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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R01CA040644-19 Interpret this number
Primary Investigator: Breslow, Norman
Organization: University Of Washington
Project Title: Statistical Methods in Cancer Epidemiology
Fiscal Year: 2004
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Abstract

DESCRIPTION (Applicant's abstract): Epidemiology plays a major role in the identification of carcinogenic agents and in the quantification of dose time response relationships upon which regulation and preventive strategies are based. Epidemiology as a science depends critically upon statistics. The goal of this project is the development of more efficient statistical designs and methods of analysis for both analytic and descriptive studies. There are two major areas of emphasis. First, many studies involve the estimation of a large number of related quantities, such as multiple disease rates in small areas for identification of "hot spots" and construction of disease incidence maps. Evaluation of community based intervention programs and meta-analyses of data from multiple studies likewise require consideration of "random effects" to represent unexplained heterogeneity at the level of the community or the study. A major goal is the development, evaluation and implementation of hierarchical statistical models that allow for the efficient estimation of both random and fixed effects in such settings. Second, two-phase case- control studies, exposure stratified case-cohort studies and other complex stratified designs are of great value in limiting the collection of costly data to those subjects who are most informative regarding disease/risk factor associations. An important example is the validation substudy conducted to alleviate the effects of measurement error. Here "gold standard" measurements are made for a small number of subjects in a random subsample. More efficient methods of study design will be developed based on stratification of the validation sample using measurements available for all subjects. More efficient methods of statistical analysis will be developed using the tools of modem semiparametric inference. Such designs and efficient new analysis methods can dramatically reduce study costs while yielding estimates that are almost as good as when "gold standard" measurements are made for everyone. The methods used to achieve these goals include mathematical and statistical analysis, computer simulation and application to important datasets collected by cancer epidemiologists and other public health scientists.

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Publications

Descriptive Epidemiology And Survival Analysis Of Nasopharyngeal Carcinoma In The United States
Authors: Burt R.D. , Vaughan T.L. , McKnight B. .
Source: International Journal Of Cancer, 1992-10-21 00:00:00.0; 52(4), p. 549-56.
PMID: 1399135
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Testing The Null Hypothesis In Small Area Analysis
Authors: Cain K.C. , Diehr P. .
Source: Health Services Research, 1992 Aug; 27(3), p. 267-94.
PMID: 1500287
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Analysing The Relationship Between Change In A Risk Factor And Risk Of Disease
Authors: Cain K.C. , Kronmal R.A. , Kosinski A.S. .
Source: Statistics In Medicine, 1992 Apr; 11(6), p. 783-97.
PMID: 1594817
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Approaches To The Analysis Of Case-control Studies Of The Efficacy Of Screening For Cancer
Authors: Weiss N.S. , McKnight B. , Stevens N.G. .
Source: American Journal Of Epidemiology, 1992-04-01 00:00:00.0; 135(7), p. 817-23.
PMID: 1595681
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Linkage Analysis Of Malignant Melanoma With The Chromosome 1 Markers D1s47 And Pnd
Authors: Blossey H. , Guo S.W. , McKnight B. , Tierney C. , Thompson E. , Wijsman E. .
Source: Cytogenetics And Cell Genetics, 1992; 59(2-3), p. 182-4.
PMID: 1737494
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Power And Detectable Risk Of Seven Tests For Standardized Mortality Ratios
Authors: Samuels S.J. , Beaumont J.J. , Breslow N.E. .
Source: American Journal Of Epidemiology, 1991-06-01 00:00:00.0; 133(11), p. 1191-7.
PMID: 2035521
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Further Studies In The Variability Of Pock Counts
Authors: Breslow N. .
Source: Statistics In Medicine, 1990 Jun; 9(6), p. 615-26.
PMID: 2171128
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Statistical Issues In The Analysis Of Data From Occupational Cohort Studies
Authors: Breslow N. .
Source: Recent Results In Cancer Research. Fortschritte Der Krebsforschung. Progre┐s Dans Les Recherches Sur Le Cancer, 1990; 120, p. 78-93.
PMID: 2236880
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Efficiency Gains From The Addition Of Controls To Matched Sets In Cohort Studies
Authors: Raboud J. , Breslow N.E. .
Source: Statistics In Medicine, 1989 Aug; 8(8), p. 977-85.
PMID: 2799126
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Logistic Regression Analysis And Efficient Design For Two-stage Studies
Authors: Cain K.C. , Breslow N.E. .
Source: American Journal Of Epidemiology, 1988 Dec; 128(6), p. 1198-206.
PMID: 3195561
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Logistic Regression For Stratified Case-control Studies
Authors: Breslow N.E. , Zhao L.P. .
Source: Biometrics, 1988 Sep; 44(3), p. 891-9.
PMID: 3203135
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Short-term Assays To Predict Carcinogenicity. Statistical Analysis Of Data From In-vitro Assays Of Mutagenesis
Authors: Breslow N. , Kaldor J. .
Source: Iarc Scientific Publications, 1986; (83), p. 457-81.
PMID: 3305350
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Nonparametric Estimation Of Relative Mortality Functions
Authors: Breslow N. , Langholz B. .
Source: Journal Of Chronic Diseases, 1987; 40 Suppl 2, p. 89S-99S.
PMID: 3667870
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Estimators Of The Mantel-haenszel Variance Consistent In Both Sparse Data And Large-strata Limiting Models
Authors: Robins J. , Breslow N. , Greenland S. .
Source: Biometrics, 1986 Jun; 42(2), p. 311-23.
PMID: 3741973
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A General Estimator For The Variance Of The Mantel-haenszel Odds Ratio
Authors: Robins J. , Greenland S. , Breslow N.E. .
Source: American Journal Of Epidemiology, 1986 Nov; 124(5), p. 719-23.
PMID: 3766505
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Methods Of Estimation In Log Odds Ratio Regression Models
Authors: Breslow N.E. , Cologne J. .
Source: Biometrics, 1986 Dec; 42(4), p. 949-54.
PMID: 3814734
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A Conditional Analysis For Two-treatment Multiple-period Crossover Designs With Binomial Or Poisson Outcomes And Subjects Who Drop Out
Authors: McKnight B. , Van den Eeden S.K. .
Source: Statistics In Medicine, 1993-05-15 00:00:00.0; 12(9), p. 825-34.
PMID: 8327802
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Power Of Affected Sibling Method Tests For Linkage
Authors: Tierney C. , McKnight B. .
Source: Human Heredity, 1993 Sep-Oct; 43(5), p. 276-87.
PMID: 8406516
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Weighted Likelihood, Pseudo-likelihood And Maximum Likelihood Methods For Logistic Regression Analysis Of Two-stage Data
Authors: Breslow N.E. , Holubkov R. .
Source: Statistics In Medicine, 1997 Jan 15-Feb 15; 16(1-3), p. 103-16.
PMID: 9004386
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Approximate Hierarchical Modelling Of Discrete Data In Epidemiology
Authors: Breslow N. , Leroux B. , Platt R. .
Source: Statistical Methods In Medical Research, 1998 Mar; 7(1), p. 49-62.
PMID: 9533261
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Generalized Linear Mixed Models For Meta-analysis
Authors: Platt R.W. , Leroux B.G. , Breslow N. .
Source: Statistics In Medicine, 1999-03-30 00:00:00.0; 18(6), p. 643-54.
PMID: 10204195
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Saddlepoint Approximations For Small Sample Logistic Regression Problems
Authors: Platt R.W. .
Source: Statistics In Medicine, 2000-02-15 00:00:00.0; 19(3), p. 323-34.
PMID: 10649299
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Are Statistical Contributions To Medicine Undervalued?
Authors: Breslow,N.E. .
Source: Biometrics, 2003 Mar; 59(1), p. 1-8.
PMID: 12762435
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