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Grant Details

Grant Number: 1R03CA094770-01 Interpret this number
Primary Investigator: Chiu, Brian
Organization: University Of Nebraska Medical Center
Project Title: Case-Control Study of Pesticides and T(14;18) Lymphoma
Fiscal Year: 2002
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Abstract

DESCRIPTION (provided by applicant): A population-based, case-control study of non-Hodgkin's lymphoma (NHL) was conducted in Nebraska between 1983 and 1986. This NCI's study collected extensive information on agricultural exposures. Herein, an ancillary molecular study is proposed to determine the role of pesticides in the occurrence of t(14;18) chromosomal translocation in this case-control study. An association between NHL and pesticides has been observed repeatedly, but not consistently. Results of epidemiologic studies of pesticides and NHL may be obscured by the aggregate evaluation of cases that are etiologically diverse. The t(14;18) is the most common cytogenetic abnormality, and t(14;18)-mediated constitutive overexpression of BCL2 protein is an important early event in NHL pathogenesis. The current proposal will classify NHL cases according to t(14;18) status to identify agricultural risk factors that may be specifically associated with t(14;18)-positive or -negative pathogenic mechanisms. The specific aims are to 1) obtain paraffin-embedded tumor blocks for NHL cases; 2) determine the presence of the t(14;18) translocation; and 3) investigate pesticides for their association with t(14;18)-positive NHL or t(14;18)-negative NHL. The hypothesis is that pesticides act specifically along a t(14;18)-dependent pathway, resulting in stronger associations with t(14;18)-positive than t(14;18)-negative NHL. The research design is a molecular case-control study. Tumor blocks will be obtained from the Lymphoma Registry Tissue Bank for all NHL cases in the original case-control study (about 270-290 tissue blocks will be available). Fluorescence in-situ hybridization (FISH) analysis will be used to determine the presence of the t(14;18) translocation. Results from FISH analyses will be used to classify NHL cases into t(14;18)-positive NHL or t(14;18)-negative NHL. Logistic regression models will be used to calculate the odds ratios for t(14;18)-positive NHL and t(14;18)-negative NHL associated with various groups and types of pesticides. The low-term objective is to improve understanding of the disease process which may ultimately lead to improved prevention of NHL in the general population.

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Publications

Pre-diagnosis cigarette smoking and overall survival in non-Hodgkin lymphoma.
Authors: Ollberding NJ, Evens AM, Aschebrook-Kilfoy B, Caces DB, Weisenburger DD, Smith SM, Chiu BC
Source: Br J Haematol, 2013 Nov;163(3), p. 352-6.
EPub date: 2013 Aug 2.
PMID: 23909494
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Dietary patterns and the risk of non-Hodgkin lymphoma.
Authors: Ollberding NJ, Aschebrook-Kilfoy B, Caces DB, Smith SM, Weisenburger DD, Chiu BC
Source: Public Health Nutr, 2014 Jul;17(7), p. 1531-7.
EPub date: 2013 May 9.
PMID: 23659580
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Dietary intake of fruits and vegetables and overall survival in non-Hodgkin lymphoma.
Authors: Ollberding NJ, Aschebrook-Kilfoy B, Caces DB, Smith SM, Weisenburger DD, Chiu BC
Source: Leuk Lymphoma, 2013 Dec;54(12), p. 2613-9.
EPub date: 2013 Apr 30.
PMID: 23488609
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An upward trend in the age-specific incidence patterns for mantle cell lymphoma in the USA.
Authors: Aschebrook-Kilfoy B, Caces DB, Ollberding NJ, Smith SM, Chiu BC
Source: Leuk Lymphoma, 2013 Aug;54(8), p. 1677-83.
EPub date: 2013 Feb 7.
PMID: 23350889
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Phytanic acid and the risk of non-Hodgkin lymphoma.
Authors: Ollberding NJ, Aschebrook-Kilfoy B, Caces DB, Wright ME, Weisenburger DD, Smith SM, Chiu BC
Source: Carcinogenesis, 2013 Jan;34(1), p. 170-5.
EPub date: 2012 Oct 5.
PMID: 23042099
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Dietary nitrate and nitrite intake and risk of non-Hodgkin lymphoma.
Authors: Aschebrook-Kilfoy B, Ward MH, Dave BJ, Smith SM, Weisenburger DD, Chiu BC
Source: Leuk Lymphoma, 2013 May;54(5), p. 945-50.
EPub date: 2012 Oct 24.
PMID: 23013327
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Meat intake and risk of non-Hodgkin lymphoma.
Authors: Aschebrook-Kilfoy B, Ollberding NJ, Kolar C, Lawson TA, Smith SM, Weisenburger DD, Chiu BC
Source: Cancer Causes Control, 2012 Oct;23(10), p. 1681-92.
EPub date: 2012 Aug 14.
PMID: 22890783
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Dietary intake of fruit and vegetables and risk of non-Hodgkin lymphoma.
Authors: Chiu BC, Kwon S, Evens AM, Surawicz T, Smith SM, Weisenburger DD
Source: Cancer Causes Control, 2011 Aug;22(8), p. 1183-95.
EPub date: 2011 Jun 22.
PMID: 21695384
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The utility of t(14;18) in understanding risk factors for non-Hodgkin lymphoma.
Authors: Chiu BC, Lan Q, Dave BJ, Blair A, Zahm SH, Weisenburger DD
Source: J Natl Cancer Inst Monogr, 2008;null(39), p. 69-73.
PMID: 18648007
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Dietary factors and risk of t(14;18)-defined subgroups of non-Hodgkin lymphoma.
Authors: Chiu BC, Dave BJ, Ward MH, Fought AJ, Hou L, Jain S, Gapstur S, Evens AM, Zahm SH, Blair A, Weisenburger DD
Source: Cancer Causes Control, 2008 Oct;19(8), p. 859-67.
EPub date: 2008 Apr 2.
PMID: 18386141
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Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma.
Authors: Chiu BC, Dave BJ, Blair A, Gapstur SM, Zahm SH, Weisenburger DD
Source: Blood, 2006 Aug 15;108(4), p. 1363-9.
EPub date: 2006 Apr 18.
PMID: 16621961
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