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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 2R01CA067264-05A1 Interpret this number
Primary Investigator: Newcomb, Polly
Organization: University Of Wisconsin Madison
Project Title: Breast Cancer in Situ: Recurrence and Quality of Life
Fiscal Year: 2002
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Abstract

DESCRIPTION (provided by applicant): Breast carcinoma in situ (BCIS) is an increasingly common diagnosis with important implications for future morbidity and quality of life. We propose to extend our highly successful population-based study of BCIS to examine how recurrence and quality of life in BCIS survivors is associated with modifiable lifestyle factors. Specifically we will investigate: 1) risk factors for recurrence, including SERMs, postmenopausal hormones, behaviors such as physical activity and diet, and their interaction with histopathologic characteristics; and 2) quality of life in relation to treatment, recurrence, and time since diagnosis among BCIS survivors. We will evaluate these relationships among 1,105 incident cases of BCIS interviewed in our current study between 1997-2001 (Phase 1), and an additional 1,487 new cases to be interviewed 2002-2005 (Phase 2) between the ages of 20 and 74. All cases are identified from Wisconsin's statewide tumor registry; based on previous experience, we anticipate high participation rates (over 85 percent) in our telephone interview. The interview will provide information on quality of life (using the SF-36), lifestyle factors--including weight, alcohol intake, diet, physical activity, and medication use--and cancer treatment. Annual newsletters will be mailed to all cohort members to update any address and health status changes, and follow-up interviews will be conducted biennially to identify recurrences, second primaries, new treatments, as well as changes in quality of life and risk factors. We anticipate 232 recurrences over the follow-up period (median 5 years post initial diagnosis), as verified by information collected from treating physicians and the statewide tumor registry. By utilizing an efficient, well-established mechanism for enrolling, interviewing, and re-contacting cases, this study will provide timely and generalizable new information. There is an urgent need to understand how women may actively minimize the risk of recurrence and how this diagnosis impacts upon the quality of women's lives. The proposed population-based cohort offers a powerful opportunity to inform women and physicians as they consider the trade-offs currently inherent in BCIS treatment.

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Publications

Collection Of Genomic Dna From Adults In Epidemiological Studies By Buccal Cytobrush And Mouthwash
Authors: García-Closas M. , Egan K.M. , Abruzzo J. , Newcomb P.A. , Titus-Ernstoff L. , Franklin T. , Bender P.K. , Beck J.C. , Le Marchand L. , Lum A. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2001 Jun; 10(6), p. 687-96.
PMID: 11401920
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Polymorphisms In Dna Double-strand Break Repair Genes And Risk Of Breast Cancer: Two Population-based Studies In Usa And Poland, And Meta-analyses
Authors: García-Closas M. , Egan K.M. , Newcomb P.A. , Brinton L.A. , Titus-Ernstoff L. , Chanock S. , Welch R. , Lissowska J. , Peplonska B. , Szeszenia-Dabrowska N. , et al. .
Source: Human Genetics, 2006 May; 119(4), p. 376-88.
PMID: 16485136
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Genetic Polymorphisms In Base-excision Repair Pathway Genes And Risk Of Breast Cancer
Authors: Zhang Y. , Newcomb P.A. , Egan K.M. , Titus-Ernstoff L. , Chanock S. , Welch R. , Brinton L.A. , Lissowska J. , Bardin-Mikolajczak A. , Peplonska B. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2006 Feb; 15(2), p. 353-8.
PMID: 16492928
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Commonly Studied Single-nucleotide Polymorphisms And Breast Cancer: Results From The Breast Cancer Association Consortium
Authors: Breast Cancer Association Consortium .
Source: Journal Of The National Cancer Institute, 2006-10-04 00:00:00.0; 98(19), p. 1382-96.
PMID: 17018785
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Genetic Variation In Tumor Necrosis Factor And Lymphotoxin-alpha (tnf-lta) And Breast Cancer Risk
Authors: Gaudet M.M. , Egan K.M. , Lissowska J. , Newcomb P.A. , Brinton L.A. , Titus-Ernstoff L. , Yeager M. , Chanock S. , Welch R. , Peplonska B. , et al. .
Source: Human Genetics, 2007 May; 121(3-4), p. 483-90.
PMID: 17216494
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Genetic Variation In Tp53 And Risk Of Breast Cancer In A Population-based Case Control Study
Authors: Sprague B.L. , Trentham-Dietz A. , Garcia-Closas M. , Newcomb P.A. , Titus-Ernstoff L. , Hampton J.M. , Chanock S.J. , Haines J.L. , Egan K.M. .
Source: Carcinogenesis, 2007 Aug; 28(8), p. 1680-6.
PMID: 17449902
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Cigarette Smoking And Risk Of Breast Carcinoma In Situ
Authors: Trentham-Dietz A. , Nichols H.B. , Egan K.M. , Titus-Ernstoff L. , Hampton J.M. , Newcomb P.A. .
Source: Epidemiology (cambridge, Mass.), 2007 Sep; 18(5), p. 629-38.
PMID: 17700252
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Oral Contraceptive Use And Risk Of Breast Carcinoma In Situ
Authors: Nichols H.B. , Trentham-Dietz A. , Egan K.M. , Titus-Ernstoff L. , Hampton J.M. , Newcomb P.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2007 Nov; 16(11), p. 2262-8.
PMID: 18006914
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Tea Consumption And Risk Of Breast Cancer
Authors: Kumar N. , Titus-Ernstoff L. , Newcomb P.A. , Trentham-Dietz A. , Anic G. , Egan K.M. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2009 Jan; 18(1), p. 341-5.
PMID: 19124518
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Prevalence Of Breast Carcinoma In Situ In The United States
Authors: Sprague B.L. , Trentham-Dietz A. .
Source: Jama, 2009-08-26 00:00:00.0; 302(8), p. 846-8.
PMID: 19706857
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Association Of Comt Haplotypes And Breast Cancer Risk In Caucasian Women
Authors: Peterson N.B. , Trentham-Dietz A. , Garcia-Closas M. , Newcomb P.A. , Titus-Ernstoff L. , Huang Y. , Chanock S.J. , Haines J.L. , Egan K.M. .
Source: Anticancer Research, 2010 Jan; 30(1), p. 217-20.
PMID: 20150638
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Change In Lifestyle Behaviors And Medication Use After A Diagnosis Of Ductal Carcinoma In Situ
Authors: Sprague B.L. , Trentham-Dietz A. , Nichols H.B. , Hampton J.M. , Newcomb P.A. .
Source: Breast Cancer Research And Treatment, 2010 Nov; 124(2), p. 487-95.
PMID: 20361251
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Availability Of Driver's License Master Lists For Use In Government-sponsored Public Health Research
Authors: Walsh M.C. , Trentham-Dietz A. , Palta M. .
Source: American Journal Of Epidemiology, 2011-06-15 00:00:00.0; 173(12), p. 1414-8.
PMID: 21571870
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Selection Bias In Population-based Cancer Case-control Studies Due To Incomplete Sampling Frame Coverage
Authors: Walsh M.C. , Trentham-Dietz A. , Gangnon R.E. , Nieto F.J. , Newcomb P.A. , Palta M. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2012 Jun; 21(6), p. 881-6.
PMID: 22490319
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Disease-free Survival By Treatment After A Dcis Diagnosis In A Population-based Cohort Study
Authors: Sprague B.L. , McLaughlin V. , Hampton J.M. , Newcomb P.A. , Trentham-Dietz A. .
Source: Breast Cancer Research And Treatment, 2013 Aug; 141(1), p. 145-54.
PMID: 23979007
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