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Grant Details

Grant Number: 5R03CA089745-02 Interpret this number
Primary Investigator: Holly, Elizabeth
Organization: Univ Of California At San Francisco
Project Title: Epidemiology of Non Hodgkins's Lymphoma Data Analysis
Fiscal Year: 2002
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Abstract

A population-based case-control study of non-Hodgkin's lymphoma (NHL) that included nearly 1600 patients with NHL and more than 2500 control participants was conducted by the Principal Investigator and colleagues in the San Francisco Bay Area between 1988 and 1995. NHL cases were obtained using rapid case ascertainment by the Northern California Cancer Center and control participants were identified using random digit dial and the Healthcare Financing Administration files. Pathology materials for the NHL patients included in the study were reviewed and classified of this study are: 1) to evaluate the association between exposure data collected in this large study and subtypes of NHL defined using the Working Formulation with emphasis on the investigation of risk factors found to be of importance in the main analyses of all NHL; and 2) to complete detailed analyses to investigate the association between risk for NHL and occupational and chemical exposures including Agent Orange, reproductive and hormonal exposures among women , support for hypotheses that indicated there are etiologic differences across NHL subtypes that can be characterized by a unique set of associated risk factors. Differentiation of risk factors by NHL subtypes will provide important clues to detailed analyses between exposures of interest and risk for NHL with adjustment for potential confounders and effect modifiers. These data may explain inconsistencies in results from earlier NHL studies constrained by limited sample size and exposure data. They also may provide important additional information about the role of exposures that alter Th1 or Th2 pathways and the process of lymphomagenesis. These data will be used as preliminary results for a larger Bay Area study of lymphoma.

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Publications

X chromosome-wide association study of follicular lymphoma.
Authors: Conde L, Foo JN, Riby J, Liu J, Darabi H, Hjalgrim H, Bracci PM, Smedby KE, Skibola CF
Source: Br J Haematol, 2013 Sep;162(6), p. 858-62.
EPub date: 2013 Jun 25.
PMID: 23795672
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Coding variants at hexa-allelic amino acid 13 of HLA-DRB1 explain independent SNP associations with follicular lymphoma risk.
Authors: Foo JN, Smedby KE, Akers NK, Berglund M, Irwan ID, Jia X, Li Y, Conde L, Darabi H, Bracci PM, Melbye M, Adami HO, Glimelius B, Khor CC, Hjalgrim H, Padyukov L, Humphreys K, Enblad G, Skibola CF, de Bakker PI, Liu J
Source: Am J Hum Genet, 2013 Jul 11;93(1), p. 167-72.
EPub date: 2013 Jun 20.
PMID: 23791106
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Rare variant association testing under low-coverage sequencing.
Authors: Navon O, Sul JH, Han B, Conde L, Bracci PM, Riby J, Skibola CF, Eskin E, Halperin E
Source: Genetics, 2013 Jul;194(3), p. 769-79.
EPub date: 2013 May 1.
PMID: 23636738
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PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium.
Authors: Nieters A, Conde L, Slager SL, Brooks-Wilson A, Morton L, Skibola DR, Novak AJ, Riby J, Ansell SM, Halperin E, Shanafelt TD, Agana L, Wang AH, De Roos AJ, Severson RK, Cozen W, Spinelli J, Butterbach K, Becker N, de Sanjose S, Benavente Y, Cocco P, Staines A, Maynadié M, Foretova L, Boffetta P, Brennan P, Lan Q, Zhang Y, Zheng T, Purdue M, Armstrong B, Kricker A, Vajdic CM, Grulich A, Smith MT, Bracci PM, Chanock SJ, Hartge P, Cerhan JR, Wang SS, Rothman N, Skibola CF
Source: Blood, 2012 Nov 29;120(23), p. 4645-8.
EPub date: 2012 Oct 9.
PMID: 23047821
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A meta-analysis of genome-wide association studies of follicular lymphoma.
Authors: Skibola CF, Conde L, Foo JN, Riby J, Humphreys K, Sillé FC, Darabi H, Sanchez S, Hjalgrim H, Liu J, Bracci PM, Smedby KE
Source: BMC Genomics, 2012 Oct 1;13, p. 516.
EPub date: 2012 Oct 1.
PMID: 23025665
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Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes.
Authors: Slager SL, Camp NJ, Conde L, Shanafelt TD, Achenbach SJ, Rabe KG, Kay NE, Novak AJ, Call TG, Bracci PM, Sille FM, Sanchez S, Akers NK, Cunningham JM, Serie DJ, McDonnell SK, Leis JF, Wang AH, Weinberg JB, Glenn M, Link B, Vachon CM, Lanasa MC, Skibola CF, Cerhan JR
Source: Br J Haematol, 2012 Dec;159(5), p. 572-6.
EPub date: 2012 Oct 1.
PMID: 23025533
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Postmenopausal hormone therapy and non-Hodgkin lymphoma: a pooled analysis of InterLymph case-control studies.
Authors: Kane EV, Bernstein L, Bracci PM, Cerhan JR, Costas L, Dal Maso L, Holly EA, La Vecchia C, Matsuo K, Sanjose S, Spinelli JJ, Wang SS, Zhang Y, Zheng T, Roman E, Kricker A, InterLymph Consortium
Source: Ann Oncol, 2013 Feb;24(2), p. 433-41.
EPub date: 2012 Sep 11.
PMID: 22967995
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Menstrual and reproductive factors, and hormonal contraception use: associations with non-Hodgkin lymphoma in a pooled analysis of InterLymph case-control studies.
Authors: Kane EV, Roman E, Becker N, Bernstein L, Boffetta P, Bracci PM, Cerhan JR, Chiu BC, Cocco P, Costas L, Foretova L, Holly EA, La Vecchia C, Matsuo K, Maynadie M, Sanjose S, Spinelli JJ, Staines A, Talamini R, Wang SS, Zhang Y, Zheng T, Kricker A, InterLymph Consortium
Source: Ann Oncol, 2012 Sep;23(9), p. 2362-74.
EPub date: 2012 Jul 10.
PMID: 22786757
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Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
Authors: Slager SL, Skibola CF, Di Bernardo MC, Conde L, Broderick P, McDonnell SK, Goldin LR, Croft N, Holroyd A, Harris S, Riby J, Serie DJ, Kay NE, Call TG, Bracci PM, Halperin E, Lanasa MC, Cunningham JM, Leis JF, Morrison VA, Spector LG, Vachon CM, Shanafelt TD, Strom SS, Camp NJ, Weinberg JB, Matutes E, Caporaso NE, Wade R, Dyer MJ, Dearden C, Cerhan JR, Catovsky D, Houlston RS
Source: Blood, 2012 Jul 26;120(4), p. 843-6.
EPub date: 2012 Jun 13.
PMID: 22700719
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Multi-locus HLA class I and II allele and haplotype associations with follicular lymphoma.
Authors: Skibola CF, Akers NK, Conde L, Ladner M, Hawbecker SK, Cohen F, Ribas F, Erlich HA, Goodridge D, Trachtenberg EA, Smith MT, Bracci PM
Source: Tissue Antigens, 2012 Apr;79(4), p. 279-86.
EPub date: 2012 Feb 2.
PMID: 22296171
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Self-reported history of infections and the risk of non-Hodgkin lymphoma: an InterLymph pooled analysis.
Authors: Becker N, Falster MO, Vajdic CM, de Sanjose S, Martínez-Maza O, Bracci PM, Melbye M, Smedby KE, Engels EA, Turner J, Vineis P, Costantini AS, Holly EA, Spinelli JJ, La Vecchia C, Zheng T, Chiu BC, Montella M, Cocco P, Maynadié M, Foretova L, Staines A, Brennan P, Davis S, Severson R, Cerhan JR, Breen EC, Birmann B, Cozen W, Grulich AE, Newton R
Source: Int J Cancer, 2012 Nov 15;131(10), p. 2342-8.
EPub date: 2012 Aug 12.
PMID: 22266776
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The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma.
Authors: Carvalho A, Cunha C, Almeida AJ, Osório NS, Saraiva M, Teixeira-Coelho M, Pedreiro S, Torrado E, Domingues N, Gomes-Alves AG, Marques A, Lacerda JF, da Silva MG, Gomes M, Pinto AC, Torres F, Rendeiro P, Tavares P, Di Ianni M, Medeiros R, Heutink P, Bracci PM, Conde L, Ludovico P, Pedrosa J, Maciel P, Pitzurra L, Aversa F, Marques H, Paiva A, Skibola CF, Romani L, Castro AG, Rodrigues F
Source: Genes Immun, 2012 Feb;13(2), p. 197-201.
EPub date: 2011 Aug 25.
PMID: 21866115
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A search for overlapping genetic susceptibility loci between non-Hodgkin lymphoma and autoimmune diseases.
Authors: Conde L, Bracci PM, Halperin E, Skibola CF
Source: Genomics, 2011 Jul;98(1), p. 9-14.
EPub date: 2011 Mar 23.
PMID: 21439368
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Association of HLA-DQB1 alleles with risk of follicular lymphoma.
Authors: Akers NK, Curry JD, Conde L, Bracci PM, Smith MT, Skibola CF
Source: Leuk Lymphoma, 2011 Jan;52(1), p. 53-8.
EPub date: 2010 Dec 6.
PMID: 21133715
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Birth order and risk of non-hodgkin lymphoma--true association or bias?
Authors: Grulich AE, Vajdic CM, Falster MO, Kane E, Smedby KE, Bracci PM, de Sanjose S, Becker N, Turner J, Martinez-Maza O, Melbye M, Engels EA, Vineis P, Costantini AS, Holly EA, Spinelli JJ, La Vecchia C, Zheng T, Chiu BC, Franceschi S, Cocco P, Maynadié M, Foretova L, Staines A, Brennan P, Davis S, Severson RK, Cerhan JR, Breen EC, Birmann B, Cozen W
Source: Am J Epidemiol, 2010 Sep 15;172(6), p. 621-30.
EPub date: 2010 Aug 18.
PMID: 20720098
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Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.
Authors: Conde L, Halperin E, Akers NK, Brown KM, Smedby KE, Rothman N, Nieters A, Slager SL, Brooks-Wilson A, Agana L, Riby J, Liu J, Adami HO, Darabi H, Hjalgrim H, Low HQ, Humphreys K, Melbye M, Chang ET, Glimelius B, Cozen W, Davis S, Hartge P, Morton LM, Schenk M, Wang SS, Armstrong B, Kricker A, Milliken S, Purdue MP, Vajdic CM, Boyle P, Lan Q, Zahm SH, Zhang Y, Zheng T, Becker N, Benavente Y, Boffetta P, Brennan P, Butterbach K, Cocco P, Foretova L, Maynadié M, de Sanjosé S, Staines A, Spinelli JJ, Achenbach SJ, Call TG, Camp NJ, Glenn M, Caporaso NE, Cerhan JR, Cunningham JM, Goldin LR, Hanson CA, Kay NE, Lanasa MC, Leis JF, Marti GE, Rabe KG, Rassenti LZ, Spector LG, Strom SS, Vachon CM, Weinberg JB, Holly EA, Chanock S, Smith MT, Bracci PM, Skibola CF
Source: Nat Genet, 2010 Aug;42(8), p. 661-4.
EPub date: 2010 Jul 18.
PMID: 20639881
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A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis.
Authors: Nieters A, Bracci PM, de Sanjosé S, Becker N, Maynadié M, Benavente Y, Foretova L, Cocco P, Staines A, Holly EA, Boffetta P, Brennan P, Skibola CF
Source: Int J Cancer, 2011 Mar 15;128(6), p. 1481-5.
PMID: 20473910
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Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium.
Authors: Skibola CF, Bracci PM, Nieters A, Brooks-Wilson A, de Sanjosé S, Hughes AM, Cerhan JR, Skibola DR, Purdue M, Kane E, Lan Q, Foretova L, Schenk M, Spinelli JJ, Slager SL, De Roos AJ, Smith MT, Roman E, Cozen W, Boffetta P, Kricker A, Zheng T, Lightfoot T, Cocco P, Benavente Y, Zhang Y, Hartge P, Linet MS, Becker N, Brennan P, Zhang L, Armstrong B, Smith A, Shiao R, Novak AJ, Maynadie M, Chanock SJ, Staines A, Holford TR, Holly EA, Rothman N, Wang SS
Source: Am J Epidemiol, 2010 Feb 1;171(3), p. 267-76.
EPub date: 2010 Jan 4.
PMID: 20047977
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Chemokine polymorphisms and lymphoma: a pooled analysis.
Authors: Bracci PM, Skibola CF, Conde L, Halperin E, Lightfoot T, Smith A, Paynter RA, Skibola DR, Agana L, Roman E, Kane E, Wiencke JK
Source: Leuk Lymphoma, 2010 Mar;51(3), p. 497-506.
PMID: 20038229
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Solvent exposure and non-Hodgkin lymphoma: no risk in a population-based study in the San Francisco Bay Area.
Authors: Tranah GJ, Holly EA, Bracci PM
Source: Cancer Epidemiol Biomarkers Prev, 2009 Nov;18(11), p. 3130-2.
PMID: 19900943
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Atopic disease and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis.
Authors: Vajdic CM, Falster MO, de Sanjose S, Martínez-Maza O, Becker N, Bracci PM, Melbye M, Smedby KE, Engels EA, Turner J, Vineis P, Costantini AS, Holly EA, Kane E, Spinelli JJ, La Vecchia C, Zheng T, Chiu BC, Dal Maso L, Cocco P, Maynadié M, Foretova L, Staines A, Brennan P, Davis S, Severson R, Cerhan JR, Breen EC, Birmann B, Cozen W, Grulich AE
Source: Cancer Res, 2009 Aug 15;69(16), p. 6482-9.
EPub date: 2009 Aug 4.
PMID: 19654312
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Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.
Authors: Skibola CF, Bracci PM, Halperin E, Conde L, Craig DW, Agana L, Iyadurai K, Becker N, Brooks-Wilson A, Curry JD, Spinelli JJ, Holly EA, Riby J, Zhang L, Nieters A, Smith MT, Brown KM
Source: Nat Genet, 2009 Aug;41(8), p. 873-5.
EPub date: 2009 Jul 20.
PMID: 19620980
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Domestic and farm-animal exposures and risk of non-Hodgkin's lymphoma in a population-based study in the San Francisco Bay Area.
Authors: Tranah GJ, Bracci PM, Holly EA
Source: Cancer Epidemiol Biomarkers Prev, 2008 Sep;17(9), p. 2382-7.
PMID: 18768507
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Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
Authors: Skibola CF, Bracci PM, Halperin E, Nieters A, Hubbard A, Paynter RA, Skibola DR, Agana L, Becker N, Tressler P, Forrest MS, Sankararaman S, Conde L, Holly EA, Smith MT
Source: PLoS One, 2008 Jun 30;3(7), p. e2816.
EPub date: 2008 Jun 30.
PMID: 18636124
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Non-Hodgkin lymphoma in women: reproductive factors and exogenous hormone use.
Authors: Lee JS, Bracci PM, Holly EA
Source: Am J Epidemiol, 2008 Aug 1;168(3), p. 278-88.
EPub date: 2008 Jun 10.
PMID: 18550561
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Hepatitis C and non-Hodgkin lymphoma among 4784 cases and 6269 controls from the International Lymphoma Epidemiology Consortium.
Authors: de Sanjose S, Benavente Y, Vajdic CM, Engels EA, Morton LM, Bracci PM, Spinelli JJ, Zheng T, Zhang Y, Franceschi S, Talamini R, Holly EA, Grulich AE, Cerhan JR, Hartge P, Cozen W, Boffetta P, Brennan P, Maynadié M, Cocco P, Bosch R, Foretova L, Staines A, Becker N, Nieters A
Source: Clin Gastroenterol Hepatol, 2008 Apr;6(4), p. 451-8.
PMID: 18387498
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A functional TNFRSF5 gene variant is associated with risk of lymphoma.
Authors: Skibola CF, Nieters A, Bracci PM, Curry JD, Agana L, Skibola DR, Hubbard A, Becker N, Smith MT, Holly EA
Source: Blood, 2008 Apr 15;111(8), p. 4348-54.
EPub date: 2008 Feb 20.
PMID: 18287517
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Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium.
Authors: Ekström Smedby K, Vajdic CM, Falster M, Engels EA, Martínez-Maza O, Turner J, Hjalgrim H, Vineis P, Seniori Costantini A, Bracci PM, Holly EA, Willett E, Spinelli JJ, La Vecchia C, Zheng T, Becker N, De Sanjosé S, Chiu BC, Dal Maso L, Cocco P, Maynadié M, Foretova L, Staines A, Brennan P, Davis S, Severson R, Cerhan JR, Breen EC, Birmann B, Grulich AE, Cozen W
Source: Blood, 2008 Apr 15;111(8), p. 4029-38.
EPub date: 2008 Feb 8.
PMID: 18263783
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Screening the human serum proteome for genotype-phenotype associations: an analysis of the IL6 -174G>C polymorphism.
Authors: Hegedus CM, Skibola CF, Bracci P, Holly EA, Smith MT
Source: Proteomics, 2007 Feb;7(4), p. 548-57.
PMID: 17309100
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Polymorphisms in the oxidative stress genes, superoxide dismutase, glutathione peroxidase and catalase and risk of non-Hodgkin's lymphoma.
Authors: Lightfoot TJ, Skibola CF, Smith AG, Forrest MS, Adamson PJ, Morgan GJ, Bracci PM, Roman E, Smith MT, Holly EA
Source: Haematologica, 2006 Sep;91(9), p. 1222-7.
PMID: 16956821
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Use of nonsteroidal antiinflammatory drugs and non-Hodgkin lymphoma: a population-based case-control study.
Authors: Flick ED, Chan KA, Bracci PM, Holly EA
Source: Am J Epidemiol, 2006 Sep 1;164(5), p. 497-504.
EPub date: 2006 Jul 13.
PMID: 16840523
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Residential history, family characteristics and non-Hodgkin lymphoma, a population-based case-control study in the San Francisco Bay Area.
Authors: Bracci PM, Dalvi TB, Holly EA
Source: Cancer Epidemiol Biomarkers Prev, 2006 Jul;15(7), p. 1287-94.
PMID: 16835325
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Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma.
Authors: Forrest MS, Skibola CF, Lightfoot TJ, Bracci PM, Willett EV, Smith MT, Holly EA, Roman E
Source: Br J Haematol, 2006 Jul;134(2), p. 180-3.
EPub date: 2006 Jun 1.
PMID: 16740140
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Changes in cancer registry coding for lymphoma subtypes: reliability over time and relevance for surveillance and study.
Authors: Clarke CA, Undurraga DM, Harasty PJ, Glaser SL, Morton LM, Holly EA
Source: Cancer Epidemiol Biomarkers Prev, 2006 Apr;15(4), p. 630-8.
PMID: 16614102
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Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium.
Authors: Rothman N, Skibola CF, Wang SS, Morgan G, Lan Q, Smith MT, Spinelli JJ, Willett E, De Sanjose S, Cocco P, Berndt SI, Brennan P, Brooks-Wilson A, Wacholder S, Becker N, Hartge P, Zheng T, Roman E, Holly EA, Boffetta P, Armstrong B, Cozen W, Linet M, Bosch FX, Ennas MG, Holford TR, Gallagher RP, Rollinson S, Bracci PM, Cerhan JR, Whitby D, Moore PS, Leaderer B, Lai A, Spink C, Davis S, Bosch R, Scarpa A, Zhang Y, Severson RK, Yeager M, Chanock S, Nieters A
Source: Lancet Oncol, 2006 Jan;7(1), p. 27-38.
PMID: 16389181
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Polymorphisms and haplotypes in the cytochrome P450 17A1, prolactin, and catechol-O-methyltransferase genes and non-Hodgkin lymphoma risk.
Authors: Skibola CF, Bracci PM, Paynter RA, Forrest MS, Agana L, Woodage T, Guegler K, Smith MT, Holly EA
Source: Cancer Epidemiol Biomarkers Prev, 2005 Oct;14(10), p. 2391-401.
PMID: 16214922
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Polymorphisms in ghrelin and neuropeptide Y genes are associated with non-Hodgkin lymphoma.
Authors: Skibola DR, Smith MT, Bracci PM, Hubbard AE, Agana L, Chi S, Holly EA
Source: Cancer Epidemiol Biomarkers Prev, 2005 May;14(5), p. 1251-6.
PMID: 15894681
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Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma.
Authors: Skibola CF, Forrest MS, Coppedé F, Agana L, Hubbard A, Smith MT, Bracci PM, Holly EA
Source: Blood, 2004 Oct 1;104(7), p. 2155-62.
EPub date: 2004 Jun 15.
PMID: 15198953
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Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma.
Authors: Skibola CF, Holly EA, Forrest MS, Hubbard A, Bracci PM, Skibola DR, Hegedus C, Smith MT
Source: Cancer Epidemiol Biomarkers Prev, 2004 May;13(5), p. 779-86.
PMID: 15159310
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Expert review of non-Hodgkin's lymphomas in a population-based cancer registry: reliability of diagnosis and subtype classifications.
Authors: Clarke CA, Glaser SL, Dorfman RF, Bracci PM, Eberle E, Holly EA
Source: Cancer Epidemiol Biomarkers Prev, 2004 Jan;13(1), p. 138-43.
PMID: 14744745
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Blood transfusions and non-Hodgkin's lymphoma.
Authors: Chow EJ, Holly EA
Source: Epidemiol Rev, 2002;24(2), p. 269-79.
PMID: 12762097
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