||5R01CA078682-07 Interpret this number
||University Of Utah
||Four-Corners Breast and Endometrial Cancer Study
DESCRIPTION: (Adapted from Applicant's Abstract) The incidence of breast and
endometrial cancers varies almost three-fold between non-Hispanic white
populations and Native American and Hispanic populations living in the
4-Corners area of the United States (Arizona, New Mexico, Colorado, and Utah).
Interestingly, although American Indian and Hispanic women have higher
prevalences of many risk factors for breast and endometrial cancer identified
in non-Hispanic white women (e.g., obesity, low levels of vigorous physical
activity, low intakes of fruits and vegetables, high rates of insulin
resistance) they have lower cancer incidence rates. In this study the
investigators focus on the metabolic factors of obesity/weight changes and
indicators of insulin status as they relate to breast and endometrial cancers.
Obesity is associated both with estrogen and insulin by two interrelated
disease pathways. Insulin may influence cancer risk directly through its
effects on insulin-like growth factor (IGF) and its binding proteins (IGFBPs)
and well as indirectly through its effect on estrogen levels. The investigators
propose focusing on the insulin pathway because of the high levels of insulin
pathway dysfunction in this population. A multi-center case-control study is
proposed that targets women living in the 4-Corners area; the study will
consist of a 2.5 hour in-person interview and a blood draw. Over a three-year
case ascertainment period, the study will enroll 3000 breast cancer cases, 450
endometrial cancer cases and 3000 controls, half of whom will be
Hispanic/Native American and half of whom will be non-Hispanic white women
between the ages of 25 and 79. Molecular variants of genes that influence
obesity and insulin (androgen receptor gene (AR), vitamin D receptor gene(VDR),
insulin receptor (ADRB3)) will be examined both independently and in
conjunction with metabolic factors to determine differences in genetic
susceptibility in the population. Because of the diverse population (Hispanics,
Native American, and non-Hispanic white women), the investigators propose to
evaluate ethnic background and genetic admixture in relationship to gene
markers, environmental factors, and breast and endometrial cancer risk. Genetic
admixture (Ameridian to European genetic mixture) is a novel and innovative way
to study the continuum of ethnic diversity. C-peptide, glycosylated hemoglobin,
IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial
cancer in a subset of women.
Validation of a historical physical activity questionnaire in middle-aged women.
DuBose KD, Edwards S, Ainsworth BE, Reis JP, Slattery ML
J Phys Act Health, 2007 Jul;4(3), p. 343-55.
Contacting controls: are we working harder for similar response rates, and does it make a difference?
Rogers A, Murtaugh MA, Edwards S, Slattery ML
Am J Epidemiol, 2004 Jul 1;160(1), p. 85-90.