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Grant Details

Grant Number: 5R03CA108370-02 Interpret this number
Primary Investigator: Holly, Elizabeth
Organization: University Of California, San Francisco
Project Title: Pancreas Cancer Analysis-Sf Bay Area Case-Control Study
Fiscal Year: 2005
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Abstract

DESCRIPTION (provided by applicant): Pancreas cancer analysis-SF Bay Area case-control study: Pancreatic cancer (PC) is the fourth most common cause of cancer death with the lowest 5-year survival rate (<5%) of all cancers. It has been designated as a high priority for NCI by the NCI-sponsored Progress Review Group and by Congress for FY 2004. The overall study goal is to continue data analyses for our large population-based case-control study of PC that was conducted between 1994 and 2002 (no proxy interviews, n=532 patients, 1701 controls). Using unconditional logistic regression, the specific aims are to: 1) perform data analyses of diet (energy-adjusted for nutrients), pancreatitis, diabetes, smoking, alcohol consumption, and hormone use in women in relation to PC; and 2) to evaluate the relationships between factors in Aim 1 and previously determined polymorphisms (GSTT1, GSTM1, CYPIA1, XRCC1). Detailed data were collected for this study about each factor of interest. Because the genes of interest play an important role in detoxification of carcinogenic polycyclic aromatic hydrocarbons and heterocyclic amines, estrogen metabolism and repair of DNA damaged by oxidative stress, it is plausible that the presence of polymorphisms in these genes will alter the association between pancreatic cancer and factors in Aim 1. Study strengths include: 1) already identified genetic polymorphisms; 2) extensive information on risk factors; 3) diet questionnaire developed by Dr. Walter Willett's group at Harvard University who have computed macro and micronutrients for this study; 4) large sample size allows combination of risk-factor and molecular data to determine possible interactions between genetic and environmental factors; 5) data were collected on food preparation methods and vitamins that may be relevant in PC etiology; 6) SEER registry provided complete case ascertainment; and 7) can evaluate potential confounding and effect modification. Data on modifiable risk factors may provide new and provocative results of 3ublic health importance for this devastating disease.

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Publications

An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population.
Authors: Klein AP, Lindstr÷m S, Mendelsohn JB, Steplowski E, Arslan AA, Bueno-de-Mesquita HB, Fuchs CS, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, Lacroix A, Li D, Mandelson MT, Olson SH, Petersen GM, Risch HA, Stolzenberg-Solomon RZ, Zheng W, Amundadottir L, Albanes D, Allen NE, Bamlet WR, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, Duell EJ, Elena J, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hassan M, Hutchinson A, Hunter DJ, Kooperberg C, Kurtz RC, Liu S, Overvad K, Palli D, Patel AV, Rabe KG, Shu XO, Slimani N, Tobias GS, Trichopoulos D, Van Den Eeden SK, Vineis P, Virtamo J, Wactawski-Wende J, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Chanock SJ, Hoover RN, Hartge P, Kraft P
Source: PLoS One, 2013;8(9), p. e72311.
EPub date: 2013 Sep 13.
PMID: 24058443
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Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Bosetti C, Lucenteforte E, Bracci PM, Negri E, Neale RE, Risch HA, Olson SH, Gallinger S, Miller AB, Bueno-de-Mesquita HB, Talamini R, Polesel J, Ghadirian P, Baghurst PA, Zatonski W, Fontham E, Holly EA, Gao YT, Yu H, Kurtz RC, Cotterchio M, Maisonneuve P, Zeegers MP, Duell EJ, Boffetta P, La Vecchia C
Source: Ann Oncol, 2013 Nov;24(11), p. 2903-10.
EPub date: 2013 Aug 22.
PMID: 23970016
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Allergies and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Case-Control Consortium.
Authors: Olson SH, Hsu M, Satagopan JM, Maisonneuve P, Silverman DT, Lucenteforte E, Anderson KE, Borgida A, Bracci PM, Bueno-de-Mesquita HB, Cotterchio M, Dai Q, Duell EJ, Fontham EH, Gallinger S, Holly EA, Ji BT, Kurtz RC, La Vecchia C, Lowenfels AB, Luckett B, Ludwig E, Petersen GM, Polesel J, Seminara D, Strayer L, Talamini R, Pancreatic Cancer Case-Control Consortium
Source: Am J Epidemiol, 2013 Sep 1;178(5), p. 691-700.
EPub date: 2013 Jul 2.
PMID: 23820785
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Dietary patterns and risk of pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area.
Authors: Chan JM, Gong Z, Holly EA, Bracci PM
Source: Nutr Cancer, 2013;65(1), p. 157-64.
PMID: 23368926
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Obesity and survival in population-based patients with pancreatic cancer in the San Francisco Bay Area.
Authors: Gong Z, Holly EA, Bracci PM
Source: Cancer Causes Control, 2012 Dec;23(12), p. 1929-37.
EPub date: 2012 Sep 27.
PMID: 23015286
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Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Duell EJ, Lucenteforte E, Olson SH, Bracci PM, Li D, Risch HA, Silverman DT, Ji BT, Gallinger S, Holly EA, Fontham EH, Maisonneuve P, Bueno-de-Mesquita HB, Ghadirian P, Kurtz RC, Ludwig E, Yu H, Lowenfels AB, Seminara D, Petersen GM, La Vecchia C, Boffetta P
Source: Ann Oncol, 2012 Nov;23(11), p. 2964-70.
EPub date: 2012 Jul 5.
PMID: 22767586
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Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer.
Authors: Li D, Duell EJ, Yu K, Risch HA, Olson SH, Kooperberg C, Wolpin BM, Jiao L, Dong X, Wheeler B, Arslan AA, Bueno-de-Mesquita HB, Fuchs CS, Gallinger S, Gross M, Hartge P, Hoover RN, Holly EA, Jacobs EJ, Klein AP, LaCroix A, Mandelson MT, Petersen G, Zheng W, Agalliu I, Albanes D, Boutron-Ruault MC, Bracci PM, Buring JE, Canzian F, Chang K, Chanock SJ, Cotterchio M, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hankinson SE, Hoffman Bolton JA, Hunter DJ, Hutchinson A, Jacobs KB, Jenab M, Khaw KT, Kraft P, Krogh V, Kurtz RC, McWilliams RR, Mendelsohn JB, Patel AV, Rabe KG, Riboli E, Shu XO, Tj°nneland A, Tobias GS, Trichopoulos D, Virtamo J, Visvanathan K, Watters J, Yu H, Zeleniuch-Jacquotte A, Amundadottir L, Stolzenberg-Solomon RZ
Source: Carcinogenesis, 2012 Jul;33(7), p. 1384-90.
EPub date: 2012 Apr 20.
PMID: 22523087
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Serum autoantibodies to pancreatic cancer antigens as biomarkers of pancreatic cancer in a San Francisco Bay Area case-control study.
Authors: Bracci PM, Zhou M, Young S, Wiemels J
Source: Cancer, 2012 Nov 1;118(21), p. 5384-94.
EPub date: 2012 Apr 19.
PMID: 22517435
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Mitochondrial DNA sequence variation and risk of pancreatic cancer.
Authors: Lam ET, Bracci PM, Holly EA, Chu C, Poon A, Wan E, White K, Kwok PY, Pawlikowska L, Tranah GJ
Source: Cancer Res, 2012 Feb 1;72(3), p. 686-95.
EPub date: 2011 Dec 15.
PMID: 22174369
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Obesity and pancreatic cancer: overview of epidemiologic evidence and biologic mechanisms.
Authors: Bracci PM
Source: Mol Carcinog, 2012 Jan;51(1), p. 53-63.
PMID: 22162231
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Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4).
Authors: Bosetti C, Lucenteforte E, Silverman DT, Petersen G, Bracci PM, Ji BT, Negri E, Li D, Risch HA, Olson SH, Gallinger S, Miller AB, Bueno-de-Mesquita HB, Talamini R, Polesel J, Ghadirian P, Baghurst PA, Zatonski W, Fontham E, Bamlet WR, Holly EA, Bertuccio P, Gao YT, Hassan M, Yu H, Kurtz RC, Cotterchio M, Su J, Maisonneuve P, Duell EJ, Boffetta P, La Vecchia C
Source: Ann Oncol, 2012 Jul;23(7), p. 1880-8.
EPub date: 2011 Nov 21.
PMID: 22104574
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Survival in population-based pancreatic cancer patients: San Francisco Bay area, 1995-1999.
Authors: Gong Z, Holly EA, Bracci PM
Source: Am J Epidemiol, 2011 Dec 15;174(12), p. 1373-81.
EPub date: 2011 Nov 1.
PMID: 22047824
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Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Lucenteforte E, La Vecchia C, Silverman D, Petersen GM, Bracci PM, Ji BT, Bosetti C, Li D, Gallinger S, Miller AB, Bueno-de-Mesquita HB, Talamini R, Polesel J, Ghadirian P, Baghurst PA, Zatonski W, Fontham E, Bamlet WR, Holly EA, Gao YT, Negri E, Hassan M, Cotterchio M, Su J, Maisonneuve P, Boffetta P, Duell EJ
Source: Ann Oncol, 2012 Feb;23(2), p. 374-82.
EPub date: 2011 May 2.
PMID: 21536662
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Cigarette, cigar and pipe smoking, passive smoke exposure, and risk of pancreatic cancer: a population-based study in the San Francisco Bay Area.
Authors: Tranah GJ, Holly EA, Wang F, Bracci PM
Source: BMC Cancer, 2011 Apr 15;11, p. 138.
EPub date: 2011 Apr 15.
PMID: 21496267
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Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Bertuccio P, La Vecchia C, Silverman DT, Petersen GM, Bracci PM, Negri E, Li D, Risch HA, Olson SH, Gallinger S, Miller AB, Bueno-de-Mesquita HB, Talamini R, Polesel J, Ghadirian P, Baghurst PA, Zatonski W, Fontham ET, Bamlet WR, Holly EA, Lucenteforte E, Hassan M, Yu H, Kurtz RC, Cotterchio M, Su J, Maisonneuve P, Duell EJ, Bosetti C, Boffetta P
Source: Ann Oncol, 2011 Jun;22(6), p. 1420-6.
EPub date: 2011 Jan 18.
PMID: 21245160
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Diabetes and risk of pancreatic cancer: a pooled analysis of three large case-control studies.
Authors: Li D, Tang H, Hassan MM, Holly EA, Bracci PM, Silverman DT
Source: Cancer Causes Control, 2011 Feb;22(2), p. 189-97.
EPub date: 2010 Nov 21.
PMID: 21104117
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Vitamin D, calcium, and retinol intake, and pancreatic cancer in a population-based case-control study in the San Francisco Bay area.
Authors: Zablotska LB, Gong Z, Wang F, Holly EA, Bracci PM
Source: Cancer Causes Control, 2011 Jan;22(1), p. 91-100.
EPub date: 2010 Nov 12.
PMID: 21072578
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Risk of pancreatic cancer by alcohol dose, duration, and pattern of consumption, including binge drinking: a population-based study.
Authors: Gupta S, Wang F, Holly EA, Bracci PM
Source: Cancer Causes Control, 2010 Jul;21(7), p. 1047-59.
EPub date: 2010 Mar 27.
PMID: 20349126
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Intake of fatty acids and antioxidants and pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area.
Authors: Gong Z, Holly EA, Wang F, Chan JM, Bracci PM
Source: Int J Cancer, 2010 Oct 15;127(8), p. 1893-904.
PMID: 20104522
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Pancreatitis and pancreatic cancer in two large pooled case-control studies.
Authors: Bracci PM, Wang F, Hassan MM, Gupta S, Li D, Holly EA
Source: Cancer Causes Control, 2009 Nov;20(9), p. 1723-1731.
PMID: 19760029
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Genetic variation in CYP17A1 and pancreatic cancer in a population-based case-control study in the San Francisco Bay Area, California.
Authors: Duell EJ, Holly EA, Kelsey KT, Bracci PM
Source: Int J Cancer, 2010 Feb 1;126(3), p. 790-5.
PMID: 19642097
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Intake of folate, vitamins B6, B12 and methionine and risk of pancreatic cancer in a large population-based case-control study.
Authors: Gong Z, Holly EA, Bracci PM
Source: Cancer Causes Control, 2009 Oct;20(8), p. 1317-25.
EPub date: 2009 May 5.
PMID: 19415507
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Sweets, sweetened beverages, and risk of pancreatic cancer in a large population-based case-control study.
Authors: Chan JM, Wang F, Holly EA
Source: Cancer Causes Control, 2009 Aug;20(6), p. 835-46.
EPub date: 2009 Mar 11.
PMID: 19277880
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Detecting pathway-based gene-gene and gene-environment interactions in pancreatic cancer.
Authors: Duell EJ, Bracci PM, Moore JH, Burk RD, Kelsey KT, Holly EA
Source: Cancer Epidemiol Biomarkers Prev, 2008 Jun;17(6), p. 1470-9.
PMID: 18559563
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Whole grains and risk of pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area, California.
Authors: Chan JM, Wang F, Holly EA
Source: Am J Epidemiol, 2007 Nov 15;166(10), p. 1174-85.
EPub date: 2007 Sep 18.
PMID: 17881383
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Pancreatic cancer, animal protein and dietary fat in a population-based study, San Francisco Bay Area, California.
Authors: Chan JM, Wang F, Holly EA
Source: Cancer Causes Control, 2007 Dec;18(10), p. 1153-67.
EPub date: 2007 Sep 1.
PMID: 17805983
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Pancreatic cancer and medical history in a population-based case-control study in the San Francisco Bay Area, California.
Authors: Ko AH, Wang F, Holly EA
Source: Cancer Causes Control, 2007 Oct;18(8), p. 809-19.
EPub date: 2007 Jul 14.
PMID: 17632765
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Diabetes mellitus and pancreatic cancer in a population-based case-control study in the San Francisco Bay Area, California.
Authors: Wang F, Gupta S, Holly EA
Source: Cancer Epidemiol Biomarkers Prev, 2006 Aug;15(8), p. 1458-63.
PMID: 16896032
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Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma.
Authors: Duell EJ, Casella DP, Burk RD, Kelsey KT, Holly EA
Source: Cancer Epidemiol Biomarkers Prev, 2006 Apr;15(4), p. 726-31.
PMID: 16614115
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Survival among patients with adenocarcinoma of the pancreas: a population-based study (United States).
Authors: Cress RD, Yin D, Clarke L, Bold R, Holly EA
Source: Cancer Causes Control, 2006 May;17(4), p. 403-9.
PMID: 16596292
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Vegetable and fruit intake and pancreatic cancer in a population-based case-control study in the San Francisco bay area.
Authors: Chan JM, Wang F, Holly EA
Source: Cancer Epidemiol Biomarkers Prev, 2005 Sep;14(9), p. 2093-7.
PMID: 16172215
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