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Grant Details

Grant Number: 7R01CA043092-20 Interpret this number
Primary Investigator: Yuan, Jian-Min
Organization: University Of Minnesota
Project Title: Dietary Factors in the Etiology of Cancer in Shanghai
Fiscal Year: 2006
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Abstract

DESCRIPTION (provided by applicant): This is a revised grant application requesting continued funding of a residential cohort of 18,244 men in Shanghai, China, assembled during 1986-89 when subjects were between the ages of 45 and 64 years. At recruitment, all cohort members provided detailed dietary and medical histories as well as blood and urine specimens. The cohort has been followed for the occurrence of cancer and death through routine ascertainment of new cases from the population-based Shanghai Cancer Registry and Shanghai Vital Statistics Units, and annual visits to all known surviving cohort members. To date, the cohort has accumulated 204,010 person-years of observation. Only 231 subjects have been lost to follow-up. There have been 1,463 incident cancer cases and 2,599 cohort members have died. The leading cancer sites are lung, liver, stomach, and colorectum. Stroke accounts for 23% of all deaths. Active follow-up of this cohort will continue for another 5 years. During the annual personal visit to each surviving cohort member, buccal cells will be collected to facilitate future etiologic studies involving DNA analysis. Although study investigators have been successful in harvesting DNA from serum samples collected at baseline, cost-based analysis revealed that it is more cost-effective for future gene-based studies to rely on this new source of DNA. It is estimated that buccal cells will be collected from about 11,000 cohort subjects. During the next 5 years, a series of nested case-control studies will be conducted to further elucidate the interplay of genetic and dietary factors in influencing cancer risk. Specifically, study investigators will assess the roles of dietary aflatoxin and antioxidants (selenium, retinol, carotenoids, tea polyphenols) in cancers of the lung and liver; the role of dietary isothiocyanates in cancers of the stomach, esophagus, and colorectum; and the role of tea polyphenols in cancers of the stomach and esophagus. In all instances of diet-cancer investigations, relevant genes with potential modifying effects on the respective diet-cancer associations will be included in the investigations.

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Publications

Urinary metabolites of a polycyclic aromatic hydrocarbon and volatile organic compounds in relation to lung cancer development in lifelong never smokers in the Shanghai Cohort Study.
Authors: Yuan JM, Butler LM, Gao YT, Murphy SE, Carmella SG, Wang R, Nelson HH, Hecht SS
Source: Carcinogenesis, 2014 Feb;35(2), p. 339-45.
EPub date: 2013 Oct 22.
PMID: 24148823
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Prediagnostic levels of serum one-carbon metabolites and risk of hepatocellular carcinoma.
Authors: Butler LM, Arning E, Wang R, Bottiglieri T, Govindarajan S, Gao YT, Yuan JM
Source: Cancer Epidemiol Biomarkers Prev, 2013 Oct;22(10), p. 1884-93.
EPub date: 2013 Jul 29.
PMID: 23897582
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Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers.
Authors: Yuan JM, Gao YT, Wang R, Chen M, Carmella SG, Hecht SS
Source: Carcinogenesis, 2012 Apr;33(4), p. 804-9.
EPub date: 2012 Jan 31.
PMID: 22298640
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Aromatase (CYP19) promoter gene polymorphism and risk of nonviral hepatitis-related hepatocellular carcinoma.
Authors: Koh WP, Yuan JM, Wang R, Govindarajan S, Oppenheimer R, Zhang ZQ, Yu MC, Ingles SA
Source: Cancer, 2011 Aug 1;117(15), p. 3383-92.
EPub date: 2011 Feb 11.
PMID: 21319151
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Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, China.
Authors: Moy KA, Yuan JM, Chung FL, Wang XL, Van Den Berg D, Wang R, Gao YT, Yu MC
Source: Int J Cancer, 2009 Dec 1;125(11), p. 2652-9.
PMID: 19610060
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Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers.
Authors: Yuan JM, Koh WP, Murphy SE, Fan Y, Wang R, Carmella SG, Han S, Wickham K, Gao YT, Yu MC, Hecht SS
Source: Cancer Res, 2009 Apr 1;69(7), p. 2990-5.
EPub date: 2009 Mar 24.
PMID: 19318550
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Prospective evaluation of hepatitis B 1762(T)/1764(A) mutations on hepatocellular carcinoma development in Shanghai, China.
Authors: Yuan JM, Ambinder A, Fan Y, Gao YT, Yu MC, Groopman JD
Source: Cancer Epidemiol Biomarkers Prev, 2009 Feb;18(2), p. 590-4.
EPub date: 2009 Feb 3.
PMID: 19190166
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Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA.
Authors: Ognjanovic S, Yuan JM, Chaptman AK, Fan Y, Yu MC
Source: Carcinogenesis, 2009 May;30(5), p. 758-62.
EPub date: 2009 Jan 6.
PMID: 19126646
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Urinary total isothiocyanates and colorectal cancer: a prospective study of men in Shanghai, China.
Authors: Moy KA, Yuan JM, Chung FL, Van Den Berg D, Wang R, Gao YT, Yu MC
Source: Cancer Epidemiol Biomarkers Prev, 2008 Jun;17(6), p. 1354-9.
PMID: 18559550
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Alcohol, tobacco, and diet in relation to esophageal cancer: the Shanghai Cohort Study.
Authors: Fan Y, Yuan JM, Wang R, Gao YT, Yu MC
Source: Nutr Cancer, 2008;60(3), p. 354-63.
PMID: 18444169
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Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma.
Authors: Yuan JM, Lu SC, Van Den Berg D, Govindarajan S, Zhang ZQ, Mato JM, Yu MC
Source: Hepatology, 2007 Sep;46(3), p. 749-58.
PMID: 17659576
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Beta-cryptoxanthin and lung cancer in Shanghai, China--an examination of potential confounding with cigarette smoking using urinary cotinine as a biomarker for true tobacco exposure.
Authors: Stram DO, Yuan JM, Chan KK, Gao YT, Ross RK, Yu MC
Source: Nutr Cancer, 2007;57(2), p. 123-9.
PMID: 17571944
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Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma.
Authors: Yuan JM, Gao YT, Ong CN, Ross RK, Yu MC
Source: J Natl Cancer Inst, 2006 Apr 5;98(7), p. 482-90.
PMID: 16595784
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Prediagnostic levels of serum micronutrients in relation to risk of gastric cancer in Shanghai, China.
Authors: Yuan JM, Ross RK, Gao YT, Qu YH, Chu XD, Yu MC
Source: Cancer Epidemiol Biomarkers Prev, 2004 Nov;13(11 Pt 1), p. 1772-80.
PMID: 15533906
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Dietary soy and increased risk of bladder cancer: a prospective cohort study of men in Shanghai, China.
Authors: Sun CL, Yuan JM, Wang XL, Gao YT, Ross RK, Yu MC
Source: Int J Cancer, 2004 Nov 1;112(2), p. 319-23.
PMID: 15352046
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Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China.
Authors: Sun CL, Yuan JM, Lee MJ, Yang CS, Gao YT, Ross RK, Yu MC
Source: Carcinogenesis, 2002 Sep;23(9), p. 1497-503.
PMID: 12189193
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Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China.
Authors: London SJ, Yuan JM, Travlos GS, Gao YT, Wilson RE, Ross RK, Yu MC
Source: J Natl Cancer Inst, 2002 May 15;94(10), p. 749-54.
PMID: 12011225
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IGF-1, IGF-2 and IGFBP-3 in prediagnostic serum: association with colorectal cancer in a cohort of Chinese men in Shanghai.
Authors: Probst-Hensch NM, Yuan JM, Stanczyk FZ, Gao YT, Ross RK, Yu MC
Source: Br J Cancer, 2001 Nov 30;85(11), p. 1695-9.
PMID: 11742490
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Fish and shellfish consumption in relation to death from myocardial infarction among men in Shanghai, China.
Authors: Yuan JM, Ross RK, Gao YT, Yu MC
Source: Am J Epidemiol, 2001 Nov 1;154(9), p. 809-16.
PMID: 11682363
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Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China.
Authors: London SJ, Yuan JM, Chung FL, Gao YT, Coetzee GA, Ross RK, Yu MC
Source: Lancet, 2000 Aug 26;356(9231), p. 724-9.
PMID: 11085692
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CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Shanghai, China.
Authors: London SJ, Yuan JM, Coetzee GA, Gao YT, Ross RK, Yu MC
Source: Cancer Epidemiol Biomarkers Prev, 2000 Sep;9(9), p. 987-91.
PMID: 11008920
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Helicobacter pylori infection and risk of gastric cancer in Shanghai, China: updated results based upon a locally developed and validated assay and further follow-up of the cohort.
Authors: Yuan JM, Yu MC, Xu WW, Cockburn M, Gao YT, Ross RK
Source: Cancer Epidemiol Biomarkers Prev, 1999 Jul;8(7), p. 621-4.
PMID: 10428200
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Body weight and mortality: a prospective evaluation in a cohort of middle-aged men in Shanghai, China.
Authors: Yuan JM, Ross RK, Gao YT, Yu MC
Source: Int J Epidemiol, 1998 Oct;27(5), p. 824-32.
PMID: 9839739
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Prospective evaluation of dietary and other predictors of fatal stroke in Shanghai, China.
Authors: Ross RK, Yuan JM, Henderson BE, Park J, Gao YT, Yu MC
Source: Circulation, 1997 Jul 1;96(1), p. 50-5.
PMID: 9236416
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Follow up study of moderate alcohol intake and mortality among middle aged men in Shanghai, China.
Authors: Yuan JM, Ross RK, Gao YT, Henderson BE, Yu MC
Source: BMJ, 1997 Jan 4;314(7073), p. 18-23.
PMID: 9001474
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An apparent lack of association between Helicobacter pylori infection and risk of gastric cancer in China.
Authors: Webb PM, Yu MC, Forman D, Henderson BE, Newell DG, Yuan JM, Gao YT, Ross RK
Source: Int J Cancer, 1996 Sep 4;67(5), p. 603-7.
PMID: 8782645
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Morbidity and mortality in relation to cigarette smoking in Shanghai, China. A prospective male cohort study.
Authors: Yuan JM, Ross RK, Wang XL, Gao YT, Henderson BE, Yu MC
Source: JAMA, 1996 Jun 5;275(21), p. 1646-50.
PMID: 8637137
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Use of carcinogen-DNA and carcinogen-protein adduct biomarkers for cohort selection and as modifiable end points in chemoprevention trials.
Authors: Kensler TW, Groopman JD, Wogan GN
Source: IARC Sci Publ, 1996;null(139), p. 237-48.
PMID: 8923034
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A cohort study of serum testosterone and hepatocellular carcinoma in Shanghai, China.
Authors: Yuan JM, Ross RK, Stanczyk FZ, Govindarajan S, Gao YT, Henderson BE, Yu MC
Source: Int J Cancer, 1995 Nov 15;63(4), p. 491-3.
PMID: 7591255
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