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Grant Details

Grant Number: 5R01CA080027-05 Interpret this number
Primary Investigator: Caan, Bette
Organization: Kaiser Foundation Research Institute
Project Title: Behavioral Correlates of Recurrence in Breast Cancer
Fiscal Year: 2003
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Abstract

The overall goal of this research project study is to conduct an observational study of post-treatment behavioral risk factors for recurrence of secondary breast tumors or new primaries. Specifically, we examine the effects of diet, physical activity, and weight gain in a cohort of 2400 women followed for an average of three and a half years after diagnosis with early stage breast cancer The study will also examine the interrelationships of the primary independent variables, specifically examining the effects of diet and activity on weight gain and activity on quality of life. The study will complement the Women's Healthy Eating Lifestyle Trial (WHEL), a high fruit and vegetable-low fat dietary intervention trial aimed at reducing breast cancer recurrence, by establishing an observational cohort of women who were screened for WHEL but not randomized, either because they were ineligible or not interested after further investigation. The primary hypotheses to be examined are whether women who have diets rich in plant sources , stable weights and high levels of physical activity have lower rates of recurrence compared to women who have diets low in plant sources, substantial weight gains and low levels of physical activity. Each of these behavioral factors will be examined individually and in combination with each other. Data will be collected on all of the above mentioned behavioral characteristics by mailed questionnaire on an annual basis. Recurrence data will be collected by mail on a semi-annual basis. Kaiser Permanente, one of the seven clinical sites in the WHEL trial will coordinate the study and recruit patients from all existing WHEL.tes. This study will allow us to examine normative time trends in breast cancer survivors with regard to recurrence rates, weight gain, dietary and physical activity habits and quality of life which will aid in the interpretation of the clinical trial. It will also establish a resource for future studies where predictors of long term survival can be examined

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Publications

Obesity and mortality after breast cancer by race/ethnicity: The California Breast Cancer Survivorship Consortium.
Authors: Kwan ML, John EM, Caan BJ, Lee VS, Bernstein L, Cheng I, Gomez SL, Henderson BE, Keegan TH, Kurian AW, Lu Y, Monroe KR, Roh JM, Shariff-Marco S, Sposto R, Vigen C, Wu AH
Source: Am J Epidemiol, 2014 Jan 1;179(1), p. 95-111.
EPub date: 2013 Oct 9.
PMID: 24107615
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Long-term prognostic role of functional limitations among women with breast cancer.
Authors: Braithwaite D, Satariano WA, Sternfeld B, Hiatt RA, Ganz PA, Kerlikowske K, Moore DH, Slattery ML, Tammemagi M, Castillo A, Melisko M, Esserman L, Weltzien EK, Caan BJ
Source: J Natl Cancer Inst, 2010 Oct 6;102(19), p. 1468-77.
EPub date: 2010 Sep 22.
PMID: 20861456
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Epidemiology of breast cancer subtypes in two prospective cohort studies of breast cancer survivors.
Authors: Kwan ML, Kushi LH, Weltzien E, Maring B, Kutner SE, Fulton RS, Lee MM, Ambrosone CB, Caan BJ
Source: Breast Cancer Res, 2009;11(3), p. R31.
EPub date: 2009 May 22.
PMID: 19463150
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Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the Life After Cancer Epidemiology study.
Authors: Guha N, Kwan ML, Quesenberry CP Jr, Weltzien EK, Castillo AL, Caan BJ
Source: Breast Cancer Res Treat, 2009 Nov;118(2), p. 395-405.
EPub date: 2009 Feb 17.
PMID: 19221874
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Physical activity and risk of recurrence and mortality in breast cancer survivors: findings from the LACE study.
Authors: Sternfeld B, Weltzien E, Quesenberry CP Jr, Castillo AL, Kwan M, Slattery ML, Caan BJ
Source: Cancer Epidemiol Biomarkers Prev, 2009 Jan;18(1), p. 87-95.
PMID: 19124485
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Dietary patterns and breast cancer recurrence and survival among women with early-stage breast cancer.
Authors: Kwan ML, Weltzien E, Kushi LH, Castillo A, Slattery ML, Caan BJ
Source: J Clin Oncol, 2009 Feb 20;27(6), p. 919-26.
EPub date: 2008 Dec 29.
PMID: 19114692
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Pre-diagnosis body mass index, post-diagnosis weight change, and prognosis among women with early stage breast cancer.
Authors: Caan BJ, Kwan ML, Hartzell G, Castillo A, Slattery ML, Sternfeld B, Weltzien E
Source: Cancer Causes Control, 2008 Dec;19(10), p. 1319-28.
EPub date: 2008 Aug 28.
PMID: 18752034
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Post-diagnosis statin use and breast cancer recurrence in a prospective cohort study of early stage breast cancer survivors.
Authors: Kwan ML, Habel LA, Flick ED, Quesenberry CP, Caan B
Source: Breast Cancer Res Treat, 2008 Jun;109(3), p. 573-9.
EPub date: 2007 Aug 3.
PMID: 17674197
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NSAIDs and breast cancer recurrence in a prospective cohort study.
Authors: Kwan ML, Habel LA, Slattery ML, Caan B
Source: Cancer Causes Control, 2007 Aug;18(6), p. 613-20.
EPub date: 2007 Apr 3.
PMID: 17404892
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Life After Cancer Epidemiology (LACE) Study: a cohort of early stage breast cancer survivors (United States).
Authors: Caan B, Sternfeld B, Gunderson E, Coates A, Quesenberry C, Slattery ML
Source: Cancer Causes Control, 2005 Jun;16(5), p. 545-56.
PMID: 15986109
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