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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R01CA083918-05 Interpret this number
Primary Investigator: Olson, Sara
Organization: Sloan-Kettering Inst Can Research
Project Title: Estrogen, Diet, Genetics and Endometrial Cancer
Fiscal Year: 2005
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Abstract

Risk factors for endometrial cancer, including weight and a high-fat diet, operate through estrogen-related mechanisms. Estrogen promotes growth of transformed cells and there is evidence that some metabolites may have carcinogenic properties. Some of the genes that are important in estrogen metabolism have been found to be polymorphic (CYP17, CYP1 Al, catechol 0-methyltransferase, CYP1 Bi, and CYP19), raising the question of whether genotypes are related to risk. The primary aim of this study is to compare endometrial cancer cases to controls to determine the associations of weight, diet, and genetic susceptibility, independently and jointly, with endometrial cancer. Most endometrial tumors are of endometrioid histology. The rarer serous and clear cell tumors are more aggressive and lethal. Aside from their higher prevalence in older women and in blacks, little is known about risk factors for these tumors, although they appear not to be related to estrogen. The secondary aim is to compare cases with these tumor types to controls to assess risk factors for these poorly-understood tumors. We will conduct a population-based case-control study in six counties in New Jersey. Cases will be women with newly-diagnosed endometrial cancer. Controls will be matched by 5-year age groups and selected by random digit dialing (for those under 65) or from HCFA files (for those aged 65 and over). There will be 600 cases with endometrioid tumors, 200 with serous or clear cell tumors, and 600 controls. Endometrial cancer, already a serious cause of morbidity in the US, is likely to become more common in future years as the population ages and obesity increases. Risk factors such as obesity and poor diets are potentially modifiable. This study will provide data on genetic susceptibility in endometrial cancer in conjunction with established risk factors, as well as the first epidemiologic data on the more lethal serous and clear cell tumors.

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Publications

Two Estrogen-related Variants In Cyp19a1 And Endometrial Cancer Risk: A Pooled Analysis In The Epidemiology Of Endometrial Cancer Consortium
Authors: Setiawan V.W. , Doherty J.A. , Shu X.O. , Akbari M.R. , Chen C. , De Vivo I. , Demichele A. , Garcia-Closas M. , Goodman M.T. , Haiman C.A. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2009 Jan; 18(1), p. 242-7.
PMID: 19124504
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Age At Last Birth In Relation To Risk Of Endometrial Cancer: Pooled Analysis In The Epidemiology Of Endometrial Cancer Consortium
Authors: Setiawan V.W. , Pike M.C. , Karageorgi S. , Deming S.L. , Anderson K. , Bernstein L. , Brinton L.A. , Cai H. , Cerhan J.R. , Cozen W. , et al. .
Source: American Journal Of Epidemiology, 2012-08-15 00:00:00.0; 176(4), p. 269-78.
PMID: 22831825
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Recent Alcohol Consumption And Risk Of Incident Ovarian Carcinoma: A Pooled Analysis Of 5,342 Cases And 10,358 Controls From The Ovarian Cancer Association Consortium
Authors: Kelemen L.E. , Bandera E.V. , Terry K.L. , Rossing M.A. , Brinton L.A. , Doherty J.A. , Ness R.B. , Kjaer S.K. , Chang-Claude J. , Köbel M. , et al. .
Source: Bmc Cancer, 2013; 13, p. 28.
PMID: 23339562
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Obesity And Risk Of Ovarian Cancer Subtypes: Evidence From The Ovarian Cancer Association Consortium
Authors: Olsen C.M. , Nagle C.M. , Whiteman D.C. , Ness R. , Pearce C.L. , Pike M.C. , Rossing M.A. , Terry K.L. , Wu A.H. , Australian Cancer Study (Ovarian Cancer) , et al. .
Source: Endocrine-related Cancer, 2013 Apr; 20(2), p. 251-62.
PMID: 23404857
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Cigarette Smoking And Risk Of Ovarian Cancer: A Pooled Analysis Of 21 Case-control Studies
Authors: Faber M.T. , Kjær S.K. , Dehlendorff C. , Chang-Claude J. , Andersen K.K. , Høgdall E. , Webb P.M. , Jordan S.J. , Australian Cancer Study (Ovarian Cancer) , Australian Ovarian Cancer Study Group , et al. .
Source: Cancer Causes & Control : Ccc, 2013 May; 24(5), p. 989-1004.
PMID: 23456270
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Identification And Molecular Characterization Of A New Ovarian Cancer Susceptibility Locus At 17q21.31
Authors: Permuth-Wey J. , Lawrenson K. , Shen H.C. , Velkova A. , Tyrer J.P. , Chen Z. , Lin H.Y. , Chen Y.A. , Tsai Y.Y. , Qu X. , et al. .
Source: Nature Communications, 2013; 4, p. 1627.
PMID: 23535648
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Type I And Ii Endometrial Cancers: Have They Different Risk Factors?
Authors: Setiawan V.W. , Yang H.P. , Pike M.C. , McCann S.E. , Yu H. , Xiang Y.B. , Wolk A. , Wentzensen N. , Weiss N.S. , Webb P.M. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2013-07-10 00:00:00.0; 31(20), p. 2607-18.
PMID: 23733771
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Aspirin, Nonaspirin Nonsteroidal Anti-inflammatory Drug, And Acetaminophen Use And Risk Of Invasive Epithelial Ovarian Cancer: A Pooled Analysis In The Ovarian Cancer Association Consortium
Authors: Trabert B. , Ness R.B. , Lo-Ciganic W.H. , Murphy M.A. , Goode E.L. , Poole E.M. , Brinton L.A. , Webb P.M. , Nagle C.M. , Jordan S.J. , et al. .
Source: Journal Of The National Cancer Institute, 2014 Feb; 106(2), p. djt431.
PMID: 24503200
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Intrauterine Devices And Endometrial Cancer Risk: A Pooled Analysis Of The Epidemiology Of Endometrial Cancer Consortium
Authors: Felix A.S. , Gaudet M.M. , La Vecchia C. , Nagle C.M. , Shu X.O. , Weiderpass E. , Adami H.O. , Beresford S. , Bernstein L. , Chen C. , et al. .
Source: International Journal Of Cancer, 2015-03-01 00:00:00.0; 136(5), p. E410-22.
PMID: 25242594
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Risk Factors For Endometrial Cancer In Black And White Women: A Pooled Analysis From The Epidemiology Of Endometrial Cancer Consortium (e2c2)
Authors: Cote M.L. , Alhajj T. , Ruterbusch J.J. , Bernstein L. , Brinton L.A. , Blot W.J. , Chen C. , Gass M. , Gaussoin S. , Henderson B. , et al. .
Source: Cancer Causes & Control : Ccc, 2015 Feb; 26(2), p. 287-96.
PMID: 25534916
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Obesity And Survival Among Women With Ovarian Cancer: Results From The Ovarian Cancer Association Consortium
Authors: Nagle C.M. , Dixon S.C. , Jensen A. , Kjaer S.K. , Modugno F. , deFazio A. , Fereday S. , Hung J. , Johnatty S.E. , Australian Ovarian Cancer Study Group , et al. .
Source: British Journal Of Cancer, 2015-09-01 00:00:00.0; 113(5), p. 817-26.
PMID: 26151456
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Genome-wide Analysis Identifies Novel Loci Associated With Ovarian Cancer Outcomes: Findings From The Ovarian Cancer Association Consortium
Authors: Johnatty S.E. , Tyrer J.P. , Kar S. , Beesley J. , Lu Y. , Gao B. , Fasching P.A. , Hein A. , Ekici A.B. , Beckmann M.W. , et al. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2015-12-01 00:00:00.0; 21(23), p. 5264-76.
PMID: 26152742
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Common Variants At The Chek2 Gene Locus And Risk Of Epithelial Ovarian Cancer
Authors: Lawrenson K. , Iversen E.S. , Tyrer J. , Weber R.P. , Concannon P. , Hazelett D.J. , Li Q. , Marks J.R. , Berchuck A. , Lee J.M. , et al. .
Source: Carcinogenesis, 2015 Nov; 36(11), p. 1341-53.
PMID: 26424751
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Body Mass Index Genetic Risk Score And Endometrial Cancer Risk
Authors: Prescott J. , Setiawan V.W. , Wentzensen N. , Schumacher F. , Yu H. , Delahanty R. , Bernstein L. , Chanock S.J. , Chen C. , Cook L.S. , et al. .
Source: Plos One, 2015; 10(11), p. e0143256.
PMID: 26606540
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