: Munhoz AM, Gemperli R, Filassi JR
Source: Breast Cancer Res Treat, 2011 Feb;126(1), p. 261-2; author reply 263-4.
EPub date: 2010 Nov 26.
PMID: 21110083
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Effects of breast cancer surgery and surgical side effects on body image over time.
Authors: Collins KK, Liu Y, Schootman M, Aft R, Yan Y, Dean G, Eilers M, Jeffe DB
Source: Breast Cancer Res Treat, 2011 Feb;126(1), p. 167-76.
EPub date: 2010 Aug 5.
PMID: 20686836
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Changes in sexual problems over time in women with and without early-stage breast cancer.
Authors: Pérez M, Liu Y, Schootman M, Aft RL, Schechtman KB, Gillanders WE, Jeffe DB
Source: Menopause, 2010 Sep-Oct;17(5), p. 924-37.
PMID: 20461020
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A longitudinal study of factors associated with perceived risk of recurrence in women with ductal carcinoma in situ and early-stage invasive breast cancer.
Authors: Liu Y, Pérez M, Schootman M, Aft RL, Gillanders WE, Ellis MJ, Jeffe DB
Source: Breast Cancer Res Treat, 2010 Dec;124(3), p. 835-44.
EPub date: 2010 May 6.
PMID: 20446031
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Accuracy of perceived risk of recurrence among patients with early-stage breast cancer.
Authors: Liu Y, Pérez M, Aft RL, Massman K, Robinson E, Myles S, Schootman M, Gillanders WE, Jeffe DB
Source: Cancer Epidemiol Biomarkers Prev, 2010 Mar;19(3), p. 675-80.
EPub date: 2010 Feb 16.
PMID: 20160274
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Impact of multiple caregiving roles on elevated depressed mood in early-stage breast cancer patients and same-age controls.
Authors: Bailey EH, Pérez M, Aft RL, Liu Y, Schootman M, Jeffe DB
Source: Breast Cancer Res Treat, 2010 Jun;121(3), p. 709-18.
EPub date: 2009 Nov 21.
PMID: 19936914
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Evaluating the utility and accuracy of a reverse telephone directory to identify the location of survey respondents.
Authors: Schootman M, Jeffe D, Kinman E, Higgs G, Jackson-Thompson J
Source: Ann Epidemiol, 2005 Feb;15(2), p. 160-6.
PMID: 15652722
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