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Grant Details

Grant Number: 5R01CA047305-12 Interpret this number
Primary Investigator: Egan, Kathleen
Organization: Harvard University (Medical School)
Project Title: Hormones, Lifestyle and Breast Cancer
Fiscal Year: 1999
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Abstract

DESCRIPTION: (Adapted from Investigator's Abstract) The investigators propose to continue their consortium of population-based case-control studies to 1) investigate the relation between postmenopausal hormone therapy and breast cancer mortality, and 2) evaluate the relation between certain lifestyle factors, including weight change, physical activity, pregnancy termination, and breast cancer incidence. (As in the past, Wisconsin, Harvard, and Dartmouth will have submitted separate applications with identical research plans.) Several studies have suggested improved survival among women using estrogen preparations at the time of breast cancer diagnosis. The investigators will evaluate the relation between postmenopausal hormone therapy and breast cancer mortality, ascertained though state vital records and the National Death Index, among cases enrolled in our previous and ongoing collaborative breast cancer studies in Wisconsin, Massachusetts, and New Hampshire (1988-95). Of the nearly 13,000 cases enrolled, they estimate that a minimum of 2600 deaths will have occurred in postmenopausal women. Thus, they will have ample power to evaluate the effects of postmenopausal hormone therapy, and to assess potential interactions with alcohol use and obesity, which may influence endogenous hormone levels. In addition, the availability of extensive questionnaire information will allow exploration of the possible effects of other exposures, including smoking and dietary factors, on breast cancer mortality. To meet their second aim, they will enroll 9000 breast cancer cases aged 20-69 and a comparable number of controls in our respective states over a 3-year period. Cases will be identified through state tumor registries, and controls through state drivers license lists and Medicare beneficiary lists. The large sample size is necessary to evaluate study hypotheses since the associations of interest are modest and patterns of exposure infrequent, e.g., weight gain at specific ages and induced abortions prior to full term pregnancies. The investigators state that the proposed studies, based on an efficient, well-established mechanism for selecting and interviewing cases and controls, and analysis of existing population-based data on thousands of women with breast cancer, will provide timely new information on potentially modifiable lifestyle determinants of breast cancer incidence and survival, in a highly cost-effective manner.

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Publications

Breast cancer susceptibility loci in association with age at menarche, age at natural menopause and the reproductive lifespan.
Authors: Warren Andersen S, Trentham-Dietz A, Gangnon RE, Hampton JM, Skinner HG, Engelman CD, Klein BE, Titus LJ, Egan KM, Newcomb PA
Source: Cancer Epidemiol, 2014 Feb;38(1), p. 62-5.
EPub date: 2013 Dec 25.
PMID: 24373701
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Pre-diagnosis oophorectomy, estrogen therapy and mortality in a cohort of women diagnosed with breast cancer.
Authors: Nichols HB, Trentham-Dietz A, Newcomb PA, Egan KM, Titus LJ, Hampton JM, Visvanathan K
Source: Breast Cancer Res, 2013;15(5), p. R99.
PMID: 24152546
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Breast cancer susceptibility associated with rs1219648 (fibroblast growth factor receptor 2) and postmenopausal hormone therapy use in a population-based United States study.
Authors: Andersen SW, Trentham-Dietz A, Figueroa JD, Titus LJ, Cai Q, Long J, Hampton JM, Egan KM, Newcomb PA
Source: Menopause, 2013 Mar;20(3), p. 354-8.
PMID: 23435034
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Postoophorectomy estrogen use and breast cancer risk.
Authors: Nichols HB, Trentham-Dietz A, Newcomb PA, Titus LJ, Egan KM, Hampton JM, Visvanathan K
Source: Obstet Gynecol, 2012 Jul;120(1), p. 27-36.
PMID: 22914389
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A multistage genetic association study identifies breast cancer risk loci at 10q25 and 16q24.
Authors: Higginbotham KS, Breyer JP, McReynolds KM, Bradley KM, Schuyler PA, Plummer WD, Freudenthal ME, Trentham-Dietz A, Newcomb PA, Parl FF, Sanders ME, Page DL, Egan KM, Dupont WD, Smith JR
Source: Cancer Epidemiol Biomarkers Prev, 2012 Sep;21(9), p. 1565-73.
EPub date: 2012 Jul 17.
PMID: 22806168
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Reproductive factors and histologic subtype in relation to mortality after a breast cancer diagnosis.
Authors: Warren Andersen S, Newcomb PA, Hampton JM, Titus-Ernstoff L, Egan KM, Trentham-Dietz A
Source: Breast Cancer Res Treat, 2011 Dec;130(3), p. 975-80.
EPub date: 2011 Jul 19.
PMID: 21769659
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A multistage association study identifies a breast cancer genetic locus at NCOA7.
Authors: Higginbotham KS, Breyer JP, Bradley KM, Schuyler PA, Plummer WD Jr, Freudenthal ME, Trentham-Dietz A, Newcomb PA, Sanders ME, Page DL, Parl FF, Egan KM, Dupont WD, Smith JR
Source: Cancer Res, 2011 Jun 1;71(11), p. 3881-8.
EPub date: 2011 May 24.
PMID: 21610108
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Late age at first full term birth is strongly associated with lobular breast cancer.
Authors: Newcomb PA, Trentham-Dietz A, Hampton JM, Egan KM, Titus-Ernstoff L, Warren Andersen S, Greenberg ER, Willett WC
Source: Cancer, 2011 May 1;117(9), p. 1946-56.
EPub date: 2010 Nov 10.
PMID: 21509772
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Bilateral oophorectomy in relation to risk of postmenopausal breast cancer: confounding by nonmalignant indications for surgery?
Authors: Nichols HB, Visvanathan K, Newcomb PA, Hampton JM, Egan KM, Titus-Ernstoff L, Trentham-Dietz A
Source: Am J Epidemiol, 2011 May 15;173(10), p. 1111-20.
EPub date: 2011 Mar 23.
PMID: 21430192
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Post-diagnosis dietary factors and survival after invasive breast cancer.
Authors: Beasley JM, Newcomb PA, Trentham-Dietz A, Hampton JM, Bersch AJ, Passarelli MN, Holick CN, Titus-Ernstoff L, Egan KM, Holmes MD, Willett WC
Source: Breast Cancer Res Treat, 2011 Jul;128(1), p. 229-36.
EPub date: 2011 Jan 1.
PMID: 21197569
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Social networks and survival after breast cancer diagnosis.
Authors: Beasley JM, Newcomb PA, Trentham-Dietz A, Hampton JM, Ceballos RM, Titus-Ernstoff L, Egan KM, Holmes MD
Source: J Cancer Surviv, 2010 Dec;4(4), p. 372-80.
EPub date: 2010 Jul 23.
PMID: 20652435
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Sleep duration and obesity in a population-based study.
Authors: Anic GM, Titus-Ernstoff L, Newcomb PA, Trentham-Dietz A, Egan KM
Source: Sleep Med, 2010 May;11(5), p. 447-51.
EPub date: 2010 Apr 3.
PMID: 20363668
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Association of COMT haplotypes and breast cancer risk in caucasian women.
Authors: Peterson NB, Trentham-Dietz A, Garcia-Closas M, Newcomb PA, Titus-Ernstoff L, Huang Y, Chanock SJ, Haines JL, Egan KM
Source: Anticancer Res, 2010 Jan;30(1), p. 217-20.
PMID: 20150638
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Body mass index before and after breast cancer diagnosis: associations with all-cause, breast cancer, and cardiovascular disease mortality.
Authors: Nichols HB, Trentham-Dietz A, Egan KM, Titus-Ernstoff L, Holmes MD, Bersch AJ, Holick CN, Hampton JM, Stampfer MJ, Willett WC, Newcomb PA
Source: Cancer Epidemiol Biomarkers Prev, 2009 May;18(5), p. 1403-9.
EPub date: 2009 Apr 14.
PMID: 19366908
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Dietary carotenoids and the risk of invasive breast cancer.
Authors: Mignone LI, Giovannucci E, Newcomb PA, Titus-Ernstoff L, Trentham-Dietz A, Hampton JM, Willett WC, Egan KM
Source: Int J Cancer, 2009 Jun 15;124(12), p. 2929-37.
PMID: 19330841
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Exposure to breast milk in infancy and risk of breast cancer.
Authors: Wise LA, Titus-Ernstoff L, Newcomb PA, Trentham-Dietz A, Trichopoulos D, Hampton JM, Egan KM
Source: Cancer Causes Control, 2009 Sep;20(7), p. 1083-90.
EPub date: 2009 Mar 29.
PMID: 19330531
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No difference between red wine or white wine consumption and breast cancer risk.
Authors: Newcomb PA, Nichols HB, Beasley JM, Egan K, Titus-Ernstoff L, Hampton JM, Trentham-Dietz A
Source: Cancer Epidemiol Biomarkers Prev, 2009 Mar;18(3), p. 1007-10.
PMID: 19273487
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Antidepressant medication use and breast cancer risk.
Authors: Wernli KJ, Hampton JM, Trentham-Dietz A, Newcomb PA
Source: Pharmacoepidemiol Drug Saf, 2009 Apr;18(4), p. 284-90.
PMID: 19226540
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Tea consumption and risk of breast cancer.
Authors: Kumar N, Titus-Ernstoff L, Newcomb PA, Trentham-Dietz A, Anic G, Egan KM
Source: Cancer Epidemiol Biomarkers Prev, 2009 Jan;18(1), p. 341-5.
PMID: 19124518
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Meat consumption, heterocyclic amines, NAT2, and the risk of breast cancer.
Authors: Mignone LI, Giovannucci E, Newcomb PA, Titus-Ernstoff L, Trentham-Dietz A, Hampton JM, Orav EJ, Willett WC, Egan KM
Source: Nutr Cancer, 2009;61(1), p. 36-46.
PMID: 19116874
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Childbearing recency and modifiers of premenopausal breast cancer risk.
Authors: Peterson NB, Huang Y, Newcomb PA, Titus-Ernstoff L, Trentham-Dietz A, Anic G, Egan KM
Source: Cancer Epidemiol Biomarkers Prev, 2008 Nov;17(11), p. 3284-7.
PMID: 18990773
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Proportion of invasive breast cancer attributable to risk factors modifiable after menopause.
Authors: Sprague BL, Trentham-Dietz A, Egan KM, Titus-Ernstoff L, Hampton JM, Newcomb PA
Source: Am J Epidemiol, 2008 Aug 15;168(4), p. 404-11.
EPub date: 2008 Jun 13.
PMID: 18552361
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Inverse association of NSAID use and ovarian cancer in relation to oral contraceptive use and parity.
Authors: Wernli KJ, Newcomb PA, Hampton JM, Trentham-Dietz A, Egan KM
Source: Br J Cancer, 2008 Jun 3;98(11), p. 1781-3.
EPub date: 2008 May 27.
PMID: 18506182
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Physical activity and survival after diagnosis of invasive breast cancer.
Authors: Holick CN, Newcomb PA, Trentham-Dietz A, Titus-Ernstoff L, Bersch AJ, Stampfer MJ, Baron JA, Egan KM, Willett WC
Source: Cancer Epidemiol Biomarkers Prev, 2008 Feb;17(2), p. 379-86.
EPub date: 2008 Feb 4.
PMID: 18250341
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Statin use and risk of breast cancer.
Authors: Pocobelli G, Newcomb PA, Trentham-Dietz A, Titus-Ernstoff L, Hampton JM, Egan KM
Source: Cancer, 2008 Jan 1;112(1), p. 27-33.
PMID: 18008366
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Oral contraceptive use and risk of breast carcinoma in situ.
Authors: Nichols HB, Trentham-Dietz A, Egan KM, Titus-Ernstoff L, Hampton JM, Newcomb PA
Source: Cancer Epidemiol Biomarkers Prev, 2007 Nov;16(11), p. 2262-8.
PMID: 18006914
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Cigarette smoking and risk of breast carcinoma in situ.
Authors: Trentham-Dietz A, Nichols HB, Egan KM, Titus-Ernstoff L, Hampton JM, Newcomb PA
Source: Epidemiology, 2007 Sep;18(5), p. 629-38.
PMID: 17700252
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Genetic variation in TP53 and risk of breast cancer in a population-based case control study.
Authors: Sprague BL, Trentham-Dietz A, Garcia-Closas M, Newcomb PA, Titus-Ernstoff L, Hampton JM, Chanock SJ, Haines JL, Egan KM
Source: Carcinogenesis, 2007 Aug;28(8), p. 1680-6.
EPub date: 2007 Apr 21.
PMID: 17449902
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Occupational exposure to electromagnetic field and breast cancer risk in a large, population-based, case-control study in the United States.
Authors: McElroy JA, Egan KM, Titus-Ernstoff L, Anderson HA, Trentham-Dietz A, Hampton JM, Newcomb PA
Source: J Occup Environ Med, 2007 Mar;49(3), p. 266-74.
PMID: 17351512
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Lifetime recreational and occupational physical activity and risk of in situ and invasive breast cancer.
Authors: Sprague BL, Trentham-Dietz A, Newcomb PA, Titus-Ernstoff L, Hampton JM, Egan KM
Source: Cancer Epidemiol Biomarkers Prev, 2007 Feb;16(2), p. 236-43.
PMID: 17301255
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Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk.
Authors: Gaudet MM, Egan KM, Lissowska J, Newcomb PA, Brinton LA, Titus-Ernstoff L, Yeager M, Chanock S, Welch R, Peplonska B, Trentham-Dietz A, Garcia-Closas M
Source: Hum Genet, 2007 May;121(3-4), p. 483-90.
EPub date: 2007 Jan 11.
PMID: 17216494
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Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium.
Authors: Breast Cancer Association Consortium
Source: J Natl Cancer Inst, 2006 Oct 4;98(19), p. 1382-96.
PMID: 17018785
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From menarche to menopause: trends among US Women born from 1912 to 1969.
Authors: Nichols HB, Trentham-Dietz A, Hampton JM, Titus-Ernstoff L, Egan KM, Willett WC, Newcomb PA
Source: Am J Epidemiol, 2006 Nov 15;164(10), p. 1003-11.
EPub date: 2006 Aug 23.
PMID: 16928728
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Familial relative risk estimates for use in epidemiologic analyses.
Authors: Yasui Y, Newcomb PA, Trentham-Dietz A, Egan KM
Source: Am J Epidemiol, 2006 Oct 1;164(7), p. 697-705.
EPub date: 2006 Aug 21.
PMID: 16923773
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Alcohol consumption and ovarian cancer risk in a population-based case-control study.
Authors: Peterson NB, Trentham-Dietz A, Newcomb PA, Chen Z, Hampton JM, Willett WC, Egan KM
Source: Int J Cancer, 2006 Nov 15;119(10), p. 2423-7.
PMID: 16921486
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Duration of sleep and breast cancer risk in a large population-based case-control study.
Authors: McElroy JA, Newcomb PA, Titus-Ernstoff L, Trentham-Dietz A, Hampton JM, Egan KM
Source: J Sleep Res, 2006 Sep;15(3), p. 241-9.
PMID: 16911025
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Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer.
Authors: Zhang Y, Newcomb PA, Egan KM, Titus-Ernstoff L, Chanock S, Welch R, Brinton LA, Lissowska J, Bardin-Mikolajczak A, Peplonska B, Szeszenia-Dabrowska N, Zatonski W, Garcia-Closas M
Source: Cancer Epidemiol Biomarkers Prev, 2006 Feb;15(2), p. 353-8.
PMID: 16492928
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Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses.
Authors: García-Closas M, Egan KM, Newcomb PA, Brinton LA, Titus-Ernstoff L, Chanock S, Welch R, Lissowska J, Peplonska B, Szeszenia-Dabrowska N, Zatonski W, Bardin-Mikolajczak A, Struewing JP
Source: Hum Genet, 2006 May;119(4), p. 376-88.
EPub date: 2006 Feb 17.
PMID: 16485136
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Oral contraceptive use and risk of breast cancer by histologic type.
Authors: Newcomer LM, Newcomb PA, Trentham-Dietz A, Longnecker MP, Greenberg ER
Source: Int J Cancer, 2003 Oct 10;106(6), p. 961-4.
PMID: 12918077
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Postmenopausal hormone therapy and risk of breast cancer by histologic type (United States).
Authors: Newcomer LM, Newcomb PA, Potter JD, Yasui Y, Trentham-Dietz A, Storer BE, Longnecker MP, Baron JA, Daling JR
Source: Cancer Causes Control, 2003 Apr;14(3), p. 225-33.
PMID: 12814201
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Postmenopausal estrogen and progestin use in relation to breast cancer risk.
Authors: Newcomb PA, Titus-Ernstoff L, Egan KM, Trentham-Dietz A, Baron JA, Storer BE, Willett WC, Stampfer MJ
Source: Cancer Epidemiol Biomarkers Prev, 2002 Jul;11(7), p. 593-600.
PMID: 12101105
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