Skip Navigation
Grant Details

Grant Number: 5P50CA084719-04 Interpret this number
Primary Investigator: Abrams, David
Organization: Miriam Hospital
Project Title: Nicotine Dependence: Risk & Recovery Over Generations
Fiscal Year: 2002
Back to top


Abstract

DESCRIPTION: (Applicant's Description) The overall aim of this TTURC is to identify familial, early childhood and lifetime psychiatric factors that determine: trajectories of progression from smoking initiation to dependence; lifetime smoking patterns; the natural course of cessation; and response to treatment. Our proposed program of research combines a treatment/prevention imperative, a genetic epidemiologic approach, and a lifespan developmental perspective, sharing common scientific resources, to advance research on human nicotine dependence from basic mechanisms to applied interventions. We will use a synergistic combination of a community-based sample, prospective design, and a multigenerational family study to examine the major pathways to nicotine dependence, and to develop and validate a lifespan taxonomy of tobacco use and nicotine dependence phenotypes. The major goal is to identify modifiable risk factors that can serve as targets for prevention and that may be harnessed to enhance smoking prevention and cessation treatment success. We recognize that many such modifiable risk factors may act in concert with or against a substrate of genetic risks, and reason that a combined environmental and genetic/familial strategy is required both to clearly identify salient environmental agents and to prepare for studies of susceptibility genes. To this end, we propose to: l) To integrate multiple disciplinary perspectives and research methods front basic science to applications including (a) longitudinal natural history research (developmental epidemiology); (b) familial aggregation methods (genetic epidemiology); (c) human laboratory studies; and (d) intervention trials; (2) To adopt this lifespan and transgenerational genetic epidemiological approach to help understand risk factors for and causal pathways of: (a) progression of nicotine dependence among youth; (b) patterns of adult smoking; (c) the natural course of smoking cessation; and (d) response to treatment; (3) To document the potential utility and cost-effectiveness of a sustained "care management" approach to treating smokers that addresses smokers' risk profiles (from relatively uncomplicated to multiple comorbidities) with a range of treatment options that vary along dimensions of intensity and modality of intervention; (4) To collect and preserve DNA with the anticipation that, after refining phenotypic definitions, characterizing candidate genes (in other samples), and identifying the most heritable forms of smoking behavior, we may inform and conduct an efficient and productive strategy to identify susceptibility genes for nicotine dependence.

Back to top


Publications

Prenatal glucocorticoids and maternal smoking during pregnancy independently program adult nicotine dependence in daughters: a 40-year prospective study.
Authors: Stroud LR, Papandonatos GD, Shenassa E, Rodriguez D, Niaura R, LeWinn KZ, Lipsitt LP, Buka SL
Source: Biol Psychiatry, 2014 Jan 1;75(1), p. 47-55.
EPub date: 2013 Sep 10.
PMID: 24034414
Related Citations

Back to top


Direct and moderating links of salivary alpha-amylase and cortisol stress-reactivity to youth behavioral and emotional adjustment.
Authors: Allwood MA, Handwerger K, Kivlighan KT, Granger DA, Stroud LR
Source: Biol Psychol, 2011 Sep;88(1), p. 57-64.
EPub date: 2011 Jul 21.
PMID: 21771636
Related Citations

Back to top


Dopamine D4 receptor gene variation moderates the efficacy of bupropion for smoking cessation.
Authors: Leventhal AM, David SP, Brightman M, Strong D, McGeary JE, Brown RA, Lloyd-Richardson EE, Munaf˛ M, Uhl GR, Niaura R
Source: Pharmacogenomics J, 2012 Feb;12(1), p. 86-92.
EPub date: 2010 Jul 27.
PMID: 20661272
Related Citations

Back to top


Quitting smoking and change in alcohol consumption in the International Tobacco Control (ITC) Four Country Survey.
Authors: Kahler CW, Borland R, Hyland A, McKee SA, O'Connor RJ, Fong GT, Cummings KM
Source: Drug Alcohol Depend, 2010 Jul 1;110(1-2), p. 101-7.
EPub date: 2010 Mar 15.
PMID: 20227840
Related Citations

Back to top


Relationships of personality and psychiatric disorders to multiple domains of smoking motives and dependence in middle-aged adults.
Authors: Kahler CW, Leventhal AM, Daughters SB, Clark MA, Colby SM, Ramsey SE, Boergers J, Abrams DB, Niaura R, Buka SL
Source: Nicotine Tob Res, 2010 Apr;12(4), p. 381-9.
EPub date: 2010 Feb 18.
PMID: 20167635
Related Citations

Back to top


Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans.
Authors: David SP, Mezuk B, Zandi PP, Strong D, Anthony JC, Niaura R, Uhl GR, Eaton WW
Source: Nicotine Tob Res, 2010 Mar;12(3), p. 251-62.
EPub date: 2010 Feb 4.
PMID: 20133381
Related Citations

Back to top


Predictors of abstinence and changes in psychiatric symptoms in a pooled sample of smokers with schizophrenia receiving combination pharmacotherapy and behavioral therapy for smoking cessation.
Authors: Weinberger AH, Hitsman B, Papandonatos GD, Sacco KA, Vessicchio JC, George TP
Source: J Clin Psychopharmacol, 2009 Dec;29(6), p. 601-3.
PMID: 19910728
Related Citations

Back to top


Personality, psychiatric disorders, and smoking in middle-aged adults.
Authors: Kahler CW, Daughters SB, Leventhal AM, Rogers ML, Clark MA, Colby SM, Boergers J, Ramsey SE, Abrams DB, Niaura R, Buka SL
Source: Nicotine Tob Res, 2009 Jul;11(7), p. 833-41.
EPub date: 2009 May 26.
PMID: 19470795
Related Citations

Back to top


Elevated maternal cortisol levels during pregnancy are associated with reduced childhood IQ.
Authors: LeWinn KZ, Stroud LR, Molnar BE, Ware JH, Koenen KC, Buka SL
Source: Int J Epidemiol, 2009 Dec;38(6), p. 1700-10.
EPub date: 2009 May 7.
PMID: 19423658
Related Citations

Back to top


Maternal smoking during pregnancy and neonatal behavior: a large-scale community study.
Authors: Stroud LR, Paster RL, Goodwin MS, Shenassa E, Buka S, Niaura R, Rosenblith JF, Lipsitt LP
Source: Pediatrics, 2009 May;123(5), p. e842-8.
PMID: 19403478
Related Citations

Back to top


Stress response and the adolescent transition: performance versus peer rejection stressors.
Authors: Stroud LR, Foster E, Papandonatos GD, Handwerger K, Granger DA, Kivlighan KT, Niaura R
Source: Dev Psychopathol, 2009 Winter;21(1), p. 47-68.
PMID: 19144222
Related Citations

Back to top


Alcohol consumption and quitting smoking in the International Tobacco Control (ITC) Four Country Survey.
Authors: Kahler CW, Borland R, Hyland A, McKee SA, Thompson ME, Cummings KM
Source: Drug Alcohol Depend, 2009 Mar 1;100(3), p. 214-20.
EPub date: 2008 Dec 3.
PMID: 19056188
Related Citations

Back to top


Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.
Authors: Uhl GR, Drgon T, Johnson C, Li CY, Contoreggi C, Hess J, Naiman D, Liu QR
Source: Ann N Y Acad Sci, 2008 Oct;1141, p. 318-81.
PMID: 18991966
Related Citations

Back to top


Linking measures of adolescent nicotine dependence to a common latent continuum.
Authors: Strong DR, Kahler CW, Colby SM, Griesler PC, Kandel D
Source: Drug Alcohol Depend, 2009 Jan 1;99(1-3), p. 296-308.
EPub date: 2008 Oct 19.
PMID: 18938047
Related Citations

Back to top


A twin study of smoking, nicotine dependence, and major depression in men.
Authors: Lyons M, Hitsman B, Xian H, Panizzon MS, Jerskey BA, Santangelo S, Grant MD, Rende R, Eisen S, Eaves L, Tsuang MT
Source: Nicotine Tob Res, 2008 Jan;10(1), p. 97-108.
PMID: 18188750
Related Citations

Back to top


Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation.
Authors: David SP, Brown RA, Papandonatos GD, Kahler CW, Lloyd-Richardson EE, Munaf˛ MR, Shields PG, Lerman C, Strong D, McCaffery J, Niaura R
Source: Nicotine Tob Res, 2007 Aug;9(8), p. 821-33.
PMID: 17654295
Related Citations

Back to top


Long-term stability of maternal prenatal steroid hormones from the National Collaborative Perinatal Project: still valid after all these years.
Authors: Stroud LR, Solomon C, Shenassa E, Papandonatos G, Niaura R, Lipsitt LP, Lewinn K, Buka SL
Source: Psychoneuroendocrinology, 2007 Feb;32(2), p. 140-50.
EPub date: 2007 Jan 31.
PMID: 17270355
Related Citations

Back to top


Specificity of familial vulnerability for alcoholism versus major depression in men.
Authors: Lyons MJ, Schultz M, Neale M, Brady K, Eisen S, Toomey R, Rhein A, Faraone S, Tsuang M
Source: J Nerv Ment Dis, 2006 Nov;194(11), p. 809-17.
PMID: 17102704
Related Citations

Back to top


Links between physical fitness and cardiovascular reactivity and recovery to psychological stressors: A meta-analysis.
Authors: Forcier K, Stroud LR, Papandonatos GD, Hitsman B, Reiches M, Krishnamoorthy J, Niaura R
Source: Health Psychol, 2006 Nov;25(6), p. 723-39.
PMID: 17100501
Related Citations

Back to top


Elevated positive mood: a mixed blessing for abstinence.
Authors: Doran N, Spring B, Borrelli B, McChargue D, Hitsman B, Niaura R, Hedeker D
Source: Psychol Addict Behav, 2006 Mar;20(1), p. 36-43.
PMID: 16536663
Related Citations

Back to top


Sibling effects on substance use in adolescence: social contagion and genetic relatedness.
Authors: Rende R, Slomkowski C, Lloyd-Richardson E, Niaura R
Source: J Fam Psychol, 2005 Dec;19(4), p. 611-8.
PMID: 16402876
Related Citations

Back to top


Associations between sleep and cortisol responses to stress in children and adolescents: a pilot study.
Authors: Capaldi Ii VF, Handwerger K, Richardson E, Stroud LR
Source: Behav Sleep Med, 2005;3(4), p. 177-92.
PMID: 16190809
Related Citations

Back to top


Home health care nurses as a new channel for smoking cessation treatment: outcomes from project CARES (Community-nurse Assisted Research and Education on Smoking).
Authors: Borrelli B, Novak S, Hecht J, Emmons K, Papandonatos G, Abrams D
Source: Prev Med, 2005 Nov-Dec;41(5-6), p. 815-21.
EPub date: 2005 Sep 22.
PMID: 16182355
Related Citations

Back to top


Recurrent event analysis of lapse and recovery in a smoking cessation clinical trial using bupropion.
Authors: Wileyto EP, Patterson F, Niaura R, Epstein LH, Brown RA, Audrain-McGovern J, Hawk LW Jr, Lerman C
Source: Nicotine Tob Res, 2005 Apr;7(2), p. 257-68.
PMID: 16036283
Related Citations