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Grant Details

Grant Number: 5R01CA087014-05 Interpret this number
Primary Investigator: Holly, Elizabeth
Organization: University Of California, San Francisco
Project Title: Molecular Epidemiology of Non Hodgkin's Lymphoma
Fiscal Year: 2005
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Abstract

A population-based case-control study of non-Hodgkin's lymphoma (NHL) will include 2000 patients and 2000 controls in the San Francisco Bay Area. A rapid case-finding system will be used to identify new cases in all hospitals in the six-county San Francisco Bay Area during the study period. Controls will be identified by random digit dial and through Health Care Financing Administration files and will be frequency-matched to cases by age and sex. Interview topics will include medical, diet, exercise, lifestyle, family, and sexual histories and will be conducted in study subjects' homes. Blood and buccal cells will be collected and processing of biological samples will provide large amounts of RNA, DNA, serum and viable cells for laboratory analyses. The specimens will be used to test for polymorphisms in key DNA repair, folate metabolism pathway and immune response genes, to search for novel genes and to test for HIV infection. After initial tests are completed the remaining viable blood cells, serum and genetic material will be banked in the event a new virus or genetic clues emerge. The lab results will be used with the questionnaire data to assess risk factors for NHL by histologic type, grade, sex, race/ethnicity, and HIV status. Multiple logistic regression and methods for genetic case-control data in the presence of stratification will be used for data analysis. Strengths include: 1. the large number of NHL patients in the San Francisco Bay Area provides the ability to examine associations by sex, race/ethnicity and histologic subtype; 2. innovative laboratory capabilities (e.g. ability to analyze many candidate loci for genetic polymorphisms and new polymorphisms for NHL), expert laboratory faculty and facilities available for laboratory tests; 3. complete dietary assessment using an established dietary questionnaire; 4. large number of patients and controls provides the potential to evaluate previously unstudied population subgroups and interactions among exposures related to NHL risk,- S. large male homosexual population permits exploration of HIV-related hypotheses and risks for NHL; 6. rapid case-finding mechanism minimizes loss of study subjects, particularly those with high-grade NHL; 7. population-based SEER tumor registry provides complete case ascertainment; 8. data later will be pooled with the NCI intramural lymphoma project to study histologic types and race/ethnicity groups in relation to questionnaire and some laboratory parameters.

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Publications

Rare variant association testing under low-coverage sequencing.
Authors: Navon O, Sul JH, Han B, Conde L, Bracci PM, Riby J, Skibola CF, Eskin E, Halperin E
Source: Genetics, 2013 Jul;194(3), p. 769-79.
EPub date: 2013 May 1.
PMID: 23636738
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Postmenopausal hormone therapy and non-Hodgkin lymphoma: a pooled analysis of InterLymph case-control studies.
Authors: Kane EV, Bernstein L, Bracci PM, Cerhan JR, Costas L, Dal Maso L, Holly EA, La Vecchia C, Matsuo K, Sanjose S, Spinelli JJ, Wang SS, Zhang Y, Zheng T, Roman E, Kricker A, InterLymph Consortium
Source: Ann Oncol, 2013 Feb;24(2), p. 433-41.
EPub date: 2012 Sep 11.
PMID: 22967995
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Menstrual and reproductive factors, and hormonal contraception use: associations with non-Hodgkin lymphoma in a pooled analysis of InterLymph case-control studies.
Authors: Kane EV, Roman E, Becker N, Bernstein L, Boffetta P, Bracci PM, Cerhan JR, Chiu BC, Cocco P, Costas L, Foretova L, Holly EA, La Vecchia C, Matsuo K, Maynadie M, Sanjose S, Spinelli JJ, Staines A, Talamini R, Wang SS, Zhang Y, Zheng T, Kricker A, InterLymph Consortium
Source: Ann Oncol, 2012 Sep;23(9), p. 2362-74.
EPub date: 2012 Jul 10.
PMID: 22786757
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Self-reported history of infections and the risk of non-Hodgkin lymphoma: an InterLymph pooled analysis.
Authors: Becker N, Falster MO, Vajdic CM, de Sanjose S, Martínez-Maza O, Bracci PM, Melbye M, Smedby KE, Engels EA, Turner J, Vineis P, Costantini AS, Holly EA, Spinelli JJ, La Vecchia C, Zheng T, Chiu BC, Montella M, Cocco P, Maynadié M, Foretova L, Staines A, Brennan P, Davis S, Severson R, Cerhan JR, Breen EC, Birmann B, Cozen W, Grulich AE, Newton R
Source: Int J Cancer, 2012 Nov 15;131(10), p. 2342-8.
EPub date: 2012 Aug 12.
PMID: 22266776
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Association of HLA-DQB1 alleles with risk of follicular lymphoma.
Authors: Akers NK, Curry JD, Conde L, Bracci PM, Smith MT, Skibola CF
Source: Leuk Lymphoma, 2011 Jan;52(1), p. 53-8.
EPub date: 2010 Dec 6.
PMID: 21133715
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Birth order and risk of non-hodgkin lymphoma--true association or bias?
Authors: Grulich AE, Vajdic CM, Falster MO, Kane E, Smedby KE, Bracci PM, de Sanjose S, Becker N, Turner J, Martinez-Maza O, Melbye M, Engels EA, Vineis P, Costantini AS, Holly EA, Spinelli JJ, La Vecchia C, Zheng T, Chiu BC, Franceschi S, Cocco P, Maynadié M, Foretova L, Staines A, Brennan P, Davis S, Severson RK, Cerhan JR, Breen EC, Birmann B, Cozen W
Source: Am J Epidemiol, 2010 Sep 15;172(6), p. 621-30.
EPub date: 2010 Aug 18.
PMID: 20720098
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A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis.
Authors: Nieters A, Bracci PM, de Sanjosé S, Becker N, Maynadié M, Benavente Y, Foretova L, Cocco P, Staines A, Holly EA, Boffetta P, Brennan P, Skibola CF
Source: Int J Cancer, 2011 Mar 15;128(6), p. 1481-5.
PMID: 20473910
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Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium.
Authors: Skibola CF, Bracci PM, Nieters A, Brooks-Wilson A, de Sanjosé S, Hughes AM, Cerhan JR, Skibola DR, Purdue M, Kane E, Lan Q, Foretova L, Schenk M, Spinelli JJ, Slager SL, De Roos AJ, Smith MT, Roman E, Cozen W, Boffetta P, Kricker A, Zheng T, Lightfoot T, Cocco P, Benavente Y, Zhang Y, Hartge P, Linet MS, Becker N, Brennan P, Zhang L, Armstrong B, Smith A, Shiao R, Novak AJ, Maynadie M, Chanock SJ, Staines A, Holford TR, Holly EA, Rothman N, Wang SS
Source: Am J Epidemiol, 2010 Feb 1;171(3), p. 267-76.
EPub date: 2010 Jan 4.
PMID: 20047977
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Chemokine polymorphisms and lymphoma: a pooled analysis.
Authors: Bracci PM, Skibola CF, Conde L, Halperin E, Lightfoot T, Smith A, Paynter RA, Skibola DR, Agana L, Roman E, Kane E, Wiencke JK
Source: Leuk Lymphoma, 2010 Mar;51(3), p. 497-506.
PMID: 20038229
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Solvent exposure and non-Hodgkin lymphoma: no risk in a population-based study in the San Francisco Bay Area.
Authors: Tranah GJ, Holly EA, Bracci PM
Source: Cancer Epidemiol Biomarkers Prev, 2009 Nov;18(11), p. 3130-2.
PMID: 19900943
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Atopic disease and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis.
Authors: Vajdic CM, Falster MO, de Sanjose S, Martínez-Maza O, Becker N, Bracci PM, Melbye M, Smedby KE, Engels EA, Turner J, Vineis P, Costantini AS, Holly EA, Kane E, Spinelli JJ, La Vecchia C, Zheng T, Chiu BC, Dal Maso L, Cocco P, Maynadié M, Foretova L, Staines A, Brennan P, Davis S, Severson R, Cerhan JR, Breen EC, Birmann B, Cozen W, Grulich AE
Source: Cancer Res, 2009 Aug 15;69(16), p. 6482-9.
EPub date: 2009 Aug 4.
PMID: 19654312
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Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.
Authors: Skibola CF, Bracci PM, Halperin E, Conde L, Craig DW, Agana L, Iyadurai K, Becker N, Brooks-Wilson A, Curry JD, Spinelli JJ, Holly EA, Riby J, Zhang L, Nieters A, Smith MT, Brown KM
Source: Nat Genet, 2009 Aug;41(8), p. 873-5.
EPub date: 2009 Jul 20.
PMID: 19620980
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Domestic and farm-animal exposures and risk of non-Hodgkin's lymphoma in a population-based study in the San Francisco Bay Area.
Authors: Tranah GJ, Bracci PM, Holly EA
Source: Cancer Epidemiol Biomarkers Prev, 2008 Sep;17(9), p. 2382-7.
PMID: 18768507
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Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
Authors: Skibola CF, Bracci PM, Halperin E, Nieters A, Hubbard A, Paynter RA, Skibola DR, Agana L, Becker N, Tressler P, Forrest MS, Sankararaman S, Conde L, Holly EA, Smith MT
Source: PLoS One, 2008 Jun 30;3(7), p. e2816.
EPub date: 2008 Jun 30.
PMID: 18636124
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Non-Hodgkin lymphoma in women: reproductive factors and exogenous hormone use.
Authors: Lee JS, Bracci PM, Holly EA
Source: Am J Epidemiol, 2008 Aug 1;168(3), p. 278-88.
EPub date: 2008 Jun 10.
PMID: 18550561
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Hepatitis C and non-Hodgkin lymphoma among 4784 cases and 6269 controls from the International Lymphoma Epidemiology Consortium.
Authors: de Sanjose S, Benavente Y, Vajdic CM, Engels EA, Morton LM, Bracci PM, Spinelli JJ, Zheng T, Zhang Y, Franceschi S, Talamini R, Holly EA, Grulich AE, Cerhan JR, Hartge P, Cozen W, Boffetta P, Brennan P, Maynadié M, Cocco P, Bosch R, Foretova L, Staines A, Becker N, Nieters A
Source: Clin Gastroenterol Hepatol, 2008 Apr;6(4), p. 451-8.
PMID: 18387498
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A functional TNFRSF5 gene variant is associated with risk of lymphoma.
Authors: Skibola CF, Nieters A, Bracci PM, Curry JD, Agana L, Skibola DR, Hubbard A, Becker N, Smith MT, Holly EA
Source: Blood, 2008 Apr 15;111(8), p. 4348-54.
EPub date: 2008 Feb 20.
PMID: 18287517
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Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium.
Authors: Ekström Smedby K, Vajdic CM, Falster M, Engels EA, Martínez-Maza O, Turner J, Hjalgrim H, Vineis P, Seniori Costantini A, Bracci PM, Holly EA, Willett E, Spinelli JJ, La Vecchia C, Zheng T, Becker N, De Sanjosé S, Chiu BC, Dal Maso L, Cocco P, Maynadié M, Foretova L, Staines A, Brennan P, Davis S, Severson R, Cerhan JR, Breen EC, Birmann B, Grulich AE, Cozen W
Source: Blood, 2008 Apr 15;111(8), p. 4029-38.
EPub date: 2008 Feb 8.
PMID: 18263783
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Screening the human serum proteome for genotype-phenotype associations: an analysis of the IL6 -174G>C polymorphism.
Authors: Hegedus CM, Skibola CF, Bracci P, Holly EA, Smith MT
Source: Proteomics, 2007 Feb;7(4), p. 548-57.
PMID: 17309100
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Polymorphisms in the oxidative stress genes, superoxide dismutase, glutathione peroxidase and catalase and risk of non-Hodgkin's lymphoma.
Authors: Lightfoot TJ, Skibola CF, Smith AG, Forrest MS, Adamson PJ, Morgan GJ, Bracci PM, Roman E, Smith MT, Holly EA
Source: Haematologica, 2006 Sep;91(9), p. 1222-7.
PMID: 16956821
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Use of nonsteroidal antiinflammatory drugs and non-Hodgkin lymphoma: a population-based case-control study.
Authors: Flick ED, Chan KA, Bracci PM, Holly EA
Source: Am J Epidemiol, 2006 Sep 1;164(5), p. 497-504.
EPub date: 2006 Jul 13.
PMID: 16840523
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Residential history, family characteristics and non-Hodgkin lymphoma, a population-based case-control study in the San Francisco Bay Area.
Authors: Bracci PM, Dalvi TB, Holly EA
Source: Cancer Epidemiol Biomarkers Prev, 2006 Jul;15(7), p. 1287-94.
PMID: 16835325
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Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma.
Authors: Forrest MS, Skibola CF, Lightfoot TJ, Bracci PM, Willett EV, Smith MT, Holly EA, Roman E
Source: Br J Haematol, 2006 Jul;134(2), p. 180-3.
EPub date: 2006 Jun 1.
PMID: 16740140
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Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium.
Authors: Rothman N, Skibola CF, Wang SS, Morgan G, Lan Q, Smith MT, Spinelli JJ, Willett E, De Sanjose S, Cocco P, Berndt SI, Brennan P, Brooks-Wilson A, Wacholder S, Becker N, Hartge P, Zheng T, Roman E, Holly EA, Boffetta P, Armstrong B, Cozen W, Linet M, Bosch FX, Ennas MG, Holford TR, Gallagher RP, Rollinson S, Bracci PM, Cerhan JR, Whitby D, Moore PS, Leaderer B, Lai A, Spink C, Davis S, Bosch R, Scarpa A, Zhang Y, Severson RK, Yeager M, Chanock S, Nieters A
Source: Lancet Oncol, 2006 Jan;7(1), p. 27-38.
PMID: 16389181
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Polymorphisms and haplotypes in the cytochrome P450 17A1, prolactin, and catechol-O-methyltransferase genes and non-Hodgkin lymphoma risk.
Authors: Skibola CF, Bracci PM, Paynter RA, Forrest MS, Agana L, Woodage T, Guegler K, Smith MT, Holly EA
Source: Cancer Epidemiol Biomarkers Prev, 2005 Oct;14(10), p. 2391-401.
PMID: 16214922
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