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Grant Details

Grant Number: 5R01CA090792-05 Interpret this number
Primary Investigator: Garshick, Eric
Organization: Brigham And Women'S Hosp., Inc.
Project Title: Diesel Particle Exposure and Lung Cancer
Fiscal Year: 2005
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Abstract

DESCRIPTION: Diesel exhaust particles are highly respirable with mutagenic and carcinogenic compounds adsorbed on their surface. Based on results from laboratory studies in rats and limited evidence in humans, the International Agency for Research on Cancer classified diesel exhaust as a probable human carcinogen in 1989. However, the interpretation of past epidemiologic studies has been limited due to lack of direct measures of diesel exposure and insufficient years of follow-up. We have identified a unique national cohort of 55,750 long-term trucking company workers employed in 1985. We propose to conduct an extensive exposure assessment and assess the association of exposure to diesel exhaust with lung cancer mortality through 2000. The US trucking fleet has included diesel vehicles since the early 1950s. Therefore, there are trucking company workers with long duration of exposure and at least 20 years since first exposure. We will use the results from the exposure assessment, along with external databases of pollution and truck registrations, to develop a prediction model for diesel exhaust exposure and form categorical groupings of exposure levels. The model will include factors that are readily available in company personnel records such as job title and terminal characteristics so that exposure levels can be linked to the individual employees. We will assess ever-exposure, cumulative and duration of exposure. We will use the results from a questionnaire mailed to all current workers to control for potential confounding by smoking. In this retrospective follow-up, we will have 80 percent power to detect a relative risk of 1.25. This large cohort provides a unique opportunity to detect (or refute) suggested carcinogenic effects of diesel exhaust based on animal toxicology and limited epidemiologic studies. Furthermore, since the range of exposure in these workers includes levels similar to the general population, the findings will be relevant to understanding general population risk of lung cancer from diesel emissions and other fine particulate air pollution.

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Publications

Potential air toxics hot spots in truck terminals and cabs.
Authors: Smith TJ, Davis ME, Hart JE, Blicharz A, Laden F, Garshick E, HEI Health Review Committee
Source: Res Rep Health Eff Inst, 2012 Dec;null(172), p. 5-82.
PMID: 23409510
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A cross-sectional study of secondhand smoke exposure and respiratory symptoms in non-current smokers in the U.S. trucking industry: SHS exposure and respiratory symptoms.
Authors: Laden F, Chiu YH, Garshick E, Hammond SK, Hart JE
Source: BMC Public Health, 2013 Feb 1;13, p. 93.
EPub date: 2013 Feb 1.
PMID: 23368999
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Ischaemic heart disease mortality and years of work in trucking industry workers.
Authors: Hart JE, Garshick E, Smith TJ, Davis ME, Laden F
Source: Occup Environ Med, 2013 Aug;70(8), p. 523-8.
EPub date: 2012 Sep 19.
PMID: 22992341
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Lung cancer and elemental carbon exposure in trucking industry workers.
Authors: Garshick E, Laden F, Hart JE, Davis ME, Eisen EA, Smith TJ
Source: Environ Health Perspect, 2012 Sep;120(9), p. 1301-6.
EPub date: 2012 May 31.
PMID: 22739103
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Comparing gravimetric and real-time sampling of PM(2.5) concentrations inside truck cabins.
Authors: Zhu Y, Smith TJ, Davis ME, Levy JI, Herrick R, Jiang H
Source: J Occup Environ Hyg, 2011 Nov;8(11), p. 662-72.
PMID: 21991940
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Structural equation models in occupational health: an application to exposure modelling.
Authors: Davis ME
Source: Occup Environ Med, 2012 Mar;69(3), p. 184-90.
EPub date: 2011 Jun 15.
PMID: 21680563
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A retrospective assessment of occupational exposure to elemental carbon in the U.S. trucking industry.
Authors: Davis ME, Hart JE, Laden F, Garshick E, Smith TJ
Source: Environ Health Perspect, 2011 Jul;119(7), p. 997-1002.
EPub date: 2011 Mar 28.
PMID: 21447452
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Long-term ambient multipollutant exposures and mortality.
Authors: Hart JE, Garshick E, Dockery DW, Smith TJ, Ryan L, Laden F
Source: Am J Respir Crit Care Med, 2011 Jan 1;183(1), p. 73-8.
EPub date: 2010 Jul 23.
PMID: 20656944
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Workplace secondhand smoke exposure in the U.S. trucking industry.
Authors: Chiu YH, Hart JE, Spiegelman D, Garshick E, Smith TJ, Dockery DW, Hammond SK, Laden F
Source: Environ Health Perspect, 2010 Feb;118(2), p. 216-21.
PMID: 20123606
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Spatial modeling of PM10 and NO2 in the continental United States, 1985-2000.
Authors: Hart JE, Yanosky JD, Puett RC, Ryan L, Dockery DW, Smith TJ, Garshick E, Laden F
Source: Environ Health Perspect, 2009 Nov;117(11), p. 1690-6.
EPub date: 2009 Jun 29.
PMID: 20049118
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Nicotine contamination in particulate matter sampling.
Authors: Chiu YH, Hart JE, Smith TJ, Hammond SK, Garshick E, Laden F
Source: Int J Environ Res Public Health, 2009 Feb;6(2), p. 601-7.
EPub date: 2009 Feb 9.
PMID: 19440403
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Predicting changes in PM exposure over time at U.S. trucking terminals using structural equation modeling techniques.
Authors: Davis ME, Laden F, Hart JE, Garshick E, Blicharz A, Smith TJ
Source: J Occup Environ Hyg, 2009 Jul;6(7), p. 396-403.
PMID: 19367483
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Lung cancer and vehicle exhaust in trucking industry workers.
Authors: Garshick E, Laden F, Hart JE, Rosner B, Davis ME, Eisen EA, Smith TJ
Source: Environ Health Perspect, 2008 Oct;116(10), p. 1327-32.
EPub date: 2008 May 30.
PMID: 18941573
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Assessment of diesel particulate matter exposure in the workplace: freight terminals.
Authors: Sheesley RJ, Schauer JJ, Smith TJ, Garshick E, Laden F, Marr LC, Molina LT
Source: J Environ Monit, 2008 Mar;10(3), p. 305-14.
EPub date: 2008 Jan 31.
PMID: 18392272
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Occupational exposure to volatile organic compounds and aldehydes in the U.S. trucking industry.
Authors: Davis ME, Blicharz AP, Hart JE, Laden F, Garshick E, Smith TJ
Source: Environ Sci Technol, 2007 Oct 15;41(20), p. 7152-8.
PMID: 17993162
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Cause-specific mortality in the unionized U.S. trucking industry.
Authors: Laden F, Hart JE, Smith TJ, Davis ME, Garshick E
Source: Environ Health Perspect, 2007 Aug;115(8), p. 1192-6.
PMID: 17687446
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Smoking behavior in trucking industry workers.
Authors: Jain NB, Hart JE, Smith TJ, Garshick E, Laden F
Source: Am J Ind Med, 2006 Dec;49(12), p. 1013-20.
PMID: 17096359
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Modeling particle exposure in U.S. trucking terminals.
Authors: Davis ME, Smith TJ, Laden F, Hart JE, Ryan LM, Garshick E
Source: Environ Sci Technol, 2006 Jul 1;40(13), p. 4226-32.
PMID: 16856739
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Overview of particulate exposures in the US trucking industry.
Authors: Smith TJ, Davis ME, Reaser P, Natkin J, Hart JE, Laden F, Heff A, Garshick E
Source: J Environ Monit, 2006 Jul;8(7), p. 711-20.
EPub date: 2006 Jun 1.
PMID: 16826284
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Exposure of trucking company workers to particulate matter during the winter.
Authors: Lee BK, Smith TJ, Garshick E, Natkin J, Reaser P, Lane K, Lee HK
Source: Chemosphere, 2005 Dec;61(11), p. 1677-90.
PMID: 15913707
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Respiratory symptoms and intensity of occupational dust exposure.
Authors: Garshick E, Laden F, Hart JE, Moy ML
Source: Int Arch Occup Environ Health, 2004 Oct;77(7), p. 515-20.
EPub date: 2004 Sep 10.
PMID: 15368060
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Vehicle traffic as a source of particulate polycyclic aromatic hydrocarbon exposure in the Mexico City metropolitan area.
Authors: Marr LC, Grogan LA, Wöhrnschimmel H, Molina LT, Molina MJ, Smith TJ, Garshick E
Source: Environ Sci Technol, 2004 May 1;38(9), p. 2584-92.
PMID: 15180054
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Residence near a major road and respiratory symptoms in U.S. Veterans.
Authors: Garshick E, Laden F, Hart JE, Caron A
Source: Epidemiology, 2003 Nov;14(6), p. 728-36.
PMID: 14569190
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