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Grant Details

Grant Number: 5R01CA071745-04 Interpret this number
Primary Investigator: Reynolds, Peggy
Organization: Impact Assessment, Inc.
Project Title: Childhood Cancer-Etiologic Clues Using Gis
Fiscal Year: 1999
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Abstract

DESCRIPTION: (Adapted from Investigator's Abstract) Little is known about the causes of childhood cancers, but there has been increasing public concern that environmental toxicants may contribute to the risk of developing this heterogeneous group of diseases. California, with the largest population-based cancer registry in the world and with a unique wealth of environmental exposure databases, provides an unusual opportunity to evaluate these rare malignancies in geographically and socio-culturally diverse settings. The proposed study seeks to evaluate the first five years (1988-1992) of California statewide population-based childhood cancer incidence data in conjunction with geographic indicators of the socio-cultural diversity of the state, and in conjunction with well characterized and temporally relevant detailed statewide environmental exposure information, to explore some of the more prominent current hypotheses about environmental influences on the etiology of these diseases. This work is designed to build on the California Department of Health Services/Environmental Health Investigation Branch's long history of work in the study of childhood cancer "clusters", in characterizing environmental exposures of concern to human health, and in developing geographic information system (GIS) analysis strategies to complement epidemiologic research efforts. Specific aims are targeted at an evaluation of: - How childhood cancer rates vary with geographically defined environmental emissions or exposures; - How childhood cancer rates vary by demographic characteristics of the population; and - The independent effects of environmental or demographic risk associations. The proposed research is designed to identify risk associations worthy of more in-depth investigation, while minimizing some of the limitations of ecologic research. The investigators state that the availability of unique existing databases to characterize both exposure and disease outcome in California's large and heterogeneous population offer an opportunity to integrate epidemiologic, environmental exposure, and GIS analytic strategies to enhance our understanding of factors influencing a group of rare diseases which constitute a major cause of death in children.

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Publications

Birth characteristics and risk of neuroblastoma in young children.
Authors: Urayama KY, Von Behren J, Reynolds P
Source: Am J Epidemiol, 2007 Mar 1;165(5), p. 486-95.
EPub date: 2006 Dec 12.
PMID: 17164463
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Agricultural pesticides and lymphoproliferative childhood cancer in California.
Authors: Reynolds P, Von Behren J, Gunier R, Goldberg DE, Hertz A
Source: Scand J Work Environ Health, 2005;31 Suppl 1, p. 46-54; discussion 5-7.
PMID: 16190149
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Agricultural pesticide use and childhood cancer in California.
Authors: Reynolds P, Von Behren J, Gunier RB, Goldberg DE, Harnly M, Hertz A
Source: Epidemiology, 2005 Jan;16(1), p. 93-100.
PMID: 15613951
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Birth characteristics and hepatoblastoma risk in young children.
Authors: Reynolds P, Urayama KY, Von Behren J, Feusner J
Source: Cancer, 2004 Mar 1;100(5), p. 1070-6.
PMID: 14983504
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Residential exposure to traffic in California and childhood cancer.
Authors: Reynolds P, Von Behren J, Gunier RB, Goldberg DE, Hertz A
Source: Epidemiology, 2004 Jan;15(1), p. 6-12.
PMID: 14712141
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Birth characteristics and brain cancers in young children.
Authors: Von Behren J, Reynolds P
Source: Int J Epidemiol, 2003 Apr;32(2), p. 248-56.
PMID: 12714545
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Childhood cancer incidence rates and hazardous air pollutants in California: an exploratory analysis.
Authors: Reynolds P, Von Behren J, Gunier RB, Goldberg DE, Hertz A, Smith DF
Source: Environ Health Perspect, 2003 Apr;111(4), p. 663-8.
PMID: 12676632
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Traffic patterns and childhood cancer incidence rates in California, United States.
Authors: Reynolds P, Von Behren J, Gunier RB, Goldberg DE, Hertz A, Smith D
Source: Cancer Causes Control, 2002 Sep;13(7), p. 665-73.
PMID: 12296514
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Birth characteristics and leukemia in young children.
Authors: Reynolds P, Von Behren J, Elkin EP
Source: Am J Epidemiol, 2002 Apr 1;155(7), p. 603-13.
PMID: 11914187
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Agricultural pesticide use in California: pesticide prioritization, use densities, and population distributions for a childhood cancer study.
Authors: Gunier RB, Harnly ME, Reynolds P, Hertz A, Von Behren J
Source: Environ Health Perspect, 2001 Oct;109(10), p. 1071-8.
PMID: 11689348
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