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Grant Details

Grant Number: 5R01CA066635-09 Interpret this number
Primary Investigator: Sandler, Robert
Organization: Univ Of North Carolina Chapel Hill
Project Title: Population Study of Rectal Cancer in Blacks and Whites
Fiscal Year: 2005
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Abstract

DESCRIPTION (provided by applicant): Between 1973 and 1995 the incidence of rectal cancer decreased 2.0 percent in blacks compared to 20.2 percent in whites. From 1989-94, the five-year relative survival was 52.5 percentin blacks and 63.0 percent in whites. These differences have not been explained. In fact, black-white differences in rectal cancer incidence and mortality have not been adequately studied. This competing renewal application seeks funds to conduct a population-based study of rectal cancer in blacks and whites in a 33-county area of North Carolina, building on the infrastructure developed in an ongoing and successful study of colon cancer. The primary goal of the proposed research is to examine possible exposure, susceptibility, and health care factors that might explain diverging incidence and mortality trends in blacks and whites. The specific aims of this research are: (1) To identify environmental and lifestyle risk factors for rectal cancer in blacks and whites. The proposed study will explore a range of exposures that may be related to rectal cancer. (2) To assess the prevalence and etiologic importance of specific inherited susceptibility characteristics in a large mixed-race population. The study will focus on the known alleles of the N-acetyltransferase genes (NAT1 and NAT2) and manganese superoxide dismutase (MnSOD) genes using DNA obtained from blood samples. The study will investigate interactions between these genes and environmental exposures. (3) To evaluate factors that might account for the higher mortality among blacks including poverty, insurance, access to care, delay in the medical system, and transportation. A secondary aim is to collect biological specimens for subsequent analyses such as the role of other inherited genetic characteristics and the presence or absence of specific somatic genetic alterations. The study will recruit 1000 cases of rectal cancer age 40-80 and 1000 population-based controls. Cancer cases (250 blacks and 750 whites) will be identified using the rapid ascertainment system of the North Carolina Central Cancer Registry. Controls (250 blacks and 750 whites) will be selected using Division of Motor Vehicle Registry data for those under age 65 and HCFA files for those age 65 and over. Dietary, lifestyle and environmental exposure information will be obtained for cases and controls by personal, in-home interviews. The interview instrument includes comprehensive questions concerning diet and the use of dietary supplements, and seeks information about medications, education, physical activity, poverty, health care access and utilization. DNA extracted from peripheral blood lymphocytes will be used to determine NAT and MnSOD genotypes.

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Publications

Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583.
Authors: Tuupanen S, Yan J, Turunen M, Gylfe AE, Kaasinen E, Li L, Eng C, Culver DA, Kalady MF, Pennison MJ, Pasche B, Manne U, de la Chapelle A, Hampel H, Henderson BE, Le Marchand L, Hautaniemi S, Askhtorab H, Smoot D, Sandler RS, Keku T, Kupfer SS, Ellis NA, Haiman CA, Taipale J, Aaltonen LA
Source: Cancer Genet, 2012 Jan-Feb;205(1-2), p. 25-33.
PMID: 22429595
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Inverse relationship between moderate alcohol intake and rectal cancer: analysis of the North Carolina Colon Cancer Study.
Authors: Crockett SD, Long MD, Dellon ES, Martin CF, Galanko JA, Sandler RS
Source: Dis Colon Rectum, 2011 Jul;54(7), p. 887-94.
PMID: 21654257
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Associations of red meat, fat, and protein intake with distal colorectal cancer risk.
Authors: Williams CD, Satia JA, Adair LS, Stevens J, Galanko J, Keku TO, Sandler RS
Source: Nutr Cancer, 2010;62(6), p. 701-9.
PMID: 20661817
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Genetic heterogeneity in colorectal cancer associations between African and European americans.
Authors: Kupfer SS, Anderson JR, Hooker S, Skol A, Kittles RA, Keku TO, Sandler RS, Ellis NA
Source: Gastroenterology, 2010 Nov;139(5), p. 1677-85, 1685.e1-8.
EPub date: 2010 Jul 24.
PMID: 20659471
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Intake of polyunsaturated fatty acids and distal large bowel cancer risk in whites and African Americans.
Authors: Kim S, Sandler DP, Galanko J, Martin C, Sandler RS
Source: Am J Epidemiol, 2010 May 1;171(9), p. 969-79.
EPub date: 2010 Apr 14.
PMID: 20392864
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Antioxidant and DNA methylation-related nutrients and risk of distal colorectal cancer.
Authors: Williams CD, Satia JA, Adair LS, Stevens J, Galanko J, Keku TO, Sandler RS
Source: Cancer Causes Control, 2010 Aug;21(8), p. 1171-81.
EPub date: 2010 Mar 30.
PMID: 20352485
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A randomized trial of tailoring and motivational interviewing to promote fruit and vegetable consumption for cancer prevention and control.
Authors: Campbell MK, Carr C, Devellis B, Switzer B, Biddle A, Amamoo MA, Walsh J, Zhou B, Sandler R
Source: Ann Behav Med, 2009 Oct;38(2), p. 71-85.
PMID: 20012809
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Dietary patterns, food groups, and rectal cancer risk in Whites and African-Americans.
Authors: Williams CD, Satia JA, Adair LS, Stevens J, Galanko J, Keku TO, Sandler RS
Source: Cancer Epidemiol Biomarkers Prev, 2009 May;18(5), p. 1552-61.
PMID: 19423533
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Studying genetic research participants: lessons from the "Learning About Research in North Carolina" study.
Authors: Corbie-Smith G, Blumenthal C, Henderson G, Garrett J, Bussey-Jones J, Moloney M, Sandler RS, Lloyd SW, Dorrance J, Darter J
Source: Cancer Epidemiol Biomarkers Prev, 2008 Aug;17(8), p. 2019-24.
PMID: 18708393
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UGT1A1 and UGT1A9 functional variants, meat intake, and colon cancer, among Caucasians and African-Americans.
Authors: Girard H, Butler LM, Villeneuve L, Millikan RC, Sinha R, Sandler RS, Guillemette C
Source: Mutat Res, 2008 Sep 26;644(1-2), p. 56-63.
EPub date: 2008 Jul 16.
PMID: 18675828
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Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study.
Authors: Butler LM, Millikan RC, Sinha R, Keku TO, Winkel S, Harlan B, Eaton A, Gammon MD, Sandler RS
Source: Mutat Res, 2008 Feb 1;638(1-2), p. 162-74.
EPub date: 2007 Oct 13.
PMID: 18022202
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GSTM1 and GSTT1 polymorphisms, cigarette smoking, and risk of colon cancer: a population-based case-control study in North Carolina (United States).
Authors: Huang K, Sandler RS, Millikan RC, Schroeder JC, North KE, Hu J
Source: Cancer Causes Control, 2006 May;17(4), p. 385-94.
PMID: 16596290
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COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States).
Authors: Sansbury LB, Millikan RC, Schroeder JC, North KE, Moorman PG, Keku TO, de Cotret AR, Player J, Sandler RS
Source: Cancer Causes Control, 2006 Apr;17(3), p. 257-66.
PMID: 16489533
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5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer.
Authors: Eaton AM, Sandler R, Carethers JM, Millikan RC, Galanko J, Keku TO
Source: Cancer Epidemiol Biomarkers Prev, 2005 Aug;14(8), p. 2023-9.
PMID: 16103455
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Use of nonsteroidal antiinflammatory drugs and risk of colon cancer in a population-based, case-control study of African Americans and Whites.
Authors: Sansbury LB, Millikan RC, Schroeder JC, Moorman PG, North KE, Sandler RS
Source: Am J Epidemiol, 2005 Sep 15;162(6), p. 548-58.
EPub date: 2005 Aug 10.
PMID: 16093288
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Impact of functional support on health-related quality of life in patients with colorectal cancer.
Authors: Sultan S, Fisher DA, Voils CI, Kinney AY, Sandler RS, Provenzale D
Source: Cancer, 2004 Dec 15;101(12), p. 2737-43.
PMID: 15536617
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Longitudinal changes in lifestyle behaviors and health status in colon cancer survivors.
Authors: Satia JA, Campbell MK, Galanko JA, James A, Carr C, Sandler RS
Source: Cancer Epidemiol Biomarkers Prev, 2004 Jun;13(6), p. 1022-31.
PMID: 15184259
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Quality of colon carcinoma pathology reporting: a process of care study.
Authors: Wei JT, Miller EA, Woosley JT, Martin CF, Sandler RS
Source: Cancer, 2004 Mar 15;100(6), p. 1262-7.
PMID: 15022295
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Associations of total energy and macronutrients with colon cancer risk in African Americans and Whites: results from the North Carolina colon cancer study.
Authors: Satia-Abouta J, Galanko JA, Potter JD, Ammerman A, Martin CF, Sandler RS, North Carolina Colon Cancer Study
Source: Am J Epidemiol, 2003 Nov 15;158(10), p. 951-62.
PMID: 14607803
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Constipation, laxative use, and colon cancer in a North Carolina population.
Authors: Roberts MC, Millikan RC, Galanko JA, Martin C, Sandler RS
Source: Am J Gastroenterol, 2003 Apr;98(4), p. 857-64.
PMID: 12738468
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Outcomes of colorectal cancer in the United States: no change in survival (1986-1997).
Authors: Rabeneck L, El-Serag HB, Davila JA, Sandler RS
Source: Am J Gastroenterol, 2003 Feb;98(2), p. 471-7.
PMID: 12591071
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5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites.
Authors: Keku T, Millikan R, Worley K, Winkel S, Eaton A, Biscocho L, Martin C, Sandler R
Source: Cancer Epidemiol Biomarkers Prev, 2002 Dec;11(12), p. 1611-21.
PMID: 12496052
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Colorectal cancer screening.
Authors: Helm JF, Sandler RS
Source: Med Clin North Am, 1999 Nov;83(6), p. 1403-22, vi.
PMID: 10584600
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Rectal mucosal proliferation, dietary factors, and the risk of colorectal adenomas.
Authors: Keku TO, Galanko JA, Murray SC, Woosley JT, Sandler RS
Source: Cancer Epidemiol Biomarkers Prev, 1998 Nov;7(11), p. 993-9.
PMID: 9829707
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Aspirin and nonsteroidal anti-inflammatory agents and risk for colorectal adenomas.
Authors: Sandler RS, Galanko JC, Murray SC, Helm JF, Woosley JT
Source: Gastroenterology, 1998 Mar;114(3), p. 441-7.
PMID: 9496933
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