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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 2R01CA046475-14 Interpret this number
Primary Investigator: Colditz, Graham
Organization: Brigham And Women'S Hospital
Project Title: Benign Breast Disease and Risk of Breast Cancer
Fiscal Year: 2005
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Abstract

DESCRIPTION (provided by applicant): To understand the multi-factorial nature of breast carcinogenesis, we must determine what factors play a role at each stage. By studying benign breast disease we can examine an earlier period in the disease process. This proposal aims to examine a full spectrum of stages on the pathway to breast cancer in Nurses' Health Study I and II: 1) early stages by focusing on the relationship between adolescent diet and incidence of proliferative breast disease; 2) intermediate and cumulative lifetime exposures by concentrating on genetic and molecular predictors of proliferative breast disease; and 3) later stages by examining protein expression in benign breast tissue and subsequent breast cancer risk. Specifically, we hypothesize that adolescent intake of total and specific subtypes of fat are associated with proliferative breast disease; polymorphisms and haplotypes in the insulin-like growth factor (IGF)-I pathway and the progesterone receptor, as well as circulating levels of IGF-1 and IGFBP-3, are related to incidence of proliferative benign breast disease; expression of molecular markers (ER-a, PR, IGF-1 R, Ki67 and cytokeratin 5/6) in benign breast disease tissue is associated with subsequent risk of breast cancer. This study offers a unique opportunity to prospectively examine adolescent diet and molecular markers in relation to proliferative breast disease. Additional follow-up of the breast cancer nested case-control data set will allow us to examine in more detail the relationship between proliferative breast disease and subsequent breast cancer. The creation of tissue microarrays using benign breast tissue will lay the foundation for this and future studies to efficiently examine the role of molecular markers in the development of breast cancer.

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Publications

Postmenopausal hormone therapy and stroke: role of time since menopause and age at initiation of hormone therapy.
Authors: Grodstein F. , Manson J.E. , Stampfer M.J. , Rexrode K. .
Source: Archives of internal medicine, 2008-04-28; 168(8), p. 861-6.
PMID: 18443262
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High school dietary dairy intake and teenage acne.
Authors: Adebamowo C.A. , Spiegelman D. , Danby F.W. , Frazier A.L. , Willett W.C. , Holmes M.D. .
Source: Journal of the American Academy of Dermatology, 2005 Feb; 52(2), p. 207-14.
PMID: 15692464
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Dietary flavonols and flavonol-rich foods intake and the risk of breast cancer.
Authors: Adebamowo C.A. , Cho E. , Sampson L. , Katan M.B. , Spiegelman D. , Willett W.C. , Holmes M.D. .
Source: International journal of cancer, 2005-04-20; 114(4), p. 628-33.
PMID: 15609322
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A prospective study of folate intake and the risk of pancreatic cancer in men and women.
Authors: Skinner H.G. , Michaud D.S. , Giovannucci E.L. , Rimm E.B. , Stampfer M.J. , Willett W.C. , Colditz G.A. , Fuchs C.S. .
Source: American journal of epidemiology, 2004-08-01; 160(3), p. 248-58.
PMID: 15257998
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Employment status, social ties, and caregivers' mental health.
Authors: Cannuscio C.C. , Colditz G.A. , Rimm E.B. , Berkman L.F. , Jones C.P. , Kawachi I. .
Source: Social science & medicine (1982), 2004 Apr; 58(7), p. 1247-56.
PMID: 14759673
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Biopsy confirmed benign breast disease, postmenopausal use of exogenous female hormones, and breast carcinoma risk.
Authors: Byrne C. , Connolly J.L. , Colditz G.A. , Schnitt S.J. .
Source: Cancer, 2000-11-15; 89(10), p. 2046-52.
PMID: 11066044
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Risk of breast cancer associated with atypical hyperplasia of lobular and ductal types.
Authors: Marshall L.M. , Hunter D.J. , Connolly J.L. , Schnitt S.J. , Byrne C. , London S.J. , Colditz G.A. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1997 May; 6(5), p. 297-301.
PMID: 9149887
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