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Grant Details

Grant Number: 5R01CA081191-05 Interpret this number
Primary Investigator: Demark-Wahnefried, Wendy
Organization: Duke University
Project Title: Promoting Health in Prostate & Breast Cancer
Fiscal Year: 2005
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Abstract

This year, nearly 1.4 million Americans will be diagnosed with cancer. Most will survive 5 years and be considered "cured." However, cancer survivors are at increased risk for developing other cancers, diabetes and/or cardiovascular disease. Reasons for increased risk across conditions may be genetic, treatment-related or because common lifestyle factors increase risk for more than one disease. Thus, if cancer survivors adopt healthier lifestyles, they also may reduce their risk for secondary cancers and other chronic disorders. Our preliminary study data on 988 prostate and breast cancer patients suggest that cancer survivors are exceptionally receptive toward improving their diet and physical activity behaviors, and that the cancer diagnosis may render a" teachable moment." Few efforts have capitalized on this apparent opportunity to promote behavioral change within this high risk population - one reason may be the barrier of distance (travel), which cancer survivors list as a leading reason for non-participation in health promotion programs. Fortunately, there are several ways to overcome this barrier. An experienced team of investigators in the fields of nutrition, exercise, behavior, aging, biostatistics & medical informatics at Duke Univ. Med. Ctr. proposes to test the efficacy of a tailored correspondence course in changing both diet & physical activity behaviors. We will recruit 530 early stage prostate & breast cancer patients in 25 NC counties & randomize them to: 1) a group that receives a 10 mth. tailored correspondence course that promotes increased physical activity, a low fat diet, and increased fruit & vegetable intake; or 2) a usual care control group that receives information in unrelated areas. Intervention efficacy will be gauged by the proportion of participants in the intervention arm who adopt two or more goal behaviors compared to control group participants. The purpose of this study is to determine: 1) the relative short (post-intervention) & long-term (1 yr follow-up) efficacy of this personalized, computer-generated intervention; 2) the effects of the intervention on other endpoints (quality of life, perceived health, etc); & 3) factors, such as gender & race that may interact with the intervention in predicting program efficacy. If effective, this program could be modified, easily disseminated & used in a variety of health care settings, thus having broad public health impact.

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Publications

Reducing breast cancer recurrence with weight loss, a vanguard trial: the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial.
Authors: Rock CL, Byers TE, Colditz GA, Demark-Wahnefried W, Ganz PA, Wolin KY, Elias A, Krontiras H, Liu J, Naughton M, Pakiz B, Parker BA, Sedjo RL, Wyatt H, Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial Group
Source: Contemp Clin Trials, 2013 Mar;34(2), p. 282-95.
EPub date: 2012 Dec 22.
PMID: 23266440
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Cancer-specific concerns and physical activity among recently diagnosed breast and prostate cancer survivors.
Authors: Ottenbacher A, Sloane R, Snyder DC, Kraus W, Sprod L, Demark-Wahnefried W
Source: Integr Cancer Ther, 2013 May;12(3), p. 206-12.
EPub date: 2012 Aug 9.
PMID: 22879576
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Long-term physical activity outcomes of home-based lifestyle interventions among breast and prostate cancer survivors.
Authors: Ottenbacher AJ, Day RS, Taylor WC, Sharma SV, Sloane R, Snyder DC, Lipkus IM, Jones LW, Demark-Wahnefried W
Source: Support Care Cancer, 2012 Oct;20(10), p. 2483-9.
EPub date: 2012 Jan 17.
PMID: 22249915
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Long-term dietary outcomes of the FRESH START intervention for breast and prostate cancer survivors.
Authors: Christy SM, Mosher CE, Sloane R, Snyder DC, Lobach DF, Demark-Wahnefried W
Source: J Am Diet Assoc, 2011 Dec;111(12), p. 1844-51.
PMID: 22117660
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Exercise among breast and prostate cancer survivors--what are their barriers?
Authors: Ottenbacher AJ, Day RS, Taylor WC, Sharma SV, Sloane R, Snyder DC, Kraus WE, Demark-Wahnefried W
Source: J Cancer Surviv, 2011 Dec;5(4), p. 413-9.
EPub date: 2011 May 20.
PMID: 21598023
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Extant health behaviors and uptake of standardized vs tailored health messages among cancer survivors enrolled in the FRESH START trial: a comparison of fighting-spirits vs fatalists.
Authors: Wilkinson AV, Barrera SL, McBride CM, Snyder DC, Sloane R, Meneses KM, Pekmezi D, Kraus WE, Demark-Wahnefried W
Source: Psychooncology, 2012 Jan;21(1), p. 108-13.
EPub date: 2010 Nov 8.
PMID: 21061408
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Comparing the 7-day physical activity recall with a triaxial accelerometer for measuring time in exercise.
Authors: Sloane R, Snyder DC, Demark-Wahnefried W, Lobach D, Kraus WE
Source: Med Sci Sports Exerc, 2009 Jun;41(6), p. 1334-40.
PMID: 19461530
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Nutrition and the cancer survivor: evidence to guide oncology nursing practice.
Authors: Toles M, Demark-Wahnefried W
Source: Semin Oncol Nurs, 2008 Aug;24(3), p. 171-9.
PMID: 18687263
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Change in self-efficacy partially mediates the effects of the FRESH START intervention on cancer survivors' dietary outcomes.
Authors: Mosher CE, Fuemmeler BF, Sloane R, Kraus WE, Lobach DF, Snyder DC, Demark-Wahnefried W
Source: Psychooncology, 2008 Oct;17(10), p. 1014-23.
PMID: 18300337
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Main outcomes of the FRESH START trial: a sequentially tailored, diet and exercise mailed print intervention among breast and prostate cancer survivors.
Authors: Demark-Wahnefried W, Clipp EC, Lipkus IM, Lobach D, Snyder DC, Sloane R, Peterson B, Macri JM, Rock CL, McBride CM, Kraus WE
Source: J Clin Oncol, 2007 Jul 1;25(19), p. 2709-18.
PMID: 17602076
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Dietary intervention in the management of prostate cancer.
Authors: Demark-Wahnefried W, Moyad MA
Source: Curr Opin Urol, 2007 May;17(3), p. 168-74.
PMID: 17414514
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Lifestyle interventions in cancer survivors: designing programs that meet the needs of this vulnerable and growing population.
Authors: Stull VB, Snyder DC, Demark-Wahnefried W
Source: J Nutr, 2007 Jan;137(1 Suppl), p. 243S-248S.
PMID: 17182834
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Promoting health and physical function among cancer survivors: potential for prevention and questions that remain.
Authors: Demark-Wahnefried W, Pinto BM, Gritz ER
Source: J Clin Oncol, 2006 Nov 10;24(32), p. 5125-31.
PMID: 17093274
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The older cancer survivor.
Authors: Rao AV, Demark-Wahnefried W
Source: Crit Rev Oncol Hematol, 2006 Nov;60(2), p. 131-43.
EPub date: 2006 Sep 11.
PMID: 16965920
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Cancer survival: time to get moving? Data accumulate suggesting a link between physical activity and cancer survival.
Authors: Demark-Wahnefried W
Source: J Clin Oncol, 2006 Aug 1;24(22), p. 3517-8.
EPub date: 2006 Jul 5.
PMID: 16822842
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Riding the crest of the teachable moment: promoting long-term health after the diagnosis of cancer.
Authors: Demark-Wahnefried W, Aziz NM, Rowland JH, Pinto BM
Source: J Clin Oncol, 2005 Aug 20;23(24), p. 5814-30.
EPub date: 2005 Jul 25.
PMID: 16043830
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Supplement use among men with prostate cancer.
Authors: Wiygul JB, Evans BR, Peterson BL, Polascik TJ, Walther PJ, Robertson CN, Albala DM, Demark-Wahnefried W
Source: Urology, 2005 Jul;66(1), p. 161-6.
PMID: 15992901
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Age-related vulnerabilities of older adults with colon adenomas: evidence from Project Prevent.
Authors: Clipp EC, Carver EH, Pollak KI, Puleo E, Emmons KM, Onken J, Farraye FA, McBride CM
Source: Cancer, 2004 Mar 1;100(5), p. 1085-94.
PMID: 14983506
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Nutrition-related issues for the breast cancer survivor.
Authors: Demark-Wahnefried W, Rock CL
Source: Semin Oncol, 2003 Dec;30(6), p. 789-98.
PMID: 14663779
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Teachable moments for promoting smoking cessation: the context of cancer care and survivorship.
Authors: McBride CM, Ostroff JS
Source: Cancer Control, 2003 Jul-Aug;10(4), p. 325-33.
PMID: 12915811
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Design of FRESH START: a randomized trial of exercise and diet among cancer survivors.
Authors: Demark-Wahnefried W, Clipp EC, McBride C, Lobach DF, Lipkus I, Peterson B, Clutter Snyder D, Sloane R, Arbanas J, Kraus WE
Source: Med Sci Sports Exerc, 2003 Mar;35(3), p. 415-24.
PMID: 12618570
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Can lifestyle modification increase survival in women diagnosed with breast cancer?
Authors: Rock CL, Demark-Wahnefried W
Source: J Nutr, 2002 Nov;132(11 Suppl), p. 3504S-3507S.
PMID: 12421877
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