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Grant Details

Grant Number: 5P50DA013332-05 Interpret this number
Primary Investigator: Leslie, Frances
Organization: University Of California-Irvine
Project Title: Center on Tobacco Use Susceptibility and Intervention
Fiscal Year: 2003
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Abstract

The proposed TTURC reflects several unique strengths. First, the Center brings together five eminent project leaders with diverse expertise in the field of tobacco research (Drs. Leslie, Janner, PotInn, Pechman, and Tengs). Each of these scholars has achieved distinction in their respective disciplines of pharmacology, neuroscience, human development, social and health psychology, community health promotion, and health policy analysis. These scientists will work collaboratively to identify key predictor of nicotine dependency in animals and tobacco susceptibility and use in humans. A major goal of the collaboration is to establish a shared conceptual model of tobacco susceptibility and use that can be used to integrate experimental findings across multiple levels of analysis (i.e., biological, behavioral, developmental, interpersonal, and epidemiological/community levels), and to translate these findings into intervention strategics (i.e., pharmacological, behavioral, social marketing, and health policy strategies) that will be evaluated for their public health efficacy and cost effectiveness. A second major strength of the TTURC is its incorporation of four highly interactive cores, each strategically designed to promote successful transdisciplinary collaboration in the field of tobacco susceptibility, use, and intervention. The Transdisciplinary Core will implement structured activities to foster scientific collaboration (e.g., team workshops, retreats), and also conduct a systematic self study of collaboration among members of the TIURC over a five-year period, based on a taxonomic model of the antecedents, intermediate processes, and scientific outcomes of transdisciplinary research. The Informatics Core (led by Dr. Shankle) will develop several valuable informational resources, including a shared relational data base to facilitate the integration of data sets and research findings across multiple TTURC projects and an interactive TTURC web site), all designed to promote more effective transdisciplinary collaboration The Career Development Core (co-directed by Drs. Whitely and Fallon) integrates the theoretical and methodological perspectives emphasized in the research projects and the Transdisciplinary, and Informatics Cores. It will afford a wide array of transdisciplinary training opportunities that are directly responsive to the training priorities outlined in the Report of the Working Groups of the Youth Tobacco Prevention Initiative (1998). Finally, the Administrative Core will be co-directed by Drs. Leslie and Stokols, both of whom have extensive university administrative experience and are active in the fields of pharmacology, neuro5cience, community health promotion, social ecology, and transdisciplinary theory development. The CO-PIs will oversee interactive activities of the TTURC with the goal of promoting effective transdisciplinary collaboration among the project team members research trainees and staff and members of the External and Internal Advisory Boards.

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Publications

Smoking to self-medicate attentional and emotional dysfunctions.
Authors: Gehricke JG, Loughlin SE, Whalen CK, Potkin SG, Fallon JH, Jamner LD, Belluzzi JD, Leslie FM
Source: Nicotine Tob Res, 2007 Nov;9 Suppl 4, p. S523-36.
PMID: 18067030
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Limiting youth access to tobacco: comparing the long-term health impacts of increasing cigarette excise taxes and raising the legal smoking age to 21 in the United States.
Authors: Ahmad S, Billimek J
Source: Health Policy, 2007 Mar;80(3), p. 378-91.
EPub date: 2006 May 12.
PMID: 16698112
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The reinforcing effects of nicotine and stimulant medication in the everyday lives of adult smokers with ADHD: A preliminary examination.
Authors: Gehricke JG, Whalen CK, Jamner LD, Wigal TL, Steinhoff K
Source: Nicotine Tob Res, 2006 Feb;8(1), p. 37-47.
PMID: 16497598
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Monoamine oxidase inhibitors allow locomotor and rewarding responses to nicotine.
Authors: Villégier AS, Salomon L, Granon S, Changeux JP, Belluzzi JD, Leslie FM, Tassin JP
Source: Neuropsychopharmacology, 2006 Aug;31(8), p. 1704-13.
EPub date: 2005 Dec 14.
PMID: 16395299
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Acetaldehyde enhances acquisition of nicotine self-administration in adolescent rats.
Authors: Belluzzi JD, Wang R, Leslie FM
Source: Neuropsychopharmacology, 2005 Apr;30(4), p. 705-12.
PMID: 15496937
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Adolescent development of forebrain stimulant responsiveness: insights from animal studies.
Authors: Leslie FM, Loughlin SE, Wang R, Perez L, Lotfipour S, Belluzzia JD
Source: Ann N Y Acad Sci, 2004 Jun;1021, p. 148-59.
PMID: 15251884
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The ADHD spectrum and everyday life: experience sampling of adolescent moods, activities, smoking, and drinking.
Authors: Whalen CK, Jamner LD, Henker B, Delfino RJ, Lozano JM
Source: Child Dev, 2002 Jan-Feb;73(1), p. 209-27.
PMID: 14717253
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Tobacco use across the formative years: a road map to developmental vulnerabilities.
Authors: Jamner LD, Whalen CK, Loughlin SE, Mermelstein R, Audrain-McGovern J, Krishnan-Sarin S, Worden JK, Leslie FM
Source: Nicotine Tob Res, 2003 Dec;5 Suppl 1, p. S71-87.
PMID: 14668088
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Is there a link between adolescent cigarette smoking and pharmacotherapy for ADHD?
Authors: Whalen CK, Jamner LD, Henker B, Gehricke JG, King PS
Source: Psychol Addict Behav, 2003 Dec;17(4), p. 332-5.
PMID: 14640830
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Co-expression of alpha7 and beta2 nicotinic acetylcholine receptor subunit mRNAs within rat brain cholinergic neurons.
Authors: Azam L, Winzer-Serhan U, Leslie FM
Source: Neuroscience, 2003;119(4), p. 965-77.
PMID: 12831856
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Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus.
Authors: Solbrig MV, Koob GF
Source: Pharmacol Biochem Behav, 2003 Mar;74(4), p. 777-87.
PMID: 12667891
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Gender specific effect of neonatal handling on stress reactivity of adolescent rats.
Authors: Park MK, Hoang TA, Belluzzi JD, Leslie FM
Source: J Neuroendocrinol, 2003 Mar;15(3), p. 289-95.
PMID: 12588518
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Neurochemical properties of the prolactin releasing peptide (PrRP) receptor expressing neurons: evidence for a role of PrRP as a regulator of stress and nociception.
Authors: Lin SH, Leslie FM, Civelli O
Source: Brain Res, 2002 Oct 11;952(1), p. 15-30.
PMID: 12363400
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Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons.
Authors: Azam L, Winzer-Serhan UH, Chen Y, Leslie FM
Source: J Comp Neurol, 2002 Mar 12;444(3), p. 260-74.
PMID: 11840479
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Agrin regulates neuronal responses to excitatory neurotransmitters in vitro and in vivo.
Authors: Hilgenberg LG, Ho KD, Lee D, O'Dowd DK, Smith MA
Source: Mol Cell Neurosci, 2002 Jan;19(1), p. 97-110.
PMID: 11817901
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The cost-effectiveness of intensive national school-based anti-tobacco education: results from the tobacco policy model.
Authors: Tengs TO, Osgood ND, Chen LL
Source: Prev Med, 2001 Dec;33(6), p. 558-70.
PMID: 11716651
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Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain.
Authors: Saito Y, Cheng M, Leslie FM, Civelli O
Source: J Comp Neurol, 2001 Jun 18;435(1), p. 26-40.
PMID: 11370009
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