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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R01CA102777-04 Interpret this number
Primary Investigator: Jeffe, Donna
Organization: Washington University
Project Title: Quality of Life Over Time: Dcis Vs Early Breast Cancer
Fiscal Year: 2006
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Abstract

DESCRIPTION (provided by applicant): Diagnosis of ductal carcinoma in situ (DCIS) of the breast has increased with more widespread use of screening mammography. Although there is considerable research about quality of life (QOL) in women with invasive breast cancer, there is little pertaining to QOL in women with DCIS, and there are no longitudinal QOL studies comparing women with DCIS, women with early-stage (Stages I and II) breast cancer, and women without breast cancer. Therefore, this study will describe and compare QOL among these three groups of women. The specific aims are to 1) characterize the QOL of women with DCIS over time, 2) Identify differences in the QOL over time among DCIS and early-stage breast cancer patients and healthy controls, and 3) identify predictors of QOL among women with DCIS from among demographic, clinical, and psychosocial factors assessed at baseline. DCIS and breast cancer patients will be identified prospectively by collaborating surgeons. Women with normal or benign mammograms will be identified prospectively at I time of screening and randomly selected for the control group after being matched by age group (40-49, 50-69, and 70+) with the patients. Recruitment letters signed by the collaborating surgeons or radiologist (controls) will be mailed with consent forms and followed up with a telephone call to answer questions. Following consent, telephone interviews at 1 month, 6 months, 1 year, and 2 years after surgery (patients) or after a screening mammogram (controls) will be used to collect data. The Functional Assessment of Cancer Therapy-Breast (FACT-B) will be used to compare QOL of women with DCIS and early breast cancer and the RAND 36-Item Health Survey 1.0 wilt be used to compare the QOL between healthy controls and women with DCIS and early breast cancer. In addition, data about demographic, clinical, and psychosocial factors that may be important predictors of QOL will be collected. Differences in QOL among the three groups over time will be tested using generalized estimating equations. Multi-level models, which take into account the longitudinal approach of the study, will identify predictors of QOL among the three groups. Findings from this study may lead to ways to improve the QOL of women diagnosed with DCIS.

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Publications

Evaluating The Utility And Accuracy Of A Reverse Telephone Directory To Identify The Location Of Survey Respondents
Authors: Schootman M. , Jeffe D. , Kinman E. , Higgs G. , Jackson-Thompson J. .
Source: Annals Of Epidemiology, 2005 Feb; 15(2), p. 160-6.
PMID: 15652722
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Impact Of Multiple Caregiving Roles On Elevated Depressed Mood In Early-stage Breast Cancer Patients And Same-age Controls
Authors: Bailey E.H. , Pérez M. , Aft R.L. , Liu Y. , Schootman M. , Jeffe D.B. .
Source: Breast Cancer Research And Treatment, 2010 Jun; 121(3), p. 709-18.
PMID: 19936914
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Accuracy Of Perceived Risk Of Recurrence Among Patients With Early-stage Breast Cancer
Authors: Liu Y. , Pérez M. , Aft R.L. , Massman K. , Robinson E. , Myles S. , Schootman M. , Gillanders W.E. , Jeffe D.B. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2010 Mar; 19(3), p. 675-80.
PMID: 20160274
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A Longitudinal Study Of Factors Associated With Perceived Risk Of Recurrence In Women With Ductal Carcinoma In Situ And Early-stage Invasive Breast Cancer
Authors: Liu Y. , Pérez M. , Schootman M. , Aft R.L. , Gillanders W.E. , Ellis M.J. , Jeffe D.B. .
Source: Breast Cancer Research And Treatment, 2010 Dec; 124(3), p. 835-44.
PMID: 20446031
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Changes In Sexual Problems Over Time In Women With And Without Early-stage Breast Cancer
Authors: Pérez M. , Liu Y. , Schootman M. , Aft R.L. , Schechtman K.B. , Gillanders W.E. , Jeffe D.B. .
Source: Menopause (new York, N.y.), 2010 Sep-Oct; 17(5), p. 924-37.
PMID: 20461020
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Effects Of Breast Cancer Surgery And Surgical Side Effects On Body Image Over Time
Authors: Collins K.K. , Liu Y. , Schootman M. , Aft R. , Yan Y. , Dean G. , Eilers M. , Jeffe D.B. .
Source: Breast Cancer Research And Treatment, 2011 Feb; 126(1), p. 167-76.
PMID: 20686836
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Effects Of Breast Cancer Surgery And Surgical Side Effects On Body Image Over Time
Authors: Munhoz A.M. , Gemperli R. , Filassi J.R. .
Source: Breast Cancer Research And Treatment, 2011 Feb; 126(1), p. 261-2; author reply 263-4.
PMID: 21110083
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A Letter To The Editor Regarding The Article By Panjari Et¿Al
Authors: Pérez M. , Jeffe D.B. .
Source: The Journal Of Sexual Medicine, 2011 Apr; 8(4), p. 1254.
PMID: 21269405
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Correlates Of Fear Of Cancer Recurrence In Women With Ductal Carcinoma In Situ And Early Invasive Breast Cancer
Authors: Liu Y. , Pérez M. , Schootman M. , Aft R.L. , Gillanders W.E. , Jeffe D.B. .
Source: Breast Cancer Research And Treatment, 2011 Nov; 130(1), p. 165-73.
PMID: 21553295
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Quality Of Life Over Time In Women Diagnosed With Ductal Carcinoma In Situ, Early-stage Invasive Breast Cancer, And Age-matched Controls
Authors: Jeffe D.B. , Pérez M. , Liu Y. , Collins K.K. , Aft R.L. , Schootman M. .
Source: Breast Cancer Research And Treatment, 2012 Jul; 134(1), p. 379-91.
PMID: 22484800
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Worry About Cancer Progression And Low Perceived Social Support: Implications For Quality Of Life Among Early-stage Breast Cancer Patients
Authors: Waters E.A. , Liu Y. , Schootman M. , Jeffe D.B. .
Source: Annals Of Behavioral Medicine : A Publication Of The Society Of Behavioral Medicine, 2013 Feb; 45(1), p. 57-68.
PMID: 22983622
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Perceived Social Support Change In Patients With Early Stage Breast Cancer And Controls
Authors: Thompson T. , Rodebaugh T.L. , Pérez M. , Schootman M. , Jeffe D.B. .
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2013 Aug; 32(8), p. 886-95.
PMID: 23477582
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Neighborhood Socioeconomic Deprivation, Tumor Subtypes, And Causes Of Death After Non-metastatic Invasive Breast Cancer Diagnosis: A Multilevel Competing-risk Analysis
Authors: Lian M. , Pérez M. , Liu Y. , Schootman M. , Frisse A. , Foldes E. , Jeffe D.B. .
Source: Breast Cancer Research And Treatment, 2014 Oct; 147(3), p. 661-70.
PMID: 25234843
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Influence Of Neighborhood-level Factors On Social Support In Early-stage Breast Cancer Patients And Controls
Authors: Thompson T. , Rodebaugh T.L. , Pérez M. , Struthers J. , Sefko J.A. , Lian M. , Schootman M. , Jeffe D.B. .
Source: Social Science & Medicine (1982), 2016-03-17 00:00:00.0; 156, p. 55-63.
PMID: 27017091
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