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Grant Details

Grant Number: 5R01CA077736-04 Interpret this number
Primary Investigator: Champion, Victoria
Organization: Indiana Univ-Purdue Univ At Indianapolis
Project Title: Community Intervention to Increase Mammography Screening
Fiscal Year: 2002
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Abstract

Low-income African American women are at relatively high risk for breast cancer mortality, due in part to their limited mammography use. The purpose of the proposed stud is to compare the effect of a tailored interactive computer program with a culturally appropriate video on mammography use. Secondly, this study will assess the effect of a booster tailored interactive computer programed and booster video program that is delivered one year after the initial intervention to improve interval mammography screening. Finally, the cost effectiveness of both delivery methods will be explored. The design for this study contrasts three groups randomly allocated to tailored interactive computer, video, or control. Subjects will include 625 African American women ages 41 to 75 years and at 150% poverty or below who have not had a mammogram in the last 18 months. A network of multi service centers located in the poorest areas of a large metropolitan are will serve as resources for recruitment and intervention delivery. The interactive computer and video programs will build on concepts found to be predictive of mammography in prior work. The intervention will be delivered to appropriate groups after a baseline interview and again at 12 months for women who are randomly assigned to receive a booster intervention. Only have of the women initially assigned to receive the interactive computer program or video will receive the booster in order to compare the women receiving the booster intervention with women who receive only the initial intervention. Baseline interviews prior to intervention) will take place in the multi service center and telephone interviews will take place a three times following intervention delivery. l. Women will receive $25.00 following each interview, for a total of $100. This study is developed to have 90% power to detect overall differences in compliance at six months and 21 months. Mammography compliance will be measured through self-report and facility verification. Belief variables built into the intervention and measured through validity and reliability. The primary outcomes at six month and 21 months will be tested by a chi-square statistic using logistic regression with two degrees of freedom. Cost effectiveness analysis is planned for the third aim.

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Publications

The interaction of perceived risk and benefits and the relationship to predicting mammography adherence in African American women.
Authors: Fair AM, Monahan PO, Russell K, Zhao Q, Champion VL
Source: Oncol Nurs Forum, 2012 Jan;39(1), p. 53-60.
PMID: 22201655
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Effects of personal characteristics on African-American women's beliefs about breast cancer.
Authors: Zollinger TW, Champion VL, Monahan PO, Steele-Moses SK, Ziner KW, Zhao Q, Bourff SA, Saywell RM, Russell KM
Source: Am J Health Promot, 2010 Jul-Aug;24(6), p. 371-7.
PMID: 20594093
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Measuring mammography and breast cancer beliefs in African American women.
Authors: Champion VL, Monahan PO, Springston JK, Russell K, Zollinger TW, Saywell RM Jr, Maraj M
Source: J Health Psychol, 2008 Sep;13(6), p. 827-37.
PMID: 18697896
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Differences in health and cultural beliefs by stage of mammography screening adoption in African American women.
Authors: Russell KM, Monahan P, Wagle A, Champion V
Source: Cancer, 2007 Jan 15;109(2 Suppl), p. 386-95.
PMID: 17133417
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Comparison of three interventions to increase mammography screening in low income African American women.
Authors: Champion VL, Springston JK, Zollinger TW, Saywell RM Jr, Monahan PO, Zhao Q, Russell KM
Source: Cancer Detect Prev, 2006;30(6), p. 535-44.
EPub date: 2006 Nov 15.
PMID: 17110056
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A cost-effectiveness comparison of three tailored interventions to increase mammography screening.
Authors: Saywell RM Jr, Champion VL, Skinner CS, Menon U, Daggy J
Source: J Womens Health (Larchmt), 2004 Oct;13(8), p. 909-18.
PMID: 15671706
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The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation.
Authors: Dong F, Qiu Y, Yi T, Touw IP, Larner AC
Source: J Immunol, 2001 Dec 1;167(11), p. 6447-52.
PMID: 11714811
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Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival.
Authors: Dong F, Gutkind JS, Larner AC
Source: J Biol Chem, 2001 Apr 6;276(14), p. 10811-6.
EPub date: 2001 Jan 17.
PMID: 11278431
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Vanadate facilitates interferon alpha-mediated apoptosis that is dependent on the Jak/Stat pathway.
Authors: Gamero AM, Larner AC
Source: J Biol Chem, 2001 Apr 27;276(17), p. 13547-53.
EPub date: 2001 Jan 19.
PMID: 11278370
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Signaling via the T cell antigen receptor induces phosphorylation of Stat1 on serine 727.
Authors: Gamero AM, Larner AC
Source: J Biol Chem, 2000 Jun 2;275(22), p. 16574-8.
PMID: 10748192
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