|Grant Number:||2R01CA067264-05A1 Interpret this number|
|Primary Investigator:||Newcomb, Polly|
|Organization:||University Of Wisconsin Madison|
|Project Title:||Breast Cancer in Situ: Recurrence and Quality of Life|
DESCRIPTION (provided by applicant): Breast carcinoma in situ (BCIS) is an increasingly common diagnosis with important implications for future morbidity and quality of life. We propose to extend our highly successful population-based study of BCIS to examine how recurrence and quality of life in BCIS survivors is associated with modifiable lifestyle factors. Specifically we will investigate: 1) risk factors for recurrence, including SERMs, postmenopausal hormones, behaviors such as physical activity and diet, and their interaction with histopathologic characteristics; and 2) quality of life in relation to treatment, recurrence, and time since diagnosis among BCIS survivors. We will evaluate these relationships among 1,105 incident cases of BCIS interviewed in our current study between 1997-2001 (Phase 1), and an additional 1,487 new cases to be interviewed 2002-2005 (Phase 2) between the ages of 20 and 74. All cases are identified from Wisconsin's statewide tumor registry; based on previous experience, we anticipate high participation rates (over 85 percent) in our telephone interview. The interview will provide information on quality of life (using the SF-36), lifestyle factors--including weight, alcohol intake, diet, physical activity, and medication use--and cancer treatment. Annual newsletters will be mailed to all cohort members to update any address and health status changes, and follow-up interviews will be conducted biennially to identify recurrences, second primaries, new treatments, as well as changes in quality of life and risk factors. We anticipate 232 recurrences over the follow-up period (median 5 years post initial diagnosis), as verified by information collected from treating physicians and the statewide tumor registry. By utilizing an efficient, well-established mechanism for enrolling, interviewing, and re-contacting cases, this study will provide timely and generalizable new information. There is an urgent need to understand how women may actively minimize the risk of recurrence and how this diagnosis impacts upon the quality of women's lives. The proposed population-based cohort offers a powerful opportunity to inform women and physicians as they consider the trade-offs currently inherent in BCIS treatment.
Disease-free survival by treatment after a DCIS diagnosis in a population-based cohort study.
Authors: Sprague BL, McLaughlin V, Hampton JM, Newcomb PA, Trentham-Dietz A
Source: Breast Cancer Res Treat, 2013 Aug;141(1), p. 145-54.
EPub date: 2013 Aug 25.
Selection bias in population-based cancer case-control studies due to incomplete sampling frame coverage.
Authors: Walsh MC, Trentham-Dietz A, Gangnon RE, Nieto FJ, Newcomb PA, Palta M
Source: Cancer Epidemiol Biomarkers Prev, 2012 Jun;21(6), p. 881-6.
EPub date: 2012 Apr 6.
Availability of driver's license master lists for use in government-sponsored public health research.
Authors: Walsh MC, Trentham-Dietz A, Palta M
Source: Am J Epidemiol, 2011 Jun 15;173(12), p. 1414-8.
EPub date: 2011 May 13.
Change in lifestyle behaviors and medication use after a diagnosis of ductal carcinoma in situ.
Authors: Sprague BL, Trentham-Dietz A, Nichols HB, Hampton JM, Newcomb PA
Source: Breast Cancer Res Treat, 2010 Nov;124(2), p. 487-95.
EPub date: 2010 Apr 2.
Association of COMT haplotypes and breast cancer risk in caucasian women.
Authors: Peterson NB, Trentham-Dietz A, Garcia-Closas M, Newcomb PA, Titus-Ernstoff L, Huang Y, Chanock SJ, Haines JL, Egan KM
Source: Anticancer Res, 2010 Jan;30(1), p. 217-20.
Prevalence of breast carcinoma in situ in the United States.
Authors: Sprague BL, Trentham-Dietz A
Source: JAMA, 2009 Aug 26;302(8), p. 846-8.
Tea consumption and risk of breast cancer.
Authors: Kumar N, Titus-Ernstoff L, Newcomb PA, Trentham-Dietz A, Anic G, Egan KM
Source: Cancer Epidemiol Biomarkers Prev, 2009 Jan;18(1), p. 341-5.
Oral contraceptive use and risk of breast carcinoma in situ.
Authors: Nichols HB, Trentham-Dietz A, Egan KM, Titus-Ernstoff L, Hampton JM, Newcomb PA
Source: Cancer Epidemiol Biomarkers Prev, 2007 Nov;16(11), p. 2262-8.
Cigarette smoking and risk of breast carcinoma in situ.
Authors: Trentham-Dietz A, Nichols HB, Egan KM, Titus-Ernstoff L, Hampton JM, Newcomb PA
Source: Epidemiology, 2007 Sep;18(5), p. 629-38.
Genetic variation in TP53 and risk of breast cancer in a population-based case control study.
Authors: Sprague BL, Trentham-Dietz A, Garcia-Closas M, Newcomb PA, Titus-Ernstoff L, Hampton JM, Chanock SJ, Haines JL, Egan KM
Source: Carcinogenesis, 2007 Aug;28(8), p. 1680-6.
EPub date: 2007 Apr 21.
Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk.
Authors: Gaudet MM, Egan KM, Lissowska J, Newcomb PA, Brinton LA, Titus-Ernstoff L, Yeager M, Chanock S, Welch R, Peplonska B, Trentham-Dietz A, Garcia-Closas M
Source: Hum Genet, 2007 May;121(3-4), p. 483-90.
EPub date: 2007 Jan 11.
Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium.
Authors: Breast Cancer Association Consortium
Source: J Natl Cancer Inst, 2006 Oct 4;98(19), p. 1382-96.
Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer.
Authors: Zhang Y, Newcomb PA, Egan KM, Titus-Ernstoff L, Chanock S, Welch R, Brinton LA, Lissowska J, Bardin-Mikolajczak A, Peplonska B, Szeszenia-Dabrowska N, Zatonski W, Garcia-Closas M
Source: Cancer Epidemiol Biomarkers Prev, 2006 Feb;15(2), p. 353-8.
Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses.
Authors: García-Closas M, Egan KM, Newcomb PA, Brinton LA, Titus-Ernstoff L, Chanock S, Welch R, Lissowska J, Peplonska B, Szeszenia-Dabrowska N, Zatonski W, Bardin-Mikolajczak A, Struewing JP
Source: Hum Genet, 2006 May;119(4), p. 376-88.
EPub date: 2006 Feb 17.
Collection of genomic DNA from adults in epidemiological studies by buccal cytobrush and mouthwash.
Authors: García-Closas M, Egan KM, Abruzzo J, Newcomb PA, Titus-Ernstoff L, Franklin T, Bender PK, Beck JC, Le Marchand L, Lum A, Alavanja M, Hayes RB, Rutter J, Buetow K, Brinton LA, Rothman N
Source: Cancer Epidemiol Biomarkers Prev, 2001 Jun;10(6), p. 687-96.