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Grant Details

Grant Number: 5P01CA068384-06 Interpret this number
Primary Investigator: Stellman, Steven
Organization: Institute For Cancer Prevention
Project Title: Tobacco and Cancer Risk-Dose, Metabolism and Genetics
Fiscal Year: 2002
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Abstract

An abstract does not currently exist for this grant

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Publications

A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers.
Authors: Nichenametla SN, Muscat JE, Liao JG, Lazarus P, Richie JP Jr
Source: Mol Carcinog, 2013 Oct;52(10), p. 791-9.
EPub date: 2012 May 18.
PMID: 22610501
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Menthol smoking in relation to time to first cigarette and cotinine: results from a community-based study.
Authors: Muscat JE, Liu HP, Stellman SD, Richie JP Jr
Source: Regul Toxicol Pharmacol, 2012 Jun;63(1), p. 166-70.
EPub date: 2012 Apr 2.
PMID: 22487419
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The nicotine dependence phenotype, time to first cigarette, and larynx cancer risk.
Authors: Muscat JE, Liu HP, Livelsberger C, Richie JP Jr, Stellman SD
Source: Cancer Causes Control, 2012 Mar;23(3), p. 497-503.
EPub date: 2012 Feb 25.
PMID: 22367700
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Nicotine dependence phenotype and lung cancer risk.
Authors: Muscat JE, Ahn K, Richie JP Jr, Stellman SD
Source: Cancer, 2011 Dec 1;117(23), p. 5370-6.
EPub date: 2011 Aug 8.
PMID: 21826644
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Nicotine dependence phenotype, time to first cigarette, and risk of head and neck cancer.
Authors: Muscat JE, Ahn K, Richie JP Jr, Stellman SD
Source: Cancer, 2011 Dec 1;117(23), p. 5377-82.
EPub date: 2011 Aug 8.
PMID: 21826643
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Association of selenium status and blood glutathione concentrations in blacks and whites.
Authors: Richie JP Jr, Muscat JE, Ellison I, Calcagnotto A, Kleinman W, El-Bayoumy K
Source: Nutr Cancer, 2011;63(3), p. 367-75.
PMID: 21462082
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A GAG trinucleotide-repeat polymorphism in the gene for glutathione biosynthetic enzyme, GCLC, affects gene expression through translation.
Authors: Nichenametla SN, Lazarus P, Richie JP Jr
Source: FASEB J, 2011 Jul;25(7), p. 2180-7.
EPub date: 2011 Mar 28.
PMID: 21444626
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A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine.
Authors: Muscat JE, Liu A, Richie JP Jr
Source: Biomarkers, 2011 May;16(3), p. 206-11.
EPub date: 2011 Feb 3.
PMID: 21288164
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Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms.
Authors: Chen G, Giambrone NE Jr, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P
Source: Cancer Res, 2010 Oct 1;70(19), p. 7543-52.
EPub date: 2010 Sep 28.
PMID: 20876810
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Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium.
Authors: Truong T, Hung RJ, Amos CI, Wu X, Bickeböller H, Rosenberger A, Sauter W, Illig T, Wichmann HE, Risch A, Dienemann H, Kaaks R, Yang P, Jiang R, Wiencke JK, Wrensch M, Hansen H, Kelsey KT, Matsuo K, Tajima K, Schwartz AG, Wenzlaff A, Seow A, Ying C, Staratschek-Jox A, Nürnberg P, Stoelben E, Wolf J, Lazarus P, Muscat JE, Gallagher CJ, Zienolddiny S, Haugen A, van der Heijden HF, Kiemeney LA, Isla D, Mayordomo JI, Rafnar T, Stefansson K, Zhang ZF, Chang SC, Kim JH, Hong YC, Duell EJ, Andrew AS, Lejbkowicz F, Rennert G, Müller H, Brenner H, Le Marchand L, Benhamou S, Bouchardy C, Teare MD, Xue X, McLaughlin J, Liu G, McKay JD, Brennan P, Spitz MR
Source: J Natl Cancer Inst, 2010 Jul 7;102(13), p. 959-71.
EPub date: 2010 Jun 14.
PMID: 20548021
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International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants.
Authors: Truong T, Sauter W, McKay JD, Hosgood HD 3rd, Gallagher C, Amos CI, Spitz M, Muscat J, Lazarus P, Illig T, Wichmann HE, Bickeböller H, Risch A, Dienemann H, Zhang ZF, Naeim BP, Yang P, Zienolddiny S, Haugen A, Le Marchand L, Hong YC, Kim JH, Duell EJ, Andrew AS, Kiyohara C, Shen H, Matsuo K, Suzuki T, Seow A, Ng DP, Lan Q, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Constantinescu V, Bencko V, Foretova L, Janout V, Caporaso NE, Albanes D, Thun M, Landi MT, Trubicka J, Lener M, Lubinski J, EPIC-lung, Wang Y, Chabrier A, Boffetta P, Brennan P, Hung RJ
Source: Carcinogenesis, 2010 Apr;31(4), p. 625-33.
EPub date: 2010 Jan 27.
PMID: 20106900
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UDP-glucuronosyltransferase 1A10: activity against the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a potential role for a novel UGT1A10 promoter deletion polymorphism in cancer susceptibility.
Authors: Balliet RM, Chen G, Dellinger RW, Lazarus P
Source: Drug Metab Dispos, 2010 Mar;38(3), p. 484-90.
EPub date: 2009 Dec 9.
PMID: 20007297
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Time to first cigarette after waking predicts cotinine levels.
Authors: Muscat JE, Stellman SD, Caraballo RS, Richie JP Jr
Source: Cancer Epidemiol Biomarkers Prev, 2009 Dec;18(12), p. 3415-20.
PMID: 19959690
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Functional characterization of low-prevalence missense polymorphisms in the UDP-glucuronosyltransferase 1A9 gene.
Authors: Olson KC, Dellinger RW, Zhong Q, Sun D, Amin S, Spratt TE, Lazarus P
Source: Drug Metab Dispos, 2009 Oct;37(10), p. 1999-2007.
EPub date: 2009 Jul 9.
PMID: 19589876
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Effects of menthol on tobacco smoke exposure, nicotine dependence, and NNAL glucuronidation.
Authors: Muscat JE, Chen G, Knipe A, Stellman SD, Lazarus P, Richie JP Jr
Source: Cancer Epidemiol Biomarkers Prev, 2009 Jan;18(1), p. 35-41.
PMID: 19124478
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Association between haplotypes of manganese superoxide dismutase (SOD2), smoking, and lung cancer risk.
Authors: Gallagher CJ, Ahn K, Knipe AL, Dyer AM, Richie JP Jr, Lazarus P, Muscat JE
Source: Free Radic Biol Med, 2009 Jan 1;46(1), p. 20-4.
EPub date: 2008 Sep 27.
PMID: 18930810
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Comparison of CYP1A2 and NAT2 phenotypes between black and white smokers.
Authors: Muscat JE, Pittman B, Kleinman W, Lazarus P, Stellman SD, Richie JP Jr
Source: Biochem Pharmacol, 2008 Oct 1;76(7), p. 929-37.
EPub date: 2008 Jul 25.
PMID: 18703023
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Blood iron, glutathione, and micronutrient levels and the risk of oral cancer.
Authors: Richie JP Jr, Kleinman W, Marina P, Abraham P, Wynder EL, Muscat JE
Source: Nutr Cancer, 2008;60(4), p. 474-82.
PMID: 18584481
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Inhibition of caspase-3 activity and activation by protein glutathionylation.
Authors: Huang Z, Pinto JT, Deng H, Richie JP Jr
Source: Biochem Pharmacol, 2008 Jun 1;75(11), p. 2234-44.
EPub date: 2008 Feb 29.
PMID: 18395187
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Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines.
Authors: Chen G, Dellinger RW, Gallagher CJ, Sun D, Lazarus P
Source: Pharmacogenet Genomics, 2008 Mar;18(3), p. 181-91.
PMID: 18300939
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Glucuronidation of tobacco-specific nitrosamines by UGT2B10.
Authors: Chen G, Dellinger RW, Sun D, Spratt TE, Lazarus P
Source: Drug Metab Dispos, 2008 May;36(5), p. 824-30.
EPub date: 2008 Jan 31.
PMID: 18238858
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The UGT2B17 gene deletion polymorphism and risk of prostate cancer. A case-control study in Caucasians.
Authors: Gallagher CJ, Kadlubar FF, Muscat JE, Ambrosone CB, Lang NP, Lazarus P
Source: Cancer Detect Prev, 2007;31(4), p. 310-5.
PMID: 17935910
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Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism.
Authors: Chen G, Blevins-Primeau AS, Dellinger RW, Muscat JE, Lazarus P
Source: Cancer Res, 2007 Oct 1;67(19), p. 9024-9.
PMID: 17909004
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Glucuronidation of PhIP and N-OH-PhIP by UDP-glucuronosyltransferase 1A10.
Authors: Dellinger RW, Chen G, Blevins-Primeau AS, Krzeminski J, Amin S, Lazarus P
Source: Carcinogenesis, 2007 Nov;28(11), p. 2412-8.
EPub date: 2007 Jul 17.
PMID: 17638922
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