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Grant Details

Grant Number: 5R01CA074000-04 Interpret this number
Primary Investigator: Emmons, Karen
Organization: Dana-Farber Cancer Institute
Project Title: Multirisk Factor Intervention for Colon Polyp Patients
Fiscal Year: 2001
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Abstract

DESCRIPTION: Colorectal cancer (CRC) is the second leading cause of cancer death; over 150,000 adults are diagnosed with CRC in the United States each year. Adenomatous polyps are a highly prevalent and treatable precursor to CRC. Consistent evidence suggests physical activity, smoking, and diets that are low in fruits/vegetables and high in red meat increase risk for polyps and CRC. Thus decreasing lifestyle risk factors could especially benefit polyp patients. Having polyps diagnosed may be a teachable moment when at-risk individuals may be particularly motivated to change their risk behaviors. The US Preventive Health Services Task Force suggests that those ages 50 and older seek CRC screening, which offers the opportunity to link interventions to this potentially important teachable moment in a large at-risk group. The proposed two-site randomized trial will evaluate a state-of-the-art comprehensive multiple risk factor intervention for polyp patients using a case management model. Polyp patients (N=1425) who agree to participate will be surveyed at baseline (following colon polyp removal) and randomly assigned to either: (1) comprehensive multiple risk factor intervention, including provider recommendations for behavior change, a goal setting session with a health educator, tailored self-help materials, telephone counseling, and personal progress reports; or (2) usual care. Primary outcomes to be assessed include changes in: (1) fruit, vegetable, and red meat consumption; (2) physical activity level; (3) multiple risk factor profile; and (4) smoking cessation (among smokers only). Follow-up assessments will occur at 6 and 12 months after polyp removal, and self-reported changes in diet and smoking will be biochemically validated. A theory-based intervention protocol (based on "social ecological" Model), computer-assisted counseling, and tailored progress reports will maximize standardization of implementation across the two study sites. The intervention is suited to the managed care environment, thus increasing its potential generalize ability and disseminability. A process tracking system will enable a detailed cost-effectiveness evaluation.

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Publications

Cancer-specific concerns and physical activity among recently diagnosed breast and prostate cancer survivors.
Authors: Ottenbacher A, Sloane R, Snyder DC, Kraus W, Sprod L, Demark-Wahnefried W
Source: Integr Cancer Ther, 2013 May;12(3), p. 206-12.
EPub date: 2012 Aug 9.
PMID: 22879576
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Long-term physical activity outcomes of home-based lifestyle interventions among breast and prostate cancer survivors.
Authors: Ottenbacher AJ, Day RS, Taylor WC, Sharma SV, Sloane R, Snyder DC, Lipkus IM, Jones LW, Demark-Wahnefried W
Source: Support Care Cancer, 2012 Oct;20(10), p. 2483-9.
EPub date: 2012 Jan 17.
PMID: 22249915
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Long-term dietary outcomes of the FRESH START intervention for breast and prostate cancer survivors.
Authors: Christy SM, Mosher CE, Sloane R, Snyder DC, Lobach DF, Demark-Wahnefried W
Source: J Am Diet Assoc, 2011 Dec;111(12), p. 1844-51.
PMID: 22117660
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Exercise among breast and prostate cancer survivors--what are their barriers?
Authors: Ottenbacher AJ, Day RS, Taylor WC, Sharma SV, Sloane R, Snyder DC, Kraus WE, Demark-Wahnefried W
Source: J Cancer Surviv, 2011 Dec;5(4), p. 413-9.
EPub date: 2011 May 20.
PMID: 21598023
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Extant health behaviors and uptake of standardized vs tailored health messages among cancer survivors enrolled in the FRESH START trial: a comparison of fighting-spirits vs fatalists.
Authors: Wilkinson AV, Barrera SL, McBride CM, Snyder DC, Sloane R, Meneses KM, Pekmezi D, Kraus WE, Demark-Wahnefried W
Source: Psychooncology, 2012 Jan;21(1), p. 108-13.
EPub date: 2010 Nov 8.
PMID: 21061408
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Comparing the 7-day physical activity recall with a triaxial accelerometer for measuring time in exercise.
Authors: Sloane R, Snyder DC, Demark-Wahnefried W, Lobach D, Kraus WE
Source: Med Sci Sports Exerc, 2009 Jun;41(6), p. 1334-40.
PMID: 19461530
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Differences in baseline characteristics and outcomes at 1- and 2-year follow-up of cancer survivors accrued via self-referral versus cancer registry in the FRESH START Diet and exercise trial.
Authors: Snyder DC, Sloane R, Lobach D, Lipkus IM, Peterson B, Kraus W, Demark-Wahnefried W
Source: Cancer Epidemiol Biomarkers Prev, 2008 May;17(5), p. 1288-94.
PMID: 18483353
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Change in self-efficacy partially mediates the effects of the FRESH START intervention on cancer survivors' dietary outcomes.
Authors: Mosher CE, Fuemmeler BF, Sloane R, Kraus WE, Lobach DF, Snyder DC, Demark-Wahnefried W
Source: Psychooncology, 2008 Oct;17(10), p. 1014-23.
PMID: 18300337
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Main outcomes of the FRESH START trial: a sequentially tailored, diet and exercise mailed print intervention among breast and prostate cancer survivors.
Authors: Demark-Wahnefried W, Clipp EC, Lipkus IM, Lobach D, Snyder DC, Sloane R, Peterson B, Macri JM, Rock CL, McBride CM, Kraus WE
Source: J Clin Oncol, 2007 Jul 1;25(19), p. 2709-18.
PMID: 17602076
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Project PREVENT: a randomized trial to reduce multiple behavioral risk factors for colon cancer.
Authors: Emmons KM, McBride CM, Puleo E, Pollak KI, Clipp E, Kuntz K, Marcus BH, Napolitano M, Onken J, Farraye F, Fletcher R
Source: Cancer Epidemiol Biomarkers Prev, 2005 Jun;14(6), p. 1453-9.
PMID: 15941955
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Prevalence and predictors of multiple behavioral risk factors for colon cancer.
Authors: Emmons KM, McBride CM, Puleo E, Pollak KI, Marcus BH, Napolitano M, Clipp E, Onken J, Farraye FA, Fletcher R
Source: Prev Med, 2005 May;40(5), p. 527-34.
PMID: 15749134
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Age-related vulnerabilities of older adults with colon adenomas: evidence from Project Prevent.
Authors: Clipp EC, Carver EH, Pollak KI, Puleo E, Emmons KM, Onken J, Farraye FA, McBride CM
Source: Cancer, 2004 Mar 1;100(5), p. 1085-94.
PMID: 14983506
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Primary care residents' characteristics and motives for providing differential medical treatment of cervical cancer screening.
Authors: Arredondo EM, Pollak KI, Costanzo P, McNeilly M, Myers E
Source: J Natl Med Assoc, 2003 Jul;95(7), p. 576-84.
PMID: 12911255
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Design of FRESH START: a randomized trial of exercise and diet among cancer survivors.
Authors: Demark-Wahnefried W, Clipp EC, McBride C, Lobach DF, Lipkus I, Peterson B, Clutter Snyder D, Sloane R, Arbanas J, Kraus WE
Source: Med Sci Sports Exerc, 2003 Mar;35(3), p. 415-24.
PMID: 12618570
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Influence of stereotyping in smoking cessation counseling by primary care residents.
Authors: Pollak KI, Arredondo EM, Yarnall KS, Lipkus I, Myers E, McNeilly M, Costanzo P
Source: Ethn Dis, 2002 Fall;12(4), p. 578-85.
PMID: 12477145
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Reported cessation advice given to African Americans by health care providers in a community health clinic.
Authors: Pollak KI, Taiwo B, Lyna P, Baldwin M, Lipkus IM, Bepler G, McBride CM
Source: J Community Health, 2002 Dec;27(6), p. 381-93.
PMID: 12458781
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Women's reports of smoking cessation advice during reproductive health visits and subsequent smoking cessation.
Authors: Pollak KI, McBride CM, Scholes D, Grothaus LC, Civic D, Curry SJ
Source: Am J Manag Care, 2002 Oct;8(10), p. 837-44.
PMID: 12395952
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Relations between self-generated positive and negative expected smoking outcomes and smoking behavior: an exploratory study among adolescents.
Authors: Anderson CB, Pollak KI, Wetter DW
Source: Psychol Addict Behav, 2002 Sep;16(3), p. 196-204.
PMID: 12236454
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Factors associated with patient-recalled smoking cessation advice in a low-income clinic.
Authors: Pollak KI, Yarnall KS, Rimer BK, Lipkus I, Lyna PR
Source: J Natl Med Assoc, 2002 May;94(5), p. 354-63.
PMID: 12069216
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How do residents prioritize smoking cessation for young "high-risk" women? Factors associated with addressing smoking cessation.
Authors: Pollak KI, Arredondo EM, Yarnall KS, Lipkus I, Myers E, McNeilly M, Costanzo P
Source: Prev Med, 2001 Oct;33(4), p. 292-9.
PMID: 11570833
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Women's perceived and partners' reported support for smoking cessation during pregnancy.
Authors: Pollak KI, McBride CM, Curry SJ, Lando H, Pirie PL, Grothaus LC
Source: Ann Behav Med, 2001 Summer;23(3), p. 208-14.
PMID: 11495221
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Psychological impact of diagnosis and risk reduction among cancer survivors.
Authors: McBride CM, Clipp E, Peterson BL, Lipkus IM, Demark-Wahnefried W
Source: Psychooncology, 2000 Sep-Oct;9(5), p. 418-27.
PMID: 11038480
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