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Grant Details

Grant Number: 5R03CA110948-02 Interpret this number
Primary Investigator: Michaud, Dominique
Organization: Harvard School Of Public Health
Project Title: A Prospective Study of Diet and Adult Gliomas
Fiscal Year: 2005
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Abstract

DESCRIPTION (provided by applicant): Gliomas account for almost half of all the primary brain tumors diagnosed in the U.S. Although these tumors are rare, survival rates are low (approximately 30% for 5-years). The only established risk factor for gliomas is ionizing radiation at therapeutic doses, but this factor can only account for a fraction of all brain tumors. Several dietary factors have been associated with the risk of gliomas, but findings are inconsistent, and most epidemiologic studies have relied on case-control designs. Unfortunately, case-control studies on brain tumors are particularly prone to biases because of the high fatality rates, and consequently, interpretation of findings from these studies is difficult. We propose to draw on three large prospective cohorts, the Health Professionals Follow-Up study, and the Nurses' Health Studies I and II to examine the relation between intakes of meat, fruits and vegetables and vitamins and the risk of gliomas. Detailed information on dietary intake was collected at baseline with food frequency questionnaires in each of the three cohorts and was updated periodically over the follow-up period. Data on detailed lifestyle factors, including smoking history, are available for the proposed analyses. We will use Cox proportional hazard models to estimate relative risks while adjusting for total energy intake and other potential confounders. This study will represent the first to examine dietary data obtained prior to brain tumor diagnosis. By combining three large cohorts, we will have approximately 321 incident cases of gliomas for the dietary analyses. Because the etiology of adult gliomas remains largely unknown, there are currently no modifiable risk factors which can be translated into prevention. This study should contribute substantially to our understanding of the relation between diet and the risk of adult gliomas, and might provide opportunities for prevention of this deadly disease.

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Publications

Coffee, tea, caffeine intake, and risk of adult glioma in three prospective cohort studies.
Authors: Holick CN, Smith SG, Giovannucci E, Michaud DS
Source: Cancer Epidemiol Biomarkers Prev, 2010 Jan;19(1), p. 39-47.
PMID: 20056621
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Prospective study of meat intake and dietary nitrates, nitrites, and nitrosamines and risk of adult glioma.
Authors: Michaud DS, Holick CN, Batchelor TT, Giovannucci E, Hunter DJ
Source: Am J Clin Nutr, 2009 Sep;90(3), p. 570-7.
EPub date: 2009 Jul 8.
PMID: 19587083
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Prospective study of cigarette smoking and adult glioma: dosage, duration, and latency.
Authors: Holick CN, Giovannucci EL, Rosner B, Stampfer MJ, Michaud DS
Source: Neuro Oncol, 2007 Jul;9(3), p. 326-34.
EPub date: 2007 May 15.
PMID: 17504930
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Prospective study of intake of fruit, vegetables, and carotenoids and the risk of adult glioma.
Authors: Holick CN, Giovannucci EL, Rosner B, Stampfer MJ, Michaud DS
Source: Am J Clin Nutr, 2007 Mar;85(3), p. 877-86.
PMID: 17344512
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