||5R01CA083918-05 Interpret this number
||Sloan-Kettering Inst Can Res
||Estrogen, Diet, Genetics and Endometrial Cancer
Risk factors for endometrial cancer, including weight and a
high-fat diet, operate through estrogen-related mechanisms. Estrogen promotes
growth of transformed cells and there is evidence that some metabolites may
have carcinogenic properties. Some of the genes that are important in estrogen
metabolism have been found to be polymorphic (CYP17, CYP1 Al, catechol
0-methyltransferase, CYP1 Bi, and CYP19), raising the question of whether genotypes are related to risk. The primary aim of this study is to compare
endometrial cancer cases to controls to determine the associations of weight,
diet, and genetic susceptibility, independently and jointly, with endometrial
Most endometrial tumors are of endometrioid histology. The rarer serous and
clear cell tumors are more aggressive and lethal. Aside from their higher
prevalence in older women and in blacks, little is known about risk factors for
these tumors, although they appear not to be related to estrogen. The secondary
aim is to compare cases with these tumor types to controls to assess risk
factors for these poorly-understood tumors.
We will conduct a population-based case-control study in six counties in New
Jersey. Cases will be women with newly-diagnosed endometrial cancer. Controls
will be matched by 5-year age groups and selected by random digit dialing (for
those under 65) or from HCFA files (for those aged 65 and over). There will be
600 cases with endometrioid tumors, 200 with serous or clear cell tumors, and
Endometrial cancer, already a serious cause of morbidity in the US, is likely
to become more common in future years as the population ages and obesity
increases. Risk factors such as obesity and poor diets are potentially
modifiable. This study will provide data on genetic susceptibility in
endometrial cancer in conjunction with established risk factors, as well as the
first epidemiologic data on the more lethal serous and clear cell tumors.
Type I and II endometrial cancers: have they different risk factors?
Setiawan VW, Yang HP, Pike MC, McCann SE, Yu H, Xiang YB, Wolk A, Wentzensen N, Weiss NS, Webb PM, van den Brandt PA, van de Vijver K, Thompson PJ, Australian National Endometrial Cancer Study Group, Strom BL, Spurdle AB, Soslow RA, Shu XO, Schairer C, Sacerdote C, Rohan TE, Robien K, Risch HA, Ricceri F, Rebbeck TR, Rastogi R, Prescott J, Polidoro S, Park Y, Olson SH, Moysich KB, Miller AB, McCullough ML, Matsuno RK, Magliocco AM, Lurie G, Lu L, Lissowska J, Liang X, Lacey JV Jr, Kolonel LN, Henderson BE, Hankinson SE, Håkansson N, Goodman MT, Gaudet MM, Garcia-Closas M, Friedenreich CM, Freudenheim JL, Doherty J, De Vivo I, Courneya KS, Cook LS, Chen C, Cerhan JR, Cai H, Brinton LA, Bernstein L, Anderson KE, Anton-Culver H, Schouten LJ, Horn-Ross PL
J Clin Oncol, 2013 Jul 10;31(20), p. 2607-18.
2013 Jun 3.
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