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Grant Details

Grant Number: 5R03CA108341-02 Interpret this number
Primary Investigator: Cho, Eunyoung
Organization: Brigham And Women'S Hosp., Inc.
Project Title: Evaluation of Biological Relevance of Choline Intake
Fiscal Year: 2005
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Abstract

DESCRIPTION (provided by applicant): Choline is an essential nutrient for human and is involved in many metabolic pathways, including methyl-group transfer. Animal studies have demonstrated choline deficiency as a condition sufficient for the development of hepatocellular carcinoma in the absence of other carcinogens. A methyl-group-deficient diet with no choline and low methionine promotes chemically induced carcinogenesis in animals. A methyl-group-deficient diet with low folate and methionine intake has been related to cancers of several organs in humans. However, understanding the role of choline in humans has been hampered by lack of food composition data for dietary choline intake. Recently, we obtained choline composition data for foods measured by our food frequency questionnaire. Before we use the intake data in populations, we propose to examine the biological relevance of variation in choline intake over the range of intake in a general population. Using data from the Framingham Offspring Study, we will examine the relation between choline intake and plasma levels of homocysteine, an intermediate product in methyl-group metabolism and an indicator of the body's methyl-group availability. We will characterize the relationship between choline intake and other dietary and life-style factors. We will also examine choline intake in relation to colorectal adenoma risk in the Nurses' Health Study, a large prospective study of women. These data will provide evidence whether measurable and physiologically important variation in choline intake exists within populations. The results from the proposed grant will enhance understanding of the role of choline intake in humans and lay the groundwork for future studies on choline intake and overall methyl-group-deficient diet and cancer.

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Publications

Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer.
Authors: Wolpin BM, Meyerhardt JA, Chan AT, Ng K, Chan JA, Wu K, Pollak MN, Giovannucci EL, Fuchs CS
Source: J Clin Oncol, 2009 Jan 10;27(2), p. 176-85.
EPub date: 2008 Dec 8.
PMID: 19064975
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Prediagnostic plasma folate and the risk of death in patients with colorectal cancer.
Authors: Wolpin BM, Wei EK, Ng K, Meyerhardt JA, Chan JA, Selhub J, Giovannucci EL, Fuchs CS
Source: J Clin Oncol, 2008 Jul 1;26(19), p. 3222-8.
PMID: 18591557
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Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancer.
Authors: Ng K, Meyerhardt JA, Wu K, Feskanich D, Hollis BW, Giovannucci EL, Fuchs CS
Source: J Clin Oncol, 2008 Jun 20;26(18), p. 2984-91.
PMID: 18565885
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Postmenopausal hormone therapy and stroke: role of time since menopause and age at initiation of hormone therapy.
Authors: Grodstein F, Manson JE, Stampfer MJ, Rexrode K
Source: Arch Intern Med, 2008 Apr 28;168(8), p. 861-6.
PMID: 18443262
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Dietary choline and betaine and the risk of distal colorectal adenoma in women.
Authors: Cho E, Willett WC, Colditz GA, Fuchs CS, Wu K, Chan AT, Zeisel SH, Giovannucci EL
Source: J Natl Cancer Inst, 2007 Aug 15;99(16), p. 1224-31.
EPub date: 2007 Aug 8.
PMID: 17686825
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Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study.
Authors: Cho E, Zeisel SH, Jacques P, Selhub J, Dougherty L, Colditz GA, Willett WC
Source: Am J Clin Nutr, 2006 Apr;83(4), p. 905-11.
PMID: 16600945
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