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Grant Details

Grant Number: 5R01CA080181-04 Interpret this number
Primary Investigator: Hartmann, Lynn
Organization: Mayo Clinic
Project Title: Prophylctic Mastectomy in Hereditary Breast Cancer
Fiscal Year: 2002
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Abstract

DESCRIPTION: (Adapted from the Investigator's Abstract) Women with hereditary breast cancer risk have limited options for management. Close cancer screening or prophylactic mastectomy (PM) is most commonly utilized. Chemoprevention with tamoxifen is another option, but data regarding long-term risk reduction are incomplete and conflicting. Unfortunately, there are insufficient data regarding the expected outcomes with either surveillance or PM. Breast cancers on the chest wall have been documented following PM, developing in residual glandular epithelium. Thus, the extent of risk reduction with PM, if any, has been questioned. The program announcement "Clinical Epidemiology Studies in Hereditary Breast/Ovarian Cancer" describes the "immediate need to address these issues through retrospective studies based on existing resources". The Mayo Clinic has served as a referral center for specialized surgeries, including PM, for many years. They have access to two groups of high-risk women who elected PM: unaffected women who have elected contralateral PM and women treated with therapeutic mastectomy for their first breast cancer who elected contralateral, unilateral PM. With the work proposed, the investigators will clarify the magnitude of breast cancer risk reduction with PM using a combination of methods, including standardized morbidity ratios using the Gail and Anderson models to predict the expected number of events, and a relative risk using sisters of women who had PM as a reference group. We will also define short- and long-term complications following PM.

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Publications

Contralateral prophylactic mastectomy: long-term consistency of satisfaction and adverse effects and the significance of informed decision-making, quality of life, and personality traits.
Authors: Frost MH, Hoskin TL, Hartmann LC, Degnim AC, Johnson JL, Boughey JC
Source: Ann Surg Oncol, 2011 Oct;18(11), p. 3110-6.
EPub date: 2011 Sep 27.
PMID: 21947589
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Contralateral prophylactic mastectomy is associated with a survival advantage in high-risk women with a personal history of breast cancer.
Authors: Boughey JC, Hoskin TL, Degnim AC, Sellers TA, Johnson JL, Kasner MJ, Hartmann LC, Frost MH
Source: Ann Surg Oncol, 2010 Oct;17(10), p. 2702-9.
EPub date: 2010 Sep 19.
PMID: 20853163
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ERBB2, TBX2, RPS6KB1, and MYC alterations in breast tissues of BRCA1 and BRCA2 mutation carriers.
Authors: Adem C, Soderberg CL, Hafner K, Reynolds C, Slezak JM, Sinclair CS, Sellers TA, Schaid DJ, Couch F, Hartmann LC, Jenkins RB
Source: Genes Chromosomes Cancer, 2004 Sep;41(1), p. 1-11.
PMID: 15236312
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Reoperations after prophylactic mastectomy with or without implant reconstruction.
Authors: Zion SM, Slezak JM, Sellers TA, Woods JE, Arnold PG, Petty PM, Donohue JH, Frost MH, Schaid DJ, Hartmann LC
Source: Cancer, 2003 Nov 15;98(10), p. 2152-60.
PMID: 14601084
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Selective estrogen-receptor modulators -- mechanisms of action and application to clinical practice.
Authors: Riggs BL, Hartmann LC
Source: N Engl J Med, 2003 Feb 13;348(7), p. 618-29.
PMID: 12584371
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TBX2 is preferentially amplified in BRCA1- and BRCA2-related breast tumors.
Authors: Sinclair CS, Adem C, Naderi A, Soderberg CL, Johnson M, Wu K, Wadum L, Couch VL, Sellers TA, Schaid D, Slezak J, Fredericksen Z, Ingle JN, Hartmann L, Jenkins RB, Couch FJ
Source: Cancer Res, 2002 Jul 1;62(13), p. 3587-91.
PMID: 12097257
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Efficacy of contralateral prophylactic mastectomy in women with a personal and family history of breast cancer.
Authors: McDonnell SK, Schaid DJ, Myers JL, Grant CS, Donohue JH, Woods JE, Frost MH, Johnson JL, Sitta DL, Slezak JM, Crotty TB, Jenkins RB, Sellers TA, Hartmann LC
Source: J Clin Oncol, 2001 Oct 1;19(19), p. 3938-43.
PMID: 11579114
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