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Grant Details

Grant Number: 5R01CA100743-04 Interpret this number
Primary Investigator: Weinmann, Sheila
Organization: Kaiser Foundation Research Institute
Project Title: Molecular Epidemiology of Fatal Prostate Cancer
Fiscal Year: 2006
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Abstract

DESCRIPTION (provided by applicant): Prostate cancer has the highest incidence and the second highest mortality of any cancer among men in the United States; the prostate cancer burden is especially high in African-Americans. The prognosis of this cancer is extremely heterogeneous, and it is of urgent clinical importance to be able to determine which early stage cancers should be treated aggressively and which should not. Although histologic grade and stage are the most important determinants of prostate cancer prognosis, some oncogene and tumor suppressor gene proteins have been linked to prostate cancer mortality in small studies; the most promising of these include PTEN, PIM-1, EGR1, P27 kipt, E-cadherin, alpha-catenin, P53, BCL-2, and HSP27. However, little information exists about interrelationships of the expression of different proteins and which proteins most strongly predict survival when other factors are taken into account. Since many clinical laboratories can now analyze the tumor protein expression levels through immunohistochemistry, there is great interest in finding immunohistochemical markers that can predict prostate cancer prognosis in the clinical setting. This application proposes to examine the relationship between protein expression of the above tumor genes and mortality from prostate cancer after prostatectomy using a population-based case-control study design. Subjects will be Caucasian and African-American prostate cancer patients of Kaiser Permanente Northwest, Kaiser Permanente Southern California, and Kaiser Permanente Northern California who have paraffin-embedded formalin-fixed tumor tissue stored in health plan laboratories. Laboratory scientists at Georgetown University's Lombardi Cancer Center will use both standard methods for immunohistochemistry and the Automated Cellular Imaging System (ChromaVision, Inc.) to assess protein expression in prostate tumor tissue. Additional subject data will be collected from automated sources and medical records to allow multivariate analysis of the association between tumor marker expression and prostate cancer mortality, taking into account demographic, pathologic, medical, and environmental variables. This study is unique in that, because of the very large health plan populations, study investigators will be able to assemble over 300 fatal cases of prostate cancer with available prostatectomy tissue and clinical data and will be able to compare them with a well-matched sample of non-fatal cases. The case-control study design will provide maximum statistical power for analysis of these relationships, particularly in the important African-American subgroup.

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Publications

Association of body mass index and prostate cancer mortality.
Authors: Haque R, Van Den Eeden SK, Wallner LP, Richert-Boe K, Kallakury B, Wang R, Weinmann S
Source: Obes Res Clin Pract, 2014 Jul-Aug;8(4), p. e374-81.
EPub date: 2013 Aug 6.
PMID: 25091359
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Immunohistochemical expression of ERG in the molecular epidemiology of fatal prostate cancer study.
Authors: Weinmann S, Van Den Eeden SK, Haque R, Chen C, Richert-Boe K, Schwartzman J, Gao L, Berry DL, Kallakury BV, Alumkal JJ
Source: Prostate, 2013 Sep;73(13), p. 1371-7.
EPub date: 2013 May 9.
PMID: 23661613
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Partner-assisted emotional disclosure for patients with GI cancer: 8-week follow-up and processes associated with change.
Authors: Porter LS, Keefe FJ, Baucom DH, Hurwitz H, Moser B, Patterson E, Kim HJ
Source: Support Care Cancer, 2012 Aug;20(8), p. 1755-62.
EPub date: 2011 Sep 24.
PMID: 21947440
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Partner-assisted emotional disclosure for patients with gastrointestinal cancer: results from a randomized controlled trial.
Authors: Porter LS, Keefe FJ, Baucom DH, Hurwitz H, Moser B, Patterson E, Kim HJ
Source: Cancer, 2009 Sep 15;115(18 Suppl), p. 4326-38.
PMID: 19731357
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Pain communication in the context of osteoarthritis: patient and partner self-efficacy for pain communication and holding back from discussion of pain and arthritis-related concerns.
Authors: Porter LS, Keefe FJ, Wellington C, de Williams A
Source: Clin J Pain, 2008 Oct;24(8), p. 662-8.
PMID: 18806530
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Don't ask, don't tell? Revealing placebo responses to research participants and patients.
Authors: Keefe F, Abernethy AP, Wheeler J, Affleck G
Source: Pain, 2008 Apr;135(3), p. 213-4.
EPub date: 2008 Feb 20.
PMID: 18282661
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Pain in its environmental context: implications for designing environments to enhance pain control.
Authors: Malenbaum S, Keefe FJ, Williams AC, Ulrich R, Somers TJ
Source: Pain, 2008 Feb;134(3), p. 241-4.
EPub date: 2008 Jan 4.
PMID: 18178010
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Attachment and pain: recent findings and future directions.
Authors: Porter LS, Davis D, Keefe FJ
Source: Pain, 2007 Apr;128(3), p. 195-8.
EPub date: 2007 Feb 23.
PMID: 17321050
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Ambivalence over emotional expression in patients with gastrointestinal cancer and their caregivers: associations with patient pain and quality of life.
Authors: Porter LS, Keefe FJ, Lipkus I, Hurwitz H
Source: Pain, 2005 Oct;117(3), p. 340-8.
PMID: 16153771
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Disclosure between patients with gastrointestinal cancer and their spouses.
Authors: Porter LS, Keefe FJ, Hurwitz H, Faber M
Source: Psychooncology, 2005 Dec;14(12), p. 1030-42.
PMID: 15712247
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