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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 1R03CA094770-01 Interpret this number
Primary Investigator: Chiu, Brian
Organization: University Of Nebraska Medical Center
Project Title: Case-Control Study of Pesticides and T(14;18) Lymphoma
Fiscal Year: 2002
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Abstract

DESCRIPTION (provided by applicant): A population-based, case-control study of non-Hodgkin's lymphoma (NHL) was conducted in Nebraska between 1983 and 1986. This NCI's study collected extensive information on agricultural exposures. Herein, an ancillary molecular study is proposed to determine the role of pesticides in the occurrence of t(14;18) chromosomal translocation in this case-control study. An association between NHL and pesticides has been observed repeatedly, but not consistently. Results of epidemiologic studies of pesticides and NHL may be obscured by the aggregate evaluation of cases that are etiologically diverse. The t(14;18) is the most common cytogenetic abnormality, and t(14;18)-mediated constitutive overexpression of BCL2 protein is an important early event in NHL pathogenesis. The current proposal will classify NHL cases according to t(14;18) status to identify agricultural risk factors that may be specifically associated with t(14;18)-positive or -negative pathogenic mechanisms. The specific aims are to 1) obtain paraffin-embedded tumor blocks for NHL cases; 2) determine the presence of the t(14;18) translocation; and 3) investigate pesticides for their association with t(14;18)-positive NHL or t(14;18)-negative NHL. The hypothesis is that pesticides act specifically along a t(14;18)-dependent pathway, resulting in stronger associations with t(14;18)-positive than t(14;18)-negative NHL. The research design is a molecular case-control study. Tumor blocks will be obtained from the Lymphoma Registry Tissue Bank for all NHL cases in the original case-control study (about 270-290 tissue blocks will be available). Fluorescence in-situ hybridization (FISH) analysis will be used to determine the presence of the t(14;18) translocation. Results from FISH analyses will be used to classify NHL cases into t(14;18)-positive NHL or t(14;18)-negative NHL. Logistic regression models will be used to calculate the odds ratios for t(14;18)-positive NHL and t(14;18)-negative NHL associated with various groups and types of pesticides. The low-term objective is to improve understanding of the disease process which may ultimately lead to improved prevention of NHL in the general population.

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Publications

Dietary Factors And Risk Of T(14;18)-defined Subgroups Of Non-hodgkin Lymphoma
Authors: Chiu B.C. , Dave B.J. , Ward M.H. , Fought A.J. , Hou L. , Jain S. , Gapstur S. , Evens A.M. , Zahm S.H. , Blair A. , et al. .
Source: Cancer Causes & Control : Ccc, 2008 Oct; 19(8), p. 859-67.
PMID: 18386141
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The Utility Of T(14;18) In Understanding Risk Factors For Non-hodgkin Lymphoma
Authors: Chiu B.C. , Lan Q. , Dave B.J. , Blair A. , Zahm S.H. , Weisenburger D.D. .
Source: Journal Of The National Cancer Institute. Monographs, 2008; (39), p. 69-73.
PMID: 18648007
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Dietary Intake Of Fruit And Vegetables And Risk Of Non-hodgkin Lymphoma
Authors: Chiu B.C. , Kwon S. , Evens A.M. , Surawicz T. , Smith S.M. , Weisenburger D.D. .
Source: Cancer Causes & Control : Ccc, 2011 Aug; 22(8), p. 1183-95.
PMID: 21695384
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Meat Intake And Risk Of Non-hodgkin Lymphoma
Authors: Aschebrook-Kilfoy B. , Ollberding N.J. , Kolar C. , Lawson T.A. , Smith S.M. , Weisenburger D.D. , Chiu B.C. .
Source: Cancer Causes & Control : Ccc, 2012 Oct; 23(10), p. 1681-92.
PMID: 22890783
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Dietary Nitrate And Nitrite Intake And Risk Of Non-hodgkin Lymphoma
Authors: Aschebrook-Kilfoy B. , Ward M.H. , Dave B.J. , Smith S.M. , Weisenburger D.D. , Chiu B.C. .
Source: Leukemia & Lymphoma, 2013 May; 54(5), p. 945-50.
PMID: 23013327
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Phytanic Acid And The Risk Of Non-hodgkin Lymphoma
Authors: Ollberding N.J. , Aschebrook-Kilfoy B. , Caces D.B. , Wright M.E. , Weisenburger D.D. , Smith S.M. , Chiu B.C. .
Source: Carcinogenesis, 2013 Jan; 34(1), p. 170-5.
PMID: 23042099
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An Upward Trend In The Age-specific Incidence Patterns For Mantle Cell Lymphoma In The Usa
Authors: Aschebrook-Kilfoy B. , Caces D.B. , Ollberding N.J. , Smith S.M. , Chiu B.C. .
Source: Leukemia & Lymphoma, 2013 Aug; 54(8), p. 1677-83.
PMID: 23350889
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Dietary Intake Of Fruits And Vegetables And Overall Survival In Non-hodgkin Lymphoma
Authors: Ollberding N.J. , Aschebrook-Kilfoy B. , Caces D.B. , Smith S.M. , Weisenburger D.D. , Chiu B.C. .
Source: Leukemia & Lymphoma, 2013 Dec; 54(12), p. 2613-9.
PMID: 23488609
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Dietary Patterns And The Risk Of Non-hodgkin Lymphoma
Authors: Ollberding N.J. , Aschebrook-Kilfoy B. , Caces D.B. , Smith S.M. , Weisenburger D.D. , Chiu B.C. .
Source: Public Health Nutrition, 2014 Jul; 17(7), p. 1531-7.
PMID: 23659580
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Pre-diagnosis Cigarette Smoking And Overall Survival In Non-hodgkin Lymphoma
Authors: Ollberding N.J. , Evens A.M. , Aschebrook-Kilfoy B. , Caces D.B. , Weisenburger D.D. , Smith S.M. , Chiu B.C. .
Source: British Journal Of Haematology, 2013 Nov; 163(3), p. 352-6.
PMID: 23909494
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Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma.
Authors: Chiu B.C. , Dave B.J. , Blair A. , Gapstur S.M. , Zahm S.H. , Weisenburger D.D. .
Source: Blood, 2006-08-15; 108(4), p. 1363-9.
EPub date: 2006-04-18.
PMID: 16621961
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