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Grant Details

Grant Number: 5P50DA013334-05 Interpret this number
Primary Investigator: O'Malley, Stephanie
Organization: Yale University
Project Title: Tobacco Dependence and Risk Factors for Treatment Failur
Fiscal Year: 2003
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Abstract

Tobacco use is one of the most significant public health issues facing our nation and the world today. Although tobacco use has declined over the past three decades, this decline has begun to level off and the remain smokers appear to have more difficulty quitting. Individuals with psychiatric comorbidity, including depression and alcohol use, as well as women find it more difficult to successful quit. In addition, adolescent smoking is on the rise and current treatments are ineffective for this important group of smokers. The goal of this center is to investigate and improve the treatment of tobacco dependence using transdisciplinary approaches to 1) understand the underlying factors associated with failure to enter treatment and poor treatment outcome, and 2) to develop and evaluate novel behavioral and pharmacological treatments that address these factors. The following specific aims will be achieved by the TTURC: 1) To galvanize research interest across different disciplines that will address the problem of tobacco dependence in these high risk groups. The theories and methods of each discipline will be brought to bear on the critical issues and the results will be synthesized at a level that transcends disciplinary boundaries. 2) To provide career development activities for graduate students, medical students, and junior investigators from different disciplines that will expose them to research on tobacco use and dependence and will potentially influence some to pursue careers studying issues related to tobacco. 3) To provide a mechanism to rapidly review and fund pilot projects that have significant promise for advancing the field. 4) To conduct a series of programmatic research studies aimed at understanding risk factors for treatment failure and developing more efficacious treatments.

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Publications

Altered hypothalamic response to food in smokers.
Authors: Geha PY, Aschenbrenner K, Felsted J, O'Malley SS, Small DM
Source: Am J Clin Nutr, 2013 Jan;97(1), p. 15-22.
EPub date: 2012 Dec 12.
PMID: 23235196
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Naltrexone reduction of long-term smoking cessation weight gain in women but not men: a randomized controlled trial.
Authors: King AC, Cao D, Zhang L, O'Malley SS
Source: Biol Psychiatry, 2013 May 1;73(9), p. 924-30.
EPub date: 2012 Nov 22.
PMID: 23177384
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Sex differences in availability of ?2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers.
Authors: Cosgrove KP, Esterlis I, McKee SA, Bois F, Seibyl JP, Mazure CM, Krishnan-Sarin S, Staley JK, Picciotto MR, O'Malley SS
Source: Arch Gen Psychiatry, 2012 Apr;69(4), p. 418-27.
PMID: 22474108
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Effect of night smoking, sleep disturbance, and their co-occurrence on smoking outcomes.
Authors: Peters EN, Fucito LM, Novosad C, Toll BA, O'Malley SS
Source: Psychol Addict Behav, 2011 Jun;25(2), p. 312-9.
PMID: 21443301
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Imaging receptor changes in human drug abusers.
Authors: Cosgrove KP
Source: Curr Top Behav Neurosci, 2010;3, p. 199-217.
PMID: 21161754
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Effect of binge eating on treatment outcomes for smoking cessation.
Authors: White MA, Peters EN, Toll BA
Source: Nicotine Tob Res, 2010 Nov;12(11), p. 1172-5.
EPub date: 2010 Oct 1.
PMID: 20889472
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Nicotine dependence as a moderator of message framing effects on smoking cessation outcomes.
Authors: Fucito LM, Latimer AE, Salovey P, Toll BA
Source: Ann Behav Med, 2010 Jun;39(3), p. 311-7.
PMID: 20502997
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Decreased Beta(2)*-nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primates.
Authors: Cosgrove KP, Kloczynski T, Bois F, Pittman B, Tamagnan G, Seibyl JP, Krystal JH, Staley JK
Source: Synapse, 2010 Sep;64(9), p. 729-32.
PMID: 20340174
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SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals.
Authors: Esterlis I, Cosgrove KP, Petrakis IL, McKee SA, Bois F, Krantzler E, Stiklus SM, Perry EB, Tamagnan GD, Seibyl JP, Krystal JH, Staley JK
Source: Drug Alcohol Depend, 2010 Apr 1;108(1-2), p. 146-50.
EPub date: 2010 Jan 13.
PMID: 20074869
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Beliefs and attitudes about bupropion: implications for medication adherence and smoking cessation treatment.
Authors: Fucito LM, Toll BA, Salovey P, O'Malley SS
Source: Psychol Addict Behav, 2009 Jun;23(2), p. 373-9.
PMID: 19586156
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beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking.
Authors: Cosgrove KP, Batis J, Bois F, Maciejewski PK, Esterlis I, Kloczynski T, Stiklus S, Krishnan-Sarin S, O'Malley S, Perry E, Tamagnan G, Seibyl JP, Staley JK
Source: Arch Gen Psychiatry, 2009 Jun;66(6), p. 666-76.
PMID: 19487632
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Bridging the digital divide by increasing computer and cancer literacy: community technology centers for head-start parents and families.
Authors: Salovey P, Williams-Piehota P, Mowad L, Moret ME, Edlund D, Andersen J
Source: J Health Commun, 2009 Apr-May;14(3), p. 228-45.
PMID: 19440907
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Risk factors for treatment failure in smokers: relationship to alcohol use and to lifetime history of an alcohol use disorder.
Authors: Leeman RF, McKee SA, Toll BA, Krishnan-Sarin S, Cooney JL, Makuch RW, O'Malley SS
Source: Nicotine Tob Res, 2008 Dec;10(12), p. 1793-809.
PMID: 19023831
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A brief 7-day estimate of alcohol consumption for use in smoking cessation clinical trials.
Authors: Toll BA, Leeman RF, McKee SA, O'Malley SS
Source: Addict Behav, 2008 Dec;33(12), p. 1606-9.
EPub date: 2008 Jul 23.
PMID: 18722721
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Time to first cigarette in the morning as an index of ability to quit smoking: implications for nicotine dependence.
Authors: Transdisciplinary Tobacco Use Research Center (TTURC) Tobacco Dependence, Baker TB, Piper ME, McCarthy DE, Bolt DM, Smith SS, Kim SY, Colby S, Conti D, Giovino GA, Hatsukami D, Hyland A, Krishnan-Sarin S, Niaura R, Perkins KA, Toll BA
Source: Nicotine Tob Res, 2007 Nov;9 Suppl 4, p. S555-70.
PMID: 18067032
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Correspondence of Interactive Voice Response (IVR) reports of nicotine withdrawal, craving, and negative mood with questionnaire ratings.
Authors: Toll BA, Cooney JL, McKee SA, O'Malley SS, Cooney NL
Source: Nicotine Tob Res, 2008 Jun;10(6), p. 1057-64.
PMID: 18584469
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Antidepressant-like effects of nicotine and transcranial magnetic stimulation in the olfactory bulbectomy rat model of depression.
Authors: Vieyra-Reyes P, Mineur YS, Picciotto MR, Túnez I, Vidaltamayo R, Drucker-Colín R
Source: Brain Res Bull, 2008 Sep 5;77(1), p. 13-8.
EPub date: 2008 Jun 26.
PMID: 18582540
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Message framing for smoking cessation: the interaction of risk perceptions and gender.
Authors: Toll BA, Salovey P, O'Malley SS, Mazure CM, Latimer A, McKee SA
Source: Nicotine Tob Res, 2008 Jan;10(1), p. 195-200.
PMID: 18188760
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Comparing gain- and loss-framed messages for smoking cessation with sustained-release bupropion: a randomized controlled trial.
Authors: Toll BA, O'Malley SS, Katulak NA, Wu R, Dubin JA, Latimer A, Meandzija B, George TP, Jatlow P, Cooney JL, Salovey P
Source: Psychol Addict Behav, 2007 Dec;21(4), p. 534-44.
PMID: 18072836
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Alcohol and tobacco cessation in alcohol-dependent smokers: analysis of real-time reports.
Authors: Cooney NL, Litt MD, Cooney JL, Pilkey DT, Steinberg HR, Oncken CA
Source: Psychol Addict Behav, 2007 Sep;21(3), p. 277-86.
PMID: 17874878
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Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction.
Authors: Mineur YS, Picciotto MR
Source: Biochem Pharmacol, 2008 Jan 1;75(1), p. 323-33.
EPub date: 2007 Jun 14.
PMID: 17632086
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