Grant Details
| Grant Number: | 5R01CA081191-05 Interpret this number |
| Primary Investigator: | Demark-Wahnefried, Wendy |
| Organization: | Duke University |
| Project Title: | Promoting Health in Prostate & Breast Cancer |
| Fiscal Year: | 2005 |
Abstract
This year, nearly 1.4 million Americans will be diagnosed with cancer. Most will survive 5 years and be considered "cured." However, cancer survivors are at increased risk for developing other cancers, diabetes and/or cardiovascular disease. Reasons for increased risk across conditions may be genetic, treatment-related or because common lifestyle factors increase risk for more than one disease. Thus, if cancer survivors adopt healthier lifestyles, they also may reduce their risk for secondary cancers and other chronic disorders. Our preliminary study data on 988 prostate and breast cancer patients suggest that cancer survivors are exceptionally receptive toward improving their diet and physical activity behaviors, and that the cancer diagnosis may render a" teachable moment." Few efforts have capitalized on this apparent opportunity to promote behavioral change within this high risk population - one reason may be the barrier of distance (travel), which cancer survivors list as a leading reason for non-participation in health promotion programs. Fortunately, there are several ways to overcome this barrier. An experienced team of investigators in the fields of nutrition, exercise, behavior, aging, biostatistics & medical informatics at Duke Univ. Med. Ctr. proposes to test the efficacy of a tailored correspondence course in changing both diet & physical activity behaviors. We will recruit 530 early stage prostate & breast cancer patients in 25 NC counties & randomize them to: 1) a group that receives a 10 mth. tailored correspondence course that promotes increased physical activity, a low fat diet, and increased fruit & vegetable intake; or 2) a usual care control group that receives information in unrelated areas. Intervention efficacy will be gauged by the proportion of participants in the intervention arm who adopt two or more goal behaviors compared to control group participants. The purpose of this study is to determine: 1) the relative short (post-intervention) & long-term (1 yr follow-up) efficacy of this personalized, computer-generated intervention; 2) the effects of the intervention on other endpoints (quality of life, perceived health, etc); & 3) factors, such as gender & race that may interact with the intervention in predicting program efficacy. If effective, this program could be modified, easily disseminated & used in a variety of health care settings, thus having broad public health impact.
Publications
Reducing breast cancer recurrence with weight loss, a vanguard trial: the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial.
Authors: Rock CL, Byers TE, Colditz GA, Demark-Wahnefried W, Ganz PA, Wolin KY, Elias A, Krontiras H, Liu J, Naughton M, Pakiz B, Parker BA, Sedjo RL, Wyatt H, Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial Group
Source: Contemp Clin Trials, 2013 Mar;34(2), p. 282-95.
EPub date: 2012 Dec 22.
PMID: 23266440
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Grant Numbers:
| NCI NIH HHS - CA81191 | NCI NIH HHS - CA148791 | NCI NIH HHS - CA90413 |
| NCI NIH HHS - CA101489 | NCI NIH HHS - CA106919 | NCI NIH HHS - CA23100 |
| NCRR NIH HHS - UL1 RR024992 |
Long-term physical activity outcomes of home-based lifestyle interventions among breast and prostate cancer survivors.
Authors: Ottenbacher AJ, Day RS, Taylor WC, Sharma SV, Sloane R, Snyder DC, Lipkus IM, Jones LW, Demark-Wahnefried W
Source: Support Care Cancer, 2012 Oct;20(10), p. 2483-9.
EPub date: 2012 Jan 17.
PMID: 22249915
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Grant Numbers:
| NCI NIH HHS - R01 CA081191 | NCI NIH HHS - R01 CA81191 | NCI NIH HHS - CA63782 |
| NCI NIH HHS - R01 CA063782 | NCRR NIH HHS - M01-RR-30 | NCI NIH HHS - CA74000 |
| NCI NIH HHS - R01 CA074000 | NCRR NIH HHS - M01 RR000030 |
MeSH Terms:
| Life Style | Humans | Adult |
| Breast Neoplasms | Aged | Middle Aged |
| Exercise | Survivors | Prostatic Neoplasms |
| Male | Female |
Long-term dietary outcomes of the FRESH START intervention for breast and prostate cancer survivors.
Authors: Christy SM, Mosher CE, Sloane R, Snyder DC, Lobach DF, Demark-Wahnefried W
Source: J Am Diet Assoc, 2011 Dec;111(12), p. 1844-51.
PMID: 22117660
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Grant Numbers:
MeSH Terms:
Exercise among breast and prostate cancer survivors--what are their barriers?
Authors: Ottenbacher AJ, Day RS, Taylor WC, Sharma SV, Sloane R, Snyder DC, Kraus WE, Demark-Wahnefried W
Source: J Cancer Surviv, 2011 Dec;5(4), p. 413-9.
EPub date: 2011 May 20.
PMID: 21598023
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Grant Numbers:
MeSH Terms:
| Humans | Prognosis | Breast Neoplasms |
| Exercise | Longitudinal Studies | Cross-Sectional Studies |
| Survival Rate | Follow-Up Studies | Middle Aged |
| Prostatic Neoplasms | Survivors | Female |
| Male |
Extant health behaviors and uptake of standardized vs tailored health messages among cancer survivors enrolled in the FRESH START trial: a comparison of fighting-spirits vs fatalists.
Authors: Wilkinson AV, Barrera SL, McBride CM, Snyder DC, Sloane R, Meneses KM, Pekmezi D, Kraus WE, Demark-Wahnefried W
Source: Psychooncology, 2012 Jan;21(1), p. 108-13.
EPub date: 2010 Nov 8.
PMID: 21061408
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Grant Numbers:
MeSH Terms:
Comparing the 7-day physical activity recall with a triaxial accelerometer for measuring time in exercise.
Authors: Sloane R, Snyder DC, Demark-Wahnefried W, Lobach D, Kraus WE
Source: Med Sci Sports Exerc, 2009 Jun;41(6), p. 1334-40.
PMID: 19461530
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Grant Numbers:
| NCI NIH HHS - CA81191 | NCI NIH HHS - R01 CA081191 | NCRR NIH HHS - M01 RR000030-430748 |
| NCI NIH HHS - CA63782 | NCRR NIH HHS - M01-RR-30 | NCI NIH HHS - R01 CA081191-01A2 |
| NCI NIH HHS - CA74000 | NIA NIH HHS - P30AG028716 |
MeSH Terms:
| Sensitivity and Specificity | Humans | Mental Recall |
| Exercise | Acceleration | Exercise Test |
| Cross-Sectional Studies | Motor Activity | Middle Aged |
| Statistics as Topic | Time Factors | Female |
| Male |
Nutrition and the cancer survivor: evidence to guide oncology nursing practice.
Authors: Toles M, Demark-Wahnefried W
Source: Semin Oncol Nurs, 2008 Aug;24(3), p. 171-9.
PMID: 18687263
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Grant Numbers:
| NCI NIH HHS - R21-CA122143 | NCI NIH HHS - R01 CA081191-05 | NCI NIH HHS - R21 CA122143-01A1 |
| NCI NIH HHS - R01-CA106919 | NCI NIH HHS - R01-CA81191 | NCI NIH HHS - R01 CA106919-04 |
MeSH Terms:
Change in self-efficacy partially mediates the effects of the FRESH START intervention on cancer survivors' dietary outcomes.
Authors: Mosher CE, Fuemmeler BF, Sloane R, Kraus WE, Lobach DF, Snyder DC, Demark-Wahnefried W
Source: Psychooncology, 2008 Oct;17(10), p. 1014-23.
PMID: 18300337
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Grant Numbers:
| NCI NIH HHS - CA81191 | NCI NIH HHS - 1F32CA130600-01 | NCI NIH HHS - R01 CA081191 |
| NCI NIH HHS - CA63782 | NCRR NIH HHS - M01-RR-3 | NCI NIH HHS - R01 CA063782 |
| NCI NIH HHS - CA74000 | NCI NIH HHS - R01 CA074000 | NCRR NIH HHS - M01 RR000030 |
MeSH Terms:
| Questionnaires | Humans | Breast Neoplasms |
| Energy Intake | Exercise | Neoplasms |
| Health Behavior | Self Efficacy | Follow-Up Studies |
| Middle Aged | Food Habits | Survivors |
| Prostatic Neoplasms | Female | Male |
Main outcomes of the FRESH START trial: a sequentially tailored, diet and exercise mailed print intervention among breast and prostate cancer survivors.
Authors: Demark-Wahnefried W, Clipp EC, Lipkus IM, Lobach D, Snyder DC, Sloane R, Peterson B, Macri JM, Rock CL, McBride CM, Kraus WE
Source: J Clin Oncol, 2007 Jul 1;25(19), p. 2709-18.
PMID: 17602076
Related Citations
Grant Numbers:
| NCI NIH HHS - CA81191 | NCI NIH HHS - CA63782 | NCRR NIH HHS - M01-RR-30 |
| NCI NIH HHS - CA74000 |
MeSH Terms:
Dietary intervention in the management of prostate cancer.
Authors: Demark-Wahnefried W, Moyad MA
Source: Curr Opin Urol, 2007 May;17(3), p. 168-74.
PMID: 17414514
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Grant Numbers:
| NCI NIH HHS - R01-CA85740 | NCI NIH HHS - R01 CA085740-01A2 | NCI NIH HHS - R01 CA106919-01 |
| NCI NIH HHS - R01 CA081191-01A2 | NCI NIH HHS - R01-CA106919 | NCI NIH HHS - R01-CA81191 |
MeSH Terms:
| Body Weight | Guideline Adherence | Humans |
| Food | Nutrition Policy | Dietary Supplements |
| Exercise | Diet | Survivors |
| Prostatic Neoplasms | Male | Carcinoma |
Lifestyle interventions in cancer survivors: designing programs that meet the needs of this vulnerable and growing population.
Authors: Stull VB, Snyder DC, Demark-Wahnefried W
Source: J Nutr, 2007 Jan;137(1 Suppl), p. 243S-248S.
PMID: 17182834
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Grant Numbers:
| NCI NIH HHS - CA92468 | NCI NIH HHS - CA81191 | NIA NIH HHS - AG11268 |
| NCI NIH HHS - CA106919 | NCI NIH HHS - CA62215 |
MeSH Terms:
| Life Style | Nutritional Sciences | Neoplasms |
| Humans | Patients | Health Education |
| Survivors |
Promoting health and physical function among cancer survivors: potential for prevention and questions that remain.
Authors: Demark-Wahnefried W, Pinto BM, Gritz ER
Source: J Clin Oncol, 2006 Nov 10;24(32), p. 5125-31.
PMID: 17093274
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Grant Numbers:
| NCI NIH HHS - CA81191 | NCI NIH HHS - CA106919 | NIAMS NIH HHS - AR52186 |
MeSH Terms:
The older cancer survivor.
Authors: Rao AV, Demark-Wahnefried W
Source: Crit Rev Oncol Hematol, 2006 Nov;60(2), p. 131-43.
EPub date: 2006 Sep 11.
PMID: 16965920
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Grant Numbers:
| NCI NIH HHS - CA92468 | NCI NIH HHS - CA81191 | NIA NIH HHS - AG11268 |
| NCI NIH HHS - CA106919 |
MeSH Terms:
| Life Style | Neoplasms | Age Factors |
| Antineoplastic Agents | Aged, 80 and over | Humans |
| Health Status | Quality of Life | Aged |
| Survivors | Health Services for the Aged | Radiation Injuries |
Cancer survival: time to get moving? Data accumulate suggesting a link between physical activity and cancer survival.
Authors: Demark-Wahnefried W
Source: J Clin Oncol, 2006 Aug 1;24(22), p. 3517-8.
EPub date: 2006 Jul 5.
PMID: 16822842
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Grant Numbers:
| NCI NIH HHS - CA81191 | NCI NIH HHS - CA85740 | NCI NIH HHS - R01 CA106919-01 |
| NCI NIH HHS - CA106919 | NIAMS NIH HHS - AR52186 | NCI NIH HHS - R01 CA081191-01A2 |
MeSH Terms:
Riding the crest of the teachable moment: promoting long-term health after the diagnosis of cancer.
Authors: Demark-Wahnefried W, Aziz NM, Rowland JH, Pinto BM
Source: J Clin Oncol, 2005 Aug 20;23(24), p. 5814-30.
EPub date: 2005 Jul 25.
PMID: 16043830
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Grant Numbers:
| NCI NIH HHS - CA92468 | NCI NIH HHS - CA81191 | NCI NIH HHS - CA106919 |
| NCI NIH HHS - R01 CA106919-02 | NCI NIH HHS - R21 CA092468-02 | NCI NIH HHS - R01 CA081191-04 |
MeSH Terms:
| Life Style | Neoplasms | Life Change Events |
| Humans | Health Knowledge, Attitudes, Practice | Survivors |
| Comorbidity | Health Promotion |
Supplement use among men with prostate cancer.
Authors: Wiygul JB, Evans BR, Peterson BL, Polascik TJ, Walther PJ, Robertson CN, Albala DM, Demark-Wahnefried W
Source: Urology, 2005 Jul;66(1), p. 161-6.
PMID: 15992901
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Grant Numbers:
| NCI NIH HHS - CA81191 |
MeSH Terms:
| Questionnaires | Humans | Aged |
| Middle Aged | Dietary Supplements | Prostatic Neoplasms |
| Male |
Age-related vulnerabilities of older adults with colon adenomas: evidence from Project Prevent.
Authors: Clipp EC, Carver EH, Pollak KI, Puleo E, Emmons KM, Onken J, Farraye FA, McBride CM
Source: Cancer, 2004 Mar 1;100(5), p. 1085-94.
PMID: 14983506
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Grant Numbers:
| NCI NIH HHS - CA81191 | NIA NIH HHS - AG11268 | NCI NIH HHS - R01 CA74000-02 |
| NINR NIH HHS - 1P20NR07795-01 |
MeSH Terms:
Nutrition-related issues for the breast cancer survivor.
Authors: Demark-Wahnefried W, Rock CL
Source: Semin Oncol, 2003 Dec;30(6), p. 789-98.
PMID: 14663779
Related Citations
Grant Numbers:
| NCI NIH HHS - CA92468 | NCI NIH HHS - CA81191 | NCI NIH HHS - CA90413 |
| NCI NIH HHS - CA69375 |
MeSH Terms:
| Body Weight | Humans | Health Status |
| Breast Neoplasms | Nutritional Physiological Phenomena | Exercise |
| Survivors | Morbidity |
Teachable moments for promoting smoking cessation: the context of cancer care and survivorship.
Authors: McBride CM, Ostroff JS
Source: Cancer Control, 2003 Jul-Aug;10(4), p. 325-33.
PMID: 12915811
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Grant Numbers:
| NCI NIH HHS - R29CA70830 | NCI NIH HHS - R01CA76945 | NCI NIH HHS - R01-CA81191-01A1 |
| NCI NIH HHS - R01CA74000 | NCI NIH HHS - R01CA90514 |
MeSH Terms:
| Smoking | Neoplasms | Humans |
| Smoking Cessation | Survival Analysis | Health Promotion |
Design of FRESH START: a randomized trial of exercise and diet among cancer survivors.
Authors: Demark-Wahnefried W, Clipp EC, McBride C, Lobach DF, Lipkus I, Peterson B, Clutter Snyder D, Sloane R, Arbanas J, Kraus WE
Source: Med Sci Sports Exerc, 2003 Mar;35(3), p. 415-24.
PMID: 12618570
Related Citations
Grant Numbers:
| NCI NIH HHS - CA81191 | NCI NIH HHS - CA63782 | NCRR NIH HHS - M01-RR-30 |
| NCI NIH HHS - CA74000 |
MeSH Terms:
| United States | Humans | Breast Neoplasms |
| Quality of Life | Exercise | Research Design |
| Eating | Treatment Outcome | Follow-Up Studies |
| Dietary Fats | Prostatic Neoplasms | Female |
| Male |
Can lifestyle modification increase survival in women diagnosed with breast cancer?
Authors: Rock CL, Demark-Wahnefried W
Source: J Nutr, 2002 Nov;132(11 Suppl), p. 3504S-3507S.
PMID: 12421877
Related Citations
Grant Numbers:
| NCI NIH HHS - CA92468 | NCI NIH HHS - CA81191 | NIA NIH HHS - AG11268 |
| NCI NIH HHS - CA90413 | NCI NIH HHS - CA69375 |
MeSH Terms:
| Obesity | Vegetables | Randomized Controlled Trials as Topic |
| Humans | Prognosis | Breast Neoplasms |
| Exercise | Health Promotion | Life Style |
| Survival Rate | Behavior Therapy | Diet |
| Fruit | Female |
