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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R35CA047448-13 Interpret this number
Primary Investigator: Whittemore, Alice
Organization: Stanford University
Project Title: Cancer Epidemiology and Biostatistics
Fiscal Year: 2000
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Abstract

Continued goals for this ongoing Outstanding Investigator Grant (OIG) are to develop and use biostatistical, biomathematical and epidemiologic methods aimed at reducing cancer occurrence. The research objectives are twofold: first, to develop new methods for the conduct of epidemiologic studies of cancer etiology in relation to modifiable personal characteristics, and second, to use these methods to collect and analyze data relating such characteristics to site- specific cancer occurrence. Both the statistical and epidemiologic work during the past four years has focussed on cancers of the colorectum, ovary, breast and prostate. The most important research accomplishments have been a study of colorectal cancer in Chinese in the US, Canada and China in relation to diet, physical activity and body size, a collaborative analysis of raw data from 12 US case- control studies of ovarian cancer, and three studies of prostate cancer. This work has been featured in editorials in several scientific journals. Future plans are to address statistical problems and epidemiologic issues that have emerged in the study of cancers of the prostate and ovary. Both the methodological and the epidemiologic effort will focus on improved understanding of the combined effects of hereditary predisposition and modifiable lifestyle characteristics in the etiologies of these cancers.

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Publications

Characteristics Relating To Ovarian Cancer Risk: Collaborative Analysis Of 12 U.s. Case-control Studies. Vi. Nonepithelial Cancers Among Adults. Collaborative Ovarian Cancer Group
Authors: Horn-Ross P.L. , Whittemore A.S. , Harris R. , Itnyre J. .
Source: Epidemiology (cambridge, Mass.), 1992 Nov; 3(6), p. 490-5.
PMID: 1329996
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Family History And Prostate Cancer Risk In Black, White, And Asian Men In The United States And Canada
Authors: Whittemore A.S. , Wu A.H. , Kolonel L.N. , John E.M. , Gallagher R.P. , Howe G.R. , West D.W. , Teh C.Z. , Stamey T. .
Source: American Journal Of Epidemiology, 1995-04-15 00:00:00.0; 141(8), p. 732-40.
PMID: 7535977
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Segregation Analysis Of Case-control Data Using Generalized Estimating Equations
Authors: Whittemore A.S. , Gong G. .
Source: Biometrics, 1994 Dec; 50(4), p. 1073-87.
PMID: 7786989
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Risks Of Cancer Among Members Of Families In The Gilda Radner Familial Ovarian Cancer Registry
Authors: Jishi M.F. , Itnyre J.H. , Oakley-Girvan I.A. , Piver M.S. , Whittemore A.S. .
Source: Cancer, 1995-10-15 00:00:00.0; 76(8), p. 1416-21.
PMID: 8620417
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Multi-stage Sampling In Genetic Epidemiology
Authors: Whittemore A.S. , Halpern J. .
Source: Statistics In Medicine, 1997 Jan 15-Feb 15; 16(1-3), p. 153-67.
PMID: 9004389
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Serum Levels Of Prostate-specific Antigen Among Japanese-american And Native Japanese Men
Authors: Shibata A. , Whittemore A.S. , Imai K. , Kolonel L.N. , Wu A.H. , John E.M. , Stamey T.A. , Paffenbarger R.S. .
Source: Journal Of The National Cancer Institute, 1997-11-19 00:00:00.0; 89(22), p. 1716-20.
PMID: 9390541
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Simple, Robust Linkage Tests For Affected Sibs
Authors: Whittemore A.S. , Tu I.P. .
Source: American Journal Of Human Genetics, 1998 May; 62(5), p. 1228-42.
PMID: 9599188
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Prostate Cancer Incidence And Mortality In The United States And The United Kingdom
Authors: Shibata A. , Ma J. , Whittemore A.S. .
Source: Journal Of The National Cancer Institute, 1998-08-19 00:00:00.0; 90(16), p. 1230-1.
PMID: 9719085
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Power Of Association And Linkage Tests When The Disease Alleles Are Unobserved
Authors: Tu I.P. , Whittemore A.S. .
Source: American Journal Of Human Genetics, 1999 Feb; 64(2), p. 641-9.
PMID: 9973303
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Detection Of Disease Genes By Use Of Family Data. I. Likelihood-based Theory
Authors: Whittemore A.S. , Tu I.P. .
Source: American Journal Of Human Genetics, 2000 Apr; 66(4), p. 1328-40.
PMID: 10739758
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The Eighth Aacr American Cancer Society Award Lecture On Cancer Epidemiology And Prevention. Genetically Tailored Preventive Strategies: An Effective Plan For The Twenty-first Century? American Association For Cancer Research
Authors: Whittemore A.S. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1999 Aug; 8(8), p. 649-58.
PMID: 10744124
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Pseudoautosomal Linkage Of Hodgkin Disease
Authors: Whittemore A.S. , Shih M.C. .
Source: American Journal Of Human Genetics, 2000 Aug; 67(2), p. 535-7.
PMID: 10889053
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Declining Ovarian Cancer Rates In U.s. Women In Relation To Parity And Oral Contraceptive Use
Authors: Gnagy S. , Ming E.E. , Devesa S.S. , Hartge P. , Whittemore A.S. .
Source: Epidemiology (cambridge, Mass.), 2000 Mar; 11(2), p. 102-5.
PMID: 11021604
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Problems In The Definition, Interpretation, And Evaluation Of Genetic Heterogeneity
Authors: Whittemore A.S. , Halpern J. .
Source: American Journal Of Human Genetics, 2001 Feb; 68(2), p. 457-65.
PMID: 11170893
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Allele-sharing Among Affected Relatives: Non-parametric Methods For Identifying Genes
Authors: Shih M.C. , Whittemore A.S. .
Source: Statistical Methods In Medical Research, 2001 Feb; 10(1), p. 27-55.
PMID: 11329690
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A Genome Screen Of Families With Multiple Cases Of Prostate Cancer: Evidence Of Genetic Heterogeneity
Authors: Hsieh C.L. , Oakley-Girvan I. , Balise R.R. , Halpern J. , Gallagher R.P. , Wu A.H. , Kolonel L.N. , O'Brien L.E. , Lin I.G. , Van Den Berg D.J. , et al. .
Source: American Journal Of Human Genetics, 2001 Jul; 69(1), p. 148-58.
PMID: 11404817
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Tests For Genetic Association Using Family Data
Authors: Shih M.C. , Whittemore A.S. .
Source: Genetic Epidemiology, 2002 Feb; 22(2), p. 128-45.
PMID: 11788959
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Comparison Of Dna- And Rna-based Methods For Detection Of Truncating Brca1 Mutations
Authors: Andrulis I.L. , Anton-Culver H. , Beck J. , Bove B. , Boyd J. , Buys S. , Godwin A.K. , Hopper J.L. , Li F. , Neuhausen S.L. , et al. .
Source: Human Mutation, 2002 Jul; 20(1), p. 65-73.
PMID: 12112659
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Segregation Analysis Of Prostate Cancer In 1,719 White, African-american And Asian-american Families In The United States And Canada
Authors: Gong G. , Oakley-Girvan I. , Wu A.H. , Kolonel L.N. , John E.M. , West D.W. , Felberg A. , Gallagher R.P. , Whittemore A.S. .
Source: Cancer Causes & Control : Ccc, 2002 Jun; 13(5), p. 471-82.
PMID: 12146852
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Oral Contraceptive Use And Ovarian Cancer Risk Among Carriers Of Brca1 Or Brca2 Mutations
Authors: Whittemore A.S. , Balise R.R. , Pharoah P.D. , Dicioccio R.A. , Oakley-Girvan I. , Ramus S.J. , Daly M. , Usinowicz M.B. , Garlinghouse-Jones K. , Ponder B.A. , et al. .
Source: British Journal Of Cancer, 2004-11-29 00:00:00.0; 91(11), p. 1911-5.
PMID: 15545966
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